<p>This dissertation examined several dimensions of the development of physical aggression and indirect aggression in a longitudinal sample of boys and girls. These data are part of the National Longitudinal Study of Children and Youth which evaluated the development of children bi-annually from 1994 to 2010. The data for this thesis come from individuals aged 10 and 11 in Cycle 1 (1994) through to Cycle 5 (2002) when they were 18 and 19. In an attempt to explore trends in the development of aggression, the research is presented as three separate projects that examine the following: (1) measurement of physical and indirect aggression by informant and sex; (2) group-based trajectories of physical and indirect aggression and outcomes of trajectories in emerging adulthood; and (3) association between indirect aggression in adolescence and depression in emerging adulthood when physical aggression is taken into account. This is the first longitudinal study to investigate group-based physical and indirect aggression trajectories in childhood and adolescence and outcomes in emerging adulthood. The contribution of this thesis to the field of epidemiological research on aggression is the importance of considering distinct subgroups within both physical and indirect aggression, and joint trajectory groups of both physical and indirect aggression when exploring developmental trends and outcomes of aggression.</p> / Doctor of Philosophy (PhD)

We classify animals into a few distinct groups: companion animals (pets and strays like dogs and cats), utility animals (animals that serve a purpose like cows farmed for dairy or meat or foxes farmed for fur), and wild animals (nondomestic animals in their natural habitat). This study will investigate empathic relationships between people and animals of these four types in two abuse scenarios (active abuse and neglect). These factors were manipulated in a 2x4 experimental design. I expect a closer relationship with humans will correlate with a higher degree of empathy for the victim such that homed companion animals will generate the most empathy, followed by stray, utility, and finally wild. Results supported this hypothesis to an extent. This research is intended to bridge gaps between empathy towards humans and empathy towards other animals. If we can manipulate the degree to which people tend to relate to animals by varying our descriptions of these animals, we can also manipulate people’s desire to protect them.

Non-suicidal self-injury (NSSI) is considered a strong predictor of suicidal behavior, although the exact relationship between NSSI and suicide is not clear. Several factors have been suggested in previous research, including attitudes toward one’s own body, thoughts and beliefs regarding death and suicide, and the ability to cause physical harm to oneself. In the current study, the researcher obtained data from 285 young adult participants who reported a history of NSSI. Two multiple mediation models were tested in which body protection, suicide-related concerns, and acquired capability for suicide were examined as mediators of the relationship between NSSI and suicide attempt frequency. The first model, in which the predictor was NSSI frequency, was not supported. The second model, in which the predictor was NSSI versatility of methods, was partially supported; the only significant mediator was suicide-related concerns. These results add to the literature regarding the relationship between NSSI and suicide.

An estimated 13.9% of Americans currently meet criteria for an alcohol use disorder. Ultimately, chronic alcohol use may result in neurological deficits, with up to 85% of alcoholics exhibiting signs of cognitive decline. However, biochemical and behavioral factors contributing to this decline have remained elusive. Our ongoing research program encompasses a multi-tiered screening of a natural product library and validation process to provide novel information about mechanisms underlying these deficits and to identify novel chemical scaffolds to be exploited in the development of pharmacological treatments for alcohol use disorders in a rodent organotypic hippocampal slice culture mode. Experiment 1 sought to establish a 48 h high throughput model for testing novel scaffolds against ethanol (EtOH) toxicity. Experiment 2 tested multiple natural product compounds for their ability to attenuate ethanol-induced cytotoxicity. Results from Experiment 1 revealed EtOH (100 mM) induced significant cytotoxicity at 48 h. Trolox (100 µM), a potent antioxidant, was found to reduce ethanol-induced cytotoxicity in this assay. Experiment 2 revealed two spoxazomicins (1, 1-1) demonstrated potent cytoprotective effects against ethanol toxicity. These findings highlight the potential applications of these novel scaffolds for use in the treatment of alcohol use disorder.

The purpose of this study was to examine the genetic and environmental influences on lifetime quit attempt in three US adolescent and young adult twin samples (N total = 6,322). The study utilized a common-contingent-causal (CCC) model to estimate these factors for lifetime quit attempts, after accounting for the factors for lifetime cigarette use and cigarettes per day. The study also examined age and sex differences, as well as the degree of relationship between these smoking phenotypes. The results demonstrated significant genetic influences for lifetime quit attempts in adolescents and young adults. No sex differences were observed for the contributions of genetic and environmental factors for lifetime quit attempts. Furthermore, separate liabilities for lifetime quit attempts and lifetime cigarette use were found for most age groups. Study findings have important implications for promoting quit attempts in adolescents and young adults.

Although integrated primary care psychology services are becoming increasingly common, the literature lacks adequate research support for the longitudinal durability of treatment effects following the conclusion of brief primary care interventions. This study served as a follow-up program evaluation of psychological services for depression and anxiety provided at the Medical College of Virginia’s Ambulatory Care Center in Richmond, Virginia. Data were collected on 47 adult primary care patients who received treatment for depression and/or anxiety between six and 18 months prior to the follow-up telephone call. Data were collected on the trajectory of depression scores throughout and following treatment, treatment received by patients in the interim, and reasons provided by patients for discontinuing treatment. Analyses of these data indicated that primary care psychology services were effective in reducing patient anxiety and depression as measured by the GAD-7 and PHQ-9 respectively, even when controlling for additional treatment in the interim, and that patients as a group continued to improve over time following the conclusion of treatment. These preliminary results should be interpreted with caution, however, due to the study’s small sample size and lack of a control group. Study limitations, strengths, and future directions are addressed.

While caffeine withdrawal has been well-characterized, research on caffeine intake and factors associated with withdrawal has been limited. The present study examined prevalence rates of caffeine use and identified psychosocial factors associated with having caffeine withdrawal headaches (CWH). Participants were N = 1,989 college freshmen who participated in the 2011 Spit for Science project. Caffeine use was reported by 80% of the sample. Females were more likely than males to consume caffeine, and soda was the primary source of caffeine for both genders. As hypothesized, daily caffeine users were more likely to report CWH than non-daily users. When multivariable analyses examined other variables identified through univariable analyses, the most parsimonious model for distinguishing between those with and without CWH included the following set of predictor variables: daily caffeine use; female; non-white minority; peers with alcohol problems; greater neuroticism, and those reporting maternal depression or anxiety.

The purpose of this dissertation was to determine the usefulness of the linguistic processes of Distortion, Deletion, Generalization, and Semantic Ill-Formedness as constructs which differentiate the verbal communication of families who express dissatisfaction with their current intrafamilial relationships from families expressing satisfaction with their current relationships. Specifically, it was hypothesized that dissatisfied families would use these linguistic structures to a greater extent in their interaction than would satisfied families. Thirty-one family triads (father, mother, and child) were obtained by asking families randomly selected from the local high school student directory to participate. The families were given a Revealed Differences questionnaire which they subsequently discussed together and a questionnaire regarding their satisfaction with their intrafamilial relationships. The discussions were recorded and transcribed. Each of 150 Surface Structures (a complete thought, usually a grammatical sentence) per family was scored for 11 subcategories of Distortion, Deletion, Generalization, and Semantic Ill-Formedness. Interrater reliabilities ranged from .86 to .98. A mean was computed for the questionnaire pertaining to satisfaction with family relationships. Six families who scored at least one half standard deviation below the mean comprised the "dissatisfied" family group, and six families who scored at least one half standard deviation above the mean comprised the "satisfied" family group. It was found that the dissatisfied families used significantly more Deletion (p The linguistic process of Deletion is theorized to result in impoverishing the speaker's model of the world and the behavioral choices available to the speaker. Similarily, the listener(s) who must respond to the impoverished model is limited in his response and behavioral options. Since all members of the dissatisfied families used this form of language, they perpetuate the impoverishing model of the world and the limitations on their behavior. It was concluded that, while not establishing an etiologic link between the use of Deletion and family dissatisfaction, Deletion is part of the current verbal interaction of families who express dissatisfaction. Further research involving families in which a member is symptomatic is warranted based on the findings of this study. Language may provide at least one form of explanation regarding the process by which families maintain homeostasis in the face of symptom development. The use of linguistic concepts shows promise as an intermediate link in family interaction theory as well as a form of intervention available to therapists.

Outpatient clients from a community mental health center were surveyed by questionnaire to examine the relationship between number of therapy sessions attended and client-judgments of therapeutic outcome. The results indicated that client-judgments of therapeutic benefit tended to be independent of length of therapy when the client-judgement is a global assessment of therapeutic benefit. Controls for mode of therapy, initial diagnosis, type of referral, and status of case yielded similar findings. The nature of these relationships was nonlinear with the possible existence of different zones of sessions that account for varying degrees of client-perceived success. It also appeared that clients evaluated overall therapeutic effectiveness along different criteria than they evaluated therapeutic effectiveness for specific problem areas. Implications for future research are discussed.

Individuals with Autistic Spectrum Disorders (ASD) often perform better than typically developing (TD) individuals in simple, albeit difficult, visual search tasks. This ability is often attributed to a lack of drive for coherence or superior local processing. We compare thirty adults with ASD with forty-nine TD individuals and twenty-seven adults with anxiety (ANX) across two real-world visual search tasks. Individuals had to find either a number superimposed over a real-world scene ("œno context" condition) or an object located in a contextually relevant location ("œcontext" condition). Each participant completed forty-one trials in each condition, each with a unique scene. Eye movements were recorded using an SR Research EyeLink 1000 eyetracker. All groups performed better in the context condition. However, the ASD group was less accurate than both groups, across conditions. All groups were quicker to find the target in the context condition but the ASD group was slower than the TD group. Furthermore, the ASD group took longer to initiate their search, fixate on the target, and decide that they had found the target than the TD group. These results suggest that individuals with ASD are able to integrate contextual information to aid the search but that their previously seen visual search advantage may not transfer to visual searches of real-world scenes.