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Serovare von Salmonella enterica subspecies enterica sind im allgemeinen pathogen für Mensch und andere Säugetiere. In dieser Arbeit habe ich anhand eines “Multilocus Sequences Typing” Typisierungsschemas die Populationsstruktur einer der am häufigsten auftretenden Serovaren dieser Subspecies, das aus Menschen und Schlachttieren isolierte Serovar Newport charakterisiert. Dieses Schema wurde auch für die Charakterisierung von Isolaten derselben Subspecies aus humanen Dauerträgern und Reptilien verwandt, um zu bestimmen, ob Isolate aus diesen Quellen sich in ihrer Populationstruktur von denjenigen unterscheiden, die aus anderen Quellen isoliert wurden. Multilocus Sequences Typing ist eine weitgehend für die Untersuchung der Evolution und Populationsstruktur von einen breiten Spektrum von Organismen verwendete Technik. 400 - 600 bp lange Fragmente von 7 Haushaltsgenen wurden sequenziert, und jede einzelne Sequenz jedes einzelnen Gens wurde eine Allelnummer zugeordnet. Jede einzelne Allelkombination wurde einem Sequenztyp zugeordnet. Die so gewonnenen Daten wurden weiter analysiert. Drei “Lineages”, Newport-I, Newport-II und Newport-III, wurden innerhalb dieses Serovars identifiziert, die jeweils aus Menschen in Europa, Tieren und Menschen in Nordamerika isoliert wurden. Der Multiresistenz-Phänotyp wurde häufiger in Newport II gefunden, während die meisten Newport III Isolate pan-sensitiv waren. Verglichen mit anderen Serovaren war die Anzahl von “Lineages” innerhalb Newport höher als bei Enteritidis, Kentucky und Typhimurium, aber niedriger als bei Paratyphi B. Das heisst, die Serovare von S. enterica subspecies enterica variieren stark in ihrer Populationsstruktur. Die Sequenztypen in Isolaten aus humanen Dauerträgern waren im allgemeinen am häufigsten in Isolaten von klinischen Patienten und Tieren vorhanden. In der Mehrheit der Serovaren waren die meisten Isolate aus Patienten und Tieren genetisch identisch mit solchen, die aus gesunden Trägern isoliert wurden. Die genetische Variabilität war zwischen Isolaten aus diesen Quellen vergleichbar. Diese Ergebnissen deuten daraufhin, dass Salmonellen aus Dauerträgern sowie Isolate aus Patienten und Tieren derselben Population angehören. Die meisten Serovare aus Reptilienisolaten waren genetisch identisch mit denen von Menschen und warmblütigen Tieren. In den Serovaren Bovismorbificans, Decatur, Miami und Oranienburg hingegen waren die meisten Isolate aus Reptilien genetisch anders als Isolate aus anderen Wirten. Allerdings wurden nur wenige Isolate der Serovaren Bovismorbificans, Decatur und Miami aus Reptilien und nur wenige Isolate der Serovaren Oranienburg aus anderen Quellen getestet; eine grössere Anzahl von Isolaten müsste daher untersucht werden, um festzustellen ob diese genetischen Unterschiede statistich signifikant sind oder nicht. / Serovars of Salmonella enterica subspecies enterica are generally pathogenic to humans and other mammals. In this study, I examined the population structure of one of the most common serovars of this subspecies isolated from humans and food animals, serovar Newport, using a multilocus sequence typing scheme. This scheme was also used to analyze isolates of this subspecies from chronic human carriers and reptiles to determine whether isolates from these sources represent distinct populations than those from other hosts. Multilocus sequence typing has extensively been used to study evolution and population structure of a wide range of organisms. 400-600 bp fragments of 7 housekeeping genes were sequenced and every unique sequence of each gene fragment was given a distinct allele number. Each unique combination of alleles was assigned a distinct sequence type number. The data were used in further analyses. Three lineages, namely Newport-I, Newport-II and Newport-III were identified within serovar Newport which were associated to European humans, animals and humans in North America, respectively. Multidrug resistance phenotypes were most common in Newport-II whereas most isolates in Newport-III were pan-susceptible. When compared to other serovars, the numbers of lineages within Newport were higher than for Enteritidis, Kentucky and Typhimurium but lower than for Paratyphi B. Therefore, serovars of S. enterica subspecies enterica vary greatly in their population structures. The sequence types observed for isolates from chronic human carriers were generally the most common among human-clinical and animal isolates. Most isolates from non-carrier humans plus animals were genetically identical to the carried isolates within most serovars. Genetic diversity was also comparable between isolates from these sources. These results suggest that salmonellae from chronic human carriers belong to the same population as isolates from non-carrier humans and animals. For most serovars, most isolates from reptiles were genetically identical to those from humans or other warm blooded animals. However, in serovars Bovismorbificans, Decatur, Miami and Oranienburg, most reptile isolates were genetically distinct from isolates from other hosts. Only few reptile isolates were tested from Bovismorbificans, Decatur and Miami and only few non-reptile isolates were tested from Oranienburg, and in larger numbers of such isolates would be needed to determine whether these differences are statistically significant.

Texte remanié de: Doct. th.--University of Chicago, 1987. / Notes bibliogr. Index.

The purpose of this dissertation is to analyze how four Southern Baptist scholars: E.Y. Mullins, John Newport, Richard Cunningham, and L. Russ Bush, understood--whether explicitly or implicitly--the nature of philosophy. Three issues will be explored as a result of their metaphilosophical views. First, what is the relationship between faith and reason? Second, is a Christian philosophy possible? And third, what role does philosophy serve in the life of the believer? Chapter 1 sets the historical context regarding the issue of metaphilosophy. Philosophy has been traditionally understood as the love of wisdom. However, since the Enlightenment and the dawning of modern Western philosophy, how thinkers understood the nature of philosophy changed dramatically. As the natural sciences progressed rapidly in the advancement of knowledge, thinkers increasingly viewed philosophy as being in need of change regarding its method and purpose. By the time of the twentieth century, philosophy's identity was in a state of confusion and uncertainty. Chapter 2 analyzes the metaphilosophy of E. Y. Mullins. For Mullins, philosophy investigated the foundational questions of human existence and operated autonomously from science and religion. The data of philosophy included all of life, including the findings of the various fields of knowledge, and sought to unify all truth into a cohesive unit. The value of philosophy is found in its ability to go beyond the descriptions of science in order to interpret the world in which one lives. Chapter 3 analyzes the metaphilosophy of John Newport. According to Newport, philosophy is identified with worldview--the structure of one's beliefs about the world. One's worldview affects how one lives and operates within the world. Philosophy includes not only the analytic task of critiquing and clarifying ideas and beliefs, but also the synthetic task of incorporating beliefs into a coherent structure. Philosophy also involves analyzing the key-principles that underlie one's belief structure--those principles that are basic to an individual. Philosophy, or worldview, is valuable to the individual by helping one to make sense of life and to avoid bad decisions. Chapter 4 focuses on the metaphilosophy of Richard Cunningham. Cunningham views philosophy as one's attempt to understand his experience in all its facets. It is a deliberate action on the part of the individual, one that leads to the development of his worldview. Philosophy involves the traditional tasks of analysis and synthesis, and its value is found in its ability to afford one to live more effectively. Chapter 5 presents the metaphilosophy of L. Russ Bush. Bush's definition of philosophy is methodological in nature as he views philosophy more as an activity than as a way of life. One employs the laws of logic and other philosophical tasks when analyzing one's own or competing worldviews in order to judge between their similarities or differences, and their strengths or weaknesses. In a day and age where many individuals lazily accept their beliefs without deep reflection, philosophy helps one to hold to beliefs that are more consistent and it helps one to better dialogue with others of differing worldviews. Chapter 6 concludes the dissertation by highlighting the strengths and weaknesses of the four thinkers presented in the preceding chapters. Suggestions are provided on how to strengthen a Baptist view of metaphilosophy in light of the weaknesses provided. Finally, the current state of philosophy in the Southern Baptist Convention is provided.

The possibility of the existence of an iron-organic interaction in Harwood's Mill Reservoir contributing to a problem with floe formation after chlorinating filter-applied water was investigated. Shortened filtration-cycle times resulted when the filter-applied water contained the floc. The effects of varying pH, temperature, alum dosage, and oxidant addition on organic and meta.ls removals were examined with jar tests. Ultrafiltration analyses were performed to determine with which molecular size range of organic matter the iron may have been associated. Particle-size analysis was used to further examine the chlorination phenomenon. The low iron concentrations in the raw water were removed easily under any experimental condition. Organic removal, however, was optimized by alum coagulation ( 50 mg/L) at pH 5. 5 and a preoxidant dose of 2 mg/L. Improvements in organics removal over that of the WTP suggested that poor organic removal contributed to the floe-formation problem. / M.S.

The thesis focuses on the reflection of the discovery of America by the Norsemen, and does so in three steps. Firstly, the approach to and the significance of the Norse voyages to America in the medieval materials, and especially in the Vinland sagas, are presented. This part is accompanied by a general introduction into the sagas. Secondly, the situation in the 19th century is introduced. In this period a lot of scientific works as well as works of art aiming at the Norse voyages to the New continent arose. The factors that led to this increased interest are explored, e.g. national movement in Scandinavia. Thirdly, the contemporary reflexion of the Norse discovery of America is analyzed (particularly its influence on works of art, society, politics and scientific research). The methodology used in this thesis is discourse analysis, which points out to the changing reflexion of the given topic.

Outreach is a small, but significant component to modern research. Developing an exhibit for public display can be an effective way to communicate science to broad audiences, although it may be a less familiar method to scientists than writing papers or giving presentations. I outline the process of developing an interactive exhibit for outreach, and evaluate and discuss the effectiveness of a computer exhibit designed to communicate estuary currents and scientific modeling using Olympia Oyster restoration in the Yaquina Bay estuary as a theme. I summarize the results of this project in three primary recommendations: 1) exhibit developers should be deliberate in the decision to use a computer and only select this media if it is determined to be the best for communicating exhibit learning outcomes, 2) the design of visualizations to convey research results should be carefully modified from their scientific forms to best meet the exhibit learning outcomes and expectations of the exhibit audience, and 3) scientists should play an integral role in the development of scientific content-based exhibits, but their expertise, and the range of expertise from other members of the exhibit development team, should be strategically utilized. / Graduation date: 2012

Thesis (Ph. D.)--Salve Regina University, 2006.