京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13232号 / 論医博第2172号 / 新制||医||1036(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 山下 潤, 教授 江藤 浩之, 教授 木村 剛 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

The QT interval in an electrocardiogram (ECG) reflects complex processes affecting the repolarization of ventricular myocardium. Increased QT interval variability (QTV) is thought to be caused by ventricular repolarization lability and has been associated with cardiac mortality. Recent publications have shown that template-based methods are more robust than traditional methods for QT interval extraction on a beat-to-beat basis. However, most studies are limited to non-movement ECG recordings, we want to analyze in this study the power of QT interval extraction for mobile non-stationary ECG recordings. The records of 7 test subjects are at least 65 min long and contain about 25 minutes of sport exercise such as running, cycling, sport climbing or acrobatic training. 2DSW was used to extract QT interval and best-fit distance of matched template for signal quality evaluation for each beat. Potential relations between QTV, motion and signal quality are segmentally compared. To determine motion activity we calculated normalized signal magnitude area (SMA). QTV was increased in patients during sport exercise, possibly reflects sympathetic activity in these specific physiological conditions. However, increased QTV could also be caused by low signal quality.

The automotive industry today is getting more and more competitive with accelerating demand to attract car consumer with new technologies. Three-dimensional user interfaces (3D UIs) support user tasks in many non-traditional interactive systems such as augmented reality and virtual environments. Although 3D UI researchers and developers have been successfully identified basic user tasks, evaluating the usability of 3D interaction techniques, as well as finding an improvement of the usability of many applications, the researches and developments are still in the direction of finding better approaches and to be more innovative to fulfill the demands in the context of automotive user interface. The concept of a framework presented in this master thesis is to integrate technology of the Qt framework that is widely used for traditional 2D interfaces on different platforms and operating systems with the availability of open sources in order to realize the goal of having the ability to import the external 3D asset completely, specifically in FBX format by Autodesk that is widely used in the automotive industry. In addition, QML as part of the Qt framework that include JavaScript as an easy Object-Oriented scheme to manipulate object properties such as position and color of the graphical object is also integrated. The main aim of the framework is to have a full access to the imported FBX asset that is created by digital content creation applications such as Autodesk 3Ds Max or Autodesk Maya and visualize them within the Qt framework. With the newest technology of the Qt framework, it seems to be a promising solution to develop an interactive user interface. Hence, the framework approach of this master thesis is based on the Qt framework and Qt3D 2.0, in order to satisfy the requirements and introduces a solution to satisfy the demands in multimedia and 3D user experiences in the automotive industry. In the last fifteen years, Qt has proven as a robust development environment that produces powerful and stable software applications. Together with the abilities of Qt3D 2.0 that offers several abstract ways to control the rendering setup that helps the framework to realize the aim of this master thesis. This master thesis contains a detailed specification and concept for the development of a framework for 3D dynamic user interface application in vehicles. As the result of this master thesis, some typical use cases for automotive industry are realized as prototype applications in order to prove that the framework has the ability to load the 3D asset, specifically in FBX format, into the Qt framework and rendered together with the components of the Qt framework as an interactive and dynamic 3D user interface.

Performing measurements of samples that contain chemical substances is a time consuming task if the measurement instruments are small and require high precision. A single measurement session can often contain a large amount of samples, which is why it is crucial to automate this process. The solution, which is discussed in this report, is a Graphical User Interface that allows a user to control three linear motors that can move in the X-, Y-, and Z-axis. Movement of the motors results in the movement of the sampling platform, which allows a measurement instrument to be inserted and ejected from each sample with a much higher precision than a human is capable of. Automating the process does not only result in a more accurate and precise measurement process, but also a more efficient process, since the sample size can be decreased. By decreasing the sample size, it is also possible to increase the number of samples to perform measurements on. The results shows an increase in accuracy and a reduction of the required supervision over the sampling process. Moreover, our solution also reduces power consumption since the equipment used in the analyses requires less uptime. / Att utföra mätningar av prover som innehåller kemiska ämnen är en tidskrävande uppgift om mätinstrumenten är små och kräver hög precision. En enda mätsession kan ofta innehålla en stor mängd prover, därför är det väsentligt att automatisera denna process. Lösningen, som diskuteras i denna rapport, är ett grafiskt användargränssnitt som låter en användare styra tre linjära motorer som kan röra sig i X-, Y- och Z-led. Rörelse av motorerna resulterar i att provtagningsplattformen rör sig, vilket gör att ett mätinstrument kan matas in och ut från varje prov med en mycket högre precision än vad en människa är kapabel till. Att automatisera processen resulterar inte bara i en mer exakt mätprocess, utan också i en mer effektiv process, eftersom provers storlek kan minskas. Genom att minska provstorleken är det också möjligt att öka antalet prover att utföra mätningar på. Resultaten visade en betydelsefull ökning av noggrannhet och en minskning av nödvändig övervakning av systemet. Vår lösning innebär också en minskning av strömförbrukningen eftersom den utrustning som används i analyserna kräver kortare drifttid.

The presented research summarizes (1) the development of a rapid prototyping framework, (2) the application of advance meshing algorithms, data structures, programming languages and libraries toward the field of numerical surface-water modeling (NSWM), (3) the application of (2) in (1), and (4) a real world application. The result of the research was the development of a prototype grid generator tool, the Mesh Generation and Refinement Tool (MGRT). MGRT supports a customizable interface and plug-and-play functionality through the use of plug-ins and incorporates a plug-in based topology/geometry system. A detailed explanation of the data structures, algorithms, and tools used to construct the MGRT are presented. Additionally, the construction of a mesh of Mobile Bay is presented. This represents a real world application of the MGRT. This tool provides many benefits over current tools in NSWM, which include faster meshing and the ability the use any grid generator that can be plugged-in.

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Long QT syndrome (LQTS) is an inherited arrhythmic disorder associated with sudden cardiac death (SCD). This study aimed to identify the clinical and molecular genetic risk factors that contribute to major arrhythmic events (MAEs) in patients with genetically confirmed childhood onset LQTS 1–3. This study was a retrospective double-center study. An MAE was defined as the occurrence of SCD, aborted SCD, appropriate implantable cardioverter defibrillator discharge, or sustained ventricular tachycardia. During a median follow-up of 4.6 years (range 0.1–24.3 years), MAEs occurred in 18 (17.8%) of 101 patients diagnosed with LQTS at a median of 7.7 years (range 0.0–18.0 years) despite the use of beta-blockers in 91.6% of patients at the last follow-up. A multivariate analysis identified a genetic diagnosis of LQTS2 and LQTS3 and variants within the KCNH2 S5-loop-S6 pore region as independent risk factors for MAEs, independent of the QTc value or a history of syncope detected from a univariate analysis. MAEs occur frequently in childhood onset LQTS despite beta-blocker treatment. A detailed molecular genetic diagnosis can contribute to the arrhythmia risk stratification and optimize the use of preventive measures in this vulnerable patient population

No description available.

No description available.

No description available.