Le sujet de thèse s’intéresse à la chimiothérapie à domicile qui est l’effet combiné de l’augmentation des patients atteints du cancer et du succès de l’hospitalisation à domicile. Nous proposons à travers ce mémoire de thèse des solutions appropriées au pilotage de la chaîne de prise en charge de la chimiothérapie à domicile permettant d’évaluer et d’améliorer la performance de celle-ci. La première partie présente le contexte socio-économique de la chimiothérapie à domicile, ainsi que les contraintes réglementaires et organisationnelles pour sa mise en œuvre. La deuxième partie précise les spécificités d’une chaîne de prise en charge de la chimiothérapie à domicile et les problématiques liées à cette chaîne basée sur une revue de la littérature. La troisième partie se focalise sur la modélisation des processus de prise en charge de la chimiothérapie à domicile à partir d’un important travail de terrain. Un modèle générique de la chimiothérapie à domicile est dégagé du travail de modélisation qui constitue le fondement d’une proposition de classification des pratiques de la chimiothérapie à domicile. Un diagnostic individuel et comparatif des différentes familles d’approches sont également présentés dans cette partie. La quatrième partie présente les différentes applications développées pour évaluer et améliorer la performance de la chaîne de prise en charge de la chimiothérapie à domicile. En conclusion, cette thèse apporte une première contribution à la généralisation de la pratique de la chimiothérapie à domicile et au développement d’outils d’aide aux pilotages destinés à l’amélioration de sa réalisation / This thesis deals with chemotherapy at home which is the fruit of increasing cancer patients and successful development of home care services. We present in this thesis appropriate solutions to evaluate and improve management performance of chemotherapy at home network. The first part concerns the socioeconomic context of chemotherapy at home, as well as its legal and organizational constraints. The second part outlines specificities and related issues of chemotherapy at home based on a literature review. The third part focuses on chemotherapy at home process modeling depending on an important field work. A generic model of chemotherapy at home is abstracted, which is the basis of a chemotherapy at home practices classification that we proposed. An individual analysis and a comparative analysis of chemotherapy at home approaches are also proposed in this part. The fourth part presents different solutions that we developed to evaluate and improve the management performance of chemotherapy at home network. In conclusion, this thesis provides an initial contribution to promote chemotherapy at home practices and to develop management support tools for its implementation

Disruptive change transforms existing organizational processes. Newspaper organizations such as Orlando Sentinel Communications (OSC) tend to resist process change. As with most newspaper companies in the United States, OSC management was confronted with unprecedented disruptive change and challenges by the accelerated evolution of its business models and processes. This investigation identified and modeled OSC circulation processes to support disruptive change initiatives. The XML Process Definition Language (XPDL) is an XML specification and process modeling solution developed by the Workflow Management Coalition (WFMC) designed to exchange workflow process semantics and graphics. This investigation focused on developing an XPDL process model of OSC circulation processes to address process transformations inherent to disruptive change. The method was a case study of OSC circulation processes through the System Development Life Cycle (SDLC) framework to develop a reproducible XPDL process model for OSC to use in planning for disruptive change. The investigation found that XPDL to be well-suited as the language for expressing workflow models to plan, align, and implement processes that anticipate disruptive change. The results of this research also confirmed that organizational values, workflow activities, and subflows play a prominent role in an incumbent organization's response to disruptive change. Finally, this study established that process model metainformation associated with workflow activities, transitions, and resources are core attributes in planning for disruptive change.

The thesis is focused on business processes with a link to a concrete small-scale enterprise. The aim of this work is the project of selected major processes. The theoretical part explains the difference between processional and functional management, describes the basic methods and standards of modeling process, selection method for the purpose of practical part with the reference to the specifics of the enterprise. The practical part contains market analysis, analysis of surrounding requirements and made project of certain process according to chosen modeling method.

La gestion des stocks et la maîtrise de la distribution sont les deux activités importantes dans le management de la chaîne logistique. L’optimisation simultanée de ces deux activités est connue sous l’intitulé du problème de gestion de stock et de tournée de livraison (Inventory Routing Problem, IRP). L’IRP traditionnelle est confronté aux différents problèmes, causé principalement par le manque d'informations complètes et/ou temps réel, tels que les changements de la demande, l’embouteillage soudain causé par un accident, etc. Le partage et la mise à jour d'information logistique peut améliorer l'efficacité d’IRP. De plus, en raison de la spécificité de l'IRP dans la logistique urbaine, il est important de considérer d'autres critères comme les critères sociaux, environnementaux et le niveau de service qui pourraient être en conflictuel. L’objectif principal de cette thèse est de développer des modèles et des méthodes des IRP avec la prise en compte des incertitudes, du niveau de service et de l’impact environnemental, social en finalement les informations du temps réel (IRP dynamique). Dans cette thèse, trois modèles mathématiques sont proposés. Le premier modèle multi-objectif est pour identifier un compromis entre le niveau de service, les critères environnementaux et économiques. Pour gérer des paramètres incertains, on applique une approche floue. Dans le deuxième modèle, nous avons étudié l'impact des critères sociaux sur les IRPs en proposant un modèle mathématique bi-objectif. Une approche stochastique basée sur des scénarios est développée pour faire face à l'incertitude dans le modèle. Enfin, le troisième model concerne l'impact de l'utilisation d'informations du temps réel dans les IRP. Il est à noter que, selon la durée de vie du produit tant sur le plan financier que sur le plan écologique, les produits périssables sont considérés dans les trois modèles proposés. Les résultats montrent une gestion dynamique est beaucoup plus efficace que la statique. / The inventory management and transportation are two main activities of supply chain management. The joint optimization of these two activities is known as Inventory Routing Problem (IRP). The main objective of IRP is to determine the set of retailers to be delivered to in each period, the delivery sequence for each vehicle, and the quantities of goods delivered to each retailer for each period of a planning horizon. The traditional IRPs are faced different problems, caused mainly by lack of complete and/or timely information such as shifts in demand, traffic caused by a sudden vehicles accident, etc. sharing of updated and reliable logistics information can meaningful improve the efficiency of IRP. Moreover, because of the specificity of IRP in urban logistic, it is important to tack into account other criteria as social, environmental criteria and service level that could be in conflict. The main objective of this thesis is to (i) choose appropriate social, environmental and service level criteria, (ii) integrate them in mathematical models, and (iii) study the impact of these criteria on dynamic optimization of IRPs for perishable products under uncertain parameters. For this purpose, three mathematical models are proposed. The first model is multi-objective mathematical model in order to make a trade-off between service level, environmental criteria and economic. To decrease quantity of expired products, a nonlinear step function as holding cost function is integrated in the model. Moreover, to solve the problem a fuzzy possibilistic approach is applied to handle uncertain parameters. In the second model, a bi-objective mathematical model is proposed to study impact of social issues on the IRPs. In the proposed model, first objective function concerns economic criteria while the second one social issues. A scenario-based stochastic approach is developed to cope with uncertainty in the model. Finally, the third model concerns impact of using real-time information in efficiency of IRPs. It is noteworthy that, according significant role of perishable products in the both financially and ecology sides of IRPs, perishable products are considered in all three proposed model while even proposed models are appropriate to nonperishable ones as well. The results show that a dynamic management is more efficient than the static one.

A globalização reforça a necessidade das empresas aprimorarem seus processos e produtos continuamente para se manterem competitivas e atenderem às expectativas de um mercado dinâmico e de acionistas cada vez mais exigentes, que buscam maximizar seus lucros. A melhoria contínua acima mencionada não se refere apenas à qualidade percebida pelo consumidor final, mas também à qualidade e confiabilidade dos processos de produção. Desta forma, quando as empresas têm melhores processos, melhores são os produtos originados e também os seus custos. Porém, a questão é como esses processos são modelados na fase de projeto e como ferramentas de qualidade, sobretudo o Seis Sigma metodologia mais em voga na atualidade podem utilizar tais modelos para obter melhores resultados. Essa dissertação propõe a utilização de ferramentas de modelagem e simulação tais como as Redes de Petri para modelagem de processos produtivos fornecem um modelo formal para a representação de sistemas de produção, capturando aspectos inerentes a tais sistemas como concorrência, paralelismo e sincronização suportando a aplicação da metodologia Seis Sigma, a qual geralmente atua somente no nível de melhoria do processo produtivo e não do projeto que o originou. Dessa forma, essa dissertação trás uma proposta de integração entre os times que projetam o processo e os que executam a produção, demonstrando tal viabilidade por meio da análise dos projetos/modelos durante a aplicação da metodologia Seis Sigma. É realizado um estudo de caso na estamparia de uma indústria automotiva que ilustra a aplicação da metodologia proposta. / The globalization strengthens the necessity for companies to improve its processes and products in order to remains competitive and to attend expectations of a dynamic market and shareholders each time more demanding and eager to maximize their profits. The continuous improvement mentioned above, is not related only to the quality perceived by the final consumer, but also to the quality and reliability of the production processes. Therefore, as better processe the company gets, as better would be their final products and as lower would be the costs. However, the question is wheter a continuous improvement using Six Sigma could benefit from the design documentation for the target process returning also an improved documentation after the cycle is completed. This work considers the use of Petri Nets for production processes modeling - even if any other design and modeling representation would return similar results - supporting the Six Sigma methodology application. The main result is a proposition of continuous improvement life cycle that maintains the design documentation consistent and up-to-date. Thus, this work pursuits the integration between the teams that design processes and those who implement them in the manufacturing plant. To show the potential of the models analysis during Six Sigma projects a case study is analyzed for the Press Shop area in an Automotive Industry.

The increasing demands on producing products in an effective and resource efficient manner has put more focus on modelling internal processes within organizations. Models of internal processes show what work is to be done and how to do the work in order to get to the desired result. Modelling internal processes is also a way to capture knowledge that by many is seen as the most meaningful resource and valuable asset in today’s organizations.  This thesis project has created a model of the project process for customized truck development (s-order) at Scania. The purpose has been to create a model that facilitates the everyday work of the project managers and can be used to improve the process. The goal of this report is to add to the theoretic field of process modelling by focusing on how to use a process model. A qualitative case study was conducted in parallel to a literature study. The result is a model in two layers providing different levels of detail. The model can be used for project planning, project execution, project control and project development the most important part being to create a standardized way of working which is the basis for a lean product development. The process of modelling can in itself generate important insights into a process, the report therefore ends with a discussion on suggestions for improvement of the s-order projects towards becoming a more lean product development process. / De ökande kraven på att producera varor på ett effektivt sätt med minskad användning av resurser ställer ökande krav på att modellera interna processer inom företag. Modeller av interna processer visar vad som ska göras i en process och när arbetet ska utföras för att få önskat resultat. Att modeller interna processer är också ett sätt att fånga kunskap som i stor utsträckning ses som den mest värdefulla tillgången i dagens organisationer. Detta projekt arbete har skapat en processmodell över projektprocessen för specialbeställda lastbilar (s-order) på Scania. Syftet har varit att skapa en modell som underlättar i projektledarnas dagliga arbete och som även kan användas som underlag för förbättringar av processen. Målet har varit att addera till det teoretiska fältet för process modellering genom att fokusera på hur modellen kan användas. En kvalitativ fallstudie har utförs parallellt med en litteraturstudie. Resultatet är en process modell i två lager med olika detaljnivå. Modellen kan användas för projektplanering, i utförandet av projekten, som kontroll av projekten och för utveckling av projekt processen, den viktigaste rollen är att en modell skapar basen för ett standardiserat arbetssätt, grunden för lean produktutveckling. Att modellera en process kan ge viktiga insikter i processen, rapporten avslutas därför med en diskussion kring åtgärder för hur s-order processen kan förbättras för att bli en mer lean produktutvecklingsprocess.

O propósito deste trabalho foi o desenvolvimento de um procedimento simulador de processo reproduzindo a etapa de destilação extrativa de uma unidade de extração de butadieno a partir de uma corrente de hidrocarbonetos na faixa de quatro átomos de carbono, através da adição do solvente n-metil-2- pirrolidona (NMP). Os resultados obtidos foram comparados e validados com dados de processo obtidos por uma unidade industrial de extração de butadieno. O aprofundamento nos conceitos do processo de separação através de uma ferramenta em simulador de processo capaz de predizer condições de operação permitiu avaliações de aumento de capacidade. A capacidade dos elementos internos dos equipamentos envolvidos na separação pode ser avaliada e a identificação do ponto inicial de engargalamento da unidade foi possível. O procedimento proposto também permite reduzir incertezas para identificação de novos pontos de engargalamento a partir de uma nova configuração dos elementos internos identificados como ineficientes com a elevação de carga processada. / The purpose of this study was the development of a model using a commercial process simulator software in order to reproduce the extractive distillation step of a butadiene extraction unit from a hydrocarbon stream by the addition of the solvent n- methyl-2-pyrrolidone (NMP). The results obtained from the simulations were compared with process data from an operational butadiene extraction unit. The knowledge of the separation process due the model should predict operating conditions allowing revamps on the actual asset. The internals capacity for the equipment involved in the separation could be evaluated and units bottlenecks points should be identified.

Business Process (BP) design reflects managerial needs and may directly influence business performance. A good design could substantially increase managerial performance, while a bad one would be inefficient, lack of flexibility, mess cost effective and eventually miss the business strategy. The widespread of information technology has raised the need to redesign or modify business processes in order to fit the trend of automation and computerization. As a result, business process reengineering (BPR) has gained much attention in 1990s. In recent years, a new paradigm, called Service Science, Management and Engineering (SSME), becomes a new management innovation. Service process design becomes a new science that can be applied to support service innovation and management. Previous research on BPR includes two major directions: one focuses on managerial aspects of business processes, including the planning, implementation, and critical factors of BPR; the other focuses on the design aspects pf business processes with a target of making processes more efficient. For research on process design, most deal with the syntactic structure of the process. They analyze the syntax structure of a process. This can help find design errors such as deadlocks, livelocks, and even infinite loops in a process. Not many studies have investigated whether a process design meets its managerial goals. This research presents a knowledge-based approach to dealing with the managerial issue of whether a process design matches specific managerial goals. This thesis contains a new business process modeling method that allows a business process to be diagnosed by knowledge-based rules. We have defined three managerial goals in process design: effectiveness, efficiency, and flexibility. Each activity in a business process has its goal. Through the analysis of activities and their associated goals, we can determine whether a business process is properly designed. In order to show the feasibility of the proposed approach, we have implemented a JAVA-based prototype expert system and used it to check two sample business processes. The contributions of the study are two-fold. Academically, it proposed a new approach for business process diagnosis, which can help determine whether a process meets its managerial goal. In practice, businesses can use the concepts developed in the thesis to make their business processes more effective by matching activities with intended managerial goals.

The managing of complex business processes, which are changed due to globalization, calls for the development of powerful information systems that offer generic process modeling and process execution capabilities. Even though contemporary information systems are more and more utilized in enterprises, their actual impact in automatizing complex business process is still limited by the difficulties encountered in design phase. Actually this design phase is time consuming, often subjective and incomplete. In the scope of this study, a reverse approach is followed. Instead of starting with process design, the method of discovering interesting patterns from the navigation traces is taken as basis and a new data analysis methodology named &ldquo / From-to Chart Based Process Discovery&rdquo / is proposed. In this hybrid methodology &ldquo / from-to chart&rdquo / , which is fundamentally dedicated to material handling issues on production floor, is used as the front-end to monitor the transitions among activities of a realistic event log and convert these raw relations into optimum activity sequence. Then a revised version of process mining, which is the back-end of this methodology, upgrades optimum activity sequence into process model.

With the rise of electronic integration between organizations, the need for a precise specification of interaction behavior increases. Information systems, replacing interaction previously carried out by humans via phone, faxes and emails, require a precise specification for handling all possible situations. Such interaction behavior is described in process choreographies. Choreographies enumerate the roles involved, the allowed interactions, the message contents and the behavioral dependencies between interactions. Choreographies serve as interaction contract and are the starting point for adapting existing business processes and systems or for implementing new software components. As a thorough analysis and comparison of choreography modeling languages is missing in the literature, this thesis introduces a requirements framework for choreography languages and uses it for comparing current choreography languages. Language proposals for overcoming the limitations are given for choreography modeling on the conceptual and on the technical level. Using an interconnection modeling style, behavioral dependencies are defined on a per-role basis and different roles are interconnected using message flow. This thesis reveals a number of modeling "anti-patterns" for interconnection modeling, motivating further investigations on choreography languages following the interaction modeling style. Here, interactions are seen as atomic building blocks and the behavioral dependencies between them are defined globally. Two novel language proposals are put forward for this modeling style which have already influenced industrial standardization initiatives. While avoiding many of the pitfalls of interconnection modeling, new anomalies can arise in interaction models. A choreography might not be realizable, i.e. there does not exist a set of interacting roles that collectively realize the specified behavior. This thesis investigates different dimensions of realizability. / Elektronische Integration zwischen Organisationen erfordert eine präzise Spezifikation des Interaktionsverhaltens: Informationssysteme, die Kommunikation per Telefon, Fax und Email ablösen, können nicht so flexibel und selbständig auf Ausnahmesituationen reagieren wie Menschen. Choreographien ermöglichen es, Interaktionsverhalten genau zu spezifizieren. Diese Modelle zählen die beteiligten Rollen, die erlaubten Interaktionen, Nachrichteninhalte und Verhaltensabhängigkeiten auf und dienen somit als Interaktionsvertrag zwischen den Organisationen. Auch als Ausgangspunkt für eine Anpassung existierender Prozesse und Systeme sowie für die Implementierung neuer Softwarekomponenten finden Choreographien Anwendung. Da ein Vergleich von Choreographiemodellierungssprachen in der Literatur bislang fehlt, präsentiert diese Arbeit einen Anforderungskatalog, der als Basis für eine Evaluierung existierender Sprachen angewandt wird. Im Kern führt diese Arbeit Spracherweiterungen ein, um die Schwächen existierender Sprachen zu überwinden. Die vorgestellten Erweiterungen adressieren dabei Modellierung auf konzeptioneller und auf technischer Ebene. Beim Verlinkungsmodellierungsstil werden Verhaltensabhängigkeiten innerhalb der beteiligten Rollen spezifiziert und das Interaktionsverhalten entsteht durch eine Verlinkung der Kommunikationsaktivitäten. Diese Arbeit stellt einige "Anti-Pattern" für die Verlinkungsmodellierung vor, welche wiederum Untersuchungen bzgl. Choreographiesprachen des Interaktionsmodellierungsstils motivieren. Hier werden Interaktionen als atomare Blöcke verstanden und Verhaltensabhängigkeiten werden global definiert. Diese Arbeit führt zwei neue Choreographiesprachen dieses zweiten Modellierungsstils ein, welche bereits in industrielle Standardisierungsinitiativen eingeflossen sind. Während auf der einen Seite zahlreiche Fallstricke der Verlinkungsmodellierung umgangen werden, können in Interaktionsmodellen allerdings neue Anomalien entstehen. Eine Choreographie kann z.B. "unrealisierbar" sein, d.h. es ist nicht möglich interagierende Rollen zu finden, die zusammen genommen das spezifizierte Verhalten abbilden. Dieses Phänomen wird in dieser Arbeit über verschiedene Dimensionen von Realisierbarkeit untersucht.