Introdução: A DPOC caracteriza-se pela limitação ao fluxo aéreo associada à resposta inflamatória anormal dos pulmões a partículas ou gases nocivos. As alterações mecânicas decorrentes da DPOC estão relacionadas com a disfunção mecânica das fibras do diafragma, já observadas nas fases iniciais da doença. Alguns estudos têm demonstrado o elevado potencial da Técnica de Oscilações Forçadas (FOT) na detecção das alterações mecânicas da DPOC. Contudo, tais aplicações da FOT não permitiam a análise em tempo real das alterações do sistema respiratório, bem como da mobilidade toracoabdominal destes indivíduos. Desta forma, os objetivos desta pesquisa foram analisar, em tempo real, as alterações de impedância do sistema respiratório nas distintas fases do ciclo em portadores de DPOC, assim como avaliar a movimentação toracoabdominal destes indivíduos. Metodologia: Trata-se de um estudo observacional controlado, prospectivo onde foram analisados 48 indivíduos, 23 indivíduos controles e 25 portadores de DPOC com grau de obstrução acentuado. Os indivíduos realizaram exames de FOT para análise da impedância do sistema respiratório e mobilidade toracoabdominal, simultaneamente. Posteriormente aos exames da FOT os indivíduos foram submetidos à Espirometria. Resultados: Os resultados demonstraram aumento da impedância do sistema respiratório nos indivíduos com DPOC em comparação ao grupo controle, em nos parâmetros estudados (Zt, Zi, Ze, Zii, Zie, Zrs e Zpp) (p<0,0001). Em relação às distintas fases do ciclo, os indivíduos deste estudo apresentaram impedâncias maiores na fase inspiratória quando comparadas à fase expiratória (p<0,004). Somente 10% dos portadores de DPOC apresentaram assincronia toracoabdominal (&#966; &#8805; 45), sendo que os valores médios não apresentaram diferença estatística quando comparados ao grupo controle. Discussão: A impedância total do sistema respiratório (Zt) aumentada nos portadores de DPOC confirma o aumento da carga mecânica do sistema respiratório destes indivíduos. Essas alterações são coerentes com o processo fisiopatológico, evidenciado pela obstrução ao fluxo aéreo e destruição do parênquima pulmonar. O aumento da impedância na fase inspiratória quando comparada à fase expiratória, sugere um aumento no trabalho resistivo e elástico. Não foram evidenciados sinais de assincronia na mobilidade toracoabdominal na maior parte dos indivíduos, sugerindo que alguns mecanismos adaptativos atuam na tentativa de evitar a fadiga do músculo respiratório. Conclusões: A DPOC resulta no aumento da carga mecânica do sistema respiratório, alterações identificadas pelo aumento da impedância do sistema respiratório, medida pela FOT em tempo real. Este aumento foi mais evidente durante a fase inspiratória. A mobilidade toracoabdominal não se mostrou alterada na maior parte dos indivíduos com DPOC. Estes resultados são consistentes com publicações prévias e fundamentos fisiopatológicos, confirmando o potencial da FOT monofreqüência na avaliação das modificações relacionadas à DPOC. / Introduction: COPD is carachterized by airflow limitation associated abnormal inflammatory response of the lung to noxious particles or gases. The mechanical alterations associated with COPD have been related with dysfunction of the diaphragm, observed since the initial phases of the disease. Several studies have confirmed the high potential of FOT in the assessment of the mechanics modifications related to COPD. However, such studies did not allow a real-time analysis of the changes in the respiratory system, and the thoracoabdominal mobility of these individuals. Thus, the goals of the present study were to analyze, in real-time, the impedance alterations of the respiratory system in different phases of the respiratory cycle of COPD patients. Methodology: This research consists of a controlled observational study where 48 individuals were analyzed, 23 controls and 25 individuals with COPD and severe airway obstruction. Firstly, they performed simultaneous analysis of impedance of the respiratory system and thoracoabdominal motion. In subsequent examinations, these subjects were submitted to spirometry. Results: The results demonstrated an increase of the respiratory system impedance in individuals with COPD compared with the control group in all of the studied parameters (Zt, Zi, Ze, Zii, Zie, &#916;Zrs e Zpp) (p<0.0001). Considering the different phases of the respiratory cycle, higher impedances were observed in the inspiratory phase (p<0.004). Only 10% of individuals with COPD showed thoracoabdominal asynchrony (&#966;&#8805; 45), and the mean values showed no statistical difference when compared to the control group. Discussions: The total impedance of the respiratory system increased in individuals with COPD, which describes the increase of the mechanic load of the respiratory system in these individuals. These alterations are coherent with the physiopathology of COPD, associated with airflow obstruction and lung parenchyma destruction. The increase of the impedance in the inspiratory phase suggests an increase of the resistive and elastic work. There were not signals of thoracoabdominal asynchrony in the major part of the studied individuals, suggesting that some adaptation mechanisms act to compensate respiratory muscle fatigue. Conclusion: The COPD results in the increase of the mechanic load of the respiratory system. These alterations were identified by the increase of the respiratory system impedance, which was more evidence in the inspiratory phase. The thoracoabdominal asynchrony was not usual in individuals with COPD. Those results are consistent with previously published data and physiopathological fundamentals, confirming the potential of monofrequency FOT in the assessment of the modifications related to COPD.

This research looks to identify precursors to women becoming involved in trafficking for prostitution and/or sexual services in the United States. The failure to find patterns or trends regarding why women are trafficked or what types of women are trafficked most often, helps dispel some myths regarding the stereotypical victim of trafficking.

Soil spectroscopy is a promising technique for soil analysis, and has been successfully utilized in the laboratory. When it comes to space, the presence of vegetation significantly affects the performance of imaging spectroscopy or hyperspectral imaging on the retrieval of topsoil properties. The Forced Invariance Approach has been proven able to effectively suppress the vegetation contribution to the mixed image pixel. It takes advantage of scene statistics and requires no specific a priori knowledge of the referenced spectra. However, the approach is still mainly limited to lithological mapping. In this case study, the objective was to test the performance of the Forced Invariance Approach to improve the estimation accuracy of soil salinity for an agricultural area located in the semi-arid region of Northwest China using airborne hyperspectral data. The ground truth data was obtained from an eco-hydrological wireless sensing network. The relationship between Normalized Difference Vegetation Index (NDVI) and soil salinity is discussed. The results demonstrate that the Forced Invariance Approach is able to improve the retrieval accuracy of soil salinity at a depth of 10 cm, as indicated by a higher value for the coefficient of determination (R2). Consequently, the vegetation suppression method has the potential to improve quantitative estimation of soil properties with multivariate statistical methods.

In South Africa, racial discrimination was witnessed through renowned segregationist acts including the Group Areas Act (No:41) of 1950, which forcibly displaced families from their homes and triggered significant social upheavals and the callous disintegration of long-established communities such as Sophiatown. The removals were a political strategy to relocate so-called “non-white” people from the inner city to townships such as Meadowlands explicitly chosen for their hazardous impure land known as mine dumps (Rodgers 1980:76). These displacements had a paradox of intergenerational homelessness triggered by instrumental racism that influenced politics of space and in effect, the disarticulation of the lives of black South Africans (Milgroom and Ribotc 2019:184). Therefore, it is important to undertake a study investigating the circumstances that gave rise to these forced removals, the subsequent breakdown of social order, a typical consequence of population relocation, which merits an examination of the contemporary implications and ramifications of disarticulation and highlights, in this regard, some significant shortcomings in post-Apartheid governance. / Anthropology and Archaeology / M.A. (Anthropology)

With the rapid somatic growth and development in infants, simultaneous accurate measurements of lung volume and airway function are essential. Raised volume rapid thoracoabdominal compression (RTC) is widely used to generate forced expiration from an airway opening pressure of 30 cmH2O (V30). The (dynamic) functional residual capacity (FRCdyn) remains the lung volume most routinely measured. The aim of this study was to develop comprehensive integrated spirometry that included all subdivisions of lung volume at V30 or total lung capacity (TLC30). Measurements were performed on 17 healthy infants aged 8.6-119.7 weeks. A commercial system for multiple-breath nitrogen washout (MBNW) to measure lung volumes and a custom made system to perform RTC were used in unison. A refined automated raised volume RTC and the following two novel single maneuvers with dual volume measurements were performed from V30 during a brief post-hyperventilation apneic pause: (1) the passive expiratory flow was integrated to produce the inspiratory capacity (IC) and the static (passive) FRC (FRCst) was estimated by initiating MBNW after end-passive expiration; (2) RTC was initiated late during passive expiration, flow was integrated to produce the slow vital capacity (jSVC) and the residual volume (RV) was measured by initiating MBNW after end-expiration while the jacket (j) was inflated. Intrasubject FRCdyn and FRCst measurements overlapped (p = 0.6420) but neither did with the RV (p < 0.0001). Means (95% confidence interval) of FRCdyn, IC, FRCst, jSVC, RV, forced vital capacity and tidal volume were 21.2 (19.7-22.7), 36.7 (33.0-40.4), 21.2 (19.6-22.8), 40.7 (37.2-44.2), 18.1 (16.6-19.7), 40.7 (37.1-44.2) and 10.2 (9.6-10.7) ml/kg, respectively. Static lung volumes and capacities at V30 and variables from the best forced expiratory flow-volume curve were dependent on age, body length and weight. In conclusion, we developed a comprehensive physiologically integrated approach for in-depth investigation of lung function at V30 in infants.

Introduktion  Genom dynamisk spirometri går det att beräkna kvoten mellan forcerad exspiratorisk volym under en sekund och forcerad vitalkapacitet (FEV1/FVC) där ett värde på ≤0,7 tyder på obstruktiv lungsjukdom. Mobil spirometriutrustning skulle kunna möjliggöra tidigare diagnostisering av obstruktiva lungsjukdomar men även fungera som ett kostnadseffektivt alternativ vid enklare undersökningar. Syftet med studien var att jämföra resultat erhållna vid dynamisk spirometri utförd på en stationär respektive en mobil spirometriutrustning. Material och metod  I studien deltog totalt 36 försökspersoner. Data samlades in mellan februari-mars 2023 och bestod av FVC och FEV1 erhållna från dynamisk spirometri på Vyntus™ One (stationär spirometriutrustning) och Aiocare™ Vyaire (mobil spirometriutrustning). Ett parat t-test (signifikansnivå 0,05) utfördes för att avgöra om det förelåg någon signifikant systematisk skillnad för data mellan de båda utrustningarna och förekomsten av slumpfel illustrerades med Bland-Altman-diagram. Intraklasskorrelationskoefficient (ICC) beräknades för samtliga variabler. Resultat och slutsats  En mycket god korrelation mellan utrustningarna förelåg med ett ICC&gt;0.9 för samtliga variabler. Ingen systematisk skillnad kunde påvisas för uppmätt FVC, FEV1 eller kvoten FEV1/FVC mellan Vyntus™ One och Aiocare™ Vyaire (p &gt;0,05) och slumpfelet bedömdes acceptabelt. / Introduction  Dynamic spirometry enables calculating the ratio of forced expiratory volume under one second and forced vital capacity (FEV1/FVC) where ≤0,7 suggests obstructive lung disease. Mobile spirometer equipment could assist in earlier detection of obstructive lung diseases, but also function as a cost-efficient alternative. The purpose of the study is to compare results obtained with dynamic spirometry performed on a stationary and a mobile spirometry equipment. Material and method  A total of 36 subjects participated in the study. Data collected between February-March 2023 consisted of FVC and FEV1 obtained from dynamic spirometry on Vyntus™ One (stationary spirometry equipment) and Aiocare™ Vyaire (mobile spirometry equipment). A paired t-test (0,05 level of significance) determined if there was any significant systematic difference between data from the two types of equipment and the magnitude of sampling error was visualized by Bland-Altman plots. Intraclass correlation coefficient (ICC) was calculated for all variables. Result and conclusion  Excellent correlation with ICC&gt;0,9 for all variables. There was no significant difference for measured FVC, FEV1 or FEV1/FVC between Vyntus™ One and Aiocare™ Vyaire (p &gt;0,05) and the sampling error was considered acceptable.

Master of Science / Department of Psychological Sciences / Mary Cain / Individuals suffering from depression primarily rely on pharmacological interventions to alleviate the incapacitating symptoms of the disorder. In addition to genetic differences underlying the etiology of depression, environmental factors play a key role as well. For example, environmental enrichment results in various neurotransmitter alterations, significantly affecting serotonin. To test the efficacy of novel antidepressant drugs in the preclinical laboratory setting, researchers commonly implement the forced swim test (FST) for rats or mice. However, the effect of environmental enrichment on the expression of depressive-like states in the FST is unclear, and it is unknown whether environmental enrichment or social isolation can alter the efficacy of the commonly prescribed antidepressant drug, fluoxetine. In the present study, locomotor activity and FST performance were measured after 30 days of rearing in enriched (EC), standard (SC), and isolated (IC) conditions. Results showed that regardless of the significant effect of fluoxetine on locomotor activity in EC, SC, and IC rats, fluoxetine failed to increase swimming and decrease immobility in all three environmental conditions, with enriched-fluoxetine rats displaying significantly less swimming behavior in the FST than enriched rats receiving vehicle control injections. These results suggest that differential rearing, specifically environmental enrichment, can alter the efficacy of antidepressants and may suggest that enrichment reverses the effects of fluoxetine.

Thesis (MScEng)--Stellenbosch University, 2012. / ENGLISH ABSTRACT: The optimal design of a heat exchanger for a specified heat transfer, pressure drop and set of ambient conditions entails minimising space, weight, material usage and overall cost. However, the variables which influence the performance as well as the overall cost of a heat exchanger are not related in a simple way and it is not obvious which variables play the most important roles (Perry & Green, 1997:11-44). Air cooled heat exchangers (ACHEs) are normally designed in three stages, by different experts in the field, and with the aid of specially designed software. This project combines these thermal, mechanical and cost estimation processes into a MS Excel model which makes it easier to see the influence that design parameters have on the overall cost of the heat exchanger. A thermal model was created to design an API 661 (2006) ACHE. The results from this model compared well with those of HTRI Xchanger Suite 6.0 software, with HTRI being more conservative in its design mode. A mechanical design model was then developed, which uses as inputs the outputs of the thermal design. The output from this mechanical design model is the minimum material thicknesses based on the stress criteria of Appendix 13 of ASME VIII div 1 (2007) Boiler and Pressure Vessel Code. An experiment on a finned tube bundle was performed in a wind tunnel facility to determine performance characteristics and compare these to existing correlations in literature. The results showed that both the heat transfer coefficient (h) and loss coefficient (Eu) correlations proposed by Ganguli et al. (1985) closely predict the measured data, and were consequently used in the thermal design model. During this experiment it was also shown that the tube bundle reached 8 % - 9 % of its allowable internal fouling factor, due to rust build up inside the tubes, and in a testing period of only nine days. The thermal and mechanical models were then combined with a cost estimation process to perform both a thermal and mechanical parametric study. The thermal study showed that to obtain an optimal solution, the design must attempt to maximise the length, increase the width rather than the number of bays, make use of two bundles per bay with fewer but larger fans and employ a large number of tube rows with the least number of tube passes. These guidelines were used to create an initial design; Excel Solver was then applied to locate the optimum combination of bundle length and width that result in the minimum heat exchanger cost. Two mechanical considerations were investigated, both requiring additional welding and thus increased welding cost. Firstly the use of stay plates result in reduced required plate thicknesses according to the stress criteria since it provides additional stiffness in the header box design. Secondly the use of more (but smaller) nozzles as opposed to less (but larger) nozzles was also considered. The mechanical parametric study showed no specific trends, but both considerations should still be checked as it can be cost beneficial in a specific design. / AFRIKAANSE OPSOMMING: Optimale ontwerp van ’n warmteoordraer vir ’n gespesifiseerde warmteoordrag, drukval en stel van omgewingstoestande behels die minimalisering van ruimte, gewig, materiaalverbruik en algehele koste. Die veranderlikes wat egter die werkverrigting, sowel as die algehele koste, van ’n warmteoordraer beïnvloed, hou nie in ’n eenvoudige sin met mekaar verband nie, en dit is nie vanselfsprekend watter veranderlikes die belangrikste rolle speel nie (Perry & Green, 1997:11-44). Lugverkoelde warmteoordraers (air-cooled heat exchangers of ACHEs) word normaalweg in drie fases ontwerp deur verskillende kundiges in die veld en met behulp van spesiaal ontwerpte programmatuur. Hierdie studie kombineer dié termiese, meganiese en kosteberamingsprosesse in ’n MS Excel-model, wat dit makliker maak om van te stel wat die invloed wat ontwerpparameters op die algehele koste van die hitteruiler is. ’n Termiese model is geskep om ’n “API 661 (2006) ACHE” te ontwerp. Die resultate van hierdie model het goed vergelyk met dié van die HTRI Xchanger Suite 6.0-program, met HTRI meer konserwatiew in die ontwerp af. Na die termiese model geskep is, is ’n meganieseontwerp-model ontwikkel, wat as insette die uitsette van die termiese ontwerp gebruik het. Die uitset van hierdie meganieseontwerp-model is die minimum materiaaldikte gebaseer op die spanningskriteria van Bylae 13 van “ASME VIII div 1 (2007) Boiler and Pressure Vessel Code.” Daar is ’n eksperiment op ’n vinbuisbundel in ’n windtonnelfasiliteit uitgevoer om werkverrigtingskarakteristieke te bepaal en dit met bestaande korrelasies in die literatuur te vergelyk. Die resultate het getoon dat sowel die warmteoordragskoëffisiënt (h) en die verlieskoeffisient (Eu) korrelasies, voorgestel deur Ganguli et al. (1985), die data wat gemeet is akkuraat voorspel, en gevolglik is die korrelasies in die termieseontwerp-model gebruik. Gedurende die eksperiment is ook getoon dat die buisbundel 8 % - 9 % van sy toelaatbare interne-aanpakkingfaktor bereik het vanweë roesopbou binne-in die buise, en dit in ’n toetsingtydperk van slegs nege dae. Die termiese en meganiese modelle was toe gekombineer met ’n kosteberamingsproses om ’n termiese sowel as ’n meganiese parametriese studie uit te voer. Die termiese studie het getoon dat, om ’n optimale oplossing te verkry, die ontwerp moet poog om die lengte te maksimeer; die wydte eerder as die aantal strate (bays) te vermeerder; van twee bundels per straat gebruik te maak met minder, maar groter waaiers; en ’n groot aantal buisrye met die kleinste hoeveelheid buisdeurvloeiweë in te span. Hierdie riglyne is gebruik in ’n aanvanklike ontwerp, waarna die Excel Solver gebruik is om die optimale kombinasie van bundellengte en –wydte vas te stel met die oog op die laagste moontlike warmteoordraerkoste. Twee meganiese oorwegings is ondersoek wat albei addisionele sweiswerk sou vereis en dus tot verhoogde sweiskoste sou lei. Eerstens lei die gebruik van ankerplate (stay plates) tot ’n vermindering in die vereiste plaatdiktes volgens die spanningskriteria, aangesien dit addisionele stewigheid in die spruitstukhouerontwerp bied. Tweedens is die gebruik van meer (maar kleiner) spuitstukke teenoor minder (maar groter) spuitstukke ook oorweeg. Die meganiese parametriese studie het geen spesifieke voorkeurneigings getoon nie, maar altwee oorgewings moet nog getoets word want dit kan koste voordelig word in 'n spesifieke ontwerp.

My dissertation research was a 14-month ethnographic study of the post-repatriation experience of forced migrants in South Sudan. It was designed to determine if alterations to gender norms and relations that refugees experienced during asylum differed as a function of the asylum environments and if these modifications remained intact upon the refugees’ return. The forced migrants in my sample, the Dinka of Bor from South Sudan, encountered two different asylum environments and experiences: Kakuma refugee camp in northern Kenya and Khartoum, in northern Sudan. After 10-15 years in asylum, these forced Dinka Bor migrants returned to South Sudan. I compared the pre-flight and post-repatriation behavior of these two groups of returnees to determine to what extent gendered behaviors could be attributed to each asylum location. I found that various global forces encountered during asylum were instrumental in forging new ways of life by changing gendered livelihood practices and gendered access to status, power, and resources after return. In addition, the resettlement context played an equally critical role in the gendered behaviors after return.

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.