• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 17
  • 16
  • 6
  • 2
  • 2
  • Tagged with
  • 45
  • 8
  • 8
  • 7
  • 7
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 5
  • 5
  • 4
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Produktivitetsmätning : En fallstudie på Schunk Nordiska i Lenhovda

Sundqvist, Alexander, Johansson, Fredrik January 2013 (has links)
Bakgrund: En viktig del i företagens jakt efter att nå lönsamhet tenderar att vara mätning och förändring av produktiviteten. Om företag lyckats med uppdraget att höja produktiviteten i verksamheten, allt annat lika, kommer detta sammanfalla med att lönsamheten förändras positivt. Det är därför produktivitetsmätning i praktiken är viktigt.   Syfte: Syftet med denna studie är att vidareutveckla produktivitetsmätningarna i författarnas fallföretag. Vidare ämnar studien finna svar på vilka faktorer som påverkar Schunks produktivitet och hur dessa kan påverkas samt hur de kan gå till väga för att använda dessa mätningar som underlag för ökad lönsamhet.   Metod: Författarna har valt att utföra en kvalitativ fallstudie på företaget Schunk. Det empiriska materialet som samlats in via semistrukturerade intervjuer har sedan jämförts med det teoretiska ramverket.   Slutsats: Resultatet presenter Schunks produktivitetspotential och de faktorer som föreligger. Författarna presenterar även ett ytterligare mått för ökad mätning och kopplar produktiviteten till lönsamheten i ett Du Pont-schema. Vidare lyfts slutsatserna ur kontext och en föreslagen arbetsgång presenteras.
12

Plano plurianual participativo 2008-2011 na bahia: uma análise

Pomponet, André Silva January 2012 (has links)
140 p. / Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2012-12-18T17:31:06Z No. of bitstreams: 1 22.pdf: 1205247 bytes, checksum: 74899fd35ba5780eaf276886eb3135f7 (MD5) / Made available in DSpace on 2012-12-18T17:31:06Z (GMT). No. of bitstreams: 1 22.pdf: 1205247 bytes, checksum: 74899fd35ba5780eaf276886eb3135f7 (MD5) Previous issue date: 2012 / O presente trabalho de dissertação tem o propósito de indicar quais os avanços e os obstáculos verificados na implementação do Plano Plurianual Participativo na Bahia no período 2008-2011. O estudo encaixa-se na categoria estudo de caso, já que busca entender o processo de escuta social conhecido como PPA Participativo, executado pelo Governo da Bahia a partir de 2007. Como referencial teórico, entre as diversas teorias da democracia existentes, optou-se pela democracia participativa, pela maior identidade com o objeto do estudo, em especial a corrente conhecida como “Nova Esquerda”, destacando-se como principais autores Nicos Poulantzas e Carole Pateman. Entre as contribuições do presente trabalho estão a sistematização de conhecimentos acerca de etapas do PPA Participativo, como as plenárias do PPA-P, a formação do Conselho de Acompanhamento do PPA e os eventos conhecidos como Diálogos Territoriais, além de uma análise sobre a adoção dos Territórios de Identidade como unidades de planejamento. No âmbito dos principais obstáculos enfrentados na experiência foram apontados a baixa territorialização das Ações do Governo, a inexistência de regionalização uniforme, as dificuldades de compatibilização entre o Plano Plurianual e a Lei Orçamentária Anual e as dificuldades relacionados aos canais de diálogo entre o Estado e a Sociedade. Também foram discutidos aspectos relacionados à estrutura precária para o funcionamento do Conselho de Acompanhamento do PPA, além dos debates sobre o foco dos conselheiros na condução do CAPPA e as dificuldades que emergiram na relação entre a Democracia Participativa e a Democracia Representativa. Como aspectos positivos trabalhados na dissertação estão a elevação da transparência nas ações governamentais e o fortalecimento do Controle Social, com a criação de canais institucionais que permitem à sociedade acompanhar mais de perto as realizações governamentais. As conclusões indicam que a experiência do PPA Participativo foi positiva e se reconhece que a implementação de processos participativos exige tempo para se consolidar, embora a superação ou minimização dos obstáculos apontados no trabalho possam ajudar no aperfeiçoamento e na consolidação do processo. / Salvador
13

Os desafios da integração entre os instrumentos de planejamento orçamentário: PPA, LDO e LOA : estudo de caso do município de Nilópolis/RJ

Galiza, Leandro Felipe 22 May 2014 (has links)
Submitted by Leandro Felipe Galiza (unedmg@gmail.com) on 2014-07-08T13:18:38Z No. of bitstreams: 1 DISSERTAÇÃO_FINAL.pdf: 1577679 bytes, checksum: a318b2e5815b57ee490bd98929804e34 (MD5) / Approved for entry into archive by ÁUREA CORRÊA DA FONSECA CORRÊA DA FONSECA (aurea.fonseca@fgv.br) on 2014-07-10T17:08:52Z (GMT) No. of bitstreams: 1 DISSERTAÇÃO_FINAL.pdf: 1577679 bytes, checksum: a318b2e5815b57ee490bd98929804e34 (MD5) / Approved for entry into archive by Marcia Bacha (marcia.bacha@fgv.br) on 2014-07-18T12:16:19Z (GMT) No. of bitstreams: 1 DISSERTAÇÃO_FINAL.pdf: 1577679 bytes, checksum: a318b2e5815b57ee490bd98929804e34 (MD5) / Made available in DSpace on 2014-07-18T12:19:29Z (GMT). No. of bitstreams: 1 DISSERTAÇÃO_FINAL.pdf: 1577679 bytes, checksum: a318b2e5815b57ee490bd98929804e34 (MD5) Previous issue date: 2014-05-22 / A presente pesquisa tem o objetivo de identificar e entender em que medida a integração entre os instrumentos orçamentários é afetada no âmbito do município de Nilópolis / RJ. Para isso, foram estudados os principais conceitos relacionados ao assunto, bem como diversos documentos, e diversas entrevistas com atores (stakeholders) do Poder Legislativo e do Poder Executivo. O Referencial teórico apresenta o orçamento como um instrumento multifacetado que pode ser entendido em três dimensões: Política, Jurídica e Econômica. Tal referencial teórico foi utilizado na presente pesquisa a fim de identificar as questões e fatores que afetam a integração dos instrumentos orçamentários (PPA, LDO e LOA) no município de Nilópolis / RJ, dando desta forma, uma perspectiva ao leitor sobre o assunto em foco. Verificou-se que os fatores identificados pelos entrevistados, não são diretamente responsáveis por um falta de integração entre o PPA, LDO e LOA. Foi concluído que os principais fatores, indicados na pesquisa, são conseqüências de causas externas ao município de Nilópolis. / This research aims to identify and understand the extent to which integration between budget instruments is affected within the municipality of Nilópolis/RJ. For this, the main concepts related to the subject, as well as various documents, and interviews with various actors (stakeholders) of the Legislative Branch and the Executive Branch were studied. The Theoretical Framework presents the budget as a multifaceted tool that can be understood in three dimensions: Political, Legal and Economic. This theoretical framework was used in this study to identify the issues and factors affecting the integration of budget instruments (PPA, LDO and LOA) in the municipality of Nilópolis/RJ, giving thus the reader a perspective on the subject in focus. It was found that the factors identified by respondents are not directly responsible for a lack of integration between the PPA, LDO and LOA. It was concluded that the main factors indicated in research, are consequences of external causes to the municipality of Nilópolis.
14

Framtidens vätgassystem : En fallstudie om vätgasproduktion mot en industriell marknad med el från havsbaserad vindkraft / Hydrogen systems in the future : A case study regarding hydrogen production for an industrial market utilizing offshore wind power

Nedar, Herman, Celsing, Alexander January 2023 (has links)
Vätgas producerad från förnybar el har en stor potential att minska utsläppen från flera olika branscher. Detta genom att införa nya innovativa ändamål och även genom storskalig ersättning av vätgas som idagproduceras med fossila bränslen. Men för en storskalig förändring behöver kostnaden för förnybar vätgasproduktionsjunka. Förutom den generella teknikutveckling och storskalighetsfördelar finns det effektivasätt att bättre nyttja existerade teknik för att sänka kostnaden för vätgas mot slutkund. Exempel på detär försäljning av spillvärme från systemet till lokala fjärrvärmesystem samt nyttjandet av vätgassystemetför att agera på balansmarknader. Denna studie undersökte hur ett vätgassystem innehållandes elektrolysörer, lager, kompressor och gasturbinerkan utformaras och driftas för att på ett effektivt sätt agera på marknader för el och vätgas. Det gjordes genom att studera hur en anläggning kopplat till vindkraftsproduktion genom ett Power purchaseagreement (PPA) kan utformas och driftas för att tillgodose ett industriellt vätgasbehov. Stort fokus ladespå hur ett sådant system kunde nyttjas för att agera på balansmarknader genom att sälja stödtjänsteroch hur erbjudandet av stödtjänster påverkade resten av vätgassystemet. Fallstudien som genomfördes utgick från ett potentiellt vätgassystem i Helsingborg med två stora industriellakunder som ville skifta från nyttjandet av vätgas producerad genom ångreforming till vätgasproducerad genom elektrolys med förnybar el. Då mycket fokus i studien var på balansmarknader ochflexibilitet ansågs PEM-elektrolsyören var den bäst lämpade. Vidare valdes komprimerad vätgaslagringoch ett antal alternativ för vätgasturbiner. Då produktionen var kopplad till en intermittent energikällagjordes bedömningen att systemet skulle vara assisterat med möjligheten att handla el på dagenföre- ochintradagsmarknaden. Om all eltillförsel skulle ske från vindkraften hade lagret behövt vara orimligt stortför att säkerställa förmågan att klara leveranskrav under perioder med låg elproduktion. För att analyseradet valda systemet modellerades ett vätgassystem i Energy Optima 3, en programvara som nyttjar linjärprogrammering för totaloptimering av energisystem. För att undersöka hur dem olika komponenternaskulle dimensioneras gjordes ett antal helårsoptimeringar med tidsupplösning om en timme för att se hursystemet presterade med olika kombinationer av storlek på elektrolysör, lager samt typ av gasturbin. Vid värdering av vilken konfiguration som var mest lämpad användes den utjämnade vätgaskostnaden.Den konfiguration som bedömdes vara mest lämpad för det studerade fallet var en PEM-elektrolysör på 55MW, ett komprimerat lager som motsvarade 12 timmars behov från kunderna och en gasturbin på 24 MW.Den konfigurationen kunde under den studerade tidsperioden producera vätgas till en utjämnad kostnadpå 4,7 EUR/kg. Allmänt kan sägas att studien visade att agerande på balansmarknaden gav stor intäkterför systemet och hade en betydande påverkan på systemets lönsamhet. Försäljning av spillvärme hade idet studerade fallet inte en lika kritiskt påverkan på systemet då intäkter var betydligt lägre. En viktigtinsikt från studien var att värdet av att agera på dem olika marknaderna ofta ställdes mot varandradå deltagande på balansmarknaden ibland innebar att elektrolysören inte kunde nyttja all kapacitet.Samtidigt innebar uppbunden kapacitet på balansmarknaden att flexibiliteten i systemet inte kundenyttjas för att agera på intradagsmarkanden och/eller hantering av prognosfel från vindkraftsproduktion. Studien visade allmänt att utformning och prissättning av PPA har en avgörande roll i ett vätgassystemsgångbarhet. I studien användes ett pay-as-produced-avtal, vilket resulterade i att elektrolysören vid vissatillfällen hade underskott på el (och el från intradagsmarknaden behövde köpas in för att kompensera)och vid vissa tillfällen var det överskott på el (och el behövde säljas vidare på dagenföre- eller intradagsmarknaden.)Vidare bedömdes försäljning av vätgas med långsiktiga kontrakt vara det mest lämpadealternativet då det säkrar intäkter för vätgas producenter och tillgången på vätgas till för industrierna. / Hydrogen produced from renewable electricity has significant potential to reduce emissions in variousindustries, both through new innovative applications and as a large-scale replacement for hydrogen currentlyproduced using fossil fuels as a feed stock. However, in order for large scale adaptation of renewablehydrogen the costs associated with it must decrease. In addition to technological advancements and economiesof scale, there are effective ways to better utilize existing technology to lower the cost of hydrogenfor end user. Examples include selling excess heat from the system to local district heating networks ifthe location of the electrolyzer allows for it, as well as utilizing the hydrogen system to participate inbalancing markets. This study investigated how hydrogen systems containing electrolyzers, storage, compressors, and gasturbines can be designed and operated to effectively participate in electricity and hydrogen markets. Itwas done by studying how a facility connected to wind power production through a Power PurchaseAgreement (PPA) can be designed and operated to meet an industrial hydrogen demand. A major focuswas placed on how such a system could be utilized to participate in balancing markets by providingancillary services and how offering these services affected the rest of the hydrogen system. The case study was focused on a potential hydrogen system in Helsingborg with two large industrialcustomers interested in transitioning from steam reforming hydrogen production to electrolysis using renewableelectricity. As the study heavily emphasized balancing markets and flexibility, a PEM electrolyzerwas chosen over other technologies. Additionally, compressed hydrogen storage and several options forhydrogen gas turbines were selected. Since the production was linked to an intermittent energy source,it was assessed that the system would need to be supported by trading electricity on the day-ahead andintraday markets. If all electricity supply were to come from wind power, the hydrogen storage wouldhave to be unreasonably large to ensure the ability to meet delivery requirements during periods of lowelectricity production. To analyze the selected system, a hydrogen system was modeled using EnergyOptima 3, a software that utilizes linear programming for total optimization of energy systems. Severalyear-long optimizations with 1-hour resolution were performed to examine how the system performedwith different combinations of electrolyzer and storage sizes, as well as types of gas turbines. When evaluating which configuration was most suitable, the levelized cost of hydrogen (LCOH) was used.The configuration deemed most suitable for the studied case consisted of a 55 MW PEM electrolyzer,compressed storage equivalent to 12 hours of customer demand, and a 24 MW gas turbine. This configurationcould produce hydrogen at a levelized cost of 4.7 EUR/kg during the studied period. Overall,the study demonstrated that participating in the balancing market generated significant revenue for thesystem and had a substantial impact on its profitability. The sale of waste heat had a less critical effecton the system in the studied case, as the revenues were considerably lower. An important insight fromthe study was that the value of participating in different markets was often weighed against each other,as participating in the balancing market some times meant that the electrolyzer could not utilize itsfull capacity, while having tied-up capacity in the balancing market limited the system’s flexibility toparticipate in the intraday market and/or manage forecast errors related to wind power production. The study generally showed that the design and pricing of Power Purchase Agreements (PPAs) plays acrucial role in the viability of a hydrogen system. In the study, a pay-as-produced design was used, whichresulted in both electricity deficits and surpluses at certain times. Furthermore, selling hydrogen throughlong-term contracts was deemed the most suitable option for large industrial producers, as it ensuresrevenue for hydrogen producers and a stable supply of hydrogen for the industries.
15

What is the feasibility of using Power Purchase Agreements as a green electricity sourcing method for a large industrial company? : A Case Study / Vad är genomförbarheten av att använda Power Purchase Agreements som en metod för att erhålla grön el för ett stort industriellt bolag?

Andersson, Oskar, Lindblad, Fredrik January 2023 (has links)
With the increasing volatility on electricity markets and a growing emphasis on sustainability, renewable electricity has gained significant attention from corporate entities seeking to secure their green energy supply. Among the various methods available for securing green electricity, one method on the rise is Power Purchase Agreements (PPA). The purpose of entering a PPA from a generator perspective is to secure future revenues and from an offtaker perspective it is to secure future electricity costs. This research aims to assess the feasibility of PPAs as a green electricity sourcing method for a large industrial company with specific requirements. The research comprises a case study focused on a specific company. It involves qualitative interviews with nine company representatives, analysis of internal documents, and a review of relevant literature on PPAs. Additionally, four external experts knowledgeable about the company's electricity sourcing method and the PPA market were interviewed. This approach provides insights into the company's practices and ensures a comprehensive understanding of PPAs. The study demonstrates that PPAs can be structured in various ways. To organize the results and strengthen the arguments and conclusions drawn, Kraljic's sourcing framework has been utilized. Importantly, the findings indicate that implementing a PPA is a highly viable green electricity sourcing method for the company given their current structure andmission for the future. The findings suggest that adopting a PPA to source green electricity can be a viable option for companies if they prioritize renewable electricity,value price predictability highly, and can leverage the agreement for sustainability and marketing efforts. It is important to note that while the risks associated with a PPA can be mitigated to a large extent through a price premium, it is crucial to tailor the PPA setup to align with the specific needs of the company. Furthermore, it would be intriguing for the research community to investigate or propose an optimal PPA structure that maximizes benefits for both sides of the value chain, considering the interdependence highlighted in this study. / Med den ökande volatiliteten på elmarknaderna och det växande fokuset på hållbarhet har förnybar el fått betydande uppmärksamhet från företag som vill säkra sin framtida gröna energiförsörjning. Bland de olika metoderna för att säkra grön elförsörjning har en metod blivit allt vanligare, nämligen Power Purchase Agreement (PPA). Syftet med att ingå en PPA ur en generators perspektiv är att säkra framtida intäkter, och från ett bolags perspektiv är det att säkra framtida elkostnader. Denna forskning syftar till att bedöma genomförbarheten av PPAs som en metod för att säkra grön el för ett stort industrielltföretag med specifika krav. Undersökningen omfattar en fallstudie fokuserad på ett specifikt företag. Den innefattar kvalitativa intervjuer med nio representanter från företaget, analys av interna dokument och en översikt av relevant litteratur om PPAs. Dessutom intervjuades fyra externa experter som har kunskap om företagets nuvarande strategi gällande elförsörjningen och PPA-marknaden. Denna ansats ger insikter i företagets verksamhet och säkerställer en omfattande förståelse för PPAs. Studien visar att PPAs kan struktureras på olika sätt. För att organisera resultaten och stärka argument och slutsatser har Kraljics inköpsramverk använts. Resultaten indikerar att införandet av en PPA är en mycket genomförbar metod för att säkra grön el för företaget med hänsyn till deras nuvarande struktur och framtida målsättningar. Resultaten antyder att användning av en PPA för att förse sig med grön el kan vara genomförbart för ett företag om de prioriterar förnybar el, värderar prisförutsägbarhet högt och kan dra nytta av avtalet för hållbarhets- och marknadsföringsinsatser. Det är viktigt att notera att medan riskerna med en PPA till stor del kan minskas genom att betala ett prispåslag, är det avgörande att skräddarsy PPA-upplägget för att passa företagets specifika behov. Vidare skulle det vara intressant för forskarsamhället att undersöka eller föreslå en optimal PPA-struktur som maximerar fördelarna för båda sidor av värdekedjan med tanke på det beroendeförhållande som lyfts fram i denna studie.
16

Planejamento governamental e capacidades estatais: por uma abordagem multidimensional de análise do Plano Plurianual (PPA) em municípios / Governmental planning and state capacity: for a multidimensional approach to the analysis of the Pluriannual Plan (PPA) in municipalities

Pereira, Luciano de Freitas 13 May 2019 (has links)
A trajetória de planejamento governamental no Brasil tem sido caracterizada por uma sucessão de esforços diversos, desde os primeiros planos de desenvolvimento, na década de 1930, até a recente sistemática de planejamento e orçamento, instituída na Constituição Federal de 1988. Na esfera municipal, a experiência ainda incipiente se soma a uma série de desafios específicos, associados a um panorama de incapacidades técnicas, administrativas, financeiras, políticas e institucionais. Diante de semelhante realidade, neste trabalho, analisa-se o processo de planejamento governamental, em lócus municipal, pela perspectiva das capacidades estatais. Para tanto, inicialmente estabeleceram-se elementos de inter-relação entre dois segmentos distintos da literatura - planejamento governamental e capacidades estatais -, culminando na formulação de um quadro conceitual de análise, a título de referencial teórico. Em seguida, foram descritas as principais etapas do ciclo do Plano Plurianual 2014-2017 e da formulação do Plano Plurianual 2018-2021, em Osasco, a partir de informações coletadas em documentos e em entrevistas semiestruturadas com diversos atores-chave, entre políticos, dirigentes públicos e técnicos. A escolha do caso se deve ao reconhecimento que a literatura doméstica oferece à experiência do município. Por fim, identificando capacidades estatais construídas, desenvolvidas ou mobilizadas no período, analisou-se a sua influência nas diversas fases do processo de planejamento governamental / The trajectory of governmental planning in Brazil has been characterized by a succession of diverse efforts, from the first development plans in the 1930s to the recent planning and budgeting system established in the 1988 Federal Constitution. At the municipal sphere, an still incipient experience adds up to a series of specific challenges associated with a panorama of technical, administrative, financial, political and institutional incapacities. In view of this reality, in this work, we investigate the process of governmental planning, in a municipal locus, by the analytical perspective of state capacity. In order to do so, it was initially established elements of interrelation between two distinct segments of the literature - governmental planning and state capacity -, culminating in the formulation of a conceptual frame of analysis, as a theoretical reference. Then, the main stages of the 2014-2017 Pluriannual Plan cycle and the formulation of the 2018-2021 Pluriannual Plan in Osasco were described, based on information collected in documents and semi-structured interviews with several key actors, among politicians, public managers and technicians. The choice of the case is due to the recognition that the domestic literature offers to the experience of the municipality. Finally, identifying state capacities built, developed or mobilized in the period, we analyze its influence in the various phases of the governmental planning process.
17

From Photons to Photos: Mapping Functional and Organizational Properties of Human Visual Cortex with fMRI

Berman, Daniel 21 May 2015 (has links)
No description available.
18

Expression of wild type and variants of human apolipoprotein A-I in Pichia pastoris / Expression de type sauvage et des variantes de l’Apolipoprotéine A-I humaine chez Pichia pastoris

Janakiraman, Vignesh Narasimhan 11 December 2015 (has links)
Les lipoprotéines de haute densité (High Density Lipoprotein, HDL) permet deréduction de risque de maladies cardio-vasculaires principalement en raison de leurcapacité à éliminer le cholestérol accumulé des artères (via transport inverse ducholestérol). Les effets protecteurs des HDL sont médiés par l'apolipoprotéine AI(ApoA1), qui est le La protéine la plus importante quantitativement du HDL. L’ApoA1favorise l'efflux de cholestérol vers le foie pour l'excrétion. Une augmentation desniveaux plasmatiques de l’ApoA1 est généralement acceptée d'êtrecardioprotecteur, ce qui en fait un potentiel thérapeutique. Deux variantes naturelle(mutants) de l’ApoA1, Milano et Paris, sont caractérisées par une mutationponctuelle unique a permis l'introduction d'un résidu cystéine. Populations avecApoA1-Milano ont été rapportés d'avoir un système cardiovasculaire, même avec defaibles niveaux de plasma de ApoA1 et HDL. Il est donc d'intérêt pour générerrecombinante de type sauvage et des variantes de ApoA1 humaine pour desapplications thérapeutiques potentielles. Dans cette étude, de type sauvagerhApoA1 a été produit chez P. pastoris et purifié par chromatographie en modemixte en une seule étape. Par la suite, un processus intégré a été le développementde la production et la récupération rapide de type sauvage rhApoA1 chez P. pastorispar chromatographie par lit expansée. En outre, les variantes de l'ApoA1, Milano &Paris, ont été générées par mutagenèse dirigée et ont été exprimés chez P. pastoris.Les motifs d’adsorption de rhApoA1-Milano et rhApoA1-Paris ont été comparés àcelle de type sauvage ApoA1 et les différences ont été discutées. / The high-density lipoprotein (HDL) complex helps reduce the risk of cardiovasculardisorders mainly due to its ability to remove accumulated cholesterol from arteriesvia reverse cholesterol transport. These protective effects of HDL are known to bemediated by Apolipoprotein A-I (ApoA1), which is the major protein component ofHDL. ApoA1 is a lipid binding protein and promotes cholesterol efflux fromperipheral tissues to the liver for excretion. An increase in the plasma levels ofApoA1 is generally accepted to be cardioprotective, making it a potentialtherapeutic. Two naturally occuring variants of ApoA1, namely the Milano & Parismutants, are characterised by a single point mutation resulting in the introduction ofa Cysteine residue. Populations with ApoA1-Milano have been reported to have ahealthier cardiovascular system even with low plasma levels of ApoA1/HDL. It ishence of interest to generate recombinant wild type and variants of human ApoA1for potential therapeutic applications. In this study, wild type rhApoA1 was producedin P. pastoris and purified by mixed-mode chromatgraphy in a single step.Subsequently, an integrated process has been development for the production andrapid recovery of wild type rhApoA1 in Pichia pastoris. This has paved way to theestablishment of a scalable integrated process that could be further developed toindustrial levels. In addition, the cysteine variants of ApoA1, Milano & Paris, havebeen generated by site directed mutagenesis and have been successfully expressedin P. pastoris. The binding patterns of rhApoA1-Milano and rhApoA1-Paris have beencompared with that of wild-type ApoA1 and the differences have been discussed.
19

O alinhamento entre o plano de governo e o PPA: o caso do município de Nilópolis

Amorim Filho, Mario Gomes de 22 May 2014 (has links)
Submitted by Mario Filho (magoamfi@ig.com.br) on 2014-07-12T03:49:21Z No. of bitstreams: 1 Disseração Mestrado.pdf: 1221977 bytes, checksum: 0f96be6dae8a0041fa9b8671f9c114dd (MD5) / Approved for entry into archive by Janete de Oliveira Feitosa (janete.feitosa@fgv.br) on 2014-07-16T16:48:20Z (GMT) No. of bitstreams: 1 Disseração Mestrado.pdf: 1221977 bytes, checksum: 0f96be6dae8a0041fa9b8671f9c114dd (MD5) / Approved for entry into archive by Marcia Bacha (marcia.bacha@fgv.br) on 2014-07-18T12:03:17Z (GMT) No. of bitstreams: 1 Disseração Mestrado.pdf: 1221977 bytes, checksum: 0f96be6dae8a0041fa9b8671f9c114dd (MD5) / Made available in DSpace on 2014-07-18T12:03:27Z (GMT). No. of bitstreams: 1 Disseração Mestrado.pdf: 1221977 bytes, checksum: 0f96be6dae8a0041fa9b8671f9c114dd (MD5) Previous issue date: 2014-05-22 / The objective of this work is to identify the factors that influenced the attempt to transpose the campaign promises of major election for mayor of Nilópolis in the 2012 election for the PPA 2014 / 2017 . For this, the concepts of federalism , public management and planning tools were discussed in the theoretical framework. Interviews with technical and executive manager , the chairmen of the constitution and justice and the finance committee were held , as well as president of the city council of Nilópolis. It was found that the factors identified are responsible for the difficulty in promoting alignment between campaign promises and agreed in the PPA . The dependence of inter -governmental transfers and the scarcity of resources were the main factors that hindered implementation in the municipality of Nilópolis. / O objetivo deste trabalho é de identificar os fatores que influenciaram a tentativa de transpor as promessas de campanha da eleição majoritária à Prefeitura de Nilópolis na eleição de 2012 para o PPA 2014 / 2017. Para isso, os conceitos de federalismo, gestão pública e instrumentos de planejamento foram abordados no referencial teórico. Foram realizadas entrevistas com os técnicos e o gestor do executivo, os presidentes das comissões de constituição e justiça e comissão de finanças, bem como o presidente da câmara dos vereadores de Nilópolis. Verificou-se que os fatores identificados são responsáveis pela dificuldade em promover o alinhamento entre as promessas de campanha e o pactuado no PPA. A dependência das transferências inter governamentais e a escassez de recursos próprios foram os principais fatores que dificultaram essa transposição no município de Nilópolis.
20

Estratégias de planejamento frente à rigidez do plano plurianual: análise de casos setoriais no Estado de Minas Gerais

Pinheiro Júnior, Fernando Antônio França Sette 28 February 2018 (has links)
Submitted by Fernando Antonio França Sette Pinheiro Júnior (fafspj7@gmail.com) on 2018-03-26T20:10:26Z No. of bitstreams: 1 Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) / Rejected by Pamela Beltran Tonsa (pamela.tonsa@fgv.br), reason: Boa tarde Fernando, Para que possamos aprovar seu trabalho é necessário alguns ajustes conforme norma ABNT/APA. * Seu titulo esta diferente da ATA, caso realmente exista essa alteração é preciso o professor orientador vir até a secretaria para fazer a alteração no verso da ATA com o titulo atual. Caso contrário não poderei aprovar. (PRÁTICAS DE "REPLANEJAMENTO" DAS AÇÕES GOVERNAMENTAIS: CASOS SETORIAIS NO ESTADO DE MINAS GERAIS) * A Capa deve ter o nome da FUNDAÇÃO GETULIO VARGAS - ESCOLA DE ADMINISTRAÇÃO DE EMPRESAS DE SÃO PAULO. * Contra Capa, não deve ter o nome da FUNDAÇÃO GETULIO VARGAS - ESCOLA DE ADMINISTRAÇÃO DE EMPRESAS DE SÃO PAULO, apenas seu nome e o titulo. Após os ajustes você deve submete-lo novamente para analise e aprovação. Qualquer duvida estamos a disposição, Att, Pâmela Tonsa on 2018-03-27T18:18:35Z (GMT) / Submitted by Fernando Antonio França Sette Pinheiro Júnior (fafspj7@gmail.com) on 2018-03-28T15:14:55Z No. of bitstreams: 2 Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) Tese VBiblioteca.pdf: 1219691 bytes, checksum: ebef912117a4ea1680b1042de013f704 (MD5) / Rejected by Pamela Beltran Tonsa (pamela.tonsa@fgv.br), reason: Boa tarde Fernando, Você tem dois arquivos submetidos, porem o arquivo correto não tem a ficha catalográfica. Por favor, peço que faça a correção, assim como a nova submissão. Lembrando que deve excluir os dois arquivos errados. Desde ja agradeço. Att, on 2018-03-28T18:00:03Z (GMT) / Submitted by Fernando Antonio França Sette Pinheiro Júnior (fafspj7@gmail.com) on 2018-03-28T18:52:58Z No. of bitstreams: 3 Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) Tese VBiblioteca.pdf: 1219691 bytes, checksum: ebef912117a4ea1680b1042de013f704 (MD5) Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) / Approved for entry into archive by Pamela Beltran Tonsa (pamela.tonsa@fgv.br) on 2018-03-28T18:58:02Z (GMT) No. of bitstreams: 3 Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) Tese VBiblioteca.pdf: 1219691 bytes, checksum: ebef912117a4ea1680b1042de013f704 (MD5) Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) / Approved for entry into archive by Suzane Guimarães (suzane.guimaraes@fgv.br) on 2018-04-02T13:54:22Z (GMT) No. of bitstreams: 3 Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) Tese VBiblioteca.pdf: 1219691 bytes, checksum: ebef912117a4ea1680b1042de013f704 (MD5) Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) / Made available in DSpace on 2018-04-02T13:54:22Z (GMT). No. of bitstreams: 3 Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) Tese VBiblioteca.pdf: 1219691 bytes, checksum: ebef912117a4ea1680b1042de013f704 (MD5) Tese Versão Impressa.pdf: 1095249 bytes, checksum: a3bc9cd03ddbb2bd9348b0934190c82d (MD5) Previous issue date: 2018-02-28 / Analisa-se aqui as estratégias de planejamento frente à rigidez do Plano Plurianual, por meio da análise da relação entre as práticas complementares de planejamento governamental frente aos engessamentos advindos do PPA, de forma a verificar como essas práticas são capazes de superar os engessamentos advindos do PPA. Do ponto de vista metodológico, a tese constitui-se de um estudo de caso comparado de duas secretarias de Estado de Minas Gerais, a Secretaria de Estado de Educação (SEE) e a Secretaria de Estado de Desenvolvimento e Integração do Norte e Nordeste (SEDINOR), no período de 2011 a 2014. O trabalho demostrou a partir da trajetória das práticas de planejamento governamental, que o mesmo deixou de se ser visto coo um instrumento meramente técnico, e passando a ser visto como um instrumento de ação política. A trajetória demonstrou existência de duas concepções de planejamento governamental: um de caráter estritamente tecnocrático e outro de caráter técnico-político, que pode ser analisado pela metodologia do Planejamento Estratégico Situacional. Ao se analisar o atual planejamento governamental brasileiro se solidifica sob a estruturação do PPA, de caráter tecnocrático, não condizente a concepção de planejamento governamental como um instrumento de ação política, fazendo com que seja necessário a adoção de práticas complementares de planejamento governamental que se adequem a essa concepção. A partir das entrevistas se constatou que essas práticas complementares são capazes de se adaptar ao contexto político- institucional, uma vez que abarcam as os fatos sobre o quais os políticos não apresentam governabilidade e/ou a real capacidade estatal de ação do Estado. Além disso, essas práticas complementares não apresentam caráter legal ou burocrático, o que permite as mudanças. Entretanto, é válido ressaltar que o PPA tem o papel fundamental de definir as ações de governo e de pactuar um compromisso entre representantes e representados, cabendo as práticas complementares apenas realizar os ajustes necessários. / We analyze the planning strategies against the rigidity of the Pluriannual Plan, by analyzing the relationship between the complementary practices of government planning in relation to the plasters from the PPA, in order to verify how these practices are able to overcome the engagements coming from the PPA. From a methodological point of view, the thesis is a comparative case study of two Minas Gerais state secretariats, the State Secretariat of Education (SEE) and the State Secretariat for Development and Integration of the North and Northeast (SEDINOR) in the period from 2011 to 2014. The work showed from the trajectory of the practices of governmental planning, that it ceased to be seen as a merely technical instrument, and began to be seen as an instrument of political action. The trajectory showed two conceptions of governmental planning: one of strictly technocratic character and the other of a technicalpolitical nature, which can be analyzed by the methodology of Situational Strategic Planning. When analyzing the current Brazilian government planning solidifies under the structuring of the PPA, of a technocratic character, not fitting the conception of governmental planning as an instrument of political action, making necessary the adoption of complementary practices of governmental planning that fit to this conception. From the interviews it was found that these complementary practices are able to adapt to the political-institutional context, since they cover the facts about which politicians do not present governability and / or the real State capacity of State action. In addition, these complementary practices are not legal or bureaucratic, which allows changes. However, it is worth mentioning that the PPA has the fundamental role of defining the actions of government and of agreeing a compromise between representatives and represented, and complementary practices should only make the necessary adjustments.

Page generated in 0.4107 seconds