Thesis (M.Sc.)--University of Hong Kong, 1998. / Includes bibliographical references (leaf 184-190) Also available in print.

Under environmental stress, such as glucose deprivation, cells form stress granules - the accumulation of cytoplasmic aggregates of repressed translational initiation complexes, proteins, and stalled mRNAs. Recent research implicates stress granules in various diseases, such as neurodegenerative disease, but the exact regulators responsible for the assembly and disassembly of stress granules are unknown. Studies detect post-translational modifications on core stress granule proteins. One modification is lysine acetylation, in which a substrate is regulated by a lysine acetyltransferase (KAT) and lysine deacetylase (KDAC). My project deciphers the impact of lysine acetylation on an essential protein found in stress granules, poly(A) binding protein (Pab1) in Saccharomyces cerevisiae. In this work, I demonstrated that acetylation mimic of Pab1-K131 reduces stress granule formation upon glucose deprivation, and other stressors such as ethanol, raffinose, and vanillin. A potential KDAC that might be facilitating this role is Rpd3. Further, electromobility shift assay studies suggest that acetylation mimic of Pab1-K131 negatively impacts poly(A) RNA binding. This work will be useful when exploring therapeutic options when combating diseases linked to stress granules.

[EN] SUMMARY "Vibraphones in jazz: the jazz vibraphone in Spain" is a thesis addressing three clearly differenciated and yet related parts - for each one of them is indispensable for the full comprehension of the next. The three topics herein addressed are: 1.- The vibraphone. In this part a description of the instrument is made, as well as references to the different types of vibraphones, performing techniques and the use of vibraphones in the 20th century. 2.- Vibraphones in international jazz. In this part an analysis of the origin of the vibraphone, its evolution and performers is carried out by connecting this topic to the different styles in jazz history. 3.- Jazz vibraphones in Spain. This is by far the most important part of this thesis. Here, starting from the Spanish Jazz history, we speak about the arrival of the vibraphone in our country, its introduction and classical conservatory teaching methodology, the main Spanish vibraphones and mallet manufacturers, predecesors of jazz vibraphones (jazz players, first jazz xylophone and vibraphone players from the 30s and 40s), Spanish Jazz vibraphone players born since the 30s, international Jazz vibraphone players with residence in Spain and main concerts performed in Spain by international vibraphone players. This thesis presents various annexes in connection to vibraphones, such as the evolution of the different models of "Deagan" vibraphones, the presence of vibraphones in chamber music, examples of vibraphone mallet models depending on manufacturers, jazz vibraphone players throughout history, jazz players, first jazz xylophone and vibraphone players in Spain, websites consulted, and finally "technical exercises for jazz vibraphone". This thesis gathers numerous figures and testimonials of the main leading figures involved with Jazz vibraphones in Spain. Apart from that, it includes several indexes, such as illustrations, tables of contents or lists of vibraphone players. This thesis ends with a specific bibliography on vibraphones, the bibliography herein used and conclusions on each of the three parts previously explained. As a main byproduct of this thesis it is noteworthy the creation of an Internet Forum -http://vibrafonojazzistico.blogspot.com- which lists and allowes Spanish Jazz vibraphone players to get in touch. In short, this thesis puts names and surnames to the protagonists of a never before told story, the story of the Jazz vibraphone players in Spain. / [ES] RESUMEN "El vibráfono en el jazz: el vibráfono jazzístico en España" es una tesis que aborda tres partes claramente diferenciadas, y a la vez relacionadas entre sí, ya que cada una de ellas es imprescindible para comprender la siguiente. Los tres temas abordados son: 1.- El vibráfono. En esta parte se realiza una descripción del instrumento y se tratan los diferentes tipos de vibráfonos, las técnicas de ejecución y la utilización del vibráfono en el siglo XX. 2.- El vibráfono en el jazz internacional. En esta parte se analiza el origen del vibráfono y su evolución e intérpretes, relacionando este tema con los diferentes estilos de la historia del jazz. 3.- El vibráfono jazzístico en España. Esta es la parte más importante de la tesis. En ella, partiendo de la historia del jazz en España, se comenta la llegada del vibráfono a nuestro país, su introducción y didáctica clásica en los conservatorios, los principales fabricantes españoles de vibráfonos y baquetas de vibráfono, los antecedentes del vibráfono jazzístico ("jazz-bandistas", primeros xilofonistas "jazzísticos" y vibrafonistas de los años 30 y 40), vibrafonistas jazzísticos españoles nacidos desde la década de los años 30 hasta la actualidad, vibrafonistas jazzísticos internacionales residentes en España y principales conciertos realizados en España por vibrafonistas internacionales. La tesis presenta diversos anexos relacionados con el vibráfono, como la evolución de los distintos modelos de vibráfonos "Deagan", la presencia del vibráfono en la música de cámara, ejemplos de modelos de baquetas de vibráfono según fabricante, vibrafonistas de jazz a lo largo de la historia, "jazz-bandistas", primeros xilofonistas "jazzísticos" y vibrafonistas jazzísticos en España, páginas web consultadas y "ejercicios técnicos para el vibráfono jazzístico". La tesis recoge numerosas figuras y testimonios de las principales figuras relacionadas con el vibráfono jazzístico en España. Además, incluye diversos índices, como por ejemplo ilustraciones, tablas o vibrafonistas. La tesis finaliza con una bibliografía específica de vibráfono, la bibliografía empleada y las conclusiones de cada una de las tres partes explicadas anteriormente. Una de las utilidades más importantes que ha supuesto la elaboración de esta tesis ha sido la creación de un foro en internet que reúne y pone en contacto a los vibrafonistas de jazz españoles, http://vibrafonojazzistico.blogspot.com. En definitiva, esta tesis pone nombre y apellidos a los protagonistas de una historia nunca contada, la historia del vibráfono jazzístico en España. / [CA] RESUM "El vibràfon en el jazz: el vibràfon jazzístic a España" és una tesi que aborda tres parts clarament diferenciades, i al mateix temps relacionades entre si, ja que cada una d'elles és imprescindible per a comprendre la següent. Els tres temes abordats són: 1.- El vibràfon. En esta part es realitza una descripció de l'instrument i es tracten els diferents tipus de vibràfons, les tècniques d'execució i la utilització del vibràfon en el segle XX. 2.- El vibràfon en el jazz internacional. En esta part s'analitza l'origen del vibràfon i la seua evolució i intèrprets, relacionant este tema amb els diferents estils de la història del jazz. 3.- El vibràfon jazzístic a Espanya. Esta és la part més important de la tesi. En ella, partint de la història del jazz a Espanya, es comenta l'arribada del vibràfon al nostre país, la seua introducció i didàctica clàssica en els conservatoris, els principals fabricants espanyols de vibràfons i baquetes de vibràfon, els antecedents del vibràfon jazzístic ("jazz-bandistas", primers xilofonistas "jazzístics" i vibrafonistas dels anys 30 i 40), vibrafonistas jazzístics espanyols nascuts des de la dècada dels anys 30 fins a l'actualitat, vibrafonistas jazzístics internacionals residents a Espanya i principals concerts realitzats a Espanya per vibrafonistas internacionals. La tesi presenta diversos annexos relacionats amb el vibràfon, com l'evolució dels distints models de vibràfons "Deagan", la presència del vibràfon en la música de cambra, exemples de models de baquetes de vibràfon segons fabricant, vibrafonistas de jazz al llarg de la història, "jazz-bandistas", primers xilofonistas "jazzístics" i vibrafonistas jazzístics a Espanya, pàgines web consultades i "exercicis tècnics per al vibràfon jazzístic". La tesi arreplega nombroses figures i testimonis de les principals figures relacionades amb el vibràfon jazzístic a Espanya. A més, inclou diversos índexs, com per exemple il¿lustracions, taules o vibrafonistas. La tesi finalitza amb una bibliografia específica de vibràfon, la bibliografia utilitzada i les conclusions de cada una de les tres parts explicades anteriorment. Una de les utilitats més importants que ha suposat l'elaboració d'esta tesi ha sigut la creació d'un fòrum en internet que reunix i posa en contacte als vibrafonistas de jazz espanyols, http://vibrafonojazzistico.blogspot.com. En definitiva, esta tesi posa nom i cognoms als protagonistes d'una història mai contada, la història del vibràfon jazzístic a Espanya. / Pérez Vigo, R. (2016). El Vibráfono en el jazz: El Vibráfono Jazzístico en España [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/62323

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro / Esta dissertação de mestrado tem como Leitmotiv (motivo principal) a análise do problema da causalidade em Kant e a interpretação desta pelos neokantianos na formulação da causalidade das ciências naturais e da causalidade das ciências do espírito. A relevância desta pesquisa reside no enraizamento da concepção de causalidade nas tradições da geografia moderna, na polêmica trazida pelos neokantianos ao separarem causalidade em geografia humana de causalidade em geografia física e no fato de que, nos movimentos de retorno à obra de Kant, a causalidade foi preterida diante de temas como espaço e physische Geographie. A hipótese desta pesquisa é que a causalidade torna-se um problema na obra crítica de Kant ao articularmos os domínios de Liberdade e Natureza. Assim, apresentaremos os preceitos filosóficos kantianos, um panorama da História Natural e a temática da causalidade nas suas obras críticas, apontando a influência do seu pensamento na estruturação da geografia alemã neokantiana / This masters degree essay has as Leitmotiv (main reason) the analysis of the problem of causality in Kant and the interpretation of this one by the Neo-Kantians in formulation of causality of natural sciences and of the causality of science of spirit. The relevance of this research is the rooting of the conception of causality in the traditions of modern geography, the controversy brought by Neo-Kantians at the separate causality in human geography of causality in the physiographic and the fact that, in the movements of return to Kants work, the causality was deprecated before subjects as space and e physische Geographie. This researchs hypothesis is that the causality becomes a problem in the critical work of Kant to articulate the areas of Freedom and Nature. Therefore, it will present the Kantians philosophical precepts, an overview of Natural History and the thematic of the causality in his critical works, pointing the influence of his thinking in structuring the Neo-Kantian German geography.

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro / Esta dissertação de mestrado tem como Leitmotiv (motivo principal) a análise do problema da causalidade em Kant e a interpretação desta pelos neokantianos na formulação da causalidade das ciências naturais e da causalidade das ciências do espírito. A relevância desta pesquisa reside no enraizamento da concepção de causalidade nas tradições da geografia moderna, na polêmica trazida pelos neokantianos ao separarem causalidade em geografia humana de causalidade em geografia física e no fato de que, nos movimentos de retorno à obra de Kant, a causalidade foi preterida diante de temas como espaço e physische Geographie. A hipótese desta pesquisa é que a causalidade torna-se um problema na obra crítica de Kant ao articularmos os domínios de Liberdade e Natureza. Assim, apresentaremos os preceitos filosóficos kantianos, um panorama da História Natural e a temática da causalidade nas suas obras críticas, apontando a influência do seu pensamento na estruturação da geografia alemã neokantiana / This masters degree essay has as Leitmotiv (main reason) the analysis of the problem of causality in Kant and the interpretation of this one by the Neo-Kantians in formulation of causality of natural sciences and of the causality of science of spirit. The relevance of this research is the rooting of the conception of causality in the traditions of modern geography, the controversy brought by Neo-Kantians at the separate causality in human geography of causality in the physiographic and the fact that, in the movements of return to Kants work, the causality was deprecated before subjects as space and e physische Geographie. This researchs hypothesis is that the causality becomes a problem in the critical work of Kant to articulate the areas of Freedom and Nature. Therefore, it will present the Kantians philosophical precepts, an overview of Natural History and the thematic of the causality in his critical works, pointing the influence of his thinking in structuring the Neo-Kantian German geography.

My diploma work follows up Czech Republic inhabitants' attitudes toward the death penalty. It also describes changes in death penalty perception in terms of historical aspect, its presentation to public society, changes in approach to death penalty and violence in general over time. It deals with execution types development, executioner's social position and craft. It brings elementary thoughts of advocates and opponents of the death penalty and describes related contemporary situation in the world. All these chapters are included for broader context description to allow me better use and identify results from the survey. The other part of my diploma work is survey with focus on attitudes toward the death penalty in Czech Republic. It was conducted in 2012-13, based on online respondent panel, with use of quantitative methods. This market research survey was executed on Millward Brown Czech Republic online panel with sample of 821 respondents. Results basically deliver knowledge of relation between attitudes toward the death penalty and sociodemographics, main arguments for and against the death penalty, clarifies the relation between attitudes toward the death penalty and some factors such as experience with crime or death penalty basic facts knowledge. I also evaluated if respondents' attitudes...

Thesis (PhD (Electrical and Electronic Engineering))--University of Stellenbosch, 2010. / ENGLISH ABSTRACT: South Africa and Australia are now the two remaining countries bidding for the Square Kilometre Array (SKA), the biggest and most sensitive project ever undertaken in radio astronomy. The South African SKA is demonstrating its technology capabilities through the Karoo Array Telescope (KAT or MeerKAT). The development of KAT is taking place in stages to optimise design and minimise risks at each stage. An array of seven 12 m antennas will be complete by the end of 2009, called KAT-7. The following phase will see the construction of MeerKAT, which will lead to eighty arrayed dishes. Lightning and RFI studies for KAT-7 are the focus of this dissertation. Due to the extent and complexity of the South African demonstrator project, these studies have largely been conducted on a single structure. Parameters for the dish antenna and pedestal design changed throughout their development. To be effective, the doctoral research had to track these changes appropriately. A Method of Moments frequency domain computational electromagnetic code, FEKO, is used throughout the study. The consequences of direct and indirect lightning strikes are examined for the KAT-7 structure. Important FEKO model verification is achieved through measurement of physical scale models in an anechoic chamber. The microwave simulation code, CST, gives direct comparison of FEKO results by using a finite volume time domain method of calculation. Using frequency domain analysis on these models, the lightning down conductor design over the dish antenna bearings is optimised with cost-effectiveness as one driving parameter. RFI coupling levels for different designs are compared to each other to identify areas requiring RFI mitigation. Analysis of resonances enables evaluation of the mitigation at frequencies sensitive to radio astronomy. A Sommerfeld integral ground plane is used together with the computational model to investigate the use of the concrete foundation steel reinforcing as part of the lightning earthing electrode system. Different interconnections of the steel reinforcing elements are critically evaluated. The KAT-7 design incorporated clear lightning protection and RFI mitigation policies derived from recommendations contained within this dissertation. / AFRIKAANSE OPSOMMING: Suid-Afrika en Australie is nou die oorblywende twee lande wat bie vir die Vierkante Kilometer Reeks (SKA), die grootste en mees sensitiewe projek nog ooit in radio astronomie onderneem. Die Suid Afrikaanse SKA demonstreer sy tegnologiese bekwaamheid met die Karoo Reeks Teleskoop (KAT of MeerKAT). Die ontwikkeling van KAT vind plaas in fases om die ontwerp te optimaliseer en risikos te minimaliseer met elke fase. ’n Reeks van sewe 12 m antennas, genaamd KAT-7, sal teen die einde van 2009 klaar wees. Die volgende fase behels die konstruksie van MeerKAT, wat sal lei tot ’n tagtig-skottel reeks. Die fokus van hierdie proefskrif hanteer weerlig en radiofrekwensie steurings (RFS) vir KAT-7. As gevolg van die omvang en kompleksiteit van die Suid-Afrikaanse demonstreerder projek, is die studies hoofsaaklik op een struktuur gedoen. Parameters vir die antenna-skottel en -voetstuk ontwerp het met hul ontwikkeling deurgaans verander. Om effektief te wees, moes die doktorale navorsing hierdie veranderinge toepaslik volg. ’n Metode-van-Momente frekwensiedomein rekenaar elektromagnetiese kode, FEKO, is deurgaans met die studie gebruik. Die gevolge van direkte en indirekte weerligslae vir die KAT-7 struktuur is ondersoek. Belangrike FEKO model bevestiging is bereik met metings van skaalmodelle in ’n anego¨ıse kamer. Die mikrogolf-simulasie kode, CST, gee ’n direkte vergelyking met die FEKO resultate deur ’n eindige-volume-tyd-domein metode van berekening te gebruik. Met behulp van frekwensiedomein analise van hierdie modelle, is die weerligafleierontwerp oor die antenna-skottel laers ge-optimaliseer, met koste-effektiwiteit as een van die drywingsparameters. RFS koppelingsvlakke vir onderskeie ontwerpe is teen mekaar opgeweeg om areas te identifiseer wat RFS tempering benodig. Analise van resonansies stel die evaluering van die tempering in staat teen frekwensies wat sensitief is vir radio astronomie. ’n Sommerfeld integrale grondvlak word saam met die rekenaarmodel gebruik om die insluiting van die beton se staalversterking as deel van die aardingselektrodestelsel te ondersoek. Verskillende bindmetodes van die onderlinge staalversterkingselemente word krities ge¨evalueer. Die KAT-7 ontwerp inkorporeer duidelike weerligbeveiligings- en RFS temperingstrategie ¨e, komende van aanbevelings in hierdie proefskrif omskryf

The dissertation titled Symbols of exclusion from society in folk tradition concentrates on the interaction of symbols and folk tradition. It explores the way the phenomenon of love and death is traditionally viewed in the Czech country, namely during the Middle Ages and modern times. The main focus of this dissertation is on the social roles of women, although it also shows proof of social exclusion of a man as an executioner. To demonstrate the reasons behind excluding individuals on the outskirts of society, the author also gives short characteristics of the views on the issue of chastity, traditional expectations of fulfilling the female social roles - as virgins, wives and mothers. The author then gives examples of behavior which, in folk tradition, were looked upon as impure/virtueless.

Abstract The purpose of this work was to determine on the basis of the national hospital discharge register and cause-of-death statistics the extent of the hospital treatment required for chronic obstructive pulmonary disease (COPD) in Finland over the period 1972–2001, i.e. the use made of hospital services, factors affecting the length of stay in hospital and the correlation of length of stay with the prognosis. Different intervals within this period were taken for study according to the themes of the individual papers. The results suggest that the length of stay in hospital varies both geographically and seasonally in Finland, the shortest times being recorded in Northern Finland in summer. The main explanations for this would appear to lie in regional differences in health care resources and treatment practises and in climatic variations. The mean length of stay in hospital in the total material in 1987–1998 was nine days. The longest periods applied to cases with concurrent pneumonia or a cerebrovascular disorder. The duration of treatment for the exacerbation stage of COPD decreased by two days between 1993 and 2001, with the longest periods of treatment observed in the case of elderly women. One week of treatment with current modalities may be regarded as optimal, as this was associated with the longest interval before the next exacerbation, just over six months. About 3% of all emergency admissions ended in death, most commonly on a Friday in winter or spring. Patients admitted at a weekend died within the first 24 hours more frequently than did those admitted on a weekday. The mean duration of treatment and frequency of hospitalization increased towards the terminal stage. About one fourth of the patients had died within a year of the first admission for COPD and about a half within five years. Hospital treatment for COPD intensified in Finland during the 1990s as the numbers of hospital beds decreased. Treatment times became shorter and deaths in hospital during exacerbation became less frequent. It will be necessary from now onwards, however, to anticipate the ageing of the population and to develop treatment modalities to replace hospitalization, in order to reduce the costs accruing from this disease. Early diagnosis and outpatient rehabilitation should be developed, and special attention should be paid to appropriate treatment at the terminal stage. / Tiivistelmä Tutkimuksen tarkoituksena oli selvittää valtakunnallisen hoitoilmoitusrekisterin ja kuolemansyytilaston avulla keuhkoahtaumataudista (KAT) aiheutunutta sairaalahoitoa Suomessa 1972–2001: sairaalapalvelujen käyttöä, hoitojakson pituuteen vaikuttavia tekijöitä sekä hoitoajan yhteyttä ennusteeseen. Lähdeaineistosta valittiin erilaisia ajanjaksoja tutkimusasetelman mukaan. Tulokset viittaavat siihen, että hoitoajan pituus vaihtelee Suomessa maantieteellisesti ja vuodenaikojen mukaan: lyhyin hoitoaika on Pohjois-Suomessa kesällä. Ilmiötä selittänevät pääosin terveydenhuollon resurssien ja hoitokäytäntöjen alueelliset erot sekä ilmasto-olosuhteiden vaihtelu. Vuosina 1987–1998 keskimääräinen hoitoaika koko aineistossa oli yhdeksän vuorokautta. Jos potilaalla oli samanaikaisina sairauksina keuhkokuume tai aivoverenkiertohäiriö, nämä johtivat pisimpiin hoitoaikoihin. KAT:n pahenemisvaiheen hoitoaika lyheni kaksi vuorokautta vuodesta 1993 vuoteen 2001. Iäkkäitten naisten hoitoajat olivat pisimmät. Viikon pituinen hoitoaika nykyisillä hoitomuodoilla oli optimaalinen, sillä tällöin aika seuraavan pahenemisvaiheen hoitojakson alkuun oli pisin: vähän yli puoli vuotta. Kaikista päivystyshoitojaksoista potilaan kuolemaan päättyi kolmisen prosenttia. Yleisimmin tällainen hoitojakso päättyi potilaan kuolemaan perjantaisin ja todennäköisimmin talvella tai keväällä. Viikonloppuna sairaalaan tulleista potilaista kuoli ensimmäisen vuorokauden aikana enemmän kuin arkipäivinä tulleista. Keskimääräinen hoitoaika oli pisin ja sairaalahoito runsainta sairauden loppuvaiheessa kuoleman lähestyessä. Ensimmäisen KAT:n aiheuttaman hoitojakson jälkeen noin neljännes potilaista oli kuollut vuoden sisällä ja viiden vuoden kuluessa noin puolet. Keuhkoahtaumataudin sairaalahoito on tehostunut Suomessa 1990-luvulla sairaansijojen vähentyessä. Hoitoajat ovat lyhentyneet ja pahenemisvaiheiden sairaalakuolleisuus on vähäistä. Väestön ikääntyminen on kuitenkin ennakoitava ja sairaalaa korvaavia hoitomuotoja kehitettävä taudista aiheutuneiden kustannusten hillitsemiseksi. Varhaisdiagnostiikkaa ja avokuntoutusta on kehitettävä ja erityinen huomio kiinnitettävä sairauden loppuvaiheen asianmukaiseen hoitoon.

This paper presents the findings of part of a research project entitled "Population Mobility and Settlement Patterns in the Eastern Cape, 1950 to 1990", which was funded by the Human Sciences Research Council. The part of the project with which this paper is concerned, is the study of resettlement in the Border/Ciskei area of the (new) Eastern Cape Province. It involves two main foci: a) the Whittlesea district of the former Ciskei, where research was done in the resettlement area of Sada (where findings are compared with research done there in 1981) and Dongwe; and b) the Fort Beaufort area, where we looked at the two 'black spot' communities of Upisdraai and Gqugesi which were uprooted and moved to the Fort Beaufort township of Bhofolo in the 1960s, and at the establishment of black citrus farmers in the Kat River Valley in the late 1980s, on previously White owned farms which were bought out by the (then) Ciskei government. In the Conclusion, some important differences are suggested between resettlement in the Eastern Cape and in QwaQwa, one of the areas of South Africa that has been most severely affected by resettlement. Ways in which the South African material may be seen in terms of prevailing models for the analysis of resettlement, and may provide an input for the modification of these approaches, are briefly considered. / Digitised by Rhodes University Library on behalf of the Institute of Social and Economic Research (ISER)