LLC resonant converters have been a popular choice for DC-DC converters due to their high efficiency, high power density, and hold-up capability in power supplies for communication systems, datacenters, consumer electronics, and automobiles. With the rapid development of wide-bandgap devices and novel magnetic materials, the push for higher switching frequencies to achieve higher power densities at lower costs is gaining traction. To demonstrate high efficiency and high power density, the Center for Power Electronics Systems (CPES) at Virginia Tech designed an 800W, 1MHz 400V/12V LLC converter for future datacenters, which could achieve a peak efficiency of 97.6% and a power density of 900 W/in3. However, with the ever-increasing demand for online services, the performance of power delivery must also be simultaneously improved to keep pace with the demand. The focus of this thesis is improving the performance of CPES’ previous 400V/12V LLC converter by investigating different aspects of its design and operation. Ultimately, design guidelines are proposed, and improvements are demonstrated to effectively achieve higher efficiency and higher power density than the previous CPES converter. Multiple aspects of the LLC converter’s design and structure are investigated to further improve its performance, and three main areas are the focus of this thesis. The output-side termination design of the planar transformer is investigated and modeled, and design guidelines for filter capacitor selection are provided for optimal efficiency. Next, the existing shielding technique for matrix transformers, which helps reduce common-mode (CM) noise without compromising on efficiency, is investigated for asymmetry and current-sharing issues, and modifications have been proposed to improve its efficiency. Thirdly, the LLC converter’s switching frequency is optimized to improve its performance over the previous CPES converter. Finally, the hardware results with the proposed improvements are demonstrated, and the converter’s performance is compared with the previous CPES converter as well as other recent proposed solutions. / M.S. / The electricity demand by datacenters has been growing exponentially over the past few decades, especially due to the boom of artificial intelligence in addition to other internet services. This has resulted in a requirement to continually improve the efficiencies of the power delivery from the grid, through the datacenter power architecture, and finally to the loads on the server racks. The overall datacenter power architecture has been improved over time to improve the total efficiency. However, the performance of each stage along the power architecture must be improved to keep in pace with the energy demand. The focus of this thesis is to improve the performance of the 400V/12V DC-DC stage for future datacenters. Previously, the Center for Power Electronics Systems (CPES) at Virginia Tech developed a 1MHz 800W 400V/12V LLC converter with 97.6% peak efficiency and 900W/in3 power density. However, the performance of the converter must be further improved to stay ahead of the competition and keep in pace with the increasing energy demand. Multiple aspects of the LLC converter’s design and structure are investigated to further improve its performance, and three main areas are the focus of this thesis. Firstly, the high-frequency termination design, or how different components are interconnected and arranged, is studied, and a capacitance selection guideline is proposed to maximize the efficiency. Next, the existing shielding technique for matrix transformers, which helps reduce common-mode (CM) noise without compromising on efficiency, is investigated for asymmetry and current-sharing issues, and modifications have been proposed to improve its efficiency. Thirdly, the LLC converter’s switching frequency is optimized to improve its performance over the previous CPES converter. Finally, the hardware results with the proposed improvements are demonstrated, and the converter’s performance is compared with the previous CPES converter as well as other recent proposed solutions.

This paper presents a single-stage inverter with variable frequency modulation (VFM) based on LLC resonant converter. And LLC converter is a common topology of dc/dc conversion. LLC resonant converter can achieve high efficiency and soft-switching performance. Since the dc gain curve of the single-resonant LLC converter is flat when the switching frequency is larger than the resonant frequency, namely fs>fr, an additional L-C series resonant branch is paralleled to the original resonant tank to introduce higher-order-harmonic resonant current and a zero-gain point to the gain curve. Higher-order-harmonics help to deliver power and the zero-gain point enlarges the gain range which improves output THD and reduces the switching frequency range. A 1.2 kW prototype is built to demonstrate the performance of the proposed inverter. Zero-voltage-switching (ZVS) and zero-current-switching (ZCS) are achieved on the primary side and secondary side, respectively. And 97.3% efficiency and 2.17% voltage THD are achieved at full load condition, while 97.2% efficiency and 3.2% voltage THD are achieved at half load condition. / M.S. / The inverter is widely used to connect renewable energy into the grid by converting dc to ac waveform, like photovoltaic (PV) technology. Basically, the two-stage topology is usually used. The inverter would consist of two stages working in high frequency, the first stage is dc/dc converter which can regulate the input voltage to the desired bus voltage for the second stage, and the second stage is dc/ac converter. The first stage works at a specific switching frequency, so it can be designed to achieve higher efficiency in dc/dc conversion. The second stage also works at high switching frequency and converts dc to ac commonly by using SPWM which changes the duty cycle ratio in a sinusoidal pattern. The single-stage inverter only has one stage working in high frequency while the second stage works at twice line frequency. The first stage converts dc to rectified ac waveform and the second stage unfolds it to ac. The topology of LLC resonant converter being applied for the first stage of the single-stage inverter has been proposed. This topology uses variable-frequency-modulation (VFM) which varying switching frequency on the primary side to output different voltage levels. And it achieves zero-voltage-switching (ZVS). However, LLC converter can hardly output very low voltage due to the flat voltage gain curve at high frequency. Also, LLC converter only transfers the fundamental harmonic component to the load. If the higher-order harmonic components help transfer power when the switching frequency equals the resonant frequency, the current shape will be more like a square wave and the peak of resonant current can be reduced. This thesis proposes a topology that has two L-C resonant branches in parallel for the resonant tank in the converter. And the paralleled resonant branches produce a zero-gain frequency point into the gain curve so that the gain range is enlarged within the reduced switching frequency range and 3rd harmonic component of the resonant current helps to transfer power so that the rms value of resonant current can also be reduced.

Distributed power system (DPS) is widely adopted in Power supplies for the telecom, computer and network applications. Constant on-time current mode control and V2 control are widely used as point-of-load (POL) converters and voltage regulators (VR) in DPS systems. Series resonant converters (SRC) are widely used in aerospace systems and LLC resonant converters are widely used as Front-end converters in DPS systems. The technological innovations bring increasing demand for optimizing the dynamic performance of the switching regulators in these applications. There has been a strong desire to develop simple and accurate equivalent circuit models to facilitate the design of these converters. Constant on-time current-mode control has been widely used in POL and VRM converters. For multi-phase application, external ramp is required to improve jittering performance using pulse distribution method. Chapter II analyzes the effect of external ramp on small-signal model of constant on-time current mode control. It is found that external ramp brings additional dynamics by introducing a moving pole and a static zero. Next, a three-terminal switch model is proposed based on non-ideal current source concept, where the non-idealness of the current source is presented by a Re2-Le2 branch. Based on the proposed model, design guidelines are proposed based on either worst case design strategy or auto-tuning strategy. V2 control has advantages of simple implementation and fast transient response and is widely used in industry for POL and VR applications. However, the capacitor voltage sideband effect, which casues the instability problem when ceramic capacitors are employed, also needs to be taken into consideration in modeling. Chapter III proposed a unified equivalent circuit model of V2 control, the model is built based on non-ideal voltage source concept. The model represents capacitor voltage sideband effect with a Re2-Le2 branch, which forms the double pole by resonating with power stage output capacitor. The equivalent circuit model is a complete model and can be used to examine all the transfer functions. Bsed on the unified equivalent circuit model, design guidelines for VR applications and general POL applications are provided in Chapter IV, for both constant on-time V2 control and constant frequency V2 control. For resonant converters, the small-sginal modelling is very challenging as some of the state variables do not have dc components but contain strong switching frequency component and therefore the average concept breaks down. For SRC, the equivalent circuit model proposed by E. Yang in [E26] based on the results by the extended describing function concept is the most successful model. However, the order of the equivalent circuit model is too high and the transfer functions are still derived based on numerical solution instead of analytical solutions. Chapter V proposes a methodology to simplify the fifth-order equivalent circuit of SRC to a third-order equivalent circuit. The proposed equivalent circuit model can be used to explain the beat frequency dynamics: when switching frequency is far away from resonant frequency, beat frequency will occur; when the two frequencies are close, beat frequency will disappear and another double pole which is determined by equivalent inductor and output capacitor will be formed. For the first time, analytical solutions are provided for all the transfer functions which are very helpful for feedback design. LLC resonant converters are widely adopted as front-end converter in distributed power system for the telecom, computer and network applications [F2]. Besides, LLC resonant converters are also very popular in other applications, such as LCD, LED and plasma display in TV and flat panels [F3]-[F6]; iron implanter arc power supply[F7]; solar array simulator in photovoltaic application[F8]; fuel cell applications[F9],and so on. For LLC, no simple equivalent circuit model is available and no analytical expressions of transfer functions are presented. Chapter VI proposes an equivalent circuit model for LLC resonant converter. When Fs ≥ Fo, Lm is clamped by the output voltage and LLC behaves very similar as SRC. As a result, the dynamic behavior is similar as SRC: when switching frequency is larger than resonant frequency, the beat frequency double pole show up and the circuit is third-order; when switching frequency is close to resonant frequency, beat frequency double pole disappear and a new double pole formed by equivalent inductor Le and equivalent output capacitor Cf show up. The circuit reduces to second order. When Fs<Fo, Lm participates in resonance during some time periods and the circuit is essentially a multiresonant structure. An approximated model is proposed where the equivalent resonant inductor is modified to include the effect of Lm. As a result, the double pole will move to a little lower frequency. For the first time, analytical solutions are provided for all the transfer functions which are very helpful for feedback design. In conclusion, the works shown in this dissertation focus on small-signal equivalent circuit modeling for Buck converters with advanced control schemes and also resonant converters. The models are simple and accurate up to very high frequency range (1/2 fsw). / Ph. D.

The intermediate bus architecture employing the 48V bus converter is one of the most popular power architecture. 48V to 12V bus converter has wide applications in telecommunications, networks, aerospace, and military, etc. However, today's state of the art products has low power rating or power density and becomes difficult to satisfy the demand of increasing power of the loads. To improve the current design, a GaN (Gallium Nitride) based two-stage solution is proposed for the bus converter. The first stage Buck converter regulates the 40V to 60V variable input to a fixed 36V bus voltage. The second stage LLC converter convert the 36V to 12V by a 3:1 transformer. The whole solution achieves the fixed frequency control. The thesis focus on the detail design and optimization of LLC converter, especially its transformer. To have high density and high efficiency, the transformer design becomes critical at MHz frequency. The matrix transformer concept is applied and a merged winding structure is used for flux cancellation, which effectively reduces the AC winding losses. A new fully interleaved termination and via design is proposed. It achieves significant reduction in loss and leakage flux. In addition, to study the current sharing of parallel winding layers, a 1-D analytic model is proposed and a symmetrical winding layer scheme is used to balance the current distribution. The hardware is built and tested. The proposed two-stage converter achieves the best performance compared to the current market. / Master of Science / Intermediate bus architecture (IBA) has wide applications in telecommunication, server and computing, and military power supplies. The intermediate bus converter (IBC) is the key stage in the IBA, where the DC bus voltage from the front-end power supply is converted to a lower intermediate bus voltage. Traditional IBC suffers from bulky magnetic components including inductors and transformers. This work illustrates the design and implementation of a two-stage IBC, where the first-stage Buck converter will provide regulation and the second stage LLC converter will provide isolation. Thanks to the soft-switching capability of LLC, the magnetic volume can be significantly reduced by raising the switching frequency of the converter. Therefore, planar magnetics can be used and placed directly inside of the printing circuit board (PCB), which allows for higher power densities and easy manufacturing of the magnetics and overall converter. However, as the frequency goes higher, the AC losses of the transformer caused by the eddy current, skin effect, and proximity effect become dominant. As a result, high-frequency transformer design becomes the key for the converter design. First, matrix transformer concept is applied to distribute the high current and reduce the conduction loss. Second, a novel merged winding structure is proposed for better transformer winding interleaving. Third, a new terminal structure of the transformer is proposed. Finally, the current sharing between parallel windings are modeled and studied. All the efforts result in great loss reduction. The prototype were verified and compared to the current converters that are on the market in the 48V – 12V area of IBCs.

The LLC resonant converter has been widely used as a DC-DC converter due to its high efficiency, high power density and hold-up capability in power supplies for communication systems, computers and consumer electronics. Use of the high-frequency LLC converter has also been increasing in recent years due to its high power density and integrated magnetics, which reduce the total cost. With the fast development of wideband gap devices and novel magnetic materials, the trend of pushing switching frequency higher continues. However, the control characteristics of the LLC resonant converter are much more complex than that of the PWM converter due to the dynamics of the resonant tank. This paper employs state-trajectory analysis to describe and analyze the behavior of the resonant tank. Control methods based on state-trajectory analysis were used to solve the challenges in the control of the LLC resonant converter, including unpredictable dynamics, burst mode for light-load efficiency, soft start-up and short circuit protection. Additionally, digital controllers are gradually taking the place of analog controllers in the control of the LLC resonant converter due to the advantages of the digital controllers over the analog controllers, such as their ability to be flexible and re-configurable, capable of non-linear control, and able to communicate with other controllers. Among the digital controllers, cost-effective microcontrollers (MCU) are preferred for industrial applications. Because of the advantages of the state-trajectory control and the industrial preference in the cost-effective digital controllers, it would be of great benefit to apply state-trajectory control to high-frequency LLC converters with cost-effective digital controllers. This thesis investigates the impact of digital delay on state-trajectory control. Simplified Optimal Trajectory Control (SOTC) for LLC converters is further simplified so that SOTC can be achieved with cost-effective digital controllers. Furthermore, the limitations caused by digital controller are explained in detail, and methods are proposed to apply the SOTC to high frequency LLC converter is proposed. A detailed analysis of fast load transient response, soft start-up, burst mode for light-load efficiency and synchronous rectification (SR) driving is provided. Multi-step SOTC for fast load transient response is proposed to apply cost-effective digital controllers to high-frequency LLC converters; SOTC for soft start-up with only sensing Vo is proposed to minimized the impact of digital delay on state-trajectory control; SOTC for burst mode with multi-step is proposed to eliminate the limitation of minimum off-time caused by digital controllers in constant burst-on time control; a generalized adaptive SR driving method using the ripple counter concept is proposed to significantly reduce controller resource utilization for the SR control of high-frequency LLC converters. The whole control system is demonstrated on a 500kHz 1kW 400V/12V LLC converter with a 60MHz MCU, which integrates all the proposed control methods. / Master of Science

Rapid expansion of the information technology (IT) sector, market size and consumer interest for off-line power supply continue to rise, particularly for computers, flat-panel TVs, servers, telecom, and datacenter applications. Normal components of an off-line power supply include an electromagnetic interference (EMI) filter, a power factor correction (PFC) circuit, and an isolated DC-DC converter. For off-line power supply, an isolated DC-DC converter offers isolation and output voltage adjustment. For an off-line power supply, it takes up significantly more room than the rest; thus, an isolated DC-DC converter is essential for enhancing the overall performance and lowering the total cost of an off-line power supply. In contrast, data center server power supplies are the most performance-driven, energy-efficient, and cost-aware of any industrial application power supply. The full extent of data centers' energy consumption is coming into focus. By 2030, it is anticipated that data centers will require around 30,000 TWh, or 7.6% of world power usage. In addition, with the rise of cloud computing and big data, the energy consumption of data centers is anticipated to continue rising rapidly in the near future. In data centers, isolated DC-DC converters are expected to supply even higher power levels without expanding their size and with much greater efficiency than the present standard, which makes their design even more challenging. LLC resonant converters are frequently utilized as DC-DC converters in off-line power supply and data centers because of their high efficiency and hold-up capabilities. LLC converters may reduce electromagnetic interference because the primary switches and secondary synchronous rectifiers (SRs) both feature zero-voltage-switching (ZVS) and zero-current-switching (ZCS) for the SRs. Almost every state-of-the-art off-line power supply uses LLC converters in their DC-DC transformations. However, LLC converters face three important challenges. First, the excessive core loss caused by the uneven flux distribution in planar magnetics, owing to the huge size and high-frequency operation of the core. These factors led to the observation of dimensional resonance within the core and an excessive amount of eddy current circulating within the core, which resulted in the generation of high eddy loss within the ferrite material. This was normally assumed to be negligible for small core sizes and lower frequencies. This dissertation proposes methods to help redistribute the flux in the core, particularly in the plates where the majority of core losses are concentrated, and to provide more paths for the flux to flow so that the plates' thickness can effectively be reduced by half and core losses, particularly eddy loss, are reduced significantly. Second, the majority of power supplies in the IT sector are needed to deliver high-current output, but the transformer is cumbersome and difficult to build because of its high conduction losses. In addition, establishing a modular solution that can be scaled up to greater power levels while attaining a superior performance relative to best practices is quite difficult. By increasing the switching frequency to several hundred kilohertz using wide-band-gap (WBG) transistors, printed circuit board (PCB) windings may include magnetics. This dissertation offers a modular and scalable matrix transformer structure and its design technique, allowing any number of elemental transformers to be integrated into a single magnetic core with significantly reduced winding loss and core loss. It has been shown that the ideal power limitations per transformer for PCB-based magnetics beat the typical litz wire design in all design areas, in addition to the unique advantages of PCB-magnetics, such as their low profile, high density, simplicity, and automated construction. Alternatively, shielding layers may be automatically put into the PCB windings between the main and secondary windings during the production process to reduce CM noise. A method of shielding is presented to reduce CM noise. The suggested transformer design and shielding method are used in the construction of a 3 kW 400V/48 V LLC converter, with a maximum efficiency of 99.06% and power density of 530W/in3. Thirdly, LLC converters with a matrix transformer encounter a hurdle for extending greater power, including the number of transformers needed and the magnetic size. In addition to the necessity of resonant inductors, which increase the complexity and size of the magnetic structure, there is a need for a resonant inductor. By interconnecting the three-phases in a certain manner, three-phase interleaved LLC converters may lower the circulating energy, but they have large and numerous magnetic components. In this dissertation, a new topology for three-phase LLC resonant converters is proposed. Three-phase systems have the advantage of flux cancellation, which may be used to further simplify the magnetic structure and decrease core loss. In addition, a study of the various three-phase topologies is offered, and a criterion for selecting the best suitable topology is shown. Compared to the single-phase LLC, the suggested topology has less winding loss and core loss. In addition, three-phase transformers have a lower volt-second rating, and smaller core sizes may be used to mitigate the impact of eddy loss in the ferrite material. In contrast, three-phase systems offer superior EMI performance, which is shown in the loss and size of the EMI filter, and much less output voltage ripple, which is reflected in the size of the output filter. Finally, several methods of integrating resonant inductors into transformer magnetics are presented in order to accomplish a simple, compact, and cost-effective magnetic architecture. By increasing the switching frequency to 500 kHz, all six transformers and six inductors may be achieved using four-layer PCB winding. To decrease CM noise, additional 2-layer shielding may be implemented. A 500 kHz, 6-8 kW, 400V/48V, three-phase LLC converter with the suggested magnetic structure achieves 99.1% maximum efficiency and a power density of 1000 W/in3. This dissertation addresses the issues of analysis, magnetic design, expansion to higher power levels, and electromagnetic interference (EMI) in high-frequency DC/DC converters used in off-line power supply and data centers. WBG devices may be effectively used to enable high-frequency DC/DC converters with a hundred kilohertz switching frequency to achieve high efficiency, high power density, simple yet high-performance, and automated manufacture. Costs will be minimized, and performance will be considerably enhanced. / Doctor of Philosophy / The IT industry, market size, and customer interest in off-line power supply continue to grow quickly, especially for computers, flat-panel TVs, servers, telecom, and datacenter applications. Off-line power supplies usually have a DC-DC converter, an EMI filter, and a PFC circuit. A DC-DC converter is needed for an off-line power supply. An isolated DC-DC converter makes an off-line power supply work better and cost less, even though it takes up more space than the rest. But power supplies for data center servers are the most performance-driven, energy-efficient, and cost-conscious industrial applications. It's becoming clear how much energy data centers use. By 2030, data centers will use 7.6% of the world's power, or 30,000 TWh. With the rise of cloud computing and big data, energy use in data centers is likely to go up by a lot. In data centers, isolated DC-DC converters are expected to have much more power without getting bigger and to be much more efficient than the current standard. This makes their design even harder. LLC resonant converters are often used as DC-DC converters in data centers and off-line power supplies because they are very efficient and easy to control. LLC converters may have less electromagnetic interference because both the primary switches and the secondary synchronous rectifiers (SRs) have zero-voltage-switching (ZVS) and zero-current-switching (ZCS). Almost every modern off-line power supply uses LLC converters for DC-DC stage. LLC converters have to deal with three big problems. Due to the large size of the core and the high frequency of operation, the uneven distribution of flux in planar magnetics causes too much core loss. This dissertation suggests ways to redistribute flux in the core, especially in the plates where most core losses are concentrated and provide more flux paths to reduce plate thickness by half and core losses, especially eddy loss. Second, most IT power supplies need to put out a lot of current, but transformers are bulky and hard to build because they lose a lot of current. It is hard to make a modular solution that can scale up to higher levels of power and perform better than best practices. With wide-band-gap (WBG) transistors, the switching frequency can be raised to several hundred kilohertz so that magnetics can be added to PCB windings. This dissertation describes a modular and scalable matrix transformer structure and design method that lets any number of elemental transformers be put into a single magnetic core with much less winding loss and core loss. PCB-based magnetics have a low profile, a high density, are easy to build, and can be built automatically. Their ideal power limits per transformer beat the typical litz wire design in every way. Shielding layers can be added automatically between the main and secondary PCB windings to cut down on CM noise. CM noise is lessened by shielding. The suggested transformer design and shielding method are used to build a 3 kW 400V/48 V LLC converter with a maximum efficiency of 99.06% and a power density of 530W/in3. Third, LLC converters with matrix transformers can't get more power without more transformers and a bigger magnetic size. Resonant inductors, which add to the size and complexity of a magnetic structure, are also needed. By connecting the three phases, three-phase interleaved LLC converters use less energy, but they have a lot of magnetic parts. In this paper, a three-phase LLC resonant converter topology is proposed. In three-phase systems, flux cancellation makes magnetic structures easier to understand and reduces core loss. There is also a study of three-phase topologies and a set of criteria for choosing one. Compared to the single-phase LLC, the topology cuts down on winding and core loss. Three-phase transformers have a lower volt-second rating, and ferrite material eddy loss can be reduced by making the core smaller. The size and loss of the EMI filter show that three-phase systems have less output voltage ripple and better EMI performance. Finally, several ways of putting resonant inductors into the magnetics of a transformer are shown to make a magnetic architecture that is simple, small, and cheap. At 500 kHz, all six transformers and all six inductors can be wound on a four-layer PCB. CM noise can be cut down with 2-layer shielding. With the suggested magnetic structure, a 500 kHz, 6-8 kW, 400V/48V, three-phase LLC converter can reach 99.1% maximum efficiency and 1000 W/in3. This dissertation presents analysis, magnetic design, expanding to higher power levels, and electromagnetic interference (EMI) in high-frequency DC/DC converters used in off-line power supplies and data centers. WBG devices can be used to make high-frequency DC/DC converters with a switching frequency of a few hundred kilohertz that are powerful, easy to use, and can be automated. Both cost and performance will get better.

The telecommunications market is one of the large rapidly growing fields in today’s power supply industry due to the increasing demand for telecom distributed power supply (DPS) systems. The half-bridge LLC (Inductor-Inductor-Capacitor) resonant converter is currently the most attractive topology for the design and implementation of 24V/48V DC telecom power converters. The current doubler rectifier (CDR) converter topology was invented and described in the early 1950s which can offer the unique characteristic of halving the output voltage while doubling the output current compared to a standard rectifier. In this thesis, the current doubler converter topology with its unique characteristic is evaluated as a complementary solution to improve the LLC resonant converter performance, especially for the low output voltage and high output current telecommunication applications. A novel half-bridge LLC resonant current doubler converter (LLC-CDR) is proposed in this thesis which can offer several performance benefits compared to conventional LLC-standard rectifier design . The unique characteristics of the LLC-CDR topology can offer significant improvements by transformation of a 48V converter into a 24V converter with the same power density. This thesis introduces a new SPICE-based simulation model to analyse the operation of this novel LLC-CDR converter circuit design. This model can be used to define the critical component parameters for the LLC -CDR circuit output inductor values. It can also be used to predict the circuit overall performance under different load conditions. Both time-domain based transient simulation analysis and frequency-domain based AC analysis provided by this simulation model showed favourable results in comparison to bench measurement results on a prototype. The model provides a valuable insight to reveal some of the unique characteristics of this LLC -CDR topology. It demonstrates a proof of concept that the conventional LLC resonant converter can be easily redesigned for low voltage, high current applications by using the LLC-CDR topology without requiring a new design for the LLC resonant stage components and the power transformer. A new magnetic integration solution was proposed to significantly improve the overall performance in the LLC-CDR topology that had not been published before. The LLC-CDR converter hardware prototypes with two output inductors coupled and uncoupled configurations were extensively modelled, constructed and bench tested.Test results demonstrated the suitability of an integrated coupled inductors design for the novel LLC-CDR converter application. The integrated coupled inductors design can significantly improve the LLC-CDR converter frequency-domain based AC simulation analysis results. In addition, these results also illustrate the potential benefit of how the magnetic integration design in general could reduce the magnetic component size, cost, and weight compared to the uncoupled inductors design. Finally, a hardware prototype circuit was constructed based on a commercial 1800 W single phase telecom power converter to verify the operation of this novel half bridge LLC-CDR topology. The converter prototype successfully operated at both no load and full load conditions with the nominal output voltage halved from 48VDC to 24VDC, and doubled the output current to match the same output power density. It also demonstrates that the efficiency of this novel half bridge LLC –CDR is 92% compares to 90% of EATON’s commercial 24VDC LLC resonant converter, which can fulfill the research goals.

La compréhension des interactions intra- et inter-moléculaires à l’échelle atomique représente un enjeu scientifique important. A l’heure actuelle, les techniques de RMN ont déjà prouvé leur efficacité pour l’analyse de ces interactions in vitro, dans les solutions tampons. Toutefois, il a également été montré que la plupart des biomolécules ont une structure et une dynamique différentes in vivo, à l’intérieur des cellules, de celle in vitro. Il est donc crucial d’analyser les biomolécules dans leur milieu naturel, la cellule. Récemment, les progrès dans le domaine de la RMN dans les cellules ont permis de mieux comprendre la dynamique et les interactions des biomolécules présentes dans le milieu cellulaire complexe. Cependant, la biomolécule étudiée étant présente en faibles concentrations, elle possède un faible signal sur le spectre RMN, qu’il est difficile de suivre. De plus, du fait de la forte viscosité du milieu cellulaire, la relaxation rapide de l’aimantation transverse se traduit par un élargissement des raies spectrales. L’utilisation des états de spin à longs temps de vie et de la Polarisation Dynamique Nucléaire suivie par la dissolution de l’échantillon (dissolution-DNP) pourraient permettre de pallier aux problèmes d’élargissement de raies et de sensibilité. L’objectif de ce travail de thèse a été d’explorer les bénéfices des ces avancées récentes de la RMN pour l’étude des petites molécules, peptides et protéines à l’intérieur des cellules. Pour la protéine c-Src, qui appartient à la classe des protéines intrinsèquement désordonnées (IDP), la dynamique de l’ensemble des conformations de l’extrémité N-terminale a été suivie utilisant des états de spin à longs temps de vie LLS. Le signal du noyau de carbone-13 de la molécule de pyruvate a été augmenté utilisant la Polarisation Dynamique Nucléaire (DNP) afin de mieux l’observer dans le milieu cellulaire. Un peptide représentatif pour la partie active d’une autre protéine, IκBα, a été introduit dans des cellules HepG2 par l’électroporation. Les observations faites lors des ces expériences sont discutées dans la perspective de faciliter les études RMN des biomolécules à l’intérieur des cellules. / Most NMR studies are carried out in vitro, but the structure and dynamics of some biomolecules inside cells differ from those in vitro. It thus becomes interesting to analyze biomolecules such as proteins in their natural environment: the cell. Recent progress of in cell NMR allowed to better understand the behaviour of proteins: their dynamics and their interactions with other biomolecules in the cell. But the low concentration of proteins leads to low signal intensity. Moreover, the viscosity of the environment induces faster transverse relaxation, resulting in line broadening for proteins signals. The use of the Long-Lived States and Coherences (LLS and LLC, respectively) as well as dissolution Dynamic Nuclear Polarization (dissolution-DNP) can improve NMR observations in cells. LLS were used to understand and characterize the structure of the N-terminal domain of c-Src, which is intrinsically disordered. To follow the phosphorylation of proteins, a first preliminary study of a 21-aa peptides derived from IKBα electroporated into HepG2 cell lines was carried out.

Na lesão renal aguda, os mecanismos de defesa atuam como genes protetores, como a proteína heat shock 32 (HSP 32), também conhecida como heme oxigenase-1 (HO-1). A polimixina B (PmxB) é um antimicrobiano nefrotóxico. O objetivo deste estudo foi caracterizar a participação da enzima HO-1 na toxicidade da PmxB em células LLC-PK1. As células foram submetidas aos seguintes tratamentos: Controle (CTL- 0µM); Hemin (indutor de HO-1, 25µM); Hemin II (250M), Protoporfirina de zinco (ZnPP - inibidor de HO-1, 10M,); Nitro-L-arginina-metilester (L-NAME - inibidor de iNOS, 0,1mM); PmxB (375µM); PmxB + Hemin (25µM de Hemin uma hora antes da PmxB); PmxB + ZnPP (10M de ZnPP uma hora antes da PmxB); PmxB + Hemin + L-NAME (25M de Hemin e 0,1mM de L-NAME uma hora antes da PmxB). Os grupos foram avaliados em 24 e 72 horas. Foram analisados os seguintes parâmetros: desidrogenase láctica (DHL), peroxidação lipídica (MDA), expressão gênica da HO-1 por RT-PCR, síntese protéica da HO-1 por imunofluorescência, óxido nítrico (NO) pelo método de Griess e expressão protéica da HO-1 e da iNOS por western blotting. Os resultados mostraram que a PmxB elevou o DHL com aumento dos níveis de MDA. O Hemin e a ZnPP elevaram as variáveis DHL, MDA e óxido nítrico (NO). O indutor de HO-1 incrementou a expressão protéica da HO-1 e da iNOS. A PmxB se confirmou como citotóxica e a HO-1 intensificou a lesão por mecanismos oxidativos. O efeito da HO-1 na lesão celular parece ser mediado pelo NO / In the acute kidney injury, the mechanisms of defense act as protector genes, as the protein heat shock 32 (HSP 32), also known as heme oxygenase-1 (HO-1). The polymyxin B (PmxB) is a nephrotoxic antimicrobial. The aim of this study was to distinguish the role of the HO-1 enzyme in the PmxB toxicity in LLC-PK1 cells. The cells were submitted to the following treatments: Control (CTL- 0µM); Hemin (inhibitor of HO-1, 25µM); Hemin II (250M), Zinc protoporphyrin (ZnPP - inhibitor of HO-1, 10M,); NG-nitro-L-arginine methyl ester (L-NAME - inhibitor of iNOS, 0,1mM); PmxB (375µM); PmxB + Hemin (25µM of Hemin one hour before the PmxB); PmxB + ZnPP (10M of ZnPP one hour before the PmxB); PmxB + Hemin + L-NAME (25M of Hemin and 0,1mM of L-NAME one hour before the PmxB). All groups were evaluated in 24 and 72 hours. The following parameters were analysed: lactate dehydrogenase (LDH), lipid peroxidation (MDA), genic expression of HO-1 by RT-PCR, protein syntesis of HO-1 by immunofluorescence, nitric oxide (NO) by Griess method and protein expression of HO-1 and of iNOS by western blotting. The results showed that PmxB increased the LDH and the levels of MDA. Hemin and ZnPP also increased the LDH variables, MDA and nitric oxide (NO). The inducer of HO-1 improved the protein expression of HO-1 and of iNOS. The PmxB was confirmed as a cytotoxic and the HO-1 intensified the failure by oxidative mechanisms. The effect of HO-1 in the cell injury seemed to be mediated by NO

Cette thèse traite de la conception d’un convertisseur DC / DC destiné aux véhicules électriques et hybrides (2,5 kW, 400V/14V, 250kHz). Dérivé de la topologie LLC à résonance, ce convertisseur bénéficie des nombreux avantages propres à cette structure particulière. C’est ainsi que le prototype réalisé présente un rendement très élevé, une densité de puissance très forte avec des perturbations EMI très réduites. La première partie de cette thèse est consacrée à l’analyse théorique du circuit LLC afin de dégager un modèle de conversion et une stratégie de contrôle adaptée à l’application visée. Afin de conserver un rendement important sur une large plage de charge, une structure basée sur la mise en parallèle de deux modules LLC est proposée. Une nouvelle stratégie de contrôle à deux boucles est également proposée pour équilibrer le courant entre les deux modules. La seconde partie de la thèse fait appel à la simulation et à l’expérimentation. Il s’agit de minimiser la masse et l’encombrement tout en maximisant le rendement. Un composant magnétique spécial est conçu puis dimensionné pour intégrer le transformateur et diverses inductances de résonance. Ce convertisseur met également en œuvre un système de redressement synchrone robuste avec une compensation de phase, un module de puissance avec une résistance thermique très faible et un système de refroidissement efficace par air. Le rendement maximal mesuré est 95%. Le rendement demeure supérieur à 94% sur une plage de puissance s’étalant de 500 W à 2 kW. La densité de puissance est 1W/cm3. La CEM du convertisseur est développée dans cette thèse. / In this dissertation, a 2.5kW 400V/14V, 250kHz DC/DC converter prototype is developed targeted for electric vehicle/hybrid vehicle applications. Benefiting from numerous advantages brought by LLC resonant topology, this converter is able to perform high efficiency, high power density and low EMI. A first part of this dissertation is the theoretical analysis of LLC: topology analysis, electrical parameter calculation and control strategy. To arrange high output current, this thesis proposes parallel connected LLC structure with developed novel double loop control to realize an equal current distribution. The second part concerns on the system amelioration and efficiency improvement of developed LLC. A special transformer is dimensioned to integrate all magnetic components, and various types of power losses are quantified based on different realization modes and winding geometries to improve its efficiency. This converter also implements a robust synchronous rectification system with phase compensation, a power semiconductor module, and an air-cooling system. The power conversion performance of this prototype is presented and the developed prototype has a peak efficiency of 95% and efficiency is higher than 94% from 500W to 2kW, with a power density of 1W/cm3. The CEM analysis of this converter is also developed in this thesis.