This master thesis deals with issues of children with ADHD, hyperactivity, on the second grade elementary school and their own view of themselves as a hyperactive individual using the narration method. Abstract The objective of the theoretical part was to define the terms MBD, ADHD, ADD and the narration method. The objective of the practical part was to analyze school experience of children with diagnosed ADHD, hyperactivity. I tried to consider the issues mainly from the insights of children themselves. In doing so, I stem from the theoretical part.

Diplomová práce popisuje vývojovou techniku model based design a její použití pro návrh a testování algoritmů. Popis této techniky je proveden na příkladu praktického využití v praxi při vývoji modulu monitorování stavu motoru ve spolupráci se společností Unis. Vývoj v oblasti současné letecké techniky klade velký důraz na monitorování životnosti zařízení. Podle výstupů algoritmu se dají naplánovat preventivní opravy s ohledem na aktuální podmínky opotřebení a provozování. Implementace algoritmů je provedena v prostředí Matlab/Simulink s následným testováním na platformě dSpace

Cone crushers are used in both the construction and mining industries for the production of aggregates and extraction of ores. Aggregates are used when building for example houses, roads and railways, hence the cone crushers are a vital part of modern society. To ensure the performance of the cone crusher, it is important to properly adjust the feeding conditions. Using computational methods to virtually analyze the performance of the crushers is a more time and cost efficient solution compared to physical testing. This thesis was divided into two parts, where the main objective of the first part was to use the discrete element method (DEM) to analyze the segregation in cone crushers. Three different methods were developed, which later were utilized to compare the segregation for four different feeding conditions. Two of the analysis methods only considered the segregation in the feed hopper, whilst the third method aimed to give an understanding ofthe segregation inside the crushing chamber. The two first methods could successfully be used to compare how segregated the feed material was for the four feeding conditions, however, the third method proved to be both hard to validate and highly dependent on proper material flow inside the crushing chamber. The main objective during the second part of the thesis was to investigate the possibility of running the DEM simulations coupled to a multibody simulation (MBS) software. The simulation routine was then used to compare the foundation loads for the same four feeding conditions as in the first part. The subframe was later modeled as a flexible body to analyze and compare the stresses the subframe was subject to during operation for the same four feeding conditions. Setting up and running the coupled simulation was successful. Different simulation settings were tested, anda general guideline on how those settings should be defined was set up. The actual impact the coupling had on the foundation loads and stresses in the subframe was however almost non-existent. This could probably be directly related to the fact that the crushing forces in EDEM are known to be many times smaller than what they have been measured to in experiments. This also meant that changing the feeding conditions to alter the segregation did not have a noticeable effect on the results.

A microbubble dispersion (MBD) was used to supply oxygen for an aerobic fermentation of Baker's yeast. The 1-liter microbubble dispersion generator supplied bubbles for 20-liter and 50-liter working volume fermentations in a 72-liter pilot scale fermenter. The microbubbles were stabilized by the surfactants naturally present in the culturing broth medium. The growth patterns of yeast Saccharomyces cerevisiae, cultured at agitation speeds of 150 rpm and 500 rpm, were compared for oxygen supplied by ordinary air sparging and by MBD sparging. Both air sparged and MBD systems were supplied air at equivalent volumetric flow rates. The volumetric oxygen transfer coefficients (KLa) were estimated by the yield coefficient method. The KLa values increased from 142.5 to 458.3 h-1 and from 136.1 to 473.3 h-1 for 20- and 50- liter runs, respectively, as the agitation speed was increased from 150 to 500 rpm in the ordinary air sparged fermentations. The oxygen transfer coefficients in the MBD sparged fermentations were found to be independent of the fermenter agitation speed at approximately 480 h-1 for 20-liter runs and 340 h-1 for 50-liter runs. The growth rates for MBD at 150 rpm were essentially equivalent with air sparged fermentations at 500 rpm. The total power consumption per unit volume of broth for the 150 rpm, MBD fermentation was 68% lower than the 500 rpm, air sparged run for the 20-liter fermentations and was 55% lower for the 50-liter fermentations. / Master of Science

Formally-based design and implementation techniques for complex safety-critical embedded systems are required not only to handle the complexity, but also to provide correctness guarantees. Traditional design approaches struggle to cope with complexity, and they generally require extensive testing to guarantee correctness. As the designs get larger and more complex, traditional approaches face many limitations. An alternate design approach is to adopt a "correct-by-construction" paradigm and synthesize the desired hardware and software from the high-level descriptions expressed using one of the many formal modeling languages. Since these languages are equipped with formal semantics, formally-based tools can be employed for various analysis. In this dissertation, we adopt one such formal modeling language - MRICDF (Multi-Rate Instantaneous Channel-connected Data Flow). MRICDF is a graphical, declarative, polychronous modeling language, with a formalism that allows the modeler to easily describe multi-clocked systems without the necessity of global clock. Unnecessary synchronizations among concurrent computation entities can be avoided using a polychronous language such as MRICDF. We have explored a Boolean theory-based techniques for synthesizing multi-threaded/concurrent code and extended the technique to improve the performance of synthesized multi-threaded code. We also explored synthesizing ASIPs (Application Specific Instruction Set Processors) from MRICDF models. Further, we have developed formal techniques to identify constructive causality in polychronous models. We have also developed SMT (Satisfiablity Modulo Theory)-based techniques to identify dimensional inconsistencies and to perform value-range analysis of polychronous models. / Ph. D.

No description available.

MBD, DAMP, ADD and ADHD are all concepts that through history have been used as labels to explain people with concentration difficulties. The purpose of this essay is to illustrate how the school's view on pupils with concentration difficulties has changed over the years. In addition, it shows how the school's view of pupils with concentration difficulties has affected both the teaching, the role of the teachers and the students. In the 1950s, the concept of MBD was used. In the 1990s, the term DAMP was used and today children with concentration problems are diagnosed with ADD or ADHD. In this essay I follow how perceptions of these difficulties has changed in line with the concept differences.

La méthylation de l’ADN est un phénomène épigénétique qui joue un rôle important dans le développement des mammifères et qui est associé à une répression transcriptionnelle. La méthylation de loci CpG de l’ADN est médiée par les méthyltransférases de l’ADN – les Dnmts. La méthylation joue également un rôle clef dès les stades précoces de la cancérogenèse dans une grande partie des tumeurs où on observe une méthylation, notamment la répression des gènes suppresseurs de tumeurs et une déméthylation, notamment l’expression de séquences d’ADN parasites. <p>\ / Doctorat en sciences biomédicales / info:eu-repo/semantics/nonPublished

Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a systemic disorder which includes abnormal bone chemistry, vascular or soft tissue calcification, and abnormal bone formation. Many of the parameters of CKD-MBD have been associated with an increased mortality risk in renal patients. There were three main facets to this research project. The first aim of this research was to perform two different studies using the Chronic Renal Insufficiency Standards Implementation Study (CRISIS) data. This prospective epidemiological study is designed to identify factors associated with renal progression and survival in the pre-dialysis CKD population. We have shown that for each 0.323mmol/L (1mg/dL) increase in serum phosphate there was a significant stepwise increased risk of death. (HR1.3 (1.1, 1.5) P=0.01). The association of baseline phenotypic data against vascular stiffness measurements was also investigated. Augmentation index measured at the radial artery was associated with a raised systolic blood pressure but no association with biochemical abnormalities was found.We hypothesised that the phosphate effect on survival was related to the effects within the CKD-MBD spectrum and therefore control of secondary hyperparathyroidism would improve bone and cardiovascular parameters. Therefore for the second part of this research we performed a randomised controlled trial to examine the effects of cinacalcet with standard therapy compared to standard therapy alone on bone and cardiovascular parameters in haemodialysis patients with uncontrolled hyperparathyroidism. The change of biochemical parameters and cardiovascular markers were also further explored in secondary analyses alongside survival data. The primary end point of change in vascular calcification at 52 weeks showed no significant difference between arms. As equivalent control of phosphate and iPTH was achieved in both arms secondary analyses were performed. This showed a significant regression of left ventricular hypertrophy and carotid intima-media thickness associated with phosphate but not iPTH reduction. Patients whose phosphate reduced during the study had a survival advantage when followed for 5 years (HR=10.2 (1.1, 104.5) P=0.049). The third part of this research was to investigate iPTH assay variability. We explored the variation in iPTH assays across the North West and paired this with regional audit data. This study showed that despite there being significant variation among iPTH assays across the region the variation in clinical management was still accounting for some variation in achieving PTH targets.In conclusion, serum phosphate, within the normal laboratory range, is associated with an increased mortality in CKD patients. Haemodialysis patients may have improvement of cardiovascular outcomes with tight control of secondary hyperparathyroidism, by whichever therapeutic means. Intact PTH assays variation may alter our clinical management but variation in practice still affects guideline achievement.

In der Entwicklung der numerischen Simulation im Laufe der letzten Jahre ist ein deutlicher Trend zur Konsolidierung tu beobachten. Neben der wirtschaftlichen Konsolidierung der Anbieter - letztendlich immer weniger Anbieter, die immer mehr anbieten • gibt es noch die technische Konsolidierung der Softwarelösungen. Das Stichwort ist Integration mit der Motivation, verschiedene Solver-Disziplinen unter einem gemeinsamen Dach zu vereinigen. Der Nutzer soll wenn möglich nur noch ein Tool benutzen, das alles kann. Das ist ein ambitioniertes Ziel und technisch in nächster Zeit nicht umsetzbar, da die Unterschiede in den Lösungsansåtzen unterschiedliche Datenmodelle verlangen. Daher ist als ObergangsIOsung die Co-Simulation das Mittel der Wahl. Damit sind verschiedene Solver gemeint, die über entsprechende Schnittstellen reibungslos und vor allem ohne Nutzerinteraktion miteinander kommunizieren, um so ihre volle Leistung zu entfalten. Auf diesem Gebiet wurden in den letzten Jahren deutliche Fortschritte erzielt. MSC Software bringt nun die Möglichkeiten technologisch auf ein neues Level. Der Vortrag zeigt den konzeptionellen Ansatz, den MSC verfolgt und schrittweise umsetzt. Gezeigt werden die Vorteile in der Anwendung für den Nutzer, aber auch die Limitationen, derer man sich immer bewusst sein muss. Mit konkreten Beispielen aus der Praxis werden die Vorteile der Co-Simulation untermauert. Der Fokus des Vortrages liegt auf den Möglichkeiten, die sich für dynamische Systeme aus der Co-Simulation ergeben und wie die traditionellen Grenzen der Mehrkörpersimulation überwunden werden können: Zum einen durch Kopplung mit nichtlinearer FEM aber auch mit CFO. Inhaltlich soll der Vortrag bestenfalls den Vorstellungshorizont der Zuhörer erweitern. in jedem Fall aber konkret belegen, wo die Co-Simulation bessere Ergebnisse erzielt als die herkömmliche, auf einen Solver beschränkte Vorgehensweise.