In our ‘projectified’ and ‘knowledge-intensive’ society, industrial projects have been proposed as important “journeys of knowledge creation” or “places for knowledge integration”. To date, such perspectives have mainly used traditional cognitive and contextual theories of knowledge and have thus mostly been focused on human actors and their interaction. However, other research suggests that a) knowledge can be seen as a process (knowing) and b) that projects can be seen as actor networks made by human as well as nonhuman elements.   Combining these two insights, a complementary epistemological perspective is created in this thesis. Drawing from the processual ontological notion of ‘project becoming’ and the actor-network theory notion of ‘heterogeneous engineering’, the processual concept of heterogeneous project making is suggested here. The purpose of this thesis is then to create a processual and interrelational perspective on how knowing is shaped through heterogeneous project making. The empirical basis of this thesis consists of a six-month ethnographical study of an industrial project in the telecom industry that was set up to develop and manufacture a radio base station.   The perspective presented in this thesis suggests that heterogeneous project making can be seen as the continuous shaping of past, present, future and context (knowing dimensions) which in turn shape and relate to a knowing trajectory. The notion of a knowing trajectory implies movement, a path, which is suggested here as elusive, fluent and influenced by the work of many heterogeneous actors, rather than being the result of a (socially or technologically) deterministic process. The perspective developed also conceptualises and illustrates how such a knowing trajectory takes shape. Finally, theoretical and practical implications of this perspective are suggested. / QC 20100804

The acquisition of relational concepts plays an integral role and is assumed to be a prerequisite for analogical reasoning. Language and token-trained apes (e.g. Premack, 1976; Thompson, Oden, and Boysen, 1997) are the only nonhuman animals to succeed in solving and completing analogies, thus implicating language as the mechanism enabling the phenomenon. In the present study, I examine the role of meaning in the analogical reasoning abilities of three different primate species. Humans, chimpanzees, and rhesus monkeys completed relational match-to-sample (RMTS) tasks with either meaningful or nonmeaningful stimuli. For human participants, meaningfulness facilitated the acquisition of analogical rules. Individual differences were evident amongst the chimpanzees suggesting that meaning can either enable or hinder their ability to complete analogies. Rhesus monkeys did not succeed in either condition, suggesting that their ability to reason analogically, if present at all, may be dependent upon a dimension other than the representational value of stimuli.

Humans are exceptional in their willingness to and frequency with which they help one another. However, nonhuman primates also exhibit prosocial behavior. Recently, a number of laboratory studies examining prosociality among primates have yielded conflicting results. These contradictory findings may be due to a reliance on human interaction, tokens, or interactions in the direct context of food, a highly valued resource for animals. The current study examined prosocial behavior among capuchin monkeys (Cebus apella) in a tool task designed to address these issues by examining whether capuchins would transfer a necessary tool to a partner in different payoff conditions. Some capuchins’ behavior indicated that they understood the task, passing the tool when a partner and food were present. Notably, tool transfer in both tasks was overwhelmingly active rather than passive, which is unusual in the context of food; indicating active prosocial behavior is present amongst primates other than cooperative breeders.

The purpose for the present study was to examine working memory for what, where, and when information in rhesus monkeys (Macaca mulatta) and adult humans using a computerized task. In Experiment 1, monkeys and humans completed three delayed matching-to-sample (DMTS) tasks: 1) identity DMTS, 2) spatial DMTS, and 3) temporal DMTS. In Experiments 2, the identity and spatial tasks were combined so that monkeys had to report both what and where information about an event. In Experiment 3, the identity, spatial, and temporal tasks were combined in order to examine what-where-when memory integration. In Experiment 4, monkeys and humans were presented with two sequential events, and a memory cue indicated which event they were required to report. The rhesus monkeys and human participants were able to report all three components of the events and there was some evidence suggesting that these components were integrated in memory for the rhesus monkeys.

This thesis focuses on the role of nonhumans in the process of value production on social media platforms. In particular, we investigate the relation between algorithm based sorting mechanisms and human work, here exemplified by the role of a hashtag in social media users’ production of identity. Previous research has shown that social media users produce identity by organising web material into coherent narratives. As suggested by Marxist media scholars (Fuchs, 2014; Bolin, 2011), such organising of material can be perceived as a value generating work process. However, little research has explored how hashtags, and other digital nonhuman actors, are involved in this process. The ambition of this study is therefore to enable a closer understanding of hastags’ relation to value producing organisational work. To do this we have selected a specific case to analyse; the hashtag rockasockorna – a Swedish version of the American hashtag rockthesocks. Our empirical material consists of a quantitative data set, collected with aid of a statistical analysis software (hashtracking.com), as well as two qualitative ethnographic case studies on the two statistically most influential users. To analyse the material we use a methodological approach based on Bruno Latour’s (2005) Actor Network Theory. Primarily, the approach is inspired by Latour’s concept of the circulating reference (1999), meaning that relations described in the qualitative material are gradually reduced into a generalised model. The model suggests that the hashtag takes a position of what we refer to as a “quasi consumer”, an imitator of human organisational work. In the paper’s final section the results are brought into dialogue with contemporary Marxist value theory. We argue that existing literature tends to neglect the aspect of nonhumans as consumers, and thus further research should investigate the implications of nonhuman consumption.

René Descartes’ 1637 “bête machine” characterization of nonhuman animals has assisted in the strengthening of the Genesis 1:26 and 1: 28 disparate categorization of nonhuman animals and human animals. That characterization appeared in Descartes’ first important published writing, the Discourse on the Method, and can be summarized as including the ideas that nonhuman animals are like machines; do not have thoughts, reason or souls like human animals; and thus, cannot be categorized with humans; and, as a result, do not experience pain or certain other feelings. This characterization has impeded the primary objective of environmental ethics - the extension of ethical consideration beyond human animals - and has supported the argument that not only the nonhuman animal but also the rest of nature has only instrumental worth/value. As is universally recognized, Gottfried Wilhelm Leibniz, just a few decades after Descartes’ death, took issue with Descartes’ dualism by arguing that the Leibnizian monad, with its active power, was the foundation of, at least, all of life. This argument must result in the conclusion that nonhuman and human animals are necessarily categorized collectively, just as Charles Darwin later argued. In fact, when the writings of Descartes and Michel de Montaigne are reviewed, it becomes apparent that Descartes never believed his bête machine characterization but embraced it to achieve not only his philosophical objectives but also his anatomical and physiological objectives. Philosophically, Descartes was answering Montaigne’s skepticism and his use of nonhuman animal examples to discredit human reason. Also, Descartes spent a major part of, at least, the last twenty-two years of his fifty-four year life dissecting nonhuman animals. Finally, the role that the politics and policies of the Christian institutions played in these matters is of primary importance. Similar politics and policies of the Christian institutions have since played, and still play, an important role in the continuing, unreasonable, disparate categorization of human animals and nonhuman animals. Philosophy seems to be the only discipline that can, if it will, take issue with that characterization.

In recent years critical projects spanning philosophy, the social sciences, science studies, and nearly everywhere that has employed the term ecology have engaged in thinking humans and non-humans together as collectively producing outcomes, where objects do work beyond how humans perceive or make use of them. Taking Zelda Fitzgerald’s Save Me the Waltz as its focus, this thesis explores how this reorientation might contribute to literary studies and to literary criticism more specifically. The thesis considers a notion that novels constitute objects with biographies running “against” the biographic material of their authors, mobilizes actor network theory as a manner of mapping that biographic assemblage, and tentatively develops a biographic network approach as one alternative to traditional literary interpretative practices. Attending to the novel as an actor shifts critical focus away from its interior – the “text” or content – and expands traditional literary criticism’s default practice – interpretation – and logic – mimetic representation – in hopes of facilitating a discussion of Zelda’s novel in a manner which destabilizes the overdetermined themes that continue to scaffold her imaginary. Ultimately, this work argues that a biographic network approach can prove instructive as a “method” for dealing with other texts which remain relatively obscured at the margins of literary consciousness.

Ebola virus (EBOV) is a zoonotic pathogen which causes a fulminant hemorrhagic fever and results in up to 90% fatality. Despite efforts over the past 38 years, a licensed prophylactic or post-exposure option remains unavailable. Several experimental vaccines have already demonstrated protection from lethal EBOV disease in nonhuman primates (NHPs). However, attempts to translate this research from bench to bedside have been hampered, since the immune responses that correlate with protection against EBOV are not well-defined. Without this information, it is not possible to reliably predict the efficacy of vaccines or treatments in humans without lethal challenge. The goal of this thesis is to determine the immune parameters that are predictive of protection against EBOV. Due to the rapid speed of EBOV pathogenesis, it was originally hypothesized that a rapid and robust CD8+ T-cell response must be crucial for survival. Using a previously-characterized adenovirus-vectored Ebola vaccine (Ad5-optGP), transgenic/knockout C57BL/6J mice with ablation for selected immune responses were vaccinated and challenged 28 days later. Surprisingly, while CD8+ T-cell knockout mice survived infection, B-cell knockout mice did not, indicating that the antibody response played a critical role in protection. Humoral and cell-mediated responses were compared between survivor and moribund guinea pigs and NHPs from previous vaccination and post-exposure therapy experiments, either with Ad5-optGP or a vesicular stomatitis virus (VSV)-vectored vaccine (VSVΔG/EBOVGP). Circulating EBOV glycoprotein (GP)-specific IgG antibody levels were the best correlation for protection independent of vaccine platform or timing of exposure (p<0.0001), strongly supporting the role of antibody responses in the control of EBOV infection. To demonstrate that antibodies are also responsible for protection, three previously-characterized monoclonal antibodies recognizing different GP epitopes were combined into a cocktail (ZMAb). Initiation of ZMAb treatment 1 and 2 days post infection (dpi) with EBOV protected 100% and 50% of NHPs, respectively. These results provide a reliable measure for predicting protection from EBOV in three commonly used animal models, and present a strong case for the use of antibodies as an effective post-exposure treatment. This knowledge will ultimately help in the development and validation of a clinical product against EBOV infection.

This study concerns an essential but, until recent years, little explored area of social work: environmental social work. The social work profession has long considered persons in their environment; however, use of the term environment has typically referred to social rather than nonhuman physical dimensions of space and place. It is common knowledge that we face today a number of serious environmental challenges, but less common is an understanding of how things came to be as they are. Why, for example, did things not develop differently? Why is our human-nonhuman relationship so strained? This research asserts human conceptualisations of the nonhuman other influence treatment of not only the nonhuman but also other human beings. Having an interdisciplinary focus involving social work, environmental studies and early Canadian history, Wendat and French conceptualisations of the nonhuman are explored through an ecofeminist framework in a culture-contact context to initiate consideration of, and in due course attending to, the uneasy intersection of the human and the nonhuman, social work and environmental issues, and current Aboriginal-non-Aboriginal relations. Through locating our environmental crisis within a historical context, it is possible to unsettle some contemporary assumptions about the human-nonhuman relationship, drawing attention to the fact that things could have been otherwise, that the environmental challenges experienced today were not inescapable. While there are certainly many ways to approach a history of our present environmental crisis, this investigation in the Canadian context involving a clearly defined case of culture contact between the Wendat and French in the early seventeenth century offers a variety of advantages deriving, in part, from the comparable but different complexities belonging to each group and the opportunity to explore two highly dissimilar cultural practices and belief systems from the time of initial contact. This study examines in detail how the two cultures understood and interacted with the nonhuman, and each other, through a forty-year period from 1609-1649. From this historical exploration of Wendat and French worldviews and land-use practices implications for social work are described and a model for place-based social work is generated.

This thesis reports on cross-sectional surveys aimed at detecting and characterizing haemoprotozoan parasites infecting wild free-ranging non human primates (NHPs) in Kenya, East Africa. Blood samples from olive baboons (Papio cynocephalus anubis), vervet monkeys or African green monkeys (AGMs, Chlorocebus aethiops) and Syke's monkeys (Cercopithecus mitis) from five provinces of Kenya were analyzed. The haemoprotozoan parasites survey was performed with microscopic evaluation of blood smears, serological techniques and molecular tools. Blood specimens and serum samples from 121 NHPs were tested for the presence of Trypanosoma brucei (Study I). Indirect antibody enzyme-linked immunosorbent assay (Ab-ELISA) detected titers of anti-T. brucei antibodies in 19% (23/121) of the sera sampled. Subsequent field-oriented latex agglutination test (LAT) detected presence of T. brucei antigens in 16% (19/121) of the sera. However, there were no active infections detected on fixed blood smears, or wet blood films. Of the 378 NHPs sera samples tested for Leishmania major exposure using Ab-ELISA, 66% had detectable anti-L. major antibodies (study II). Western blot (WB) assay detected anti-L. major antibodies in sera from 46% (175/378) of the NHPs samples. Specific proliferation of peripheral blood mononuclear cells to L. major antigen was demonstrated in 23% (17/57) of AGMs samples. Haemoprotozoan parasites, Entopolypoides macaci and Hepatocystis kochi were detected by microscopic evaluation of Giemsa-stained blood smears from 179 NHPs (study III). The prevalence rate of E. macaci was 43% in African green monkeys, 35% in Syke’s monkeys and 33% in baboons. H. kochi infection rate was 18% in African green monkeys, 23% in baboons and 25% in Syke’s monkeys. Subsequent indirect immunofluorescent antibody test (IFAT) supported the morphologic appearance of E. macaci observed by microscopy. Molecular tools were used to detect and identify haemoprotozoan parasites in wild free-ranging NHPs (study IV). Nested polymerase chain reaction (PCR) targeting Babesia β-tubulin gene detected a 22% (27/125) B. microti infections in free-ranging NHPs in Kenya. PCR also detected 22% mixed infections by Hepatocystis and Entopolypoides, 12% Hepatocystis and Babesia and 7% Entopolypoides and Babesia (study V). Phylogenetic analysis inferred from mitochondrial cytochrome b (Cyt-b) gene confirmed the presence of Hepatocystis kochi whereas analysis of 18SS rRNA gene confirmed presence of two piroplasms, Babesia sp. and Entopolypoides macaci. In conclusion, epidemiological results from sero-prevalence studies provide strong circumstantial evidence that some species of Kenyan NHPs are naturally exposed to L. major and T. brucei infections and could be potential reservoir hosts for these haemoparasites. Molecular diagnosis revealed the occurrence of mixed parasite infections and confirmed the circulation of Babesia and Entopolypoides species in the same populations of Kenyan NHPs.