Uppsatsen syftar till att undersöka huruvida begrepp som maskulint och feminint kan uppfattas i den nonfigurativa bilden. Med exempel ur den abstrakta expressionismen studeras detta utifrån genus och semiotisk teori. Även konstvärldens roll i producerandet av genus undersöks. En mindre enkätundersökning och bildanalys ingår i studien. / This thesis purpose is to examine whether notions as masculine and feminine can be understood in a nonfigurative picture. Thru gender theories and semiotics some examples from the Abstract Expressionist movement are studied. The art world’s participation in construction of gender is also examined. A picture analysis supported by a small survey is also included in the study.

Studies have shown that there is a strong correlation between aging and neurodegenerative diseases. Aging is considered the number one risk factor to develop neuropathologies such as memory loss, senile dementia, Alzheimer's disease (AD), and Parkinson's disease. Neurodegenerative diseases tend to start during adulthood, and aggravate over time, making them difficult to prevent and to treat. In the Unites States, demographic studies by U.S. Bureau of the Census have determined that our aging population of >65 years is expected to increase from the present 35 million to 78 million in 2030. This would result, not only to an increase of age-related chronic illness, and mental disability, but to a decrease of quality of life, and an elevation of medical cost. Thus, this dissertation has focused on investigating the molecular mechanisms during the process of aging and its correlation to chronic inflammation and cognitive impairments. The etiology of neurodegenerative diseases is not very well understood, but research has shown that the process of aging is a key factor, which involved oxidative stress, an over reactive microglia, and increased production of pro-inflammatory cytokines. All these factors are known to decrease cell proliferation, which limit neuroplasticity and they might lead the transition from normal aging to more severe cognitive dysfunction associated with neurodegenerative diseases. Previously, we have shown that natural compounds such as polyphenols from blueberry, and green tea, and amino acids like carnosine are high in antioxidant and anti-inflammatory activity that decreases the damaging effects of reactive oxygen species (ROS), in the blood, brain, and other tissues of the body. Therefore, we examined the hypothesis that the pro-inflammatory cytokine TNF-[U+F061] may be a critical factor that modulates classical conditioning behavior, the effects of NT-020 on adult neurogenesis, inflammatory markers of the CNS, and the effect of NT-020 on cognitive function as shown using spatial navigation task. The results show that in aged rats, endogenous production of pro-inflammatory cytokine TNF-α impairs the acquisition of learning and memory consolidation in the delay eyeblink classical conditioning task (EBC). It was shown that this effect can be replicated by infusing young rats with exogenous TNF-α prior to EBC. Using NT-020 as a dietary supplement for one month, it was found that NT-020 ameliorates the age-related impairments typically found in aged rats in the spatial navigation tasks Morris water maze and radial arm water maze. By looking at immunohistochemistry analysis, it was found a decreased number of OX6 MHC II positive cells, increased neurogenesis, and increased number of proliferating cells in the dentate gyrus (DG) of the hippocampus in the aged rats fed with NT-020 relative with their counterpart aged control. In the CNS, Inflammatory markers were analyzed, and it was found that aged rat fed with NT-020 supplemented diet has decrease levels of pro-inflammatory cytokines in compared with aged rats fed with NIH-31 control diet. In conclusion, TNF-α, a pro-inflammatory cytokine has shown to have a modulatory effect during classical conditioning. Moreover, NT-020 may promote a healthy CNS milieu, proliferation of neuronal progenitors, and maintenance of nature neurons in the aged rats and it might exert anti-inflammatory actions which promote a functional stem cell pool in the CNS of aged rats.

Brutalist architecture, popularized in Britain in the late 1950s and heralded as a progressive form of Modernism in the United States until the 1970s, now presents a conundrum to preservationists as it ages. Once critically acclaimed, many Brutalist buildings have lost their appeal over time. The unpolished materials have proven unpopular with many who live and work in these structures, and key examples of the style are now facing demolition. Though “Brutalism” has become a nebulous architectural designation in the preservation community, this paper focuses on a specific subset of late Modernist architecture that primarily utilizes unfinished concrete to promote the philosophy of material truth and unapologetic permanence. While artistry of form and overall functionality affect preservation of Brutalist buildings in the United States, an important factor in the decision to demolish is often overlooked: the interplay of public opinion with critical acclaim, both in the past and within current architectural climates. This project examines the Brutalist approach to architecture and chronicles the shifts in critical and public perspective of several key case studies, focusing on university structures (the Yale Art and Architecture Building, Harry Ransom Center, and the University of Texas School of Nursing), theaters (Morris Mechanic Theater and Alley Theater), and civic buildings (Orange County Government Center, Boston City Hall, and Prentice Women’s Hospital). Understanding how and why shifts in opinion took place is critical in making informed preservation decisions about Brutalist architecture. / text

As Aristotle wrote, rhetoric is an art or faculty of finding the available means of persuasion in a given circumstance, and the late nineteenth century was a time in American history when many authors used utopian fiction as the best available means of persuasion. For a few years, the utopian novel became a widespread, versatile and common rhetorical trope. Edward Bellamy was the most popular of these writers. Bellamy’s utopian novel Looking Backward was not only the third best-selling book of nineteenth century America, it inspired over a hundred other utopian novels and helped create a mass movement of “Bellamy clubs” along with a political party (Nationalism). During the latter part of the nineteenth century, American public discourse underwent a general shift from a focus on communal values to a focus on individuals as the source of truth. Utopian fiction of the era helps illuminate why and how this shift occurred. In nineteenth century America, literature was generally not considered to be rhetorical. At most, critics treated fiction as a form of epideictic rhetoric, aiming only to delight, educate, or create discussion. When fiction was used to promote legislative agendas and thus entered into the realm of deliberative rhetoric, critics argued that its transgression of rhetorical boundaries supposedly ruined its appeal. Utopian literature came the closest to breaking down the barriers between literature and rhetoric, as hundreds of utopian novels were published, most of them in response to Edward Bellamy. A close rhetorical reading of Looking Backward details its rhetorical nature and helps account for its rhetorical success. I treat each of the novels as participants in the larger cultural conversation, and detail the ways in which they address Bellamy, each other, and issues such as the temperance movement and the decline of classical languages in higher education. In modern times, though Bellamy has faded from the public memory, he has proven useful in a variety of contexts, from a political punching bag to a way to lend an air of erudition to various types of popular fiction. / text

"'The Burden of the Image:' Jane Morris in Art and Life" examines the work and life of Pre-Raphaelite model Jane Burden Morris (1839-1914). Burden Morris, an embroiderer and wife of the arts and crafts designer William Morris (1834-96), became famous in her own lifetime as the model for a number of Pre-Raphaelite works, particularly the paintings of Dante Gabriel Rossetti (1828-82). Although she was not considered conventionally beautiful by Victorian standards, artists drew heavily upon Burden Morris’s appearance, particularly her striking features and unusual artistic dress, in order to heighten the exoticism of their works and to suggest moments outside contemporary Victorian time and place. Burden Morris’s features became synonymous with the Pre-Raphaelite ideal in female beauty and several contemporaries reflected upon the surreal experience of meeting the enigmatic woman thought only to exist in paintings. Borrowing from a material culture approach which views images as both reflective and formative of identity, this work considers the relationship between Jane Burden Morris and her painted representation, and focuses in particular on the works produced through Burden Morris’s long-standing collaboration with Rossetti. Through an examination of Burden Morris’s appearance, activities, and demeanour, this dissertation considers the aspects of Burden Morris’s identity which contributed to her use in numerous Pre-Raphaelite images, and further explores the way in which these paintings may have altered how Burden Morris conceived of her own identity. “The Burden of the Image” examines three dominant modes of representing Burden Morris, including depictions of Burden Morris as medieval damsel, myth, and monster. It also considers Jane Burden Morris’s role within the broader context of aestheticism, and explores her relationship to the artistic dress movement and the aesthetic interior. / Thesis (Ph.D, Art History) -- Queen's University, 2014-03-31 13:33:52.106

Résumé Cet ouvrage examine les fondements du mouvement de conservation architecturale moderne. Dans ce contexte, la création de la « Society for the Protection of Ancient Buildings » par William Morris est considéré comme le point culminant d’un processus historique qui mena à l’apparition du mouvement. Sa genèse est présentée comme ayant été le résultat d’une confrontation entre deux visions utopiques du moyen-âge; celle de l’Église Anglicane et celle de William Morris. Un survol détaillé des origines, des résultats et des effets de la « Renaissance Gothique » ouvre tout grand sur les sources littéraires, idéologiques et religieuses qui y donnèrent sa force. Les grands programmes de restaurations qui ont vu le jour en Angleterre à l’ère victorienne sont examinés en relation avec l’Église Anglicane et caractérisés par les motivations idéologiques de celle-ci. Bien que ce memoire ne réussit pas à démontré de manière sans équivoque que la création du mouvement de conservation architectural moderne par Morris fut essentiellement en reaction au programme idéologique de l’Église Anglicane au dix-neuvième siècle, nous y retrouvons néanmoins une réévaluation des causes et de l’impact de la « Renaissance Gothique » qui, de manière significative, allaient à l’encontre des croyances et des principes les plus chers à Morris. Il existe une quantité admirable d’ouvrages examinant les travaux et l’impact de William Morris en littérature et en arts, ainsi que son activisme socialiste. Cependant, il serait juste de constater qu’en comparaison, la grande contribution qu’il apporta à la protection de l’architecture patrimoniale a certainement été négligée dans les publications à son sujet. Ce projet de recherche examine les éléments et les conditions qui ont motivé Morris à créer un mouvement qui encore aujourd’hui continue de croitre en importance et en influence. / Abstract This research seeks to examine and contextualize the origins of the modern architectural conservation movement. In this context, William Morris’ founding of the Society for the Protection of Ancient Buildings is considered to be the culmination of a complex history and process that lead to the movement’s creation. Its genesis is presented as having resulted from the confrontation between diverging views and idealizations of the middle ages, the Anglican Church, and William Morris. An extensive survey of the origins, results, and effects of Gothic Revival points to the literary, ideological, and religious components which gave it its main impetus. The widespread restoration programs carried out in Victorian England in the nineteenth century are largely examined in relation to the Anglican Church and presented as having been motivated by its ideological concerns. Although this research does not manage to demonstrate unequivocally that William Morris’ founding of the modern architectural conservation movement sprang from a direct reaction to the Anglican Church’s religious program in the nineteenth century, it does reevaluate the causes and impact of the Gothic Revival and demonstrates how these were at odds with some of Morris’ most fundamental beliefs and principles. While there is a sizeable body of scholarly work examining William Morris’ work as a poet, artist and socialist, his great contribution to the conservation of ancient buildings has clearly been minimized in comparison. This research project examines the factors and conditions that led Morris towards the creation of an organization which to this day remains highly pertinent and influential.

The abuse of anabolic androgenic steroids (AAS) is becoming increasingly common and may result in a range of physiological as well as psychological effects such as altered behavior in terms of increased aggression, cognitive dysfunction and addictive behavior. AAS comprise testosterone and its derivatives, of which nandrolone is one of the more common. Previous studies have shown nandrolone-induced effects in male rats on peptide levels within the Substance P (SP) system and the dynorphinergic system; these effects may be linked to some of the reported behavior alterations. The studies presented in this thesis aimed to investigate the mechanisms underlying these peptide alterations and also to further investigate neuropeptidergic effects attributed to nandrolone administration. The results display significant effects on the enzymatic conversion of SP and Dynorphin A into their bioactive metabolites SP(1-7) and Leu-enkephalin-Arg6, respectively, as a result of nandrolone treatment. More profound investigations on the dynorphinergic system displayed effects on the kappa opioid receptor density in various brain regions. There was also a significant increase in the expression of the gene transcript of prodynorphin in the hippocampus, a brain region associated with cognitive processes. In addition, impaired spatial learning and memory in the Morris water maze task following nandrolone administration was encountered. The results provide further understanding regarding neuropeptidergic mechanisms underlying AAS-induced behavioral effects.

Ce travail de thèse avait pour objectif d’étudier le rôle de l’hippocampe (HPC) ventral et des noyaux reuniens (Re) et rhomboïde (Rh) du thalamus dans les processus cognitifs qui sous-tendent la mémoire spatiale chez le Rat. Par l’utilisation d’approches complémentaires combinant l’imagerie cérébrale, la lésion excitotoxique, l’inactivation fonctionnelle réversible et des évaluations comportementales, nos résultats ont mis en évidence : (1) l’implication spécifique de l’HPC ventral uniquement dans le rappel d’informations spatiales ; (2) un rôle-clé des noyaux Re et Rh dans la persistance d’un souvenir spatial ; (3) l’implication des noyaux Re et Rh dans le labyrinthe du double-H, un nouveau test nécessitant d’une part, l’utilisation d’informations spatiales dépendant de l’intégrité de l’HPC dorsal, et d’autre part, une flexibilité comportementale, impliquant le cortex préfrontal médian. Ainsi, l’ensemble de ces résultats permet de proposer l’existence d’un circuit HPC-préfronto-thalamique impliqué dans divers aspects du traitement des informations spatiales. / The main objective of this thesis was to investigate the role of the ventral hippocampus (HPC) and the reuniens (Re) and rhomboid (Rh) thalamic nuclei in the cognitive processes underlying spatial memory in the Rat. If our results first confirmed, in the Morris water maze, the role of the dorsal HPC in the acquisition and retrieval of a spatial reference memory, we demonstrated the specific involvement of the ventral HPC only in the recall of spatial information. In addition, by using complementary approaches combining brain imaging, excitotoxic lesion and reversible functional inactivation, we were able to show for the first time a key role for the Re and Rh in the persistence of a spatial memory (25 days). Finally, the third set of experiments has highlighted the involvement of the Re and Rh in a mnemonic task performed in a new test, the double-H maze, which requires the use of spatial information depending on the integrity of the dorsal HPC, and a behavioral flexibility, involving the medial prefrontal cortex. Thus, taken together, these results suggest the involvement of a HPC-prefronto-thalamic network in various aspects of spatial information processing.

The Semantic web was created for a purpose of conceptualization data available on the Internet. Through formalized representations, that are determined for data sharing and reusing, should have been its vision realized. Main aims of Semantic web are high exactness and relevance for searching question. The controversy and polysemy of the term "Semantic web" let us consider the question: "Where is the limit of involving semantic aspects provided on Semantic web?" Is it not only the amount of determinations of specific standards that are connected with data itself? The main aim of this thesis is the comparison of using terms on the Semantic web in semantic metadiscourse with traditional academic semiotics approaches appeared from pragmatic of Ch. S. Peirce, Ch. W. Morris and H. P. Grice. The thesis should help with mapping the problematic area that is connected with using terms like "meaning" and "understanding" and clarify the possibilities of the function of the Semantic web based on the semiotics conceptions.

Diploma thesis deals with the determination of the intrinsic value of Philip Morris ČR a.s. shares using methods of fundamental stock analysis. The theoretical part is focused on clarifying the basic concepts and methods that relate to this issue and will be used in the processing of the following parts. The analytical part contains fundamental stock analysis compiled on macroeconomic, branch and corporate level. The proposal part focuses on the application of selected methods to quantify the intrinsic value of shares, including the subsequent recommendation for investors.