No description available.

Many big organizations who are in existence since before the term agile came into existence are pursuing agile transformations and trying to integrate it with their existing structure. It has been an accepted fact that agile integrations are difficult in big organizations and many of such organizations fail the transformations. This is especially true for multisite software organizations where a traditional mix of old and new ways of working ends up creating issues. The result of such failure is the implementation of a hybrid way of working which ultimately leads to lower output and higher cost for the organizations.This paper looks at the integration challenges for multisite software engineering organizations and correlates with the theoretical findings by earlier with practical findings using survey and interviews as data collection tools. This paper specifically focusses on integration challenges involving self-organizing teams, power distribution, knowledge hiding and knowledge sharing, communications and decision making. The paper also has empirical evidence that shows that there is a communication and understanding gap between the employees and management in basic understanding of agile concepts.

The aim of my Ph.D. thesis is to summarize my research on the development of multimateiral multifunctional fibers for bio-related application, mainly in the fields of neural interfacing and bioimpedance sensing. Understanding the cytoarchitecture and wiring of the brain requires improved methods to record and stimulate large groups of neurons with cellular specificity. This requires the development of improved miniaturized neural interfaces that integrate into brain tissue without altering its properties. Despite the advancement of the existing neural interface technologies such as microwires, silicon-based multielectrode arrays, and electrode arrays with flexible substrates, the physical properties of these devices limit their access to one, small brain region with single implantation. Beyond neural interfacing, extracting molecular information is crucial for understanding many neurological diseases and disorders. The most adapted methods are fast scan cyclic voltammetry and microdialysis. However, both have some limitations such as offline sensing or lack of selectivity. Furthermore, by concentrating optical fields at the nanoscale, plasmonic nanostructures can serve as optical nanoantennas to achieve ultrasensitive bio-/chemical sensing. But due to the limitation of the sensing mechanism, it is hard to perform the plasmonic sensing in live animals. Moreover, the relatively poor electrical performance of the electrode materials that can be utilized in the thermal drawing process limits the function of the fiber in other types of biomedical application, such as deep brain stimulation and electrochemical sensing. For example, the large inherent electrical resistance of the electrode material will significantly interference the electrical impedance result while the main purpose of this kind of study is to explore the frequency-dependent electrical properties of the tested subjects. To overcome above difficulties This thesis introduces broad application of multimaterial multiplexed fibers in biomedical areas. I first describe the development and application of spatially expandable multifunctional fiber-based probes for mapping and modulating brain activities across distant regions in the deep brain (Chapter 2). Secondly, I present the flexible nano-optoelectrodes integrated multifunctional fiber probes that can have hybrid optical-electrical sensing multimodalities, including optical refractive-index sensing, surface-enhanced Raman spectroscopy, and electrophysiological recording (Chapter 3). Thirdly, I demonstrate that hollow multifunctional fibers enable in-line impedimetric sensing of bioink composition and exhibit selectivity for real-time classification of cell type, viability, and state of differentiation during bioprinting (Chapter 4). The same device allows for local delivery of immune checkpoint blockade antibodies and for monitoring of clinical outcomes by tumor impedance measurement over the course of weeks with the photodynamic therapy option to enhance anti-tumor immunity and prolong intratumoral drug retention (Chapter 5). An overview future work has been summarized (Chapter 6). / Doctor of Philosophy / Electrode technology has played an indispensable role in neuroscience community since the first employment of insulated tungsten wire in cat brain in 1950s. The electrophysiological signal acquired from or the electrical current delivered to the brain tissue using the implanted electrode, has permitted us to understand the functional networks in the brain and treat neurological diseases. Over the past decades, significant progress has been made in developing miniaturized electrical neural interfaces. The development of optogenetics involving genetically-modified neurons that express light-sensitive proteins (opsins) has provided a powerful tool for modulating the neuronal activity to be switched on or off using light at a particular wavelength. Leveraging the thermal drawing process (TDP) from optical fiber industry for producing conventional silica fibers, multifunctional fiber-based neural probes have recently been developed, allowing for simultaneous optical stimulation, electrical recording, and drug delivery in vivo. However, the interfacing sites in these fiber-based neural probes have been restricted to a single location (at the fiber tip) so far, making the broad application of these probes unfeasible. Beyond neural interfacing, extracting molecular information is crucial for understanding many neurological diseases and disorders. The most adapted methods are fast scan cyclic voltammetry and microdialysis. However, both have some limitations such as offline sensing or lack of selectivity. Furthermore, by concentrating optical fields at the nanoscale, plasmonic nanostructures can serve as optical nanoantennas to achieve ultrasensitive bio-/chemical sensing. But due to the limitation of the sensing mechanism, it is hard to perform the plasmonic sensing in live animals. To overcome these limitations, we first developed a platform that provides three-dimensional coverage of brain tissue through multifunctional polymer fiber-based neural probes capable of interfacing simultaneously with neurons in multiple sites (Chapter 2). In a later study, we demonstrate that conductive nanoantenna arrays can be integrated with microelectrodes on the tip of multifunctional fiber probes as nano-optoelectrodes to enable optical bio-/chemical spectroscopy as well as to improve electrophysiology recording (Chapter 3). Besides, inspired by a convergence fiber drawing method, we have also managed to incorporate copper wires inside multifunctional fibers with a hollow channel in the center, in favor of high electrical conductivity. This technology developed here holds great promise for electrochemical impedance sensing of the tested media without the interference from the utilized electrodes' high resistance. Hence, by exploiting the functional fibers and the superior electrical performance, the copper-electrode-based fiber has been used for in vitro bioink bioimpedance sensing during 3D printing process (Chapter 4) and in vivo tumor impedance monitoring and drug delivery (Chapter 5). In summary, my research produces unique platforms for fundamental research studies as well as the readily translational application for human subjects. Given the scalable, straightforward, and versatile fabrication method, the multifunctional fibers delivered by our team would pave the way for new engineered tools for broad biomedical community.

Submitted by Silvana Teresinha Dornelles Studzinski (sstudzinski) on 2015-03-27T21:50:24Z No. of bitstreams: 1 000009DB.pdf: 3388615 bytes, checksum: 09209b15990dc85ffd9afd9251ff2304 (MD5) / Made available in DSpace on 2015-03-27T21:50:24Z (GMT). No. of bitstreams: 1 000009DB.pdf: 3388615 bytes, checksum: 09209b15990dc85ffd9afd9251ff2304 (MD5) Previous issue date: 2013-10-28 / Nenhuma / No mundo empresarial as respostas às mudanças devem ser cada vez mais ágeis, quando se fala em uma sociedade do conhecimento. Com isto, a capacitação passa a ser um tema central no mundo corporativo, onde tradicionalmente se promoviam ações de treinamento e desenvolvimento (T&D). A aprendizagem passa por um processo de transformação e neste sentido nasce a Educação Corporativa (EC) que pode ser definida como um conjunto de estratégias educacionais contínuas, fundamentada em metas futuras e na cultura organizacional, com o objetivo de desenvolver as competências críticas para o negócio, envolvendo o público interno e externo à empresa. Como uma ação dentro da EC, o desenvolvimento de lideranças, em um contexto social, está atrelado às necessidades das organizações, que buscam uma forma estruturada de elaborar programas para o desenvolvimento contínuo. Para o desenvolvimento da liderança diferentes estratégias, modalidades e Tecnologias da Informação e Comunicação (TIC), podem ser utilizadas. Diante deste cenário, a presente pesquisa foi motivada devido aos poucos estudos acadêmicos localizados sobre o tema EC e desenvolvimento de lideranças, no contexto brasileiro. Seu principal objetivo é identificar e analisar quais estratégias e TIC vem sendo utilizadas na Educação Corporativa para o desenvolvimento de lideranças em organizações multisite na região metropolitana de Porto Alegre – RS. A investigação foi realizada por meio de pesquisa qualitativa exploratória, através de entrevistas em 12 empresas de grande porte, envolvendo 24 entrevistados por meio de um roteiro semi-estruturado. Um protocolo de análise foi criado a partir das categorias identificadas na revisão da literatura, de forma dedutiva, e a análise dos dados foi realizada com o auxílio do software Nvivo. Os resultados da investigação indicam que a maioria das empresas, ainda não adota a abordagem de Educação Corporativa em sua totalidade. As estratégias de ensino e aprendizagem mais utilizadas são (em ordem decrescente): aulas expositivas, debates, coachinge workshops; a modalidade presencial predomina e a utilização das TIC ainda é limitada para esses fins, sendo as tecnologias citadas os AVA (Ambientes Virtuais de Aprendizagem) e ferramentas da Web2.0. Pelo fato das empresas pesquisadas serem multisite, o maior desafio encontrado no processo de desenvolvimento de lideranças é a aprendizagem e disseminação da cultura organizacional. Como resultados dos programas de desenvolvimento de lideranças os entrevistados citaram: o desenvolvimento de líderes internos, a disseminação do conhecimento, a visão coletiva (objetivo comum) e resultados financeiros, mas ficou evidente que há ainda grande dificuldade, na maior parte das empresas pesquisadas, para se avaliar, de forma sistemática, os resultados da EC e do desenvolvimento de lideranças. / In the business world, answers for changes must be increasingly agile, mainly speaking of information based society. Therefore, the capability becomes a top trend in the corporate world where training and development (T&D) actions used to be promoted. Learning is currently in a transformation process and, in this context; we have Corporate Education (CE), which can be defined as a set of continuous educational strategies grounded on future goals and organizational culture, aiming at developing critical competencies for business, involving internal and external company parties. As an actionwithin CE, leadership development, in a social context, is attached to organization needs, and seeks for a structured way to elaborate programs for continuous development. In order to achieve leadership development, different strategies, modalities and Information Technology and Communication (ITC) can be used. This research is motivated by this scenario, since there are few academic studies about CE and leadership development in multisite organization in Porto Alegre metropolitan area. This investigation is based on an exploratory qualitative research, through interviews in 12 big companies, with 24 people by means of a semi-structured script. An analysis protocol was created based on categories identified in the bibliography review using Nvivo software. The results point out that the majority of the companies still do not have adopted Corporate Education completely. The most popular teaching and learning strategies are: expositive classes, debates, coaching and workshops; mainly inplace and ITC are barely applied, such technologies are also known as Virtual Learning Environments (VLE) and Web 2.0 tools. Considering that the researched companies are multisite, the main challenge in leadership development is the organizational culture learning and dissemination. With the leadership development programs results, the interviewees cited: knowledge dissemination, collective vision (common objectives) and financial results, but it is evident that there are still a big issue in most of the researched companies in terms of evaluation, in a systematic way, CE and leadership development results.

Les travaux de recherche de cette thèse s'inscrivent dans le cadre de la mise en place de l'Ingénierie Simultanée au sein du secteur de l'industrie aéronautique européenne. C'est la thématique du projet de recherche ENHANCE. Il est établi dans un premier temps que les problématiques d'Ingénierie Collaborative Multisite sont au coeur du concept d'Ingénierie Simultanée, le rôle de la tâche COSITE a donc été de mettre en place les outils et les méthodes associées les mieux adaptées aux besoins du secteur. Sur la base d'une étude de cas types de collaboration rencontrés par les partenaires du projet ENHANCE, et sur la base d'une classification fonctionnelle, nous avons élaboré une approche de spécification d'environnement d'Ingénierie Collaborative Multisite. Ces cas étant si multiples, aucun outil unique du marché ne peut encore prétendre satisfaire l'ensemble des besoins. C'est pourquoi, nous avons développé un outil d'aide à la décision qui fournit à l'utilisateur un moyen de déterminer un environnement couvrant ses besoins spécifiques. La conception de cet outil a été possible grâce à la définition d'une liste exhaustive de critères d'évaluation qui traduisent les besoins de collaboration. Ainsi, grâce à cet outil, il est possible de déterminer, quelque soit le cas de collaboration, l'environnement le mieux adapté. Pour démontrer l'efficacité, à la fois de l'approche de spécification proposée et de l'outil d'aide à la décision, nous avons mis en oeuvre de les appliquer à deux types de collaboration: les réunions impromptues et les réunions planifiées. La mise en place d'une salle de revue de conception collaborative multisite à Eurocopter a été réalisée. Un retour d'expériences de la part des utilisateurs a permis de valider les propositions présentées dans cette thèse.

No description available.

A utilização de fungicidas multissítios, como é o caso do mancozebe (Mz), tem crescido bastante nas últimas safras com o intuito de evitar a resistência de fungos a fungicidas sítio-específico, além de aumentar sua eficiência no controle de doenças. No entanto, além do efeito fungicida, em áreas que receberam a aplicação destes produtos tem sido observados efeitos fisiológicos nas plantas, que vão desde a redução do nível de estresse até o aumento no teor de clorofila, o que repercute na produtividade. Associado a isto, o ácido salicílico também se torna uma estratégia importante, visto que este hormônio promove redução do nível de estresse, além de atuar na indução de resistência contra doenças. No entanto, pouco se sabe sobre os efeitos fisiológicos que este produtos isolados e em associação podem causar na cultura do feijoeiro comum. Portanto, o objetivo do trabalho foi avaliar o efeito da aplicação de Mz e ácido salicílico em características fisiológicas, componentes de produção e produtividade da cultura do feijoeiro comum. O ensaio foi conduzido em área comercial de produção de feijão irrigado em Patos de Minas-MG entre os meses de abril e agosto de 2017. Foi adotado delineamento em blocos casualizados em esquema fatorial 5 x 2 constituído por cinco doses de ácido salicílico (0, 50, 100, 200 e 400 mg ha-1) associados ou não a aplicação de Mz na dose de 400 g ha-1 e cinco repetições. Para cada tratamento, foram realizadas três aplicações, sendo estas aos 22, 37 e 52 dias após a semeadura. Foram realizadas avaliações de massa de matéria seca de vagens, produtividade, atividade da nitrato redutase, urease, enzimas antioxidantes (SOD, POD e CAT), teor de prolina, peróxido de hidrogênio e peroxidação de lipídios. A aplicação de Mz proporcionou o aumento da atividade da SOD, sendo assim também ocorreu o incremento POD e da CAT, consequentemente reduzindo o peróxido de hidrogênio em folhas de feijoeiro, o que manteve baixo os níveis de peroxidação lipídica. Além disso, os níveis de prolina caíram significativamente após a aplicação de Mz. Quando se utilizou o Mz associado com o ácido salicílico, se observou que ocorreu o aumento da atividade da SOD, atingindo o seu pico para a dose de 200 mg ha-1. Além disso o ácido salicílico promoveu o incremento de prolina quando associado ao Mz, em relação ao tratamento com Mz isolado. Nesta situação a prolina foi reponsável pela eliminação de H2O2, mantendo os níveis das enzimas SOD e CAT reduzidos. Com os baixos níveis de peróxido de hidrogênio a peroxidação lipídica reduziu significativamente. As aplicações de Mz refletiram na maior massa seca de vagens e implicando na maior produtividade do feijoeiro, ao passo que o ácido salicílico proporcionou o aumento de produtividade, porém dependente da dose utilizada que apresentou o melhor resultado na dose de 200 mg ha-1. / The use of multisite fungicides, such as mancozeb (Mz), has grown in the last few seasons in order to avoid fungal resistance to specific-site fungicides, in addition to increasing its efficiency in disease control. However, in addition to the fungicidal effect, in areas that have received the application of these products, physiological effects have been observed in the plants, ranging from the reduction of the stress level to the increase in chlorophyll content, which has an impact on productivity. Associated with this, salicylic acid also becomes an important strategy, since this hormone promotes reduction of stress level, besides acting in the induction of resistance against diseases. However, knowledge about physiological effects is well limited on what isolated and associated products can cause on the common bean crop. Therefore, the objective of this work was to evaluate the effect of Mz and salicylic acid applications on physiological characteristics, production components and productivity of the common bean crop. The experiment was carried out in a commercial area of irrigated common bean production in \'Patos de Minas\'-MG between April and August 2017. A randomized complete block design was used in a 5 x 2 factorial scheme consisting of five doses of salicylic acid (0, 50, 100, 200 and 400 mg ha-1) with or without the application of Mz at a dose of 400 g ha-1 and five replications. For each treatment, three applications were performed, being these at 22, 37 and 52 days after sowing. Nitrate reductase activity, urease, antioxidant enzymes (SOD, POD and CAT), proline content, hydrogen peroxide and lipid peroxidation were evaluated. The application of Mz provided the increase of the SOD activity, thus also the POD and CAT increase, consequently reducing the hydrogen peroxide in leaves of common bean, which kept the levels of lipid peroxidation low. In addition, proline levels dropped significantly after application of Mz. When Mz associated with salicylic acid was used, it was observed that the increase in SOD activity occurred, reaching its peak at the 200 mg ha-1 dose. In addition, salicylic acid promoted the increase of proline when associated with Mz, in relation to the treatment with Mz alone. In this situation proline was responsible for the elimination of H2O2, keeping the levels of the SOD and CAT enzymes reduced. With the low levels of hydrogen peroxide the lipid peroxidation reduced significantly. The Mz applications reflected in the higher dry mass of pods and implying a higher yield of common bean, while salicylic acid provided the increase in productivity, however, depending on the dose used, which presented the best result at 200 mg ha-1.

This thesis presents the development and application of a downscaling framework for multi site simulation of daily rainfall. The rainfall simulation is achieved in two stages. First, rainfall occurrences at multiple sites are downscaled, which is followed by the generation of daily rainfall amounts at each site identified as wet. A continuous weather state based nonparametric downscaling model conditional on atmospheric predictors and a previous day average rainfall state is developed for simulation of multi site rainfall occurrences. A nonparametric kernel density approach is used for simulation of rainfall amounts at individual sites conditional on atmospheric variables and the previous day rainfall amount. The proposed model maintains spatial correlation of rainfall occurrences by simulating concurrently at all stations and of amounts by using random innovations that are spatially correlated yet serially independent. Temporal dependence is reproduced in the occurrence series by conditioning on previous day average wetness fraction and assuming the weather states to be Markovian, and in the amount series by conditioning on the previous day rainfall amount. The seasonal transition is maintained by simulating rainfall on a day-to-day basis using a moving window formulation. The developed downscaling framework is calibrated using the relevant atmospheric variables and rainfall records of 30 stations around Sydney, Australia. Results indicate a better representation of the spatio-temporal structure of the observed rainfall as compared to existing alternatives. Subsequently, the framework is applied to predict plausible changes in rainfall in warmer conditions using the same set of atmospheric variables for future climate obtained as a General Circulation Model simulation. While the case studies presented are restricted to a specific region, the downscaling model is designed to be useful in any generic catchment modelling and management activity and/or for investigating possible changes that might be experienced by hydrological, agricultural and ecological systems in future climates.

Processes that take place in the Earth’s mantle are not accessible to direct observation. Natural samples of mantle material that have been transported to the surface as xenoliths provide useful information on phase relations and compositions of phases at the pressure and temperature conditions of each rock fragment. In the past, considerable effort has been devoted by petrologists to investigate upper mantle processes experimentally. Results of high temperatures, high pressure experiments have provided insight into lower crust-upper mantle phase relations as a function of temperature, pressure and composition. However, the attainment of equilibrium in these experiments, especially in complex systems, may be very difficult to test rigorously. Furthermore, experimental results may also require extrapolation to different pressures, temperatures or bulk compositions. More recently, thermodynamic modeling has proved to be a very powerful approach to this problem, allowing the deciphering the physicochemical conditions at which mantle processes occur. On the other hand, a comprehensive thermodynamic model to investigate lower crust-upper mantle phase assemblages in complex systems does not exist. ¶ In this study, a new thermodynamic model to describe phase equilibria between silicate and/or oxide crystalline phases has been derived. For every solution phase the molar Gibbs free energy is given by the sum of contributions from the energy of the end-members, ideal mixing on sites, and excess site mixing terms. It is here argued that the end-member term of the Gibbs free energy for complex solid solution phases (e.g. pyroxene, spinel) has not previously been treated in the most appropriate manner. As an example, the correct expression of this term for a pyroxene solution in a general (Na-Ca-Mg-Fe2+-Al-Cr-Fe3+-Si-Ti) system is presented and the principle underlying its formulation for any complex solution phase is elucidated.¶ Based on the thermodynamic model an algorithm to compute lower crust-upper mantle phase equilibria for subsolidus mineral assemblages as a function of composition, temperature and pressure has been developed. Included in the algorithm is a new way to represent the total Gibbs free energy for any multi-phase complex system. At any given temperature and pressure a closed multi-phase system is at its equilibrium condition when the chemical composition of the phases present in the system and the number of moles of each are such that the Gibbs free energy of the system reaches its minimum value. From a mathematical point of view, the determination of equilibrium phase assemblages can, in short, be defined as a constrained minimization problem. To solve the Gibbs free energy minimization problem a ‘Feasible Iterate Sequential Quadratic Programming’ method (FSQP) is employed. The system’s Gibbs free energy is minimized under several different linear and non-linear constraints. The algorithm, coded as a highly flexible FORTRAN computer program (named ‘Gib’), has been set up, at the moment, to perform equilibrium calculations in NaO-CaO-MgO-FeO-Al2O3-Cr2O3-Fe2O3- SiO2-TiO2 systems. However, the program is designed in a way that any other oxide component could be easily added.¶ To accurately forward model phase equilibria compositions using ‘Gib’, a precise estimation of the thermodynamic data for mineral end-members and of the solution parameters that will be adopted in the computation is needed. As a result, the value of these parameters had to be derived/refined for every solution phase in the investigated systems. A computer program (called ‘GibInv’) has been set up, and its implementation is here described in detail, that allows the simultaneous refinement of any of the end-member and mixing parameters. Derivation of internally consistent thermodynamic data is obtained by making use of the Bayesian technique. The program, after being successfully tested in a synthetic case, is initially applied to pyroxene assemblages in the system CaO-MgO-FeO-Al2O3-SiO2 (i.e. CMFAS) and in its constituent subsystems. Preliminary results are presented.¶ The new thermodynamic model is then applied to assemblages of Ca-Mg-Fe olivines and to assemblages of coexisting pyroxenes (orthopyroxene, low Ca- and high Ca clinopyroxene; two or three depending on T-P-bulk composition conditions), in CMFAS system and subsystems. Olivine and pyroxene solid solution and end-member parameters are refined, in part using ‘GibInv’ and in part on a ‘trial and error’ basis, and, when necessary, new parameters are derived. Olivine/pyroxene phase relations within such systems and their subsystems are calculated over a wide range of temperatures and pressures and compare very favorably with experimental constraints.

A utilização de fungicidas multissítios, como é o caso do mancozebe (Mz), tem crescido bastante nas últimas safras com o intuito de evitar a resistência de fungos a fungicidas sítio-específico, além de aumentar sua eficiência no controle de doenças. No entanto, além do efeito fungicida, em áreas que receberam a aplicação destes produtos tem sido observados efeitos fisiológicos nas plantas, que vão desde a redução do nível de estresse até o aumento no teor de clorofila, o que repercute na produtividade. Associado a isto, o ácido salicílico também se torna uma estratégia importante, visto que este hormônio promove redução do nível de estresse, além de atuar na indução de resistência contra doenças. No entanto, pouco se sabe sobre os efeitos fisiológicos que este produtos isolados e em associação podem causar na cultura do feijoeiro comum. Portanto, o objetivo do trabalho foi avaliar o efeito da aplicação de Mz e ácido salicílico em características fisiológicas, componentes de produção e produtividade da cultura do feijoeiro comum. O ensaio foi conduzido em área comercial de produção de feijão irrigado em Patos de Minas-MG entre os meses de abril e agosto de 2017. Foi adotado delineamento em blocos casualizados em esquema fatorial 5 x 2 constituído por cinco doses de ácido salicílico (0, 50, 100, 200 e 400 mg ha-1) associados ou não a aplicação de Mz na dose de 400 g ha-1 e cinco repetições. Para cada tratamento, foram realizadas três aplicações, sendo estas aos 22, 37 e 52 dias após a semeadura. Foram realizadas avaliações de massa de matéria seca de vagens, produtividade, atividade da nitrato redutase, urease, enzimas antioxidantes (SOD, POD e CAT), teor de prolina, peróxido de hidrogênio e peroxidação de lipídios. A aplicação de Mz proporcionou o aumento da atividade da SOD, sendo assim também ocorreu o incremento POD e da CAT, consequentemente reduzindo o peróxido de hidrogênio em folhas de feijoeiro, o que manteve baixo os níveis de peroxidação lipídica. Além disso, os níveis de prolina caíram significativamente após a aplicação de Mz. Quando se utilizou o Mz associado com o ácido salicílico, se observou que ocorreu o aumento da atividade da SOD, atingindo o seu pico para a dose de 200 mg ha-1. Além disso o ácido salicílico promoveu o incremento de prolina quando associado ao Mz, em relação ao tratamento com Mz isolado. Nesta situação a prolina foi reponsável pela eliminação de H2O2, mantendo os níveis das enzimas SOD e CAT reduzidos. Com os baixos níveis de peróxido de hidrogênio a peroxidação lipídica reduziu significativamente. As aplicações de Mz refletiram na maior massa seca de vagens e implicando na maior produtividade do feijoeiro, ao passo que o ácido salicílico proporcionou o aumento de produtividade, porém dependente da dose utilizada que apresentou o melhor resultado na dose de 200 mg ha-1. / The use of multisite fungicides, such as mancozeb (Mz), has grown in the last few seasons in order to avoid fungal resistance to specific-site fungicides, in addition to increasing its efficiency in disease control. However, in addition to the fungicidal effect, in areas that have received the application of these products, physiological effects have been observed in the plants, ranging from the reduction of the stress level to the increase in chlorophyll content, which has an impact on productivity. Associated with this, salicylic acid also becomes an important strategy, since this hormone promotes reduction of stress level, besides acting in the induction of resistance against diseases. However, knowledge about physiological effects is well limited on what isolated and associated products can cause on the common bean crop. Therefore, the objective of this work was to evaluate the effect of Mz and salicylic acid applications on physiological characteristics, production components and productivity of the common bean crop. The experiment was carried out in a commercial area of irrigated common bean production in \'Patos de Minas\'-MG between April and August 2017. A randomized complete block design was used in a 5 x 2 factorial scheme consisting of five doses of salicylic acid (0, 50, 100, 200 and 400 mg ha-1) with or without the application of Mz at a dose of 400 g ha-1 and five replications. For each treatment, three applications were performed, being these at 22, 37 and 52 days after sowing. Nitrate reductase activity, urease, antioxidant enzymes (SOD, POD and CAT), proline content, hydrogen peroxide and lipid peroxidation were evaluated. The application of Mz provided the increase of the SOD activity, thus also the POD and CAT increase, consequently reducing the hydrogen peroxide in leaves of common bean, which kept the levels of lipid peroxidation low. In addition, proline levels dropped significantly after application of Mz. When Mz associated with salicylic acid was used, it was observed that the increase in SOD activity occurred, reaching its peak at the 200 mg ha-1 dose. In addition, salicylic acid promoted the increase of proline when associated with Mz, in relation to the treatment with Mz alone. In this situation proline was responsible for the elimination of H2O2, keeping the levels of the SOD and CAT enzymes reduced. With the low levels of hydrogen peroxide the lipid peroxidation reduced significantly. The Mz applications reflected in the higher dry mass of pods and implying a higher yield of common bean, while salicylic acid provided the increase in productivity, however, depending on the dose used, which presented the best result at 200 mg ha-1.