L’objectif de ce travail est d’améliorer la durée de vie en fluage d’un alliage résistant à haute température. L’alliage étudié, nommé « C », appartient à la classe des aciers austénitiques de type HP utilisés pour la fabrication des tubes de reformage. L’évolution microstructurale de l’alliage « C » a été étudiée dans une vaste gamme de températures, s’étendant de 700 à 1040°C pour des temps de vieillissement allant jusqu’à 1000 h. La caractérisation de ces états vieillis a été réalisée au moyen de la microscopie électronique (MEB-FEG, MET) et de la diffraction des rayons X. L’accent a été mis sur une caractérisation fine de la précipitation secondaire présente Ces résultats ont ensuite été utilisés afin d’identifier les conditions thermiques optimales pour l’affinement de la précipitation en vue d’amélioration du comportement macroscopique de l’alliage. La cinétique de précipitation a été modélisée à l’aide du logiciel PRISMA ThermoCalc. Un bon accord entre la simulation et les mesures expérimentales a pu être obtenu.Dans la gamme de températures étudiée, la précipitation secondaire est majoritairement constituée de deux carbures : M23C6 (M=Cr, Fe) et NbC. En condition de service (980°C), la croissance du M23C6 est rapide. La coalescence des précipités survient dès 200 h de vieillissement. Nous avons prouvé qu’un vieillissement à des températures plus basses (700-750°C) permet d’affiner cette précipitation. De plus, notre étude a montré l’efficacité d’un prétraitement à des températures basses, effectué avant la mise en service du matériau à 980°C. Une nette amélioration de la résistance en fluage dans des essais accélérés a été obtenue pour l’alliage « C » ayant subi le prétraitement cité ci-dessus. Outre l’affinement et le retardement de la coalescence du M23C6, la présence d’une précipitation nanométrique du NbC sur des lignes de dislocations est probablement à l’origine de cet effet. / The purpose of this work is to optimise the microstructure of a creep-resistant alloy of the type HP, called “C” (industrial denomination). These austenitic steels are used for the manufacture of reformer tubes. The microstructural evolution of the alloy "C" has been studied in a wide range of temperatures, ranging from 700 to 1040 °C for aging times up to 1000 h. The characterization of these aged states was performed using electron microscopy (FEG-SEM, TEM) and X-ray diffraction, with emphasis on a detailed characterization of this secondary precipitation. This knowledge was then used to identify the optimal thermal conditions for the refinement of precipitation to improve the macroscopic behaviour of the alloy. The precipitation kinetics was modelled using the PRISMA ThermoCalc. A good agreement between simulation and experimental measurements has been obtained.In the studied range of temperature, the secondary precipitation consists mainly of two carbides M23C6 (M = Cr, Fe) and NbC. In the service conditions (980°C), the growth of M23C6 is fast. The coalescence of the precipitates starts after only 200h of aging. Aging at lower temperatures (700-750°C) refines this precipitation. Our study showed the efficacy of pre-treatment of the alloy at low temperatures, before the service of the material at 980°C. In the alloy "C", treated in such conditions, a significant increase in creep resistance was obtained in accelerated testing. In addition to refinement of the secondary precipitation and delaying the effects of coalescence of M23C6, the presence of a nanoscale precipitation of NbC on dislocation lines is probably the origin of this effect.

Les glioblastomes (GBM) sont les formes les plus agressives de tumeurs gliales avec une survie médiane des patients traités n’excédant pas 2 ans. Ce mauvais pronostic est dû, entre autres, à l’hétérogénéité de ces tumeurs avec la présence de cellules souches cancéreuses (CSCs) en prolifération ou quiescentes, particulièrement résistantes aux traitements conventionnels. Cibler ces cellules au sein du microenvironment tumoral hypoxique et acides fait donc partie des thérapies d’avenir des GBMs. Le laxatif bisacodyl a été identifié par criblage de la chimiothèque Prestwick comme un composé induisant la mort par nécrose des CSCs de glioblastome (GSCs en prolifération et en quiescence), uniquement dans des conditions de faible acidité retrouvées également au sein des tumeurs. Une activité antitumorale in vivo a également été démontrée pour ce composé. Cette thèse présente l’identification du mode d’action du bisacodyl dans les GSCs. Celui-ci implique la serine/thréonine kinase WNK1 et ses partenaires, les kinases Akt et SGK1 et des co-transporteurs Na+/HCO3- NBC. Nos résultats ont également révélé un rôle de WNK1 dans la physiopathologie des GSCs. / Glioblastoma (GBM), the most aggressive glial tumor, is currently incurable with a very short-term patient survival (< 2 years). The heterogeneity of GBM and the presence of highly resistant proliferating and quiescent cancer stem-like cells (CSCs), is largely responsible for poor prognosis in this disease. Thus, new approaches targeting glioblastoma CSCs (GSCs), within the acidic/hypoxic tumor microenvironment, are promising strategies for treating GBM. The laxative bisacodyl was identified in a high throughput screening of the Prestwick chemical library as a compound inducing necrotic cell death in proliferating and quiescent GSCs only in acidic microenvironments similar to those found in tumors. Bisacodyl was further shown to induce tumor shrinking and to increase survival in in vivo GBM models. In this thesis work, we identify bisacodyl’s mechanism of action in GSCs. This mechanism involves the serine/threonine kinase WNK1 and its signaling partners including protein kinases Akt and SGK1 and NBC Na+/HCO3- cotransporters. Our data also highlight a previously unknown role of WNK1 in GSC physiopathology.

Submitted by Eduarda Figueiredo (eduarda.ffigueiredo@ufpe.br) on 2015-03-10T14:59:09Z No. of bitstreams: 2 Antonello, R. T._DISSERTAÇÃO.pdf: 11868567 bytes, checksum: 37f02ff74a4b9a3a993814861c25e4db (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) / Made available in DSpace on 2015-03-10T14:59:09Z (GMT). No. of bitstreams: 2 Antonello, R. T._DISSERTAÇÃO.pdf: 11868567 bytes, checksum: 37f02ff74a4b9a3a993814861c25e4db (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2012 / FACEPE / Aços rápidos obtidos por técnicas de metalurgia do pó (MP) apresentam propriedades melhoradas quando comparados aos aços rápidos obtidos pelo processo convencional. A inserção do nióbio (Nb) como elemento de liga nos aços rápidos iniciou-se com o objetivo de substituir elementos de liga como o vanádio (V) e o tungstênio (W). A sinterização com fase líquida é uma das técnicas de fabricação de aços rápidos obtidos pela metalurgia do pó. O objetivo deste trabalho é a obtenção dos aços rápidos AISI M2 e M3:2 com e sem a adição de carboneto de nióbio (NbC) por compactação uniaxial a frio e sinterização a vácuo com fase líquida. Os pós dos aços rápidos AISI M2 e M3:2 foram processados por moagem de alta energia (MAE) com e sem adição de carboneto de nióbio e compactado uniaxialmente a frio a 700 MPa e sinterizados nas temperaturas de 1240 °C, 1270 °C, para os aços sem a adição de NbC e 1250 °C, para os aços com a adição de 6% de NbC. Os pós dos aços rápidos AISI M2 e M3:2 com a adição de carboneto de nióbio (NbC) processados por uma técnica de moagem de alta energia (MAE) foram caracterizados por difração de raios-X e Microscopia eletrônica de varredura (MEV) e espectroscopia de baixa energia dispersiva de raios-X (EDS) para avaliar a incorporação do reforço do carboneto de nióbio (NbC) aos pós elementares dos aços rápidos. Amostras dos aços rápidos AISI M2 e M3:2 sinterizadas a vácuo com e sem a adição de carboneto de nióbio (NbC) tiveram suas densidades avaliadas e as microestruturas foram caracterizadas por microscopia óptica (MO) para avaliar as microestruturas (porosidades, tamanho e distribuição de carbonetos). Os aços rápidos AISI M2 e M3:2 objetos desse trabalho de pesquisa foram avaliados ainda no que concerne a propriedade mecânica de dureza através de ensaios de dureza Vickers (HV).

Anti-Semitism is still very much alive in the United States and has increased in the pastyears (ADL, 2023). Anti-Semitic rhetoric was brought to light by the world-famousrapper Kanye West, who in the fall of 2022 committed several anti-Semitic acts on hissocial platforms. When a person with great influence on the public sphere expresseshimself anti-Semitic, people can copy the behavior and believe that it is accepted. Thestudy's purpose is to expand the understanding of how American media frames antiSemitic rhetoric depending on their political ideology. This essay examines how KanyeWest was portrayed in American media in the end of 2022, where all articles found inthe timeperiod that included Kanye and antisemitism were collected. A total of 120articles were collected from four different news sources; New York Post and Fow Newthat are righwinged as well as CNN and NBC that are leftwinged. The applied methodis a mixed method with a focus on qualitative thematic content analysis. The methodhas been applied by finding patterns (themes) in the articles to answer the study'squestions: (1) When Kanye expressed anti-Semitic rhetoric, how was he framed inAmerican media? (2) How does the media's political ideological background affect theportrayal? (3) Has Kanye's anti-Semitism influenced the rise of anti-Semitism in theUS? This study does not examine media outside of the United States and no other mediathan written articles by journalists. The limitation gives a clear result of framing in thecontext of politics in one country. Existing research of Entman (1993, 2007, 2010) isused in the study to show the impact that framing has on the public and how it affectspolitics. The result shows that Kanye was framed primarily as an artist but also as ananti-semite and half of the material had negative frames of Kanye. The comparisonbetween the rightwinged and leftwinged media, showed that the left focused more onhow Kanye affected antisemitism in the U.S. and how antisemitism has increased. Thestudy concluded that Kanye had a big part in spreading antisemitism in the U.S

No description available.

No description available.

Professional development is used by teachers to improve their teaching to enhance student learning, and research indicates that the National Board Certification (NBC) process contains high-quality professional development characteristics. Engagement in the NBC process can lead to professional growth by changing teachers’ knowledge, instructional practices, and students’ learning. This quantitative study investigated the extent to which characteristics of the NBC process influenced National Board Certified Teachers’ (NBCTs) professional growth. Using an online survey, the study collected responses from 119 NBCTs who participated in a specific NBC support program. Key findings included that all 20 high-quality professional development characteristics investigated had a perceived positive influence on professional growth, with some notable differences. The characteristics involving individual analysis of student work and teaching videos along with reflection were perceived to be most important, while those centering on collaboration with other candidates were perceived as less important. Second, characteristics that had the greatest perceived impact were those that focused on changing pedagogy rather than increasing content knowledge. Furthermore, a significant relationship was found between the perceived importance of duration in the experience and the length of time the candidate was in the process: NBCTs who achieved in one year, as compared to NBCTs who achieved in two or three years, had statistically significant lower ratings on the influence that the duration had on their professional growth. Additionally, those who engaged in the process for financial reasons, as compared to professional growth, had a lower rating of perceived importance when all characteristics were combined.

Submitted by Silvana Teresinha Dornelles Studzinski (sstudzinski) on 2015-07-01T18:20:11Z No. of bitstreams: 1 Geovana Zimmermann Los.pdf: 1707837 bytes, checksum: 42f45d5024c990c07d9c215480e1fa6d (MD5) / Made available in DSpace on 2015-07-01T18:20:11Z (GMT). No. of bitstreams: 1 Geovana Zimmermann Los.pdf: 1707837 bytes, checksum: 42f45d5024c990c07d9c215480e1fa6d (MD5) Previous issue date: 2014-03-28 / Nenhuma / O objetivo do estudo foi verificar o impacto no valor adicionado a distribuir das variáveis evidenciadas, segundo a NBCT 15, por empresas classificadas no ISE. A pesquisa foi realizada com uma amostra formada por 75 relatórios de sustentabilidade, de 25 empresas que permaneceram na carteira do ISE no período de 2010 a 2012. Os resultados revelam que o grupo de indicadores do corpo funcional apresenta o maior percentual de atendimento à evidenciação de informações requeridas pela NBC T 15, uma vez que estes são evidenciados em 62,67% dos relatórios das empresas da amostra, seguidos do grupo de indicadores sociais internos, com 55,92%, e do grupo de indicadores sociais externos, divulgados em 47,33% dos relatórios. Já o grupo de indicadores relacionados com o meio ambiente apresenta o percentual médio mais baixo em termos de aderência, com índices de 26,67%. Com isso, o nível geral de aderência das empresas da amostra aos indicadores da NBC T 15 é de 49,6%, revelando fragilidade no quesito transparência. Nesse sentido, utilizando-se a análise de regressão com dados em painel para modelo de efeito fixo e de efeito aleatório, foi testado o impacto das variáveis “gastos sociais internos”, “número de funcionários”, “gastos sociais externos” e “gastos em meio ambiente no valor adicionado a distribuir das empresas”. No resultado para o modelo de efeito aleatório, é possível rejeitar H0, diante da hipótese H0,1, e confirmar a hipótese H1 formulada. Assim, o estudo revela que quanto maior o gasto com indicadores sociais internos, maior seria o valor adicionado a distribuir das organizações da amostra. Para as hipóteses H0,2 e H0,4 , é rejeitada a hipótese H0 a 5% de significância e, com isso, pode-se confirmar as hipóteses H2 e H4 do estudo, respectivamente. Dessa forma, o resultado demonstra que quanto maior o nível de funcionários das empresas da amostra, bem como quanto maiores forem os gastos com meio ambiente, maior será o valor adicionado a distribuir por elas. / The aim of the study was to determine the impact, on the added value to distribute of evidenced variables, according to NBCT 15, by companies classified on the ISE. The survey was conducted with a sample consisting of 75 sustainability reports, of 25 companies which remained on the ISE in the period 2010-2012. The results show that the group of indicators of functional staff shows the highest percentage of attendance to the disclosure of information required by NBC T 15, since these are observed in 62.67% of sample companies’s reports, followed by the group of internal social indicators, with 55.92%, and the group of external social indicators, published in 47.33% of the reports. The group of indicators related to the environment presents the lowest average percentage in terms of adhesion, with rates of 26.67%. With this, the overall adherence level of the sample companies to the indicators of NBC T 15 is 49.6%, revealing weaknesses in the category transparency. In this sense, using regression analysis, with panel data for the fixed effect and random effect model, it was tested the impact of variables "internal social spending," "number of employees", "external social costs" and "Spending on the environment in the value added to be distributed by companies". In the results for the random effect model, it is possible to reject H0,, given the hypothesis H0,1, Thus, the study reveals that higher is the spending on domestic social indicators, higher is the sample organizations’ added value to distribute; For the hypotheses H0,2 e H0,4 , is rejected hypothesis H0 at 5% significance, and, thus, it can be confirmed the H2 and H4 hypotheses of the study, respectively. Thus, the result shows that higher is the level of employees of companies in the sample, as well as higher is the spending on the environment, higher will be the value added to be distributed by them.

Abstrakt The diploma thesis is focused on the issue of securing serviceability of decontamination sites using the forces and the means available after cancellation of rescue battalions, and on the current position of the Fire Rescue Service. The objective of the thesis was to draw attention to the problem arising from insufficient securing of decontamination after cancellation of the rescue battalions intended for this activity. The output of the analysis of the present state and the state before cancellation of the rescue batallions is the finding that the solution currently used to secure decontamination is less effective. Therefore I have proposed a more effective solution based on maintaining rescue battalions together with the Fire Rescue Service. The raised hypotheses were confirmed through the concise charts that addressed the capabilities of the rescue units and the communication between individual brigades and departments will be verified in the planned exercise ZÓNA 2010 that will take place from 22 to 23 September 2010. In my thesis I made use of the available literature, findings from my bachelor thesis and from exercises ZÓNA 2007 and ZÓNA 2008, observations of experts, and terrain reconnaissance leading to proposing a suitable decontamination site. The thesis includes a proposal of a decontamination site in Hluboká nad Vltavou {--} Zámostí. I believe that there would be justification for submission of this proposal to the competent bodies. I regard my thesis as a good material for assessing the current state of this issue, proposing various solutions, and returning to greater care of citizens, as it used to be in previous year.

Lors des années 2000, le paysage télévisuel américain a été profondément bouleversé par l’arrivée d’Internet. Que ce soit dans sa production, sa création ou sa réception, l’évolution rapide des technologies numériques et l’apparition des nouveaux médias ont contraint l’industrie télévisuelle à changer, parfois contre son gré. C’est le cas de la chaîne généraliste américaine NBC, pour qui cette période de transition a été particulièrement difficile à traverser. Au coeur de ce moment charnière dans l’histoire de la télévision aux États-Unis, la sitcom Community (NBC, 2009-2014; Yahoo!Screen, 2015) incarne et témoigne bien de différentes transformations amenées par cette convergence entre Internet et la télévision et des conséquences de cette dernière dans l’industrie télévisuelle. L’observation du parcours tumultueux de la comédie de situation ayant débuté sur les ondes de NBC dans le cadre de sa programmation Must-See TV, entre 2009 et 2014, avant de se terminer sur le service par contournement Yahoo! Screen, en 2015, permet de constater que Community est un objet télévisuel qui a constamment cherché à s’adapter à un média en pleine mutation. Son incapacité à survivre à l’instabilité secouant l’industrie télévisuelle, par l’entremise de la télévision traditionnelle et de la télévision en ligne, souligne ainsi que le passage de la télévision vers cette ère numérique est plus complexe qu’il ne paraît. / During the 2000s, the American televisual landscape was deeply shaken by the arrival of the Internet. The quick growth of digital technologies and the emergence of new types of media forced a reluctant television industry to change; be that in production, creation or reception. This transition from a pre-digital to a digital form of television was particularly difficult for the National Broadcasting Company (NBC). In the midst of this defining moment in American television history came Community (NBC, 2009-2014; Yahoo!Screen, 2015), a sitcom that embodied and reflected the various transformations brought by the convergence of the Internet and television, as well as the consequences this confluence bore to that industry. From being broadcast on NBC’s Must-See TV lineup between 2009 and 2014 to then moving to Yahoo!’s online platform in 2015, Community’s journey in television revealed its multiple attempts at adapting to a media in mutation. Therefore, the inability of the series to survive an unstable television industry through both traditional and online means underlines the complexity pertaining to television’s transition to a digital era.