Les crises des dernières décennies montrent l’entrelacement entre matérialités, humains et technologies. Malgré les 3RV-E (réduire, réemployer, recycler, valoriser, éliminer), les matières résiduelles ne cessent d’augmenter. Cette thèse de recherche-création médiatique est un questionnement sur l’expérimentation artistique et technologique avec les matières résiduelles, comme engagement esthétique-politique. La thèse s’attarde à ce qui se crée avec les traitements des eaux usées, le lieu d’enfouissement technique de déchets, ainsi que la pollution atmosphérique et électromagnétique. J’analyse comment ces opérations retentissent au cœur même de la production des œuvres réalisées depuis 2006 par ma cellule de recherche artistique Ælab, cofondée en 1996 avec le compositeur Stéphane Claude. Mes alliés philosophiques principaux sont Joselita Ciaravino, Gilles Deleuze, Félix Guattari, Brian Massumi, Gilbert Simondon et Isabelle Stengers. Ciaravino discute d’un 3e ordre du disegno à la Renaissance, pratiqué par de Vinci, un dessin non représentationnel. Ce type de dessin active un processus de transduction simondonien, lorsqu’un élément perturbateur est l’amorce d’une décharge d’énergie potentielle qui déborde sur des éléments avoisinants, qui participent d’un milieu sous tension, pouvant à leur tour générer de nouveaux pivots d’interrelation. Ces agencements rejoignent la manière dont Guattari discute de l’écosophie, un entrelacement triple et dynamique entre la subjectivation, la collectivité et l’environnement, des milieux fertiles pour saisir les transductions en cours avec l’art. Une nouvelle puissance d’agir accompagne leur dessin, et un « faire attention » (Stengers) en émerge, acte solidaire de résistance. Les expérimentations éthico-esthétiques avec les matières résiduelles peuvent contribuer à remettre en question les dualismes pouvant restreindre une exploration technologique des matérialités, afin de participer au déploiement transductif de l'écosophie. Au travers des restes s’accomplit une relation amplifiée, amplifiante avec la pratique technologique qui se singularise, tout en débordant d’elle-même, dans les collectivités. La thèse s’exprime en cinq chapitres où se rencontrent pratiques et théories. Chaque fois, deux concepts sont mis en relation : Dessin et Diagrammatique ; Milieux et Intervalles ; Traduction et Transduction ; Écosophie et Faire Attention ; Postmédia et Communs. Des « blocs de sensations » (Deleuze et Guattari) surgissent entre la théorisation et le récit a-chronologique de la pratique artistique, l’un « au travers » de l’autre (perScapere), l’un avec l’autre. Les œuvres construisent un plan de composition (Deleuze et Guattari) que je nomme le « perse_plan ». Le perse_plan se dédouble en phases sous l’action de la fente, l’intervalle, l’ondulation et la cascade, venant de l’expérimentation ontogénétique des cinq œuvres et de leurs processus enchevêtrés avec dessin numérique, vidéo, audio, lumière, matérialités, senseurs, performances, installations. En fonction des seuils, des résonances, fortes et moins fortes, leurs « milieux associés » (Simondon) se dessinent dans le temps. / Multiple crises over the last several decades demonstrate the entanglement of materialities, humans, and technologies. Despite the 3RV-Es (Reduce, Reuse, Recycle, Valorisation and Elimination), waste increases. This media-based research-creation dissertation is an investigation of technological artistic experimentation with residual matter as aesthetic/political engagement. This dissertation is concerned with what wastewater treatment, engineered landfill sites, and atmospheric and electromagnetic pollution create. I analyze how these operations are at the very heart of artworks produced since 2006 by Ælab, an artistic research unit I cofounded with composer Stéphane Claude in 1996. Joselita Ciaravino, Gilles Deleuze, Félix Guattari, Brian Massumi, Gilbert Simondon, and Isabelle Stengers are my primary philosophical allies. Ciaravino discusses disegno’s third order, a form of non-representational drawing practiced by da Vinci during the Renaissance. This type of drawing activates a transduction process as described by Simondon: a disruptive element participating in a milieu under tension triggers a potential energy discharge that overflows onto neighbouring elements, which can, in turn, generate new pivots of interrelation. These assemblages recall Guattari’s discussion of ecosophy, a dynamic, triple intertwining of subjectivation, collectivity, and the environment that provides fertile milieus to follow the transductions art brings about. A new force accompanies their drawing and a “paying attention” (Stengers) emerges, act of resistance and solidarity. Ethico-aesthetic experiments with waste are a way of questioning dualisms that may hamper the technological exploration of materialities in order to participate in the transductive reticulation of ecosophy. Working with waste creates an amplified relation; it amplifies a technological practice that, as it resingularizes, also extends to collectivities. This dissertation presents five chapters in which practice and theory meet. In each, two concepts are placed in dialogue: Drawing and Diagrammatic; Milieus and Intervals; Translation and Transduction; Ecosophy and Paying Attention; Postmedia and Commons. “Blocks of sensation” (Deleuze and Guattari) arise between theorization and an a-chronological telling of artistic practice, one “through” (au travers) the other (perScapere), one with the other. The works build a plan of composition (Deleuze and Guattari) I call the “perse_plan”. The phases of the perse_plan are split by the actions of fissure, interval, undulation, and cascade. These phases are the result of ontogenetic experimentation through five artworks and their related processes interconnected with digital drawing, video, audio, light, materialities, sensors, performances, and installations. Across thresholds and various resonances, their “associated milieus” (Simondon) are drawn out over time.

One major reason of CNS pharmacotherapy's impediment is the existence of "barriers" between blood and CNS, especially the Blood-Brain Barrier (BBB), a neurovascular structure localized at the level of brain microvasculature. Main factors responsible for this barrier function are drug efflux transporters type ABC (ATP-Binding Cassette) and SLC (SoLute Carrier) expressed at BBB level and known to be at the origin of multi-drug resistance phenomenon. Recent researches aim at unraveling the signaling mechanisms regulating these transporters in order to modulate their activity and improve pharmacotherapy in brain diseases. For years, these transporters have been studied in adult organism. But, there is a wide spread belief that the BBB in embryo, fetus, new born and infant is "immature", implying caution in giving drugs to infants. However, current knowledge on the functional status of the BBB in immature organism remains very limited.This study was performed in the aim of understanding: 1) The ontogenesis of ABC and SLC transporters during brain maturation, 2) the functional role of four BBB drug efflux transporters (P-glycoprotein (P-gp), Breast Cancer Resistance Protein (bcrp), Organic Anion Transporter 3 (oat3), and Transporting Peptide 1a4 (oatp1a4) transporters) in children's brain, and 3) the mechanisms that regulate their functional expression under normal and pathological conditions, mostly under inflammatory conditions, because indeed alterations in structural and functional components of the BBB have been reported in a long list of CNS pathologies in adults. Our results showed changing properties of the BBB during ontogenesis, as well as an age-related differential regulation of BBB drug efflux transporters under normal and inflammatory conditions.These findings highlight the importance of considering an age-related response of CNS to drugs and of taking into account the specific properties of juvenile BBB during definition of therapeutic strategies designed to treat childhood brain diseases, and this in the clinical perspective of developing new drugs with enhanced efficacy in children's CNS.

Pyrethroids are ones of the most used pesticides worldwides. The widespread use and high stability of pyrethroids lead to the assumption of that their occurrence in the environment could be quite frequent. They can reach water ecosystem as pollutants. Residues of pyrethroids are not only detected in the water column, but also in sediments and in fish tissues. The first study was devoted to the product Nexide containing 60 g.l-1 of active substance gamma-cyhalothrin. Tested Nexide concentrations were 5, 25, 50, 100, and 250 &microg.l-1. Early life stage test was used.Common carp (Cyprinus carpio) was tested. There were significant mortalities in all concentrations except the lowest concentration during the trial. The lowest concentration tested 5 &microg.l-1 only caused a slightly increased mortality. This lowest concentration influenced the growth in length and weight negatively, decelerated ontogenetic development, and made the body surface of the individuals darker. Histopathology of individuals from this concentration revealed dystrophy in liver. Examination of kidney, intestine and gills did not show significant histopathological differences compared with control. The evaluation of selected parameters of oxidative stress demonstrated a significantly higher activity of detoxification enzyme glutathione-S.transferase (GST) and a significantly lower activity of defensive enzyme glutathione peroxidase (GPx) compared with the control group. The other examined parameters of oxidative stress such as catalase (CAT), glutation reductase (GR), and lipid peroxidation determined by using the thiobarbituric acid-reactive substances (TBARs) were comparable to the control group. Changes in oxidative stress parameters suggest that exposure of the organism to the product Nexide in the given concentration leads to dysbalance of defensive enzymes. The second study was devoted to the product Cyperkill 25 EC containing 250 g.l-1. Tested Cyperkill 25 EC concentrations were 7.2, 36, 72, 144, and 360 &microg.l-1. The procedure of the trial was the same as the preceded one. There were 100% mortalities in all concentrations except the lowest concentration during the trial. The lowest tested concentration 7.2 &microg.l-1 allowed 90% of individuals to stay alive till the end of experiment. The lowest concentration influenced the growth in length and weight negatively and decelerated ontogenetic development compared with the control. Any individual exposed to this concentration did not reach juvenile stage until the end of the trial. Dark pigmentation was visible in 68% of these exposed individuals on the last day. Similar darkening was visible in individuals from higher concentrations shortly before death too. Histological examination did not revealed significant changes in intestine, liver, kidney, and gills compared with the control group. Evaluation of selected parameters of oxidative stress demonstrated significantly lower activities of GST, GR, and GPx. Activities of CAT and TBARS were comparable with the control group. Changes in oxidative stress parameters suggest that exposure of the organism to the product Cyperkill 25 EC in the given concentration could induce oxidative stress and interfere with the activities of antioxidant enzymes. The presented thesis summarises actual data about pyrethroids and their influence on fish. The demonstrated effects confirm high susceptibility of early developmental stages of fish to tested pesticides. When interpreting the results, we have to take into account the fact that studies showed this risk even on single pyrethroid substances. But water organisms are exposed to many other more or less toxic products and substances in a real environment. These xenobiotics could react with each other and their mixture could even potentiate negative effects. The performed studies also clearly show the significant differences in the sensitivity of embryonic and embryolarval tests.

This diploma thesis focuses on the communication competence of young learners with speech impediments. The theoretical part describes the development of young learners at primary school, speech ontogenesis from the child´s birth to their entering the first class. Then there is also analyzed communication and related communicative competence. Another section focuses on speech disorders, their classification. It is important to mention the prevention of speech therapy and the subsequent development of communication skills. The practical part is focused on research to determine the influence of defects on the level of speech communication skills of young pupils. This section is based on information obtained through interviews with teachers and five selected students´ parents at the basic school of speech therapy and the analysis of governesses and teachers´ diaries. The resulting data is recorded in case reports, tables and graphs.

Made available in DSpace on 2016-06-02T20:12:10Z (GMT). No. of bitstreams: 1 TeseJRBM.pdf: 1767918 bytes, checksum: 200ee529156f1dbfe98eeab387ba9dc6 (MD5) Previous issue date: 2006-12-15 / This doctoral thesis intends to analyze the main concepts of mental disease and the problematic relation between the organicism and the psychodinamism throughout the history of the psychopathologic ideas that came to constitute the scientific clinical psychiatry, from Philippe Pinel, in the beginning of XIX century, until the chaos of the no theoretical pretense descriptive of the official nosography of the end of XX century and beginning of XXI century (I.C.D.-10). The epistemologic conflict between the psychogenic and organogenic doctrines had resulted in many frustrated attempts of solution. The hermeneuticsynthetic psychopathology of Carl Gustav the Jung (1875-1961) and the phenomenonstructural psychopathology of Eugène Minkowski (1885-1972) stand out among the most promising proposals of XX century. The basic concepts of these authors keep an essential similarity, besides belonging to schools have different thoughts. However, their theorization go in parallel thinking about a psychopathologic formularization psychorganodinamic that is similar in its most essential principles. The antimechanist solution, anti-atomicist and antireductionist, of both, remind the current biological psychiatry that the desired and necessary consensual psychiatric theory will not do without a Metapsychopatology of the psychiatry that consider the irreducible biopsychosocial complexity of the normal or pathological human being. And, neither psychiatry will gain a satisfactory nosographic formularization while they don t reveal the mysteries of the complex etiology of mental disorders. / A presente tese de doutorado pretende analisar os principais conceitos de doença mental e a problemática relação entre o organicismo e o psicodinamismo ao longo da história das idéias psicopatológicas que vieram constituir a psiquiatria clínica científica, a partir de Philippe Pinel, no início do século XIX, até o caos da pretensa ateoricidade descritiva da nosografia oficial do final do século XX e início do século XXI (C.I.D.-10). O conflito epistemológico entre as doutrinas psicogênicas e organogênicas resultou em várias tentativas frustradas de solução. Dentre as mais promissoras propostas do século XX, destacam-se as da psicopatologia hermenêutico-sintética de Carl Gustav Jung (1875-1961) e da psicopatologia fenomeno-estrutural de Eugène Minkowski (1885-1972). Os conceitos fundamentais desses autores guardam uma semelhança essencial, apesar de pertencerem a escolas de pensamento diferentes; todavia, suas teorizações caminham paralelamente no sentido de uma formulação psicopatológica psicorganodinâmica muito parecida em seus princípios mais essenciais. A solução antimecanicista, anti-atomicista e anti-reducionista, de ambos, lembram à psiquiatria biológica atual que a tão desejada e necessária teoria psiquiátrica consensual não prescindirá de uma Metapsicopatologia da psiquiatria que considere a complexidade biopsicossocial irredutível do ser humano normal ou patológico. E, tampouco a psiquiatria chegará a uma formulação nosográfica satisfatória enquanto não desvendar os mistérios da etiologia complexa dos transtornos mentais.

This thesis deals with the collection, sorting and by reflecting artistic expressions of a particular child during the school year. The theoretical part contains information obtained from the study of literature concerning the concepts of art education, perception, sensitivity, imagination, creation, communication, portfolio assessment, children's drawing, ontogeny, psychiatric diagnosis, developmental disorders. The empirical part focused on the development of intellectual and social abilities in connection with the development of drawings, a boy with psychiatric diagnosis. The work is processed by the methods of qualitative research. It is a case study with subsequent analysis results of operations,ie his artistic expressions.

Key words: communication, communication skills, ontogenesis of speech, influencing factors, communication skills, general educational program for preschool education, preschool age, family, teacher, nursery school, a stimulus program ANNOTATION The thesis of the possibility of development of communication skills in children of preschool age. He is interested in aspects of communication skills, and characterizes the speech ontogenesis stages of language development. It looks disordered, the possibility of development and factors that may affect it. It builds on language education in pre- school education from historical and contemporary perspective. Practical use of monitors of speech to describe situational picture among children aged 3-6 (7) years. The stimulus program to help identify the state of the continuous expression of children aged 5-6 (7) years, and considering the possibility of his influence. Finally, we discussed proposals for changes that could help develop communication skills in preschool children.

L’échec thérapeutique des maladies cérébrales est lié, entre autres, à la présence de barrières entre le sang et le Système Nerveux Central (SNC), en particulier la Barrière Hémato-Encéphalique (BHE). La BHE est une structure neuro-vasculaire localisée au niveau des MicroVaisseaux Cérébraux (MVC) limitant l’entrée des molécules thérapeutiques dans le cerveau. Ce rôle barrière est dû à plusieurs facteurs, dont principalement, l’existence du côté luminal et/ou abluminal de la BHE de plusieurs transporteurs d’efflux, dont les transporteurs de type ABC (ATP Binding Casette) et SLC (SoLute Carrier) et qui sont à l’origine des phénomènes de résistance aux médicaments. Les études de recherche actuelles visent à identifier les voies de signalisation régulant l’activité de ces protéines d’efflux afin d’optimiser la pharmacothérapie cérébrale. Mais la majorité de ces études sont effectuées chez l’adulte. Très peu de données existent chez l’enfant.Cette étude a été réalisé dans la perspective de 1) Etudier l’ontogenèse des transporteurs ABC et SLC de la BHE au cours de la maturation cérébrale, 2) Elucider le rôle fonctionnel de quatre transporteurs d’efflux ((P-glycoproteine (P-gp), Breast Cancer Resistance Protein (bcrp), Organic Anion Transporter 3 (oat3), and Transporting Peptide 1a4 (oatp1a4) transporters) dans le cerveau des enfants et 3) Elucider les mécanismes qui régulent leur expression fonctionnelle dans des conditions normales et pathologiques, notamment inflammatoires, parce que des modifications dans les composantes structurales et fonctionnelles de l'unité neurovasculaire ont été rapportées dans une longue liste de pathologies du SNC chez les enfants et les adultes. Nos résultats ont montré l’existence de différences fonctionnelles, en terme de passage de molécules, entre la BHE pédiatrique et celle adulte. De plus, cette étude a mis en évidence une régulation différentielle liée à l'âge des transporteurs d'efflux de médicaments de la barrière dans des conditions normales et inflammatoires.Ces résultats fournissent des preuves sur l’intérêt de prendre en compte les propriétés spécifiques de la BHE pédiatrique et la distinguer de la BHE adulte lors des définitions des stratégies thérapeutiques destinées à traiter les maladies cérébrales chez les enfants. / One major reason of CNS pharmacotherapy’s impediment is the existence of “barriers” between blood and CNS, especially the Blood-Brain Barrier (BBB), a neurovascular structure localized at the level of brain microvasculature. Main factors responsible for this barrier function are drug efflux transporters type ABC (ATP-Binding Cassette) and SLC (SoLute Carrier) expressed at BBB level and known to be at the origin of multi-drug resistance phenomenon. Recent researches aim at unraveling the signaling mechanisms regulating these transporters in order to modulate their activity and improve pharmacotherapy in brain diseases. For years, these transporters have been studied in adult organism. But, there is a wide spread belief that the BBB in embryo, fetus, new born and infant is “immature”, implying caution in giving drugs to infants. However, current knowledge on the functional status of the BBB in immature organism remains very limited.This study was performed in the aim of understanding: 1) The ontogenesis of ABC and SLC transporters during brain maturation, 2) the functional role of four BBB drug efflux transporters (P-glycoprotein (P-gp), Breast Cancer Resistance Protein (bcrp), Organic Anion Transporter 3 (oat3), and Transporting Peptide 1a4 (oatp1a4) transporters) in children’s brain, and 3) the mechanisms that regulate their functional expression under normal and pathological conditions, mostly under inflammatory conditions, because indeed alterations in structural and functional components of the BBB have been reported in a long list of CNS pathologies in adults. Our results showed changing properties of the BBB during ontogenesis, as well as an age-related differential regulation of BBB drug efflux transporters under normal and inflammatory conditions.These findings highlight the importance of considering an age-related response of CNS to drugs and of taking into account the specific properties of juvenile BBB during definition of therapeutic strategies designed to treat childhood brain diseases, and this in the clinical perspective of developing new drugs with enhanced efficacy in children’s CNS.

The following text constitutes an attempt to present the French philosopher Gilbert Simondon's genetic ontology through an account of his reconfiguration of the problem of individuation in his doctoral thesis from 1958, L'individuation à la lumière des notions de forme, information, potentiel, métastabilité. The intention is to show how Simondon through this reconfiguration of a classical philosophical problem – in which concepts and schemas from contemporary physics and technology is utilised in a critique of the bi-polar hylomorphic schema as its traditional, substantialistic solution – becomes able to articulate an anti-substantialistic and anti-reductionistic ontogenesis as first philosophy. A systematic philosophical conception that according to Simondon precedes every critical investigation of the subject as well as every scientific ontology – not by establishing a pre-critical position, but by exceeding Kant's critical position: that is, through a displacement toward a conception of the transcendental conditions for the genesis of being and thought as real conditions, rather than conditions of mere possibility. A displacement that in turn appears to respond to the question that frames this basic account of important concepts and schemas in Simondon, namely: in what sense and to what extent is it necessary for philosophical thought to be thought and developed in relation to other forms of thought?

7 Abstract This master's thesis engages moving images of contemporary art in order to sketch out certain ontological qualities of the digital image and imaginary, as they increasingly spill out of all fixed frames and fill the spaces between screens, contexts, and human and non-human agents. Following Steven Shaviro's observation that digital media brought about a completely "new regime" of mutable technical imaging often independent of any preceding "real" space, but instead able to produce its own space-time, this text treats moving images as performative world-shaping fictions with tangible traction on reality. Instead of understanding their growing proliferation in terms of the often-mourned disappeared correspondence to some previous reality, depth or truth, it suggests taking their fluidity as an opportunity to rethink the very divide placed between reality and fiction, as it continues to blur throughout our interactions with digital media, and to treat images not as mere representations but as material forces intensively active in the physical matter of the world, as well as in our own cognition. To articulate this irreducible materiality of digital image-fictions, the thesis weaves together on one hand respective philosophical concepts of François Laruelle and Gillese Deleuze and Félix Guattari -...