Yes / Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX enzyme activity which affects the inflammatory response. Inflammation is associated with increasing cancer incidence. Pre-clinical and clinical studies have shown that NSAID treatment could cause an anti-tumor effect in cancers. In the present study, blood was taken from healthy individuals (n = 17) and patients with respiratory diseases or lung cancer (n = 36). White blood cells (WBC) were treated with either a micro-suspension, i.e., bulk (B) or nano-suspension (N) of aspirin (ASP) or ibuprofen (IBU) up to 500 μg/ml in the comet assay and up to 125 μg/ml in the micronucleus assay. In this study results were compared against untreated lymphocytes and their corresponding treated groups. The results showed, that NSAIDs in their nano form significantly reduced the DNA damage in WBCs from lung cancer patients in bulk and nano compared to untreated lymphocytes. Also, there was a decrease in the level of DNA damage in the comet assay after treating WBCs from healthy individuals, asthma and COPD groups with aspirin N (ASP N) but not with IBU N. In addition, the number of micronuclei decreased after treatment with NSAIDs in their nano form (ASP N and IBU N) in the healthy as well as in the lung cancer group. However, this was not the case for micronucleus frequency in asthma and COPD patients. These data show that lymphocytes from different groups respond differently to treatment with ASP and IBU as measured by comet assay and micronucleus assay, and that the size of the suspended particles of the drugs affects responses. / The present study was part funded by United Kingdom India Education Research Initiative (UKERI) SA 07-067.

Yes / New multicomponent solid forms of sildenafil have been discovered by means of a combined virtual/experimental cocrystal screening. Coformer selection of candidates was conducted based on an in silico screening method from a database of more than 2000 organic compounds, and the intensive experimental screen produced 23 new solid forms. Since the 12 coformers chosen have a combination of phenol and carboxylic acid groups, a variety of cocrystals, salts, and hybrid salt-cocrystals were discovered and characterized.

Yes / We investigated the protective role of myricetin bulk and nanoforms, against reactive oxygen species (ROS)-induced oxidative stress caused by hydrogen peroxide and tertiary-butyl hydro peroxide in lymphocytes in vitro from healthy individuals and those from pre-cancerous patients suffering with monoclonal gammopathy of undetermined significance (MGUS). The change in intracellular reactive oxygen species was measured once cells were treated with myricetin bulk forms and nanoforms with and without either hydrogen peroxide or tertiary-butyl hydro peroxide co-supplementation. The direct and indirect antioxidant activity of myricetin was spectrofluometrically measured using the fluorescent dye 2',7'-dichlorofluorescin diacetate and using the Comet assay, respectively. Hydrogen peroxide (50 µM) and tertiary-butyl hydro peroxide (300 µM) induced a higher level of reactive oxygen species-related DNA damage and strand breaks. Addition of myricetin nanoform (20 µM) and bulk (10 µM) form could, however, significantly prevent hydrogen peroxide- and tertiary-butyl hydro peroxide-induced oxidative imbalances and the nanoform was more effective. Glutathione levels were also quantified using a non-fluorescent dye. Results suggest that myricetin treatment had no significant effect on the cellular antioxidant enzyme, glutathione. The current study also investigates the effect of myricetin on the induction of double-strand breaks by staining the gamma-H2AX foci immunocytochemically. It was observed that myricetin does not induce double-strand breaks at basal levels rather demonstrated a protective effect.

Yes / 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) is a central dietary mutagen, produced when proteinaceous food is heated at very high temperatures potentially causing DNA strand breaks. This study investigates the protective potential of a well-researched flavonoid, myricetin in its bulk and nano-forms against oxidative stress induced ex vivo/in vitro by PhIP in lymphocytes from pre-cancerous monoclonal gammopathy of undetermined significance (MGUS) patients and those from healthy individuals. The results from the Comet assay revealed that in the presence of myricetin bulk (10 µM) and myricetin nano (20 µM), the DNA damage caused by a high dose of PhIP (100 µM) was significantly (P < 0.001) reduced in both groups. However, nano has shown better protection in lymphocytes from pre-cancerous patients. Consistent results were obtained from the micronucleus assay where micronuclei frequency in binucleated cells significantly decreased upon supplementing PhIP with myricetin bulk (P < 0.01) and myricetin nano (P < 0.001), compared to the PhIP treatment alone. To briefly determine the cellular pathways involved in the protective role of myricetin against PhIP, we studied gene expression of P53 and ATR kinase (ATM- and Rad3-related), using the real-time PCR technique.

Yes / The present study investigated the genoprotective and genotoxic effects of myricetin bulk (10 μM) and nano forms (20 μM) in the lymphocytes from pre-cancerous, monoclonal gammopathy of unknown significance (MGUS) patients and healthy individuals using the Comet and micronucleus assays. The study also evaluated the effect of myricetin on P53 expression levels, using the Western blot technique. Results showed that throughout the in-vitro treatment, lymphocytes from the patients group had higher levels of baseline DNA damage compared to the healthy group. Myricetin in both forms induced significant DNA damage, only at higher concentrations (>40 μM). The micronucleus assay showed a significant reduction (P < 0.01) in the frequency of micronuclei in mono-nucleated cells in the patient group treated with the nano form of myricetin at the non-toxic dose of 20 μM. There was a significant increase in both gene and protein P53 levels in lymphocytes isolated from healthy individuals and pre-cancerous patients. These results suggested a protective effect of myricetin and indicated its nutritional supplement potential for protection against cancer development among patients suffering from MGUS. / This study was kindly funded by Mr Nasir Qayyum, Bradford, UK.

This thesis analyzes data from seven Swedish craft cider entrepreneurs to examine how they respond to challenges within the entrepreneurial contexts–institutional, business, social, and spatial–defined by Welter. Thematic analysis is used to identify the major challenges within each context and then Bourdieusian capital theory is employed to analyze how these artisan entrepreneurs use, convert, and combine capitals to overcome obstacles. Findings reveal that two major challenges are present within the various contexts–cider’s symbolic deficit in Sweden and the formation of a Swedish craft cider community and industry. In the face of these challenges Swedish craft cidermakers demonstrate creativity in using and converting non-economic capitals–social capital in particular.

Text in Afrikaans / Summaries in Afrikaans and English / Die inhoud en vorm van 'n preek is 'n eenheid. Beide aspekte vorm deel van die teologiese teorie van die prediking. In hierdie studie word daar teoreties besin oor 'n bepaalde vorm van prediking. Dit behels 'n ondersoek na die literere vorm waarin die boodskap gestruktureer en verwoord word. Die Skrif bevat 'n verskeidenheid literere vorme wat deur Bybelskrywers aangewend is om die intensie van die teks effektief te kommunikeer. Elk van hierdie vorme besit 'n eiendomlike kommunikatiewe aard. Die ontwikkeling van die moderne literatuurwetenskap sedert die tagtigerjare van die twintigste eeu het stukrag verleen aan die insig dat die Bybel ook as 'n versameling godsdienstige literatuur bestudeer kan word. Dit het meegebring dat die intensie van die teks van die Bybel op 'n teologies verantwoordbare wyse, met inagneming van die historiese verbande, beter begryp kan word deur die gebruikmaking van insigte uit ander literatuur. As sodanig word erkende literere kunsvorme wat naas die logies-analitiese ook die emotiewe betrek, aanvaar. Die resultaat van hierdie ondersoek dui aan dat die preek as kunsvorm geevalueer en in die moderne preekteorie geregverdig kan word. Die proses van transformasie wat die moderne hermeneutiese benadering kenmerk; die veranderde beleweniswereld en verstaanshorison van die huidige hoorders asook die eiesoortige aard van Bybelse literatuur is vanuit 'n kommunikatiewe aanname in 'n kunsvorm binne die moderne homiletiese teorie haalbaar. Die teorie orienteer binne die kommunikatiewe handelingsteorie as meta-teorie wat ingestel is op dialogiese kommunikasie wat betekenisgewing deur waarnemerbetrokkenheid bevorder en 'n bepaalde denkwyse by die hoorders tot gevolg het. Die tradisionele vorm van prediking, gekenmerk deur absolute dominasie van die rede en intellektualisme uit die modernistiese tydvak, het teen die einde van die tweede millennium in ernstige diskrediet gekom. Die radikale verandering in die samelewing deur die moderniseringsproses met gepaardgaande paradigma verskuiwinge dwing die homiletiek om teoreties te herbesin. In hierdie studie word die preek as kunsvorm afgebaken tot die verhalende preekvorm, konseptueel ontwikkel en teoreties omskryf asook geplaas binne die moderne homiletiese teorie as komponent wat daarby pas. Die resultaat is verkry deur 'n vergelykende studie van gemeenskaplike wesenstrekke wat voorkom by erkende kunsvorme in die moderne kunsteorie; die verhalende kunsvorm in die moderne literere teorie met spesifieke verwysing na die Afrikaanse roman asook die verhalende preekvorm in die moderne homiletiese teorie. Deur hierdie vorm van prediking in die moderne preekteorie op te neem, kan 'n sinvolle bydrae gemaak word om die Christelike boodskap deur oortuiging sander enige vorm van dwang te kommunikeer. / In a sermon form and content are one. Both aspects form part of the theological theory of preaching. This theoretical survey investigates one of the various literary forms through which the biblical writers attempted to communicate the intention of the biblical text in the most effective way. Each of these forms possesses a distinctive communicative character. The development of modern literary theory since the eighties of the twentieth century was a propulsive force leading to the conviction that the Bible was also a collection of religious literature. This conviction implied that the intention of the biblical text could be more clearly understood in a theological justified manner within the historical context by using insights gained from other literature. Acknowledged literary art forms adhering to the emotive as well as the logic-analytical are embraced as such. In this study the sermon as an art form is limited to narrative preaching, developed as a concept; theoretically described and placed within the modern homiletical theory as a suitable component. Results are obtained by means of a comparative study of mutual features that are distinctive to acknowledged art forms in the modern theory of art; narrative art forms in modern literature theory specifically in the modern Afrikaans novel, as well as the narrative form of preaching in the modern homiletical theory. The modern homiletical theory is orientated within the communicative acts theory as meta-theory focusing on dialogical communication which promotes meaning through the involvement of the observer. The conclusions reached indicate that the sermon as an art form can be evaluated and justified within the modem homiletical theory. Taken up in this theory, it can prove significant in communicating the Christian message to the listeners in a convincing rather than compulsive manner. / Practical Theology / D.Th. (Practical theology)

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66 Abstract - Flexible forms of working hours This diploma thesis deals with the flexible forms of working hours and its goal is to describe this issue in intelligible and comprehensive way. It is being very interesting and current theme which is to a great extent not subject to direct legal regulations and provides its contracting parties with a big amount of freedom of contract. This fact assists in bigger flexibilization of labour market and represents a significant instrument in the fight against unemployment and economic crisis. This thesis is composed of six chapters. Chapter One introduces the term flexible forms of working hours and briefly describes the content of following chapters. Chapter Two delimits the area of labour law in relation to other branches of law and describes law principles relating to labour law. The following Chapter Three deals with legal regulations of working hours, its length, ways of allotment and international legal regulations. Chapter Four represents an introduction to the flexible forms of working hours. The basic methods of division of flexibility in the relation to the labour market are mentioned here as well as flexible forms of work are divided on the basis of typology which is used in this diploma thesis. This chapter is followed by Chapter Five, which is the most...

1 The European Private Company Dissertation thesis Mgr. et Mgr. Igor Augustinič Abstract Supranational corporate forms as a means for supporting cross-border entrepreneurial activities on the internal market of the European Union are in the centre of interest of legislation and legal doctrine almost from the beginning of the European integration. However, a full-function corporate form oriented above all to small and medium-sized enterprises (SME) cannot be found among the existing European corporate forms. It was this primary target group, the overwhelming majority of enterprises in Europe belongs to, and the project of the European private company - societas privata europaea - should be aimed at. The origins of the SPE project can be seen in academic debates on which supranational corporate form would be the most suitable for SMEs going back to the seventies of the twentieth century. Under the auspices of CREDA, Centre for Research of Commercial Law by the Paris Chamber of Commerce, the discussions were taken up again in the nineties of the twentieth century and led to the first Draft SPE Regulation being prepared by CREDA in 1997. It was a private draft that has served as a basis for further discussions on the SPE project. Since 2001, the initiative regarding the project has been taken over by the...