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Empati är en grundförutsättning för människors interaktion, kommunikation och förståelse för varandra. Forskning har visat att individer med depression och olika personlighetsstörningar har en tendens till nedsatt empati. I en enkätstudie med 205 deltagare, varav 162 kvinnor, undersöktes om sinnesstämning har ett samband med empati. Deltagarna försattes i en sinnesstämning, de fick tänka på positiva eller negativa händelse. Sedan läsa en negativt riktad vinjett om en gripande händelse. Sinnesstämning mättes med The Brief Mood Introspection Scale (BMIS) och empati med hjälp av Batsons empatiskala. Studien avser att fylla luckan som finns om sinnesstämning och empati hos människor i allmänhet. Manipulationen gav inget signifikant resultat. Resultatet visar dock ett positivt samband mellan sinnesstämning och empati från självskattningsskalorna. Deltagarna med positiv sinnesstämning rapporterade mer empati. Kvinnor kände mer empati är män och de äldre mer än yngre. Studien relaterar till att högre välmående hos individer kan skapa mer empati i samhället.

En studie med syftet att undersöka de generella temana i individers upplevelse av negativa emotioner. Tidigare forskning inom området har fokuserat på det frågeställningar som exempelvis handlar om negativa emotioners påverkan på individers hälsa. Den här studien söker att utveckla det kvalitativa området inom emotionspsykologi. Två frågeställningar undersöktes: Vad är de generella temana i män och kvinnors upplevelse av negativa emotioner?Finns det en skillnad i upplevelse av negativa emotioner mellan kvinnor och män? Deltagare var 66 individer, i åldrarna 19 till 77 varav 33 män. Materialet samlades in via en kvalitativ enkät och analyserades med meningskoncentrering och genom fenomenologisk tolkning. Resultatet gav fem generella teman: (1) Situation med minskad kontroll, (2) fysiskt upplevelse, (3) psykisk upplevelse, (4) agerande och (5) uppmärksammande. Resultatet gick i linje med tidigare studier men bidrog med att fylla en kunskapslucka med dess kvalitativa inriktning, temat (5) uppmärksammande var ett nytt tema som upptäcktes.

For this work, the decision was made to contrast two serological tests, that of the tube agglutination technique and the fluorescent antibody technique for correlation with the coagulase and other characteristics of Staphylococcus strains. This has been a preliminary survey in the hope that as further knowledge is obtained about the staphylococci, grouping of the organisms will become more routine and relatively less complex.

A number of clinicians have reported that narcissists show grandiosity in self-concept, and rage after receiving disconfirming feedback. This is the first empirical study to test these claims. Subjects with differing levels of narcissism and self-esteem were compared on distortion in self-perception and emotional reaction to negative feedback. Ninety-six college students predicted their levels of intelligence, attractiveness, and interpersonal understanding (empathy) as compared to their peers. Objective measures of these characteristics were obtained, and subjects' predictions, with their actual scores held constant, provided measures of reality distortion in selfperception. Subjects were given feedback comparing their predictions to objective measures at the end of the experiment, and reaction to feedback was assessed by comparing subjects' pre- and post-feedback scores on the Multiple Affect Adjective Checklist-Revised (Zuckerman & Lubin, 1985). Narcissists were expected to react to negative feedback with greater hostility than nonnarcissists. Narcissists evidenced significant distortion in perceptions of their own intelligence, attractiveness, and interpersonal understanding. This finding provided empirical evidence supporting the clinical phenomenon of grandiosity. Narcissists did not react with greater hostility after negative feedback, but as compared to nonnarcissists, they did react with less depression following negative feedback. This supported Kernberg's (1980) assertion that narcissists do not react to loss with depression. In contrast to the inflated self-image associated with narcissism, self-esteem was associated with a comparatively accurate view of self.

Breast cancer is a complex heterogenous disease that consists of several different subtypes displaying distinct behaviors and responses to different treatments. It is the second leading cause of cancer death among women, and is the most commonly diagnosed cancer in women. Although recent developments have helped shed light into this disease, there is still much to investigate. One particular subtype of breast cancer, known as triple-negative breast cancer, remains the most aggressive, as this tumor type is of high histological grade and preferentially affects women with BRCA1 mutations and women who are younger than 40 years of age. Unlike other subtypes with better prognoses, triple-negative breast cancer still has no targeted therapy, and chemotherapy remains the primary systemic treatment. Recently, there has been an increase of interest in the SOXC family of high mobility group transcription factors and their roles in tumor development. Studies have revealed some of the effects that SOXC genes may have on various tumor types. However, further studies are still needed to elucidate the roles, functions, regulations, and mechanisms of these transcription factors. This study aims to focus on one particular gene in the SOXC family known as sex determining region Y-box 11. Recent studies have shown that sex determining region Y-box 11, also known as SOX11, is one of the factors required for maintaining the basal-like breast cancer phenotype and is also critical in regulating growth, migration, invasion, and expression of signature basal-like breast cancer genes. Emerging evidence also reveals that this transcription factor may have an impact on homologous recombination repair when DNA damage occurs, in triple-negative breast cancer. Using SOX11 overexpression and knockout cell models combined with basic science laboratory techniques and omics, the next generation of laboratory tools, this study seeks to explore the role and function of SOX11 in DNA damage in triple-negative breast cancer. The results of this study have confirmed the recent findings of the role of SOX11 in cell proliferation and growth in triple-negative breast cancer. It has also revealed that overexpression of SOX11 in triple-negative breast cancer cell lines leads to an increase in DNA damage, loss of BRCA1 function, and dysregulation in the cell cycle. High expression of SOX11 is also associated with worse prognostic outcomes in triple-negative breast cancer patients. Because overexpression of SOX11 resulted in a loss of BRCA1 function, there may be a potential role for SOX11 in inducing the BRCAness phenotype commonly seen in basal-like breast cancers. The results of this study strongly suggest that SOX11 is involved in defective DNA damage repair pathways. Further studies need to be conducted in order to evaluate SOX11 as an inducer of the BRCAness phenotype, which occurs when there is a homologous recombination repair defect and no germline BRCA1 mutation present. Because of this, SOX11 may also have the potential to act as a functional biomarker for therapies targeting DNA damage, as recent developments in identifying therapies that could potentially target homologous recombination repair defects have been promising.

This work deals with channel-tunnel dependent multidrug efflux pumps and type I secretion systems, more concrete with the improved classification of the adaptor protein family, the characterization of the TolC-homologue protein HI1462 of Haemophilus influenzae, and the molecular characterization of the interaction between TolC and AcrA of Escherichia coli. / Diese Arbeit beschäftigt sich mit Channel-Tunnel-abhängigen Multidrug Efflux Pumpen und Typ I Sekretionssystemen, genauer gesagt mit der verbesserten Klassifikation der Familie der Adapter-Proteine, der Charakterisierung des TolC-homologen Proteins HI1462 aus Haemophilus influenzae, und der molekularen Charakterisierung der Interaktion zwischen TolC und AcrA aus Escherichia coli.