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31	“If Someone Finds Out You're a Perv:” The Experience and Management of Stigma in the BDSM Subculture Brown, Toni O.L. 22 September 2010 (has links) No description available. Behaviorial Sciences Personal Relationships Social Psychology Social Research Sociology BDSM Bondage Discipline Dominance submission slavery Sadism Masochism Sadomasochism Stigma Sexuality Subculture Ethnography Deviance Kink Pervert Fetish Poly Dungeon Reappropriation Labeling Paraphilia DSM Leather Spank
32	Computational studies of protein helix kinks Wilman, Henry R. January 2014 (has links) Kinks are functionally important structural features found in the alpha-helices of many proteins, particularly membrane proteins. Structurally, they are points at which a helix abruptly changes direction. Previous kink definition and identification methods often disagree with one another. Here I describe three novel methods to characterise kinks, which improve on existing approaches. First, Kink Finder, a computational method that consistently locates kinks and estimates the error in the kink angle. Second the B statistic, a statistically robust method for identifying kinks. Third, Alpha Helices Assessed by Humans, a crowdsourcing approach that provided a gold-standard data set on which to train and compare existing kink identification methods. In this thesis, I show that kinks are a feature of long -helices in both soluble and membrane proteins, rather than just transmembrane -helices. Characteristics of kinks in the two types of proteins are similar, with Proline being the dominant feature in both types of protein. In soluble proteins, kinked helices also have a clear structural preference in that they typically point into the solvent. I also explored the conservation of kinks in homologous proteins. I found examples of conserved and non-conserved kinks in both the helix pairs and the helix families. Helix pairs with non-conserved kinks generally have less similar sequences than helix pairs with conserved kinks. I identified helix families that show highly conserved kinks, and families that contain non-conserved kinks, suggesting that some kinks may be flexible points in protein structures. 572
33	Optimisation d'un code de dynamique des dislocations pour l'étude de la plasticité des aciers ferritiques / Improvements on Dislocation Dynamics Codes for the study of irradiated RPV ferritic steel's plasticity Garcia Rodriguez, Daniel 15 February 2011 (has links) Ces travaux de thèse s’inscrivent au sein d’une démarche multi-échelles visant à améliorer lacompréhension de la fragilisation par l’irradiation de l’acier de cuve. Dans ce cadre, nous nousintéressons à la description de la mobilité des dislocations dans la ferrite, l’une des entrées clépour les codes de dynamique de dislocations (DD). Nous présentons ainsi une revuebibliographique exhaustive des différentes théories et expressions de la mobilité, à partir delaquelle nous proposons une nouvelle expression pour les dislocations vis. Cette loi, utilisablepour la première fois dans le régime de transition ductile-fragile, permet de reproduire lesprincipales observations expérimentales disponibles à ce niveau. Finalement, nous montronsles améliorations apportées au code de DD Tridis BCC 2.0, qui intègrent la nouvelle loi demobilité avec une nouvelle gestion des segments de dislocation permettant de stabiliser etaccélérer des simulations complexes avec prise en compte du glissement dévié. / The present work is part of a larger multi-scale effort aiming to increase knowledge of thephysical phenomena underneath reactor pressure vessel irradiation embrittlement. Withinthis framework, we focused on the description of dislocation mobility in BCC iron, which is oneof the key inputs to dislocation dynamics (DD) simulation codes. An extensive bibliographicreview shows that none of the available expressions can deal with the ductile-fragile transitiondomain of interest. Here, a new screw mobility law able to reproduce the main experimentalobservations is introduced building on the previous models. The aforementioned law is usedtogether with an improved dislocations dynamics code Tridis BCC 2.0, featuring bothperformance and dislocations segments interaction management enhancements, that allowsfor complex DD simulations of BCC iron structures with cross-slip Dislocation Vis Mobilité Double décrochement Transition Athermique Thermique Plasticité Acier Ferrite Fer CC Cubique centré Simulation Dinamique des dislocations Glissement dévié Dislocation Screw Mobility Double kink Transition Thermal Athermal Plasticity Steel BCC iron Ferrite Body-centred cubic Simulation Dislocation dynamics Cross-slip

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