Submitted by Erika Demachki (erikademachki@gmail.com) on 2017-06-21T21:21:46Z No. of bitstreams: 2 Dissertação - Liliane de Azevedo Oliveira - 2017.pdf: 1274368 bytes, checksum: 9b7a4aa781e0951c3f12045277a55582 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2017-06-29T18:27:23Z (GMT) No. of bitstreams: 2 Dissertação - Liliane de Azevedo Oliveira - 2017.pdf: 1274368 bytes, checksum: 9b7a4aa781e0951c3f12045277a55582 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) / Made available in DSpace on 2017-06-29T18:27:23Z (GMT). No. of bitstreams: 2 Dissertação - Liliane de Azevedo Oliveira - 2017.pdf: 1274368 bytes, checksum: 9b7a4aa781e0951c3f12045277a55582 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2017-02-22 / Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG / In this work we applied an algorithm based on the resolution of integer linear models for the problem of packing boxes into a single container considering the cargo stability constraint. The problem consists of arranging items (boxes) of different sizes inside a large object (container) to maximize the occupied container volume while respecting the imposed constraints. Four methods are investigated and compared due to vertical cargo stability, in which three of these methods are proposed in this work and based on the equilibrium of rigid bodies, and the other one is based on the factor of support of boxes bottom faces. In the case of the factor of support, a set of constraints can be inserted totally in the integer formulation, while in the other methods cutting planes are inserted during optimization of the formulation by a branch-and-cut algorithm. Computational tests on instances from the literature show that the usage of a factor of support underestimates the value of the optimal solution. The computational tests showed that the use of the factor of support may underestimate the solution, but its use with integer linear programming models has the advantage that feasible solutions are stable, while the other developed methods only verify stability and thus they depend of the integer linear program to return feasible solutions more quickly. By the way, the methods for the cargo stability developed here also overcame the factor of support for tests involving different types of mesh to pack into the container. / Aplica-se um algoritmo baseado na resolução de modelos de programação linear inteira para o problema de carregamento de caixas dentro de um único contêiner considerando a restrição de estabilidade de carga. O problema em estudo consiste em arranjar itens (caixas) de diferentes tamanhos dentro de um objeto maior (contêiner), de maneira maximizar a ocupação do volume do contêiner enquanto respeita as restrições dadas. Quatro métodos são investigados e comparados quanto a estabilidade vertical do empacotamento, sendo que três deles são desenvolvidos neste trabalho e baseados em conceitos do equilíbrio de corpos rígidos, enquanto um deles é baseado no fator de suporte da base das caixas. No caso do fator de suporte, um conjunto de restrições pode ser inserido totalmente dentro da formulação inteira, enquanto nos demais métodos planos de corte são inseridos durante a resolução da formulação por um algoritmo branch-and-cut. Os testes computacionais mostraram que o uso do fator de suporte pode subestimar a solução, porém seu uso com modelos de programação linear inteira tem a vantagem das soluções viáveis poderem ser estáveis, enquanto os demais métodos desenvolvidos apenas verificam a estabilidade e, assim, dependem do programa linear inteiro retornar soluções viáveis mais rapidamente. Os métodos para a estabilidade de carga desenvolvidos neste trabalho mostraram-se superiores ao fator de suporte para testes envolvendo diferentes tipos de malhas para o empacotamento no contêiner.

INTRODUÇÃO: A limpeza prévia de endoscópios rígidos (ER) seguida de desinfecção de nível intermediário com álcool etílico a 70% p/v após o exame de endoscopia nasal é uma prática adotada em muitos serviços de otorrinolaringologia. A literatura atual, no entanto, recomenda a esterilização ou desinfecção de alto nível como o método de descontaminação mais aceito para produtos para saúde classificados como semicríticos. No entanto, há que se fazer distinção entre equipamentos de alta complexidade e sua invasividade como os endoscópios flexíveis com lumens longos e estreitos utilizados na endoscopia digestiva, daqueles de conformação simples sem lumens de baixa invasividade como os endoscópios rígidos utilizados em otorrinolaringologia. OBJETIVO: Avaliar a segurança da desinfecção de nível intermediário com álcool etílico 70% p/v, após limpeza prévia dos endoscópios rígidos utilizados em procedimentos clínicos de endoscopia nasal considerando a carga microbiológica recuperada após o uso. MÉTODO: Imediatamente após a realização do exame, uma gaze úmida foi utilizada para o arraste da carga biológica do endoscópio rígido, gerando as amostras do Controle Positivo e, após a aplicação do POP, um novo arraste para constituir as amostras do Grupo Experimental. Estas gazes foram inicialmente submetidas à sonicação e agitação imersas em soro fisiológico e em seguida a solução foi submetida a uma técnica de extração de carga microbiológica por filtragem por meio de uma Membrana de Celulose de 0,22um de poro que foi, em seguida, semeada nos meios de ágar Sangue, Chocolate, Sabouraud, Löwenstein-Jensen e Tioglicolato. Estes meios ficaram incubados em estufa a 37ºC ± 2ºC e avaliados, no máximo, até por 60 dias conforme o perfil de crescimento dos diferentes microrganismos de interesse; foram analisados de maneira quantitativa e qualitativa para identificação e classificação dos micro-organismos recuperados após as semeaduras. RESULTADO: Os resultados da análise estatística evidenciaram diferença significativa entre Controle Positivo e Grupo Experimental quando comparados em relação à presença de Streptococcus coagulase negativa (p < 0,001), Bacillus spp (p < 0,001) e Staphylococcus aureus (p=0,001). No Controle Positivo, foram encontradas presença desses micro-organismos respectivamente na seguinte frequência: 63,2%, 28,9% e 28,9%, enquanto que, no Grupo Experimental, não foi houve recuperação microbiana alguma. CONCLUSÃO: Os resultados desta pesquisa demonstram a eficiência, na prática diária, da desinfecção de nível intermediário dos endoscópios utilizados na otorrinolaringologia por meio da fricção com álcool etílico 70% p/v por 90 segundos, com protocolo de limpeza prévia / INTRODUCTION: Prior cleaning of rigid endoscopes (REs) followed by intermediate-level disinfection with 70% ethyl alcohol (w/v) after nasal endoscopy is a common practice in many otolaryngology services. Current literature, in turn, recommends high-level sterilization or disinfection as the most accepted decontamination method for health products classified as semi-critical. However, it is necessary to distinguish highly complex equipment according to their invasiveness, e.g., flexible endoscopes with long and narrow lumens used in digestive endoscopy and those with a simple conformation without lumens of low invasiveness, such as rigid endoscopes used in otorhinolaryngology. OBJECTIVE: To evaluate the safety of intermediate-level disinfection with 70% ethyl alcohol (w/v) after cleaning of REs used in clinical procedures of nasal endoscopy considering the microbiological load recovered after use. METHOD: Immediately after the test, a wet gauze was used to drag the biological load from the RE, generating positive control samples; after applying POP, dragging was carried out again to generate samples of the experimental group. These gasses were initially subjected to sonication and shaking while immersed in physiological saline; the solution was then subjected to the microbiological loading technique by filtration through a 0.22-um pore cellulose membrane and then cultivated on blood, chocolate, Sabouraud, Löwenstein-Jensen, and thioglycolate agar media. These media were incubated at 37ºC ± 2ºC and evaluated for up to 60 days, according to the growth profile of the different microorganisms of interest. A quantitative and qualitative analysis was performed for the identification and classification of microorganisms recovered after cultivation. RESULTS: The results of statistical analysis showed a significant difference between the positive control and experimental groups for the presence of coagulase-negative Streptococcus (p < 0.001), Bacillus spp (p < 0.001), and Staphylococcus aureus (p=0.001). In the positive control group, these microorganisms were found in the following proportions: 63.2%, 28.9%, and 28.9%, respectively, whereas in the experimental group, no microorganisms were recovered. CONCLUSION: The results of this study demonstrate the efficiency of the daily practice of intermediate-level disinfection of endoscopes used in otorhinolaryngology by means of treatment with 70% ethyl alcohol (w/v) for 90 seconds, using a previous cleaning protocol

In nature, many of the flapping wings and fins in swimming and flying animals have various degrees of flexibility with strong and coupled solid-fluid interactions between the structure and the fluid. In most cases, the wing structure, the flow and their interactions are complex. This thesis experimentally investigates a ‘simple’ fluid-flexible foil interaction problem: flow generated by a pitching foil with chordwise flexibility. To explore the effect of flexibility on the flow, we study the flow generated in quiescent water (the limiting case of infinite Strouhal number) by a sinusoidally pitching rigid symmetrical NACA0015 foil to which is attached a 0.05 mm thick chordwise flexible polythene flap at the trailing edge. The chordwise length of flap is 0.79 c, where c = 38 mm is the chord length of the rigid foil; span of the foil and flap is 100 mm. Detailed particle image velocimetry (PIV) and flow visualization measurements have been made for twelve cases, corresponding to three pitching amplitudes, ±10◦,± 15◦, ±20◦, and four frequencies, 1, 2, 3 and 4 Hz for each amplitude. For most of these cases, a narrow coherent jet aligned along the center-line, containing a reverse B’enard–K´arm´an vortex street, and a corresponding unidirectional thrust are generated. This thrust is similar to the upward force generated during hovering, but motion of our foil is much simpler than the complex wing kinematics found in birds and insects; also the thrust generation mechanism seems to be different. In our case, the thrust is from a coordinated pushing action of the rigid foil and the flexible flap. Control volume analysis reveals the unsteady nature of thrust generation. In this intricately coupled flow generation problem, chordwise flexibility is found to be crucial in producing the coherent jet. In this thesis, we explore in detail the physics of jet flow produced by the foil with a flexible flap, and identify the importance of flexibility in flow generation. Flap motion ensures appropriate spatial and temporal release of vortices, and also imparts them convective motion, to obtain the staggered pattern that produces the jet. To describe the fluid-flap interaction, we conveniently characterize the flap through a non-dimensional stiffness, ‘effective stiffness’ (EI)∗ of the flap, that captures the effects of both the flap properties as well as the external forcing. With the same flap by changing the pitching parameters, we cover a fairly large (EI)∗ range varying over nearly two orders of magnitude. However, we observed that only moderate (EI)∗ (~0.1 - 1) generates sustained narrow, orderly jet. We provide thrust estimates useful for the design of flapping foil thrusters/propulsors. Although this study has only indirect connections with the hovering in nature, it may be useful in understanding the role of flexibility of bird and insect wings during hovering. In contrast, a foil with a rigid trailing edge produces a weak jet whose inclination changes continually with time. This meandering is observed to be random and independent of the initial conditions over a wide range of pitching parameters.

Lors de l'analyse 3D du mouvement humain basée sur des marqueurs cutanés, la position des os ne peut être qu'indirectement estimée. Au cours d'une tâche, les déformations des tissus mous génèrent des déplacements des marqueurs par rapport à l'os : les artefacts de tissus mous (STA), entraînant des effets dévastateurs sur l'estimation de la position. La compensation des STA demeure une question ouverte. L'objectif de cette thèse est de contribuer à la solution de cette question cruciale. La modélisation des STA en utilisant des variables spécifiques mesurables est une condition préalable à son élimination. Un modèle corrigeant les trajectoires individuelles de marqueurs de la cuisse, calibré par des mesures directes des STA, est d'abord présenté. Les STA sont modélisés comme une combinaison linéaire des angles articulaires impliqués. Trois représentations des STA par une série de modes sont proposées : déplacements de marqueurs individuels, transformations géométriques de clusters de marqueurs (MCGT), et variations de forme de l'enveloppe de peau. Le MCGT permet de dissocier les composantes rigides et non rigides. Il a été démontré que seule la composante rigide affecte la cinématique articulaire. Un modèle de cette composante est alors défini pour les clusters cuisse et jambe. Un compromis acceptable entre la correction des STA et le nombre de paramètres a ainsi été obtenu. Les principales applications sont de générer une simulation réaliste des STA ; et surtout, en se concentrant sur la composante rigide, le modèle permet une reconstruction satisfaisante des STA avec moins de paramètres, ce qui facilite son incorporation dans un algorithme d'estimation de la position osseuse / In 3D human movement analysis performed using stereophotogrammetry and skin markers, bone pose can be only indirectly estimated. During a task, soft tissue deformations make the markers move with respect to the underlying bone generating soft tissue artefacts (STA), causing devastating effects on pose estimation and its compensation remains an open issue. The thesis’ aim was to contribute to the solution of this crucial issue. Modelling STA using measurable trial-specific variables is a prerequisite for its removal from marker trajectories. Two STA model architectures are proposed. A thigh marker-level model is first presented. STA was modeled as a linear combination of joint angles involved in the task. The model was calibrated with direct STA measures. The considerable number of model parameters led to defining STA approximations. Three definitions were proposed to represent STA as series of modes : individual marker displacements, marker-cluster geometrical transformations (MCGT), and skin envelope shape variations. Modes were selected using two criteria : modal energy and selecting them a priori. The MCGT allows to select either rigid or non-rigid components. It was also demonstrated that only the rigid component affects joint kinematics. A model of thigh and shank rigid component at cluster-level was then defined. An acceptable trade-off between STA compensation and number of parameters was obtained. These results lead to two main potential applications : generate realistic STAs for simulation

The present thesis involves the study of introducing passive exit flexibility in a two dimensional starting jet. This is relevant to various biological flows like propulsion of aquatic creatures (jellyfish, squid etc.) and flow in the human heart. In the present study we introduce exit flexibility in two ways. The first method was by hinging rigid plates at the channel exit and the second was by attaching deformable flaps at the exit. In the hinged flaps cases, the experimental arrangement closely approximates the limiting case of a free-to-rotate rigid flap with negligible structural stiffness, damping and flap inertia; these limiting structural properties permitting the largest flap openings. In the deformable flaps cases, the flap’s stiffness (or its flexural rigidity EI) becomes an important parameter. In both cases, the initial condition was such that the flaps were parallel to the channel walls. With this, a piston was pushed in a controlled manner to form the starting jet. Using this arrangement, we start the flow and visualize the flap kinematics and make flow field measurements. A number of parameters were varied which include the piston speed, the flap length and the flap stiffness (in case of the deformable flaps). In the hinged rigid flaps cases, the typical motion of the flaps involves a rapid opening with flow initiation and a subsequent more gradual return to its initial position, which occurs while the piston is still moving. The initial opening of the flaps can be attributed to an excess pressure that develops in the channel when the flow starts, due to the acceleration that has to be imparted to the fluid slug between the flaps. In the case with flaps, additional pairs of vortices are formed because of the motion of the flaps and a complete redistribution of vorticity is observed. The length of the flaps is found to significantly affect flap kinematics when plotted using the conventional time scale L/d. However, with a newly defined time-scale based on the flap length (L/Lf ), we find a good collapse of all the measured flap motions irrespective of flap length and piston velocity for an impulsively started piston motion. The maximum opening angle in all these impulsive velocity program cases, irrespective of the flap length, is found to be close to 15 degrees. Even though the flap kinematics collapses well with L/Lf , there are differences in the distribution of the ejected vorticity even for the same L/Lf . In the deformable flap cases, the initial excess pressure in the flap region causes the flaps to bulge outwards. The size of the bulge grows in size, as well as moves outwards as the flow develops and the flaps open out to reach their maximum opening. Thereafter, the flaps start returning to their initial straight position and remain there as long as the piston is in motion. Once the piston stops, the flaps collapse inwards and the two flap tips touch each other. It was found that the flap’s flexural rigidity played an important role in the kinematics. We define a new time scale (t ) based on the flexural rigidity of the flaps (EI) and the flap length (Lf ). Using this new time scale, we find that the time taken to reach the maximum bulge (t* 0.03) and the time taken to reach the maximum opening (t* 0.1) were approximately similar across various flap stiffness and flap length cases. The motion of the flaps results in the formation of additional pairs of vortices. Interestingly, the total final circulation remains almost the same as that of a rigid exit case, for all the flap stiffness and flap lengths studied. However, the final fluid impulse (after all the fluid had come out of the flap region) was always higher in the flap cases as compared to the rigid exit case because of vorticity redistribution. The rate at which the impulse increases was also higher in most flap cases. The final impulse values were as large as 1.8 times the rigid exit case. Since the time rate of change of impulse is linked with force, the measurements suggest that introduction of flexible flaps at the exit could result in better propulsion performances for a system using starting jets. The work carried out in this thesis has shown that by attaching flexible flaps at the exit of an unsteady starting jet, dramatic changes can be made to the flow field. The coupled kinematics of the flaps with the flow dynamics led to desirable changes in the flow. Although the flaps introduced in this work are idealized and may not represent the kind of flexibility we encounter in biological systems, it gives us a better understanding of the importance of exit flexibility in these kinds of flows.

[pt] Nos projetos de engenharia é comum desconsiderar-se o comportamento semirrígido das ligações, ou seja, as ligações são assumidas com as condições ideais de rigidez. A primeira condição ideal é aquela na qual há transferência total de momento fletor, assumindo-se que não existe rotação relativa entre os elementos ligados, estas ligações são as chamadas rígidas. Na segunda opção, a transferência de momento fletor é desconsiderada e a ligação é definida como rotulada ou simples. Entretanto, sabe-se que a maioria das ligações comporta-se como semirrígida e o problema é que ao se fazer essas simplificações em projeto, dois aspectos podem ser comprometidos: segurança estrutural e custo do projeto. Neste trabalho, uma ligação semirrígida mista é proposta e estudada com o objetivo de obter-se as suas características principais e necessárias para utilizá-la em projeto: curva momento-rotação, rigidez de serviço e momento fletor resistente. Com a ligação mista proposta, busca-se uma nova maneira de transferência de forças na região de momento negativo em uma viga semicontínua. Adotou-se para a transferência dos esforços, entre a laje de concreto e a viga de aço, conectores de cisalhamento do tipo Perfobond Rib. Este conector foi inicialmente utilizado em pontes e depois alguns estudos o viabilizaram para o uso em edificações. Para atingir os objetivos do trabalho, foram realizados dois ensaios em escala real das ligações propostas. Os testes experimentais foram feitos em modelos cruciformes invertidos e realizados no laboratório de estruturas e materiais da PUC-Rio. Os resultados experimentais foram comparados com dois modelos analíticos: o método proposto por Leon et al. em 1996 e o método presente no Anexo R da NBR 8800:2008. / [en] In engineering design it is common to disregard the semi-rigid behavior of connections, i.e., connections are assumed to have the ideal conditions of rigidity. The first ideal condition is the one in which there is full transfer of bending moment, assuming that there is no relative rotation between the connected elements, this connection is defined rigid. In the second option, the transfer of bending moment is disregarded and the connection is defined simple. However, it is known that most connections have a semi-rigid behavior and the problem is that when making these simplifications in design, two aspects can be compromised: structural safety and project cost. In this work, a composite semi-rigid connection is studied in order to obtain its main and necessary features to use it in design: moment-rotation curve, service rigidity and bending moment capacity. With the proposed composite connection, a new way to transfer forces in the negative moment region on a semicontinous beam. Shear connectors like the Perfobond Rib were adopted for the transfer of efforts between the concrete slab and the steel beam. This connector was first used on bridges and since then some studies have made possible its use in buildings, showing its advantages over the more usual connectors. To achieve this work s objectives, two real scale tests of the proposed connections were conducted. Experimental tests were done in inverted cruciform models and carried out in the laboratory of structures and materials at PUC-Rio. Information on these tests was obtained, such as displacements, strains, and cracking of the slab. The experimental results were compared to two analytical models: the method proposed by Leon et al. in 1996 and the present method in Annex R of NBR 8800: 2008.

L'analyse des changements morphologiques du cerveau dans des séries temporelles d'images est un sujet important en neuroimagerie. Bien que le développement des bases de données longitudinales ait aidé à réduire la variabilité inter-individu, il reste encore de nombreux biais qui doivent être évités lors de l'estimation des évolutions longitudinales. De plus, lorsque les changements intra-sujet sont très faibles par rapport à la variabilité inter-sujet, il est crucial de savoir si les méthodes existantes peuvent capturer sans biais les changements longitudinaux. Dans la plupart des études, les changements longitudinaux sont limités à leur composante volumétrique scalaire afin d'en faciliter l'analyse. Cependant, les changements cérébraux ne sont généralement pas uniquement volumétriques et dans ce cas multivarié, l'interprétation est alors plus difficile. Cette thèse adresse ces problèmes en suivant trois axes principaux. Premièrement, nous proposons une chaîne de traitement longitudinale reposant sur la morphométrie à partir de déformations et ayant pour but d'estimer de manière robuste les changements longitudinaux. Afin d’éviter de rajouter du biais, nous détaillons tout l'enchaînement des étapes de traitement. En plus de cette contribution, nous intégrons une modification de l'algorithme de recalage non-linéaire qui consiste à masquer le terme de similarité tout en conservant la symétrie de la formulation. Cette contribution augmente la robustesse des résultats vis-à-vis des artefacts d'intensité situés en bordure du cerveau et augmente ainsi la sensibilité de l'étude statistique réalisée sur les déformations longitudinales / Analysing the progression of brain morphological changes in time series of images is an important topic in neuroimaging. Although the development of longitudinal databases has helped reducing the inter-individual variability, there still exist numerous biases that need to be avoided when capturing longitudinal evolutions. Moreover, when the intra-subject changes are very small with respect to the inter-subject variability it is crucial to know if the available methods can capture the longitudinal change with no bias. In most of the studies, these longitudinal changes are limited to scalar volumetric changes in order to ease their analysis. However, one can observe that brain changes are not limited to volumetry. In this multivariate case, the interpretation is more difficult. This thesis addresses these problems along three main axes. First, we propose a longitudinal Deformation-based Morphometry processing pipeline to robustly estimate the longitudinal changes. We detail the whole sequencing of the processing steps as they are key to avoid adding bias. In addition to this contribution we integrate a modification to the non-linear registration algorithm by masking the similarity term while keeping the symmetry of the formulation. This change increases the robustness of the results with respect to intensity artifacts located in the brain boundaries and leads to increased sensitivity of the statistical study on the longitudinal deformations. The proposed processing pipeline is based on freely available software and tools so that it is fully reproducible

Cette thèse porte sur un problème de calibration d'un modèle électromécanique de cœur, personnalisé à partir de données d'imagerie médicale 3D+t ; et sur celui - en amont - de suivi du mouvement cardiaque. A cette fin, nous adoptons une méthodologie fondée sur l'apprentissage statistique. Pour la calibration du modèle mécanique, nous introduisons une méthode efficace mêlant apprentissage automatique et une description statistique originale du mouvement cardiaque utilisant la représentation des courants 3D+t. Notre approche repose sur la construction d'un modèle statistique réduit reliant l'espace des paramètres mécaniques à celui du mouvement cardiaque. L'extraction du mouvement à partir d'images médicales avec quantification d'incertitude apparaît essentielle pour cette calibration, et constitue l'objet de la seconde partie de cette thèse. Plus généralement, nous développons un modèle bayésien parcimonieux pour le problème de recalage d'images médicales. Notre contribution est triple et porte sur un modèle étendu de similarité entre images, sur l'ajustement automatique des paramètres du recalage et sur la quantification de l'incertitude. Nous proposons une technique rapide d'inférence gloutonne, applicable à des données cliniques 4D. Enfin, nous nous intéressons de plus près à la qualité des estimations d'incertitude fournies par le modèle. Nous comparons les prédictions du schéma d'inférence gloutonne avec celles données par une procédure d'inférence fidèle au modèle, que nous développons sur la base de techniques MCMC. Nous approfondissons les propriétés théoriques et empiriques du modèle bayésien parcimonieux et des deux schémas d'inférence / This thesis focuses on the calibration of an electromechanical model of the heart from patient-specific, image-based data; and on the related task of extracting the cardiac motion from 4D images. Long-term perspectives for personalized computer simulation of the cardiac function include aid to the diagnosis, aid to the planning of therapy and prevention of risks. To this end, we explore tools and possibilities offered by statistical learning. To personalize cardiac mechanics, we introduce an efficient framework coupling machine learning and an original statistical representation of shape & motion based on 3D+t currents. The method relies on a reduced mapping between the space of mechanical parameters and the space of cardiac motion. The second focus of the thesis is on cardiac motion tracking, a key processing step in the calibration pipeline, with an emphasis on quantification of uncertainty. We develop a generic sparse Bayesian model of image registration with three main contributions: an extended image similarity term, the automated tuning of registration parameters and uncertainty quantification. We propose an approximate inference scheme that is tractable on 4D clinical data. Finally, we wish to evaluate the quality of uncertainty estimates returned by the approximate inference scheme. We compare the predictions of the approximate scheme with those of an inference scheme developed on the grounds of reversible jump MCMC. We provide more insight into the theoretical properties of the sparse structured Bayesian model and into the empirical behaviour of both inference schemes

L’objectif de cette thèse est d’appliquer des méthodes de contrôle optimal en réso- nance magnétique nucléaire et en information quantique. Dans un premier temps, on introduit les domaines étudiés et la dynamique des modèles traités. On donne les outils nécessaires pour appliquer le principe du maximum de Pontryagin ainsi qu’un algorithme d’optimisation appelé GRAPE.Le premier travail consiste à appliquer le PMP pour contrôler une chaîne de trois spins inégalement couplés. On étudie ensuite un problème de physique classique appelé "l’effet de la raquette de tennis", qui est un phénomène non-linéaire du modèle de la toupie d’Euler. On se sert de cette étude pour déterminer des lois de commande d’un système quantique à deux niveaux dans le chapitre suivant. Le dernier chapitre présente une méthode numérique qui permet d’améliorer la robustesse d’une porte NOT et de tester la pertinence de différentes approches analytiques déjà développées dans la littérature. / The goal of this thesis is to apply the optimal control theory to Nuclear Magnetic Resonance and Quantum Information. In a first step, we introduce the different topics and the dynamics of the analyzed systems. We give the necessary tools to use the Pontryagin Maximum Principle, and also an optimization algorithm, namely GRAPE.The first work is an application of the PMP to the control of a three-spin chain with unequal couplings. We continue with the study of a classical problem called "the tennis racket effect", which is a non-linear phenomenon occuring during the free rotation of a three-dimensional rigid body. We use the results in the following chapter to determine some control laws for a two- level quantum system. The last chapter presents a numerical method which aims at improving the robustness of a quantum NOT gate and at investigating the efficiency of different analytical approaches proposed in the literature.

Cette thèse aborde une étude biomécanique de l’Articulation Temporo Mandibulaire (ATM), dont l’un des objectifs est la définition d’une approche complète, faisant appel à des outils modernes, permettant la conception d’une prothèse d’ATM personnalisée. Tout d’abord, nous avons conçu et réalisé un tribomètre reproduisant les conditions physiologiques de fonctionnement de l’ATM, afin d’étudier les interactions entre un matériau prothétique et de l’os porcin et de quantifier leurs usures respectives. La conception prothétique personnalisée passe par la réalisation d’un « état des lieux ». Nous avons donc défini un protocole de caractérisation non invasif de l’ATM. Il correspond à l’acquisition de sa géométrie actuelle et des mouvements élémentaires de la mandibule. Dans un deuxième temps, des simulations numériques en dynamique des corps rigides et/ou en éléments finis ont été réalisées pour accéder à des grandeurs mécaniques, telles que contraintes et déformations, nécessaires à la conception d’une prothèse. La totalité du protocole a été menée sur deux sujets d’étude : un sujet présentant une résorption condylienne et un sujet asymptomatique. Des modèles numériques personnalisés ont été construits pour chaque cas. Ces modèles nous ont permis d’étudier le fonctionnement articulaire de chaque individu. Nous avons effectué des comparaisons entre ces deux sujets et nous avons pu constater des différences notables concernant le fonctionnement articulaire. Il s’est avéré que les changements morphologiques occasionnés par la résorption osseuse ont des conséquences sur l’activité musculaire, ainsi que sur les efforts articulaires. Ce travail a permis d’enrichir les connaissances fondamentales par rapport au fonctionnement de l’ATM. Il a également permis de valider des outils d’évaluation de l’état fonctionnel de l’articulation. L’approche développée durant cette thèse est mise en pratique au sein de la société OBL, spécialisée dans la conception et la réalisation de prothèses maxillo-faciales sur mesure. Elle peut également être utilisée comme outil d’évaluation de solutions prothétiques existantes et à venir / This thesis deals with a biomechanical study of the Temporo-Mandibular Joint (TMJ); one of the objectives of this work is the definition of a complete approach, using modern tools, allowing the design of a personalized TMJ prosthesis. First of all, a tribometer reproducing the TMJ physiological conditions was designed and built, in order to study the interactions between porcine bone and a prosthetic material and to quantify their respective wears. Through this device, the relationships between the contact parameters and bone wear were determined. Personalized prosthetic design needs first to carry out “a state-of-the-art”. We defined a non invasive protocol for TMJ characterization. It corresponds to the acquisition of its current geometry and of the mandible elementary motions. In a second step, numerical simulations of rigid bodies and/or finite elements were achieved to obtain the mechanical quantities, such as stresses and strains, necessary for the prosthesis design. The entire protocol was conducted on two subjects: an asymptomatic one and a second one with condylar resorption. Personalized numerical models were built for each case. These models allowed us study the joint functioning of each subject. We made comparisons between these subjects and significant differences were found. It was proved that the changes produced by bone resorption have an impact on muscle activity, as well as contact forces in joints. This work allowed enhancing the fundamental knowledge regarding TMJ operating conditions. It also enabled to validate evaluation tools of the functional state of the joint. The approach developed during this thesis is applied by OBL society, specialized in the design of customed maxillofacial prostheses. The approach proposed in this work can also be used as an evaluation tool of existing prosthetic solutions, as well as future solutions