Bakgrund: Axelskador är vanligt förekommande inom idrott. Det finns ett tydligt samband mellan axelskador och idrotter som innefattar hand- och armrörelser ovanför huvudhöjd, som till exempel handboll. Axellederna utsätts för såväl hård fysisk kontakt som hög belastning vid repetitiva kaströrelser vilket ställer stora krav på axelledens strukturer. Prevalensen av aktuell eller tidigare axelskada rapporteras vara mellan 58 till 75 % hos spelarna. Syfte: Syftet med studien var att undersöka hur ett preventivt träningsprogram riktat mot riskfaktorer för skada i axelleden, utfört under åtta veckor i slutskedet av tävlingssäsong, påverkade prevalensen av överbelastningsskador i axelleden hos elithandbollsspelare i Sverige. Hur påverkas prevalensen av överbelastningskador och av allvarliga överbelastningsskador i axelleden under åtta veckor med samtidigt genomförande av ett preventivt träningsprogram för axelleden på elithandbollsspelare i Sverige? Metod: Studien var av kvasi-experimentell design vilken bestod av sex mättillfällen under åtta veckor. Nio elithandbollslag aktiva i Mellansverige rekryterades, varav 110 av 162 tillgängliga spelare inkluderades vid studiestart. Exkludering under och efter studieperioden gjorde att analysen utfördes på ett färre antal spelare. Lagen delades in i interventions- (n = 48) eller kontrollgrupp (n = 32) genom stratifierat urval, medelålder (± SD) 22.0 (3.3) respektive 21.9 (4.0). Interventionsgruppen tilldelades ett preventivt träningsprogram bestående av tre övningar i syfte att förbättra riskfaktorer för axelskador hos ”overhead athletes”. Kontrollgruppen tilldelades ingen intervention. Träningsprogrammet utvärderades genom att analysera prevalensen av överbelastningsskada och allvarlig överbelastningsskada i axelleden mätt med en modifierad version av The Oslo Sports Trauma Research Centre Overuse Injury Questionnaire. Resultat: Totalt 455 överbelastningssymtom rapporterades hos 42 spelare (53 %) varav 95 symtom var allvarliga hos 18 spelare (23 %). Prevalensen av överbelastningsskada minskade för både interventions- och kontrollgruppen från 42 % (95 % CI 28-56 %) till 25 % (95 % CI 13-37 %) respektive 53 % (95 % CI 36-70 %) till 31 % (95 % CI 15-47 %). Prevalensen av allvarliga överbelastningsskador minskade för både interventions- och kontrollgruppen från 15 % (95 % CI 5-25 %) till 6 % (95 % CI -1-13 %) respektive 19 % (95 % CI 5-32 %) till 13 % (95 % CI 1-24 %). Det fanns ingen signifikant skillnad mellan grupperna gällande prevalensen efter åtta veckors intervention. Allvarlighetspoängen minskade genomgående med en signifikant skillnad (p = 0.001) över tid för båda grupperna där kontrollgruppen förbättrades något mer. Det fanns en tendens till skillnad mellan grupperna (p = 0.064) gällande allvarlighetspoäng. Slutsats: Resultaten av denna studie visar på att prevalensen av allvarlig överbelastningsskada i axelleden hos elithandbollsspelare i Sverige möjligtvis kan reduceras till viss del genom utförande av ett preventivt träningsprogram två eller fler gånger per vecka under åtta veckor. Prevalensen av allvarliga symtom för överbelastningsskada minskade till ett något lägre värde för interventionsgruppen. Skillnaden för prevalens av överbelastningsskada inom interventionsgruppen, undergrupperade på antal utförda förebyggande träningspass, var signifikant (p = 0.044). Allvarlighetspoängen minskade i båda grupperna under studien. Det fanns en tendens till signifikant skillnad mellan grupperna (p = 0,.064), där kontrollgruppen förbättrades något mer trots ett högre värde vid mätning vecka 8. Axelskada och dysfunktioner hos ”overhead athletes” kan orsakas av olika faktorer vilket innebär att även riskfaktorerna bakom var och en av dessa tillstånd kan variera. Det är därför viktigt att upplysa om att träningsprogrammets påverkan på individnivå kan se annorlunda ut jämfört med resultatet på gruppnivå i den större populationen. / Background: Shoulder injuries are common in sport. In particular there is a clear relationship between shoulder injuries and sports that includes hand- and arm movements over the head, for example handball. In handball, the shoulder joints are exposed to hard physical contact as well as high loads during repetitive throwing which puts high demands on the structures inside and surrounding the shoulder joint. The prevalence of current or previous shoulder injuries is reported to be between 58 to 75 % in studies of handball players. Aim: The purpose of this study was to investigate how a preventive training program aimed at risk factors for shoulder injuries in the shoulder joint, performed during eight weeks in the final stage of competitive season, affected the prevalence of overuse injuries in the shoulder joint for elite handball players in Sweden.  How is the prevalence of overuse injuries and severe overuse injuries in the shoulder joints of elite Swedish handball players affected by the implementation of an eight-week preventive training program? Method: The study was of a quasi-experimental design which consisted of six measurements taken during eight weeks. Nine elite handball teams active in the middle regions of Sweden were recruited, from which 110 of the 162 available players were included. Exclusions during and after the study period reduced the number of players. The teams were divided into an intervention (n = 48) or control group (n = 32) through stratified sampling, with mean age (± SD) 22.0 (3.3) and 21.9 (4.0), respectively. The intervention group was assigned a preventive exercise program consisting of three exercises with the purpose of improving riskfactors for shoulder injuries for overhead athletes. The control group was not assigned any intervention. The training program was evaluated by analyzing the prevalence of overuse and severe overuse symptoms in the shoulder measured with a modified version of The Oslo Sports Trauma Research Centre Overuse Injury Questionnaire. Results: A total of 455 overuse symptoms were reported by 42 players (53 %) of which 95 symptoms in 18 players (23 %) were severe. The prevalence of overuse injuries decreased in both the intervention and the control group from 42 % (95 % CI 28-56 %) to 25 % (95 % CI 13-37 %) and 53 % (95 % CI 36-70 %) to 31 % (95 % CI 15-47 %), respectively. The prevalence of severe overuse injuries decreased in both the intervention and the control group from 15 % (95 % CI 5-25 %) to 6 % (95 % CI -1-13 %) and 19 % (95 % CI 5-32 %) to 13 % (95 % CI 1-24 %), respectively. There was no significant difference between the groups regarding prevalence after the intervention of eight weeks. Severity score consistently decreased with a significant difference over time (p = 0.001) for both groups, with a slightly greater improvement in the control group. There was a tendency towarda difference between the groups (p = 0.064) regarding the severity score. Conclusions: The results of this study show that the prevalence of severe overuse injuries in the shoulder joint of elite handball players in Sweden might be reduced to some extent by performing a preventive exercise program two or more times per week for eight weeks. The prevalence of severe symptoms of overload injury decreased to a slightly lower value for the intervention group. The difference of prevalence of overuse injuries within the intervention group, stratified by the number of executed preventive exercise programs (<2 and ≥2), was significant (p = 0.044). Severity score decreased in both groups during the study. However, there was a tendency to a significant difference between the groups (p = 0.064), where the control group improved slightly more in spite of a higher value when measured at week 8. Shoulder injury and dysfunctions of overhead athletes can be caused by various factors, which means that the riskfactors for each of these conditions may vary. It is therefore important to highlight that the effects of a training program may be different at the individual level compared with the results at group level.

Introduction: Blood- and injection phobia is an anxiety disorder with a prevalence of approximately 3-5% in the general population. The etiology is often a combination of genetic factors and a conditioning experience. The symptoms of blood- and injection phobia are dizziness, confusion, nausea, epigastria discomfort, anxiety and sometimes panic attacks when receiving injections, seeing blood or having a blood sample taken. Unique for this specific phobia is the high probability of fainting when the phobic situation is encountered if there is no possibility to escape or to avoid the stimuli. During pregnancy and labor, women with blood- and injection phobia are exposed to most of their fears and they therefore find themselves in anxiety-ridden situations. Stress and anxiety during pregnancy is known to be risk factors for adverse obstetric and neonatal outcomes. Studies have shown an altered hypothalamic-adrenal-pituitary axis in women with stress or/and anxiety during pregnancy and increased cortisol concentrations can imply negative consequences for the unborn child. Cognitive behavioral therapy (CBT) is known to be effective in treating specific phobias such as blood- and injection phobia. Aim: The prevalence, obstetric and neonatal consequences, impact on the hypothalamic adrenal-pituitary axis and treatment aspects of blood- and injection phobia in a pregnant population have not been investigated before. The aims of this thesis were to study each of these phenomena. Material and methods: During 2005 a total of 1606 pregnant women were approached at their first visit in an antenatal care clinic in the southeast region in Sweden. They were asked to complete the “Injection Phobia Scale-Anxiety” questionnaire. All women who scored ≥ 20 on the “Injection Phobia Scale-Anxiety” questionnaire (N=347), were interviewed and either diagnosed for blood- and injection phobia or dismissed. In total, 110 women were diagnosed as having blood- and injection phobia. Among the women who scored <20 on the “Injection Phobia Scale-Anxiety” questionnaire, 220 women were randomly stratified for age and parity as a control group. The women in the study population answered questionnaires in gestational week 25, 36 and postpartum concerning symptoms of blood- and injection phobia, depression and anxiety. Samples of cortisol in the saliva were collected in the morning and evening in gestational week 25 and 36 in both groups of pregnant women. The medical records from the antenatal care visits, the delivery and postpartum check-up was used to collect data of importance. A treatment study was conducted using a two session cognitive behavioral therapy in a group of pregnant woman with blood- and injection phobia. Results: The prevalence of blood- and injection phobia is 7 % in a pregnant population. Pregnant women with blood- and injection phobia stated more often a fear of childbirth (p<0.001) and were more frequently delivered by elective cesarean section (p=0.032). The incidence of having a baby diagnosed with a complication (p=0.001) was also higher among these women. The women with blood- and injection phobia had increased cortisol concentrations in the saliva compared to the healthy controls (p=0.014). A two-session CBT in group for pregnant women with blood- and injection phobia reduced phobic (p<0.001) anxiety (p<0.001) and depressive (p<0.001) symptoms during pregnancy. Conclusions: Blood- and injection phobia during pregnancy is rather common. Pregnant women with blood- and injection phobia are more likely to be delivered by elective cesarean section and having a baby born with a complication compared to women not suffering from this specific phobia. Untreated blood- and injection phobia during pregnancy increases salivary cortisol concentrations indicating an altered hypothalamic-adrenal-pituitary axis during these weeks of pregnancy. To enhance psychological well being in pregnant women with blood- and injection phobia a two-session program providing CBT for groups of pregnant women is valuable and produces stable results for at least 3 months after delivery.

Hospitalization, surgery and anaesthesia are for some children associated with anxiety and could be a frightful experience which may result in later problematic behaviour. Pain is associated with the fears of hospitalization. The first aim was to investigate how pain in children is treated in Swedish hospitals as well as to assess the results of this treatment. Behaviour after hospitalization has been measured by the Post Hospital Behaviour Questionnaire (PHBQ). A second aim was to translate this instrument into Swedish and to validate it. The third aim was to analyze which factors (sociodemographic back¬ground; earlier experience; events at the hospital) that might be associated with changes in behaviour. Methods: A questionnaire regarding acute pain, its treatment methods and results of treatments as well as contributing factors to inadequate results, was sent to all departments in hospitals that might treat children. One form was answered by phy¬sicians and another form by nurses. In the second part of the study, a cohort of 340 children ages 2-13 were followed from two weeks before hospitalization until two weeks after. Data regarding socio¬demography and earlier health care experience were collected. The Child Behav¬iour Checklist was issued before and after hospitalization, the PHBQ was issued after. During hospitalization staff and parents assessed anxiety, pain and nausea mainly by VAS and Likert scales, (parents assessed own and child emotions). Children, older than 4-5 years of age, assessed their own pain using a faces scale. Results: Despite treatment, moderate to severe pain occurred postoperatively in 23% of patients and in 31% of patients with pain of other origin. Postoperative pain seemed to be a greater problem in units where children were treated together with adults and in departments where fewer children were treated. Pain could often or always be treated more efficiently according to 45% of physi¬cians and nurses. Of all departments, pain assessments were performed regularly in 43%, but pain measurement was less frequent. Opioids were never or infrequently used by 15 %. A five factor model fitted data better than the original 6 factor model when confir¬mative factor analyse was performed. Cronbach’s alpha was adequate for factors and excellent for the total score (0.92). Risk factors for increased problematic be¬haviour included the following: age less than 5 years of age, living in a one adult family, anxiety at anaesthesia induction, nausea at hospital and pain at home. Liv¬ing in a rural area and midazolam in premedication seem to be protective. Conclusions: Acute pain in children is still a problem. Inadequate pain treatment is mainly associated with organisational factors (missing prescriptions; a low rate of pain assessments). The PHBQ in Swedish translation is a reliable instrument and its relation to CBCL warrants its further use in research and quality control espe¬cially in younger children. Hospital-induced stress in older children needs further investigation. One third of the children who have been hospitalized and exposed to anaesthesia will have in¬creased problematic behaviour when returning home. Pro¬active interventions are suggested to prevent this by improving pain treatment at home.

Darbo tikslas – nustatyti dažniausių alerginių ligų ir joms būdingų simptomų paplitimą bei jo kaitą (1994-2002 m.) tarp skirtingo amžiaus Kauno miesto vaikų. Uždaviniai: 1. Ištirti bronchų astmos ir jai būdingų simptomų paplitimą ir kaitą tarp 6–7 ir 13–14 metų amžiaus vaikų. 2. Ištirti alerginio rinito ir jam būdingų simptomų paplitimą ir kaitą tarp 6–7 ir 13–14 metų amžiaus vaikų. 3. Ištirti atopinio dermatito ir jam būdingų simptomų paplitimą ir kaitą tarp 6–7 ir 13–14 metų amžiaus vaikų. 4. Nustatyti alerginių ligų derinių paplitimą bei kaitą skirtingose vaikų amžiaus grupėse. 5. Įvertinti bronchų astmos, alerginio rinito ir atopinio dermatito paplitimo priklausomybę nuo aplinkos veiksnių. / The aim of the study To assess the changes in prevalence of asthma, allergic rhinitis, atopic dermatitis and their symptoms in 6-7 and 13-14 years old children in Kaunas. Objectives of the study: 1. To examine the changes in the prevalence of asthma and its symptoms in 6-7 and 13-14 years old children. 2. To examine the changes in the prevalence of allergic rhinitis and its symptoms in 6-7 and 13-14 years old children. 3. To examine the changes in the prevalence of atopic dermatitis and its symptoms in 6-7 and 13-14 years old children. 4. To assess the changes in the prevalence of allergic diseases combinations in different age-groups in children. 5. To measure environmental risk factors‘ impact on the prevalence of asthma, allergic rhinits and atopic dermatitis.

Over the past few years, workers have been confronted with increasing pressures at work and at home. This is mainly the result of the growing number of dual-earner couples as well as changes and pressures in the nature of the workplace. Workers are challenged to manage multiple roles in both their work and home domains. Recently, a new measuring instrument was developed to measure work-home interaction, namely the Survey Work-Home Interaction - Nijmegen (SWING). This instrument measures both the direction of influence (work-to-home and home-to-work) and the quality of influence (negative vs. positive). The objectives of this study were firstly to determine the construct validity and reliability of the Survey Work-Home Interaction - Nijmegen (SWING), and secondly to determine the prevalence of work-home interaction in various demographic groups in the nursing environment. A cross-sectional survey design was used. Random samples (N = 363) were taken from hospital nursing staff in Johannesburg, Klerksdorp, Krugersdorp, Potchefstroom and Pretoria. The SWING and a biographical questionnaire were administered. Structural equation modelling (SEM), Cronbach alpha coefficients, multivariate analysis of variance (MANOVA) and one-way analysis of variance (ANOVA) were used to reach the objectives. SEM showed that a four-factor model, which measures negative work-home interference, positive work-home interference, negative home-work interference and positive home-work interference, fitted the data best. Cronbach alpha coefficients showed that all four factors were reliable. Regarding the prevalence of work-home interaction among different demographic groups, the results indicated that there were statistically significant differences between demographic groups based on race, educational level, type of position, flexibility of arrangements at the workplace as well as between full-time and part-time work. Recommendations for future research are made. / Thesis (M.A. (Industrial Psychology))--North-West University, Potchefstroom Campus, 2006.

Bakalauro darbe analizuojamas žalingų įpročių paplitimas bei vartojimas pagrindinio ugdymo mokykloje bei priežastys, paskatinusios vartoti tabaką, alkoholį ir kitas narkotines medžiagas. Tyrime dalyvavo 75 pagrindinių mokyklų IX- X klasių moksleiviai bei 25 šiuos mokinius ugdantys pedagogai. Anketinės apklausos metodu tirta, kiek pagrindinėse mokyklose paplitęs tabako, alkoholio ir kitų narkotinių medžiagų vartojimas ir kas sąlygoja šių medžiagų paplitimą, taip pat aiškintasi koks yra pedagogų požiūris į narkotinių medžiagų vartojimo problemiškumą jų mokyklose, kaip jie siūlo organizuoti prevencinę veiklą paaugliams. Tyrimu nustatyta, kad 9- 10 klasių moksleiviai tabaką išbando gana jauname amžiuje. Daugelis mokinių nurodė per pastarąjį mėnesį vartoję silpnus alkoholinius gėrimus. Tiek tarp vaikinų, tiek tarp merginų populiariausias yra alus, tarp merginų dar vartojamas vynas ( šampanas) bei alkoholiniai kokteiliai. Mokiniai alkoholį vartoja iš neturėjimo ką veikti, norėdami atsipalaiduoti, pamiršti slegiančias problemas, apsvaigti bei vedami smalsumo. Tyrimas parodė, jog reikia daugiau dėmesio skirti moksleivių laisvalaikio organizavimui, gyvenimo įpročių ugdymui. Mokinių nuomone narkotikus jaunimas vartoja norėdami atsipalaiduoti. Tuo tarpu pedagogai mano, jog jaunimas narkotikus vartoja norėdami neišsiskirti iš bendraamžių, iš smalsumo. Pačius mokinius nuo ketinimo vartoti narkotikus dažniausiai sulaiko baimė tapti priklausomiems, suvokiama neigiama narkotikų žala. / Prevalence of addictions and reasons stimulating use of tobacco, alcohol and other drugs at basic schools are analysed in the Bachelor Thesis. 75 9th – 10th form pupils and their 25 teachers working at Rusnė and Kairiai Basic Schools took part in the research. A questionnaire survey method was employed when investigating tobacco, alcohol and other drug use as well as the reasons for prevalence of the harmful substances at the basic schools. Moreover, teachers’ attitude towards a complex of problems of drug use and their proposals for organizing prevention activities for teenagers at the schools were investigated. It has been ascertained that 9th – 10th form pupils start using tobacco at a relatively young age. The majority of questioned pupils indicated that during the last month they had tried mild alcoholic drinks. Beer was the most popular drink among boys and girls. Besides, wine (champagne) and alcoholic cocktails were girls’ favourite drinks. The pupils indicated that they had used alcohol because of not having anything fun to do or willing to relax, forget about their problems, inebriate as well as being led by curiosity. The research has revealed that it is necessary to pay greater attention to organization of pupils’ free-time and education of their healthy life habits. According to the questioned pupils young people use drugs when they are willing to relax, whereas teachers are of the opinion that pupils use drugs being led by curiosity and willing not to stand... [to full text]

Darbo tikslas. Įvertinti viešosios įstaigos Kauno Dainavos poliklinika teikiamų odontologinių paslaugų kokybę pacientų požiūriu. Tyrimo metodika. Lietuvių ir užsienio autorių mokslinės literatūros šaltinių, teisinių dokumentų analizė, anketinės apklausos analizė. Taikyti įvairūs statistinės analizės metodai. Anketinė apklausa buvo vykdoma 2008 m. vasario mėn. Dainavos poliklinikos odontologiniame skyriuje. Apklausta 200 respondentų, kurie apklausos vykdymo metu gydėsi odontologijos skyriuje ir sutiko dalyvauti tyrime. Rezultatai. Kauno Dainavos poliklinikos Odontologinio skyriaus paslaugų kokybę pacientai vertina teigiamai (vertinimų vidurkis 4,16 balo iš 5). Aukščiausiai vertinamas gydytojų bendravimas su pacientais, profesionaliai atliekamos procedūros ir jų saugumas, žemiausiai – informavimas apie paslaugas ir medžiagų kainas, registravimosi patogumas, patekimas pas gydytoją pageidaujamu laiku ir fizinė aplinka. Tiriant atskirų kokybės aspektų vertinimus nustatyta, kad respondentų demografiniai duomenys turėjo įtakos jų vertinimui. Daugiau nei pusė apklaustųjų, naudodamiesi Dainavos poliklinikos odontologinėmis paslaugomis, su jokiais sunkumais nesusidūrė. Tie, kurie patvirtino, kad odontologinių paslaugų teikimo metu nesklandumų pasitaikė, nurodė šiuos: fizinės aplinkos nepatogumas (laukiamajame nėra kur atsisėsti), nepatogus gydytojo darbo laikas, per dažnas siuntinėjimas į kitus kabinetus konsultacijoms ir nemandagus registratūros darbuotojų elgesys (visi šie aspektai... [toliau žr. visą tekstą] / Aim of the study: evaluation of the patients’ views about the quality of odontology services in Kaunas “Dainava” outpatient clinic. Methods. Review of Lithuanian and foreign academic literature, analysis of legal documents and analysis of a questionnaire survey results. Various statistical analysis methods were applied. The survey was carried out in the Department of Odontology of “Dainava” clinic in February 2008. 200 patients who were undergoing treatment in the Department of Odontology during the period of survey and agreed to take part in the study were surveyed. Results. The quality of the services provided by the Department of Odontology of Kaunas “Dainava” clinic was evaluated positively by the clients (average evaluation was 4.16 points out of 5). Communication of the doctors with the patients, professional treatment procedures and their safety received the highest evaluation, while information about services and material prices, convenience of registration procedure, flexibility of appointment time and physical surroundings were given the lowest evaluation. The analysis of evaluation of individual quality aspects showed that the evaluation was influenced by demographical factors of the respondents. More than a half of the respondents experienced no discomfort when using the odontology services in “Dainava” clinic. The ones who said they had felt discomfort when receiving odontology services named the following problems: physical environment (no place to sit down in... [to full text]

This thesis was to determine the prevalence and distribution of paratuberculosis in the Ontario dairy sheep and dairy goat industries, identify potential risk factors for herds which tested positive, evaluate the accuracy of seven commercially available individual and two bulk tank diagnostic tests in these two populations, and determine the circulating strains of Mycobacterium avium ssp. paratuberculosis in faecal isolates obtained. A cross-sectional study was conducted between October 2010 and August 2011 in 29 goat herds and 21 sheep flocks located in Ontario. On each farm, 20 lactating animals over the age of two years were randomly selected and faeces, blood, and milk were sampled from each animal, and a bulk milk sample from each herd. A questionnaire inquiring about herd management and biosecurity behaviours was also completed. The seven individual animal tests evaluated were: faecal culture using the BACTEC® MGIT™ 960 liquid culture system, direct faecal PCR (Tetracore®, Rockville, MD) based on the hspX gene, the Prionics® ELISA on serum and milk, the IDEXX® ELISA on serum and milk, and the agar gel immunodiffusion (AGID) test on serum. The test evaluations used both frequentist (faecal culture - reference test) and Latent Class Analysis/Bayesian (LCA/BM) methods (no reference test). In goat herds, faecal culture demonstrated the highest sensitivity (Se), 81.1% (LCA/BM). In sheep, while faecal culture demonstrated the highest Se, 49.5%, there was a small probability it was higher than faecal PCR Se at 42.4%. The bulk tank tests evaluated were the 'Hyper-ELISA' test and real-time PCR test based on IS900 (AntelBio®). While PCR did not demonstrate sufficiently high Se to be used as a herd-level test, the Hyper-ELISA performed well as a herd-level test identifying farms with high prevalence when the cut-off was reduced to 0.05. Overall herd-level apparent prevalence was 79.3% in goat herds and 57.1% in sheep flocks when faecal culture was the reference standard and true herd-level prevalence (LCA/BM) was 83.0% and 66.8% in each population respectively. This high prevalence reveals a need for the implementation of a small ruminant paratuberculosis control program in Ontario, Canada based on testing, improving youngstock management, and strengthening biosecurity practices. / AHSI, OMAF

Environmental factors more often is thought to have influence in determining children’s health and development. Prevalence of allergic diseases over the last decades is increasing, especially in Western Europe. Despite lots of performed surveys it is still unclear why the prevalence of food allergy is mounting. Incidence of food allergy is age dependent and usually manifest as one of the first forms of allergy. It is considered as the first step of „atopic march“. To accurately assess the occurrence of possible risk factors for a disease that can start already in infancy and may resolve by school age, a prospective birth cohort with regular follow-up of participating children and families provides the best possible study design. EuroPrevall birth cohort study, in which participated Vilnius University, was the first in the world investigation specially created just for evaluation of food allergy. During in this dissertation presented project for the first time real prevalence of food hypersensitivity and allergy in infants and small children in Lithuania have been determined, the most common food allergens were assessed and changes in prevalence of sensitization to them during first 30 months of life were analysed, also the role of possible determinants for the development of food allergies, such as genetic background, maternal diet during pregnancy and breastfeeding, way of birth, infections, medicines, psycho-social and environmental factors, were examined and different... [to full text] / Svarbus vaidmuo, nulemiantis vaikų sveikatą ir vystymąsi, vis dažniau priskiriamas vaiką supančiai aplinkai. Sergamumas alerginėmis ligomis sparčiai didėja, o pastaraisiais dešimtmečiais jis itin išaugo, ypač Vakarų Europoje. Nepaisant daugelio atliktų tyrimų, vis dar lieka neaišku, kodėl alerginių ligų paplitimas nuolat didėja. Alergijos maistui paplitimas įvairiose amžiaus grupėse skiriasi ir yra viena iš anksčiausiai pasireiškiančių alergijos formų. Manoma, kad ji gali būti pirmasis „atopinio maršo“ žingsnis. Norint tiksliai įvertinti galimų rizikos veiksnių įtaką ligos atsiradimui, kuri gali prasidėti jau kūdikystėje ir išnykti iki mokyklinio amžiaus, tinkamiausias tyrimo metodas yra prospektyvinis naujagimių kohortos tyrimas su reguliaria į tyrimą įtrauktų vaikų ir jų šeimų stebėsena. EuroPrevall naujagimių kohorta - tai pirmasis pasaulyje tyrimas, kuriame dalyvavo ir Vilniaus Universitetas, specialiai suformuotas tik alergijos maistui ištyrimui. Šio disertacijoje pateikiamo tyrimo metu Lietuvoje pirmąkart ištirtas padidėjusio jautrumo maistui ir alergijos maistui paplitimas tarp mažų vaikų ir nustatyti dažniausiai alergiją sukeliantys maisto produktai ir sensibilizacijos maisto alergenams kaita pirmaisiais 30 gyvenimo mėnesiais, taip pat išanalizuoti tėvų ir kūdikių rizikos veiksniai, tokie kaip genetinis pagrindas, mamos mityba nėštumo metu ir žindant, gimdymo būdas, infekcijos, vartoti medikamentai, psicho-socialiniai ir aplinkos faktoriai, įtakojantys alergijos... [toliau žr. visą tekstą]

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