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171	Výzkum nenasycené zóny v severní části Moravského krasu / Study of vadose zone in northern part of Moravian Karst Gregorová, Anita January 2012 (has links) This study is focused on the flow through the uppermost part of the unsaturated zone in karstified areas. The information about distribution of transit times and chemical reactions taking place in the unsaturated zone is based on isotopic and chemical composition of cave dripwaters, precipitations and water caught by gravitation lysimeters. The water balance was calculated using measurements of intensity of dripwaters and amounts of water caught by lysimeters and rain gauges. The velocity of a hydraulic shockwave between monitored objects was also estimated according to the delay between significant precipitation event and dripwater intensity increase. The field study took place in the Němcova 1 cave in the northern part of Moravian Karst, near the village Suchdol. It was carried out during the hydrological year 2010/2011. The cave is about 13 m under the surface. The information about composition of overlaying rock above the cave was obtained using geoelectrical and electromagnetic measurements. Studied geological environment is built of 0.5 - 1.5 m of soil, 0.5 - 3.5 m of epikarst and a layer of massive limestone as thick as 10 m. About 70 to 90 % of dripwaters have residence time over 4 years. The distribution of transit time of younger water can be described using the exponencial model (well...
172	Dětská léčebna se speleoterapií Ostrov u Macochy / Sanatorium with Speleotherapy for Childern Ostrov u Macochy Vitoulová, Alena January 2015 (has links) Diploma thesis has been prepared as an architectural study on the completion of the Children's Hospital Ostrov u Macochy using the method of speleotherapy (in the Imperial cave). The new building respects the valuable natural surroundings (CHKO Moravian karst) and the existing sloping terrain, which adapts. Resort spa is designed as a single interconnected complex of three operations - building the house, primary school and the hospital itself. The complex includes: services to visitors, restaurant, pension, clinic, primary school, administration, children accommodation, dining, hospital and sports. The structural system of the object is combined. The idea of urban and architectural solutions is the simplicity of shapes, respecting the existing landscape, copy the shape of the terrain, functionality and aptness plan.
173	Dětská léčebna Ostrov u Macochy / Childern´s Sanatorium Ostrov u Macochy Skládaná, Jana January 2020 (has links) The subject of this diploma thesis is the design of an architectural study of a new building of a children's hospital with speleotherapy. The building is situated in the village of Ostrov u Macochy, which is located in the Moravian Karst Protected Landscape Area. The main goal was to integrate the building into the surrounding terrain as much as possible. From this was derived both the formation of the object itself and the choice of materials used. The design includes two mutually separated buildings – a treatment center and a covered parking lot. The hospital building consists of three interconnected pavilions of various functions. The individual parts of the building are arranged in such a way as to achieve the best possible operational connections. Thanks to the pavilion layout, the adjacent outdoor space was subdivided, creating two play areas for children of different ages. To achieve maximum fusion of the buildings with the surroundings, the buildings were partially embedded into the terrain, covered with terrain wave, and the surrounding landscaping was carried out to the smallest possible extent.
174	Město místo továrny - polyfunkční městský blok na Starém Brně / The city instead of the factory - multifunctional city block in the area of the Old Brno Šrajerová, Hana January 2010 (has links) The main design philosophy is gentle extension of the existing block with emphasis on keeping the character of Stare Brno untouched and enhance the area with missing functions, which would complement and rejuvenate both completed and projected house building development.
175	Polycomb group proteins Bmi1 and Ring1B are involved in cell plasticity and tumorigenesis of the pancreas Martínez Romero, Carles 21 December 2009 (has links) L'adenocarcinoma ductal pancreàtic (PDAC) és un dels càncers més letals. Per tal de millorar el diagnòstic precoç, s'estan investigant les etapes inicials de la formació del càncer, com és el cas de les lesions preneoplàstiques, i es vol desxifrar l'origen cel·lular de la malaltia. Les proteïnes Polycomb constitueixen una família de silenciadors epigenètics que es troben en una varietat de tumors sòlids. La hipòtesi principal és que Polycomb pot estar participant en els processos preneoplàstics del pàncreas i en l'aparició i progressió del tumor. La expressió de Bmi1 i Ring1B fou analitzada durant el desenvolupament del pàncreas, en teixit pancreàtic de diferents models murins de la malaltia i en mostres humans de teixit pancreàtic. Es va dur a terme l'anàlisi del mecanisme de Bmi1 mitjançant models in vitro i induint la depleció de Bmi1. Bmi1 i Ring1B s'expressaren en precursors pancreàtics durant etapes primerenques del desenvolupament i en cèl·lules ductals i dels illots,però no en els acins, en el pàncrees adult. Bmi1 s'induí en cèl·lules acinars durant lesió aguda, en lesions metaplàstiques acinoductals, en neoplàsies intraepitelials pancreàtiques (PanIN) i en PDAC. Ring1B s'incrementà significativament en PanINs de grau alt i en PDAC. La disminució dels nivells de Bmi1 en la línia cel·lular acinar canvià l'expressió dels enzims digestius pancreàtics. Aquests resultats suggereixen que Bmi1 i Ring1B podrien estar contribuint de diferent manera en la progressió tumoral. / Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. To improve early diagnosis, research efforts are focused in characterising early events of cancer formation like preneoplastic lesions and deciphering the cell origin of the malignancy. Polycomb proteins constitute a family of epigenetic silencers found in a variety of solid tumours. The main hypothesis is that Polycomb might play a role in preneoplastic states in the pancreas and in tumour development and progression. The expression of Bmi1 and RingB was analysed during pancreatic development, in pancreatic tissue from mouse models of disease and in human pancreatic tissue samples. Mechanistic insights of Bmi1 were performed using in vitro models and with induced Bmi1 depletion. Bmi1 and Ring1B were expressed in pancreatic exocrine precursors during early development and in ductal and islet cells, but not in acinar cells, in the adult pancreas. Bmi1 was induced in acinar cells during acute injury, in acinar-ductal metaplastic lesions, in pancreatic intraepithelial neoplasia (PanIN) and PDAC. In contrast, Ring1B was significantly increased in high-grade PanINs and in PDAC. Bmi1 knockdown in acinar cell line changed the expression of pancreatic digestive enzymes. These results suggest that Bmi1 and Ring1B could contribute differently to tumour development. embrió rata ratolí humà PDAC tumor Ring1B Bmi1 Polycomb epigenètica cancer ductal acinar Pàncrees immunohistochemistry primary culture western blot PCR protein DNA RNA knockdown transdifferentiation acinoductal metaplasia KRAS PanIN caerulein pancreatitis preneoplastic embryo rat mouse human PDAC tumour Ring1B Bmi1 Polycomb epigenetics cancer ductal acinar Pancreas preneoplàsic pancreatitis ceruleïna PanIN KRAS metaplàsia acinoductal transdiferenciació "knockdown" ARN ADN proteïna PCR western blot cultiu primari immunohistoquímica 57
176	Dětská léčebna Ostrov u Macochy / Childern´s Sanatorium Ostrov u Macochy Horenský, Dominik January 2020 (has links) The point od this master thesis is to propose a new Sanatorium with speleotherapy for children as an architectural concept. The building site is located on the northeast hill of township Ostrov u Macochy near the main entarnce to the cave, which is crucial for correct rehabilitation and treatment of the children. Sanatorium building contains everything needed for seasonal stay of the children – accomodation, school cafeteria with kitchen, medical space, rehabilitation with small wellness and one pool, cloakroom with equipment neccesary for the cave trip, administration part, common leisure spaces, spacious outside playgrounds and lastly all technical and technological things needed to keep the sanatorium running. In the surroundings of the building are couple of newly build family houses and the rest are meadows and forest.
177	Dětská léčebna se speleoterapií v Ostrově u Macochy / Sanatorium with speleotherapy for children in Ostrov u Macochy Promna, Denisa Unknown Date (has links) The main idea was to choose a child as a measure of design. Immerse yourself in his world and his perception of space - keep in mind his needs. What did the place where he would be able to recover from respiratory problems look like? Was she in the hospital? What kind of room was that? What was that for? place? Did nature play any meaning in that? Would you like to go back there? How does she remember him? The aim was to create a place that resembles the hospital environment as little as possible, is in direct contact with nature and attracts to get to know it more. The stay in the hospital should be more reminiscent of spending holidays at school in nature. How to avoid austere hospital premises? Is there such a guide at all? Should I draw inspiration elsewhere? Where do we go to gain strength from everyday worries? In nature, of course. And how does this need translate into architecture? And we have at all such architecture? The answer to the questions I asked was the cottage. House created for a stay in nature. But how to lift it to something richer and more interesting? There was something else that fascinated me as a child spending time in Luhačovice - the spa environment. How these two forms to connect?

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