Patients with classical vitiligo lose partially their protecting inherited pigment. The cause of the disease is still unknown. Despite massive epidermal oxidative / nitrative stress and signs for DNA-damage in the skin and in the plasma, these patients have no higher prevalence for sun induced non-melanoma skin cancer and increased photo-damage. Protection and DNA-repair have been attributed to a functioning up-regulated wild type p53 / p21 cascade in association with up-regulated p76 MDM2. As some patients with cutaneous melanoma develop depigmentations away from their primary tumour site post surgical excision, it became of our interest, whether this melanoma associated leucoderma (MAL) is the same as classical vitiligo. The purpose of this thesis was two-fold. In part I, we wanted to further substantiate the reasons behind the constantly up-regulated wild-type functioning p53 / p21 cascade in classical vitiligo utilising a panel of proteins with direct and / or indirect action on p53 regulation, including p21, p76MDM2, MDM4/MDM4phospho, SPARC, VEGF-A and TGF-β1. In part II, we wanted to characterize MAL and compare this peculiar leucoderma with classical vitiligo using the same protein panel and methodologies. To achieve our goals, we used in vivo FT-Raman spectroscopy, in vitro cell cultures, in vitro and in situ immuno-fluorescence labelling, Western blot, dot blot and computer modelling techniques. Our data showed distinct differences between classical vitiligo and MAL. Our results in MAL exhibited a concentration dependent protein expression gradient between the basal / suprabasl layers and the upper layers of the epidermal compartment using catalase, ONOO-, p53, p21, MDM4, p76MDM2, TGF-β1 and VEGF-A expression gradient. Moreover, we document for the first time the presence of a nitrated non-fuctional SPARC protein in classical vitiligo which is absent in MAL. Although we show in vivo considerable ROS / RNS- mediated stress in MAL and classical vitiligo documented by FT-Raman spectroscopy, Western blot and in situ immuno-fluorescence, our results prove that MAL and classical vitiligo are two distinct entities.

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Patients with classical vitiligo lose partially their protecting inherited pigment. The cause of the disease is still unknown. Despite massive epidermal oxidative / nitrative stress and signs for DNA-damage in the skin and in the plasma, these patients have no higher prevalence for sun induced non-melanoma skin cancer and increased photo-damage. Protection and DNA-repair have been attributed to a functioning up-regulated wild type p53 / p21 cascade in association with up-regulated p76 MDM2. As some patients with cutaneous melanoma develop depigmentations away from their primary tumour site post surgical excision, it became of our interest, whether this melanoma associated leucoderma (MAL) is the same as classical vitiligo. The purpose of this thesis was two-fold. In part I, we wanted to further substantiate the reasons behind the constantly up-regulated wild-type functioning p53 / p21 cascade in classical vitiligo utilising a panel of proteins with direct and / or indirect action on p53 regulation, including p21, p76MDM2, MDM4/MDM4phospho, SPARC, VEGF-A and TGF-β1. In part II, we wanted to characterize MAL and compare this peculiar leucoderma with classical vitiligo using the same protein panel and methodologies. To achieve our goals, we used in vivo FT-Raman spectroscopy, in vitro cell cultures, in vitro and in situ immuno-fluorescence labelling, Western blot, dot blot and computer modelling techniques. Our data showed distinct differences between classical vitiligo and MAL. Our results in MAL exhibited a concentration dependent protein expression gradient between the basal / suprabasl layers and the upper layers of the epidermal compartment using catalase, ONOO-, p53, p21, MDM4, p76MDM2, TGF-β1 and VEGF-A expression gradient. Moreover, we document for the first time the presence of a nitrated non-fuctional SPARC protein in classical vitiligo which is absent in MAL. Although we show in vivo considerable ROS / RNS- mediated stress in MAL and classical vitiligo documented by FT-Raman spectroscopy, Western blot and in situ immuno-fluorescence, our results prove that MAL and classical vitiligo are two distinct entities.

LIVE ART is a program for students with special needs and students who are typically developed. They work collaboratively, with integrated forms of performance and visual art, culminating in a live performance. LIVE ART sought to use innovative methods of pedagogy, peer support and artistic influence to create a new curriculum where all students, regardless of ability, could grow. Along with this account, this thesis illustrates the experience of one teaching artist and his growth and journey through the program. His personal struggles with previous educational systems are mirrored in the struggles of the students, with their successes leading to his own. The thesis culminates in the revelation of teaching as a necessary mode for his own growth.

[Truncated abstract] Approximately 35% of women worldwide have stress incontinence, which is defined as involuntary leakage of urine on effort, exertion, or on sneezing and coughing. There are various surgical techniques for stress incontinence; however, minimally invasive operations are increasingly being chosen by surgeons and their patients. Of these procedures, tension-free vaginal tape (TVT) has a cure rate of approximately 90% and is now perceived as the standard technique for stress incontinence. Reported complications of TVT include arterial laceration, bladder perforation, bowel perforation, de novo urgency, dyspareunia, excessive blood loss, haematoma, nerve injuries, urethral erosion, urge incontinence, urinary tract infection, vascular injury, vaginal mesh erosion, voiding dysfunction and death. Suprapubic urethral support sling (SPARC) is a very similar minimally invasive operation and early indications suggested that the success rate for treating stress incontinence was expected to be identical or better than those obtained with the earlier TVT approach, with possibly fewer adverse perioperative events. Our trial sought to establish equivalence between TVT and SPARC in relation to short-term complications and efficacy. OBJECTIVES The primary outcome was bladder perforation. Secondary outcomes were blood loss, voiding difficulty, urgency, and cure of stress incontinence symptoms. METHOD A randomised controlled one-sided equivalence trial (RCT) was conducted in Perth, Western Australia during 2003 and 2004 by researchers in the School of Population Health, University of Western Australia (UWA) and King Edward Memorial Hospital (KEMH). Patients were recruited from the public Urology/Urogynaecology Clinic at the primary women's hospital and the consultant surgeons' private practices. ... However, acute urinary retention requiring a return to theatre to loosen the tape (TVT 0%, SPARC 6.5%; OR: [infinity], 95% CL: 2.2, [infinity]; p=0.002) and subjective short-term cure (TVT 87.1%, SPARC 76.5%; OR: 2.07, 95% CL: 1.13, 3.81; p=0.03) were statistically significantly different. CONCLUSIONS The results are consistent with clinical equivalence between TVT and SPARC in relation to the incidence of bladder perforation. No statistically significant difference was found between TVT and SPARC in blood loss, urgency or short-term objective cure of stress incontinence at the six week post-discharge visit to the surgeon. However, the tapes were more difficult to adjust correctly in SPARC procedures and a statistically significant number of patients required a return to theatre for loosening of the tape (TVT 0/147, 0% and SPARC 10/154, 6.5%, p=0.002). Compared with SPARC, TVT was statistically significantly higher for subjective short-term cure. In ii relation to vaginal mesh erosion, TVT was lower than SPARC, though not statistically significantly. Overall, voiding difficulty (loosening of the tape), urgency and vaginal mesh erosion were the most important clinical problems. This randomised controlled trial demonstrates the importance of testing new devices which appear to be similar, but which may have clinically relevant differences. A follow up study to assess the long-term efficacy of tension-free vaginal tape and suprapubic urethral support sling and associated complications is planned.

In this master thesis a small modular sodium-cooled metal-fuelled pool-type fast reactor design, called SPARC - Safe and Passive with Autonomous Reactivity control, has been designed. The long term reactivity changes in the SPARC are managed by implementation of the the Autonomous Reactivity Control (ARC) system, which is the novelty of the design. The overall design is mainly based on the Integral Fast Reactor project (IFR), which experimentally demonstrated the passive safety characteristics of a metal fuelled, sodium-cooled, pool-type reactor system. Whilst mimicking the passive safety features of the IFR, the vision of the SPARC design is a battery type reactor, which can operate with minimum interference from human actors. In this thesis, two reactor examples have been developed which operate using different fuel compositions. One reactor operates on recycled nuclear waste from today's nuclear power plants, and the other reactor operates on enriched uranium. Both reactors have a thermal power of 150 MW, and are meant to operate for 30 years without refuelling. The design was developed using the ADOPT software, and was simulated in Serpent. Using Serpent, criticality analyses were carried out which show that the ARC system is able to control the long term reactivity changes of the reactors.

Made available in DSpace on 2014-12-17T15:47:57Z (GMT). No. of bitstreams: 1 RodrigoSLSR.pdf: 1278461 bytes, checksum: ac21fe12bc1ce120cf688ba59e4bf754 (MD5) Previous issue date: 2006-05-19 / This work presents the concept, design and implementation of a MP-SoC platform, named STORM (MP-SoC DirecTory-Based PlatfORM). Currently the platform is composed of the following modules: SPARC V8 processor, GPOP processor, Cache module, Memory module, Directory module and two different modles of Network-on-Chip, NoCX4 and Obese Tree. All modules were implemented using SystemC, simulated and validated, individually or in group. The modules description is presented in details. For programming the platform in C it was implemented a SPARC assembler, fully compatible with gcc s generated assembly code. For the parallel programming it was implemented a library for mutex managing, using the due assembler s support. A total of 10 simulations of increasing complexity are presented for the validation of the presented concepts. The simulations include real parallel applications, such as matrix multiplication, Mergesort, KMP, Motion Estimation and DCT 2D / Este trabalho apresenta o conceito, desenvolvimento e implementa??o de uma plataforma MP-SoC, batizada STORM (MP-SoC DirecTory-Based PlatfORM). A plataforma atualmente ? composta pelos seguintes m?dulos: processador SPARC V8, processador GPOP, m?dulo de Cache, m?dulo de Mem?ria, m?dulo de Diret?rio e dois diferentes modelos de Network-on-Chip, a NoCX4 e a ?rvore Obesa. Todos os m?dulos foram implementados usando a linguagem SystemC, simulados e validados, tanto separadamente quanto em conjunto. A descri??o dos m?dulos ? apresentada em detalhes. Para a programa??o da plataforma usando C foi implementado um montador SPARC, totalmente compat?vel com o c?digo assembly gerado pelo compilador gcc. Para a programa??o concorrente foi implementada uma biblioteca de fun??es para gerenciamento de mutexes, com o devido suporte por parte do montador. S?o apresentadas 10 simula??es do sistema, de complexidade crescente, para valida??o de todos os conceitos apresentados. As simula??es incluem aplica??es paralelas reais, como a multiplica??o de matrizes, Mergesort, KMP, Estima??o de Movimento e DCT 2D

L’objectif de ce travail était d’examiner la spécificité fonctionnelle du traitement et des représentations des hauteurs musicales. À cette fin, ce traitement a été comparé à celui des phonèmes de la parole, d’une part, et aux associations spatiales évoquées par des séquences ordonnées, d’autre part. Nos quatre études avaient pour point commun d’adapter à un nouvel objet de recherche des méthodes bien établies en psychologie cognitive. Ainsi, nous avons exploité la tâche de classification accélérée (Etude 1) de Garner (1974), l’analyse des conjonctions illusoires en mémoire (Etude 2), l’additivité de la composante mismatch negativity (MMN) des potentiels évoqués (Etude 3) et l’observation d’associations spatiales de codes de réponse (Etude 4).<p>Les trois premières études, menées chez des participants non-musiciens, portaient sur la spécificité de traitement des hauteurs par rapport à celui des phonèmes au sein de stimuli chantés. Les deux premières études ont mis en évidence un effet surprenant de la nature des phonèmes sur leurs interactions avec le traitement des mélodies :les voyelles apparaissaient plus intégrées à la mélodie que les consonnes. Ceci était vrai à la fois lors du traitement en temps réel de non-mots chantés (Etude 1) et au niveau des traces en mémoire de ces mêmes non-mots (Etude 2, utilisant une tâche de reconnaissance à choix forcé permettant la mise en évidence de conjonctions illusoires). Cette dissociation entre voyelles et consonnes quant à leur intégration avec les traitements mélodiques ne semblait pas causée par des caractéristiques acoustico-phonétiques telles que la sonorité. Les résultats de la troisième étude indiquaient que les MMNs en réponse à des déviations de hauteur et de voyelle n’étaient pas additives et que leur distribution topographique ne différait pas selon le type de déviation. Ceci suggère que, même au niveau pré-attentionnel, le traitement des voyelles n’est pas indépendant de celui des hauteurs. <p>Dans la quatrième étude, nous avons comparé le traitement des hauteurs musicales à un autre domaine :la cognition spatiale. Nous avons ainsi montré que les non-musiciens comme les musiciens associent les notes graves à la partie inférieure et les notes aiguës à la partie supérieure de l’espace. Les deux groupes liaient aussi les notes graves au côté gauche et les notes aiguës au côté droit, mais ce lien n’était automatique que chez les musiciens. Enfin, des stimuli musicaux plus complexes (intervalles mélodiques) n’évoquaient ces associations spatiales que chez les musiciens et ce, uniquement sur le plan horizontal.<p>Ces recherches contribuent de plusieurs manières à la compréhension de la cognition musicale. Premièrement, nous avons montré que les consonnes et les voyelles diffèrent dans leurs interactions avec la musique, une idée à mettre en perspective avec les rôles différents de ces phonèmes dans l’évolution du langage. Ensuite, les travaux sur les représentations spatiales des hauteurs musicales ouvrent la voie à un courant de recherche qui aidera à dévoiler les liens potentiels entre habiletés musicales et spatiales.<p>/<p>The purpose of this work was to examine the functional specificity of musical pitch processing and representation. To this aim, we compared musical pitch processing to (1) the phonological processing of speech and (2) the spatial associations evoked by ordered sequences. The four studies described here all use classical methods of cognitive psychology, which have been adapted to our research question. We have employed Garner’s (1974) speeded classification task (Study 1), the analysis of illusory conjunctions in memory (Study 2), the additivity of the mismatch negativity (MMN) component of event-related potentials (Study 3), as well as the observation of spatial associations of response codes (Study 4).<p>The three first studies examined, in non-musician participants, the specificity of pitch processing compared to phoneme processing in songs. Studies 1 and 2 revealed a surprising effect of phoneme category on their interactions with melodic processing: vowels were more integrated with melody than were consonants. This was true for both on-line processing of sung nonwords (Study 1) and for the memory traces of these nonwords (Study 2, using a forced-choice recognition task allowing the occurrence of illusory conjunctions). The difference between vowels and consonants was not due to acoustic-phonetic properties such as phoneme sonority. The results of the third study showed that the MMN in response to pitch and to vowel deviations was not additive and that its brain topography did not differ as a function of the kind of deviation. This suggests that vowel processing is not independent from pitch processing, even at the pre-attentive level.<p>In the fourth study, we compared pitch processing to another domain: spatial cognition. We showed that both musicians and non-musicians map pitch onto space, in that they associate low-pitched tones to the lower spatial field and high-pitched tones to the higher spatial field. Both groups of participants also associated low pitched-tones with the left and high-pitched tones with the right, but this association was automatic only in musicians. Finally, more complex musical stimuli such as melodic intervals evoked these spatial associations in the horizontal plane only in musicians.<p>This work contributes to the understanding of music cognition in several ways. First, we have shown that consonants and vowels differ in their interactions with music, an idea related to the contrasting roles of these phonemes in language evolution. Second, the work on the spatial representation of pitch opens the path to research that will help uncover the potential links between musical and spatial abilities.<p> / Doctorat en sciences psychologiques / info:eu-repo/semantics/nonPublished

This project is a study of the wastescape - a network of waste - of Bhubaneswar and Cuttack in Odisha, India.  The study incorporates key locations, e.g. landfills, urban wastelands and waste warehouses; major actors in the formal and informal waste sector; and flows of waste through economic and social systems. Drawing from the studies, multiple interventions within the wastescape are proposed for improvement of the economic, ecologic and social situation. An important aspect of the project is the development of an approach for how to, as architects, work with big, complex, contingent networks; how to map and understand such a system; and how to determine where to intervene. To improve the existing wastescape, interventions must consciously and holistically address multiple scales; levels of formal-informal; and phases within the waste cycle. The study includes a vast amount of possible interventions. Some of the interventions are further detailed to show feasibility; impact on the wastescape; and synergies with other interventions within the wastescape. / Projektet “Wastescape of Bhubaneswar &amp; Cuttack” är en studie av ett nätverk av skräpflöden genom Bhubaneswar och Cuttack i Odisha, Indien. Studien inkorporerar viktiga platser, t.ex. deponier, urbana ödemarker och lokaler för skräphandel; stora aktörer i den formella och informella skräpsektorn; och flöden av skräp genom ekonomiska och sociala system. Utifrån dessa studier, ett flertal interventioner i “the wastescape” föreslås för att förbättra den ekonomiska, ekologiska och sociala situationen. En viktig aspekt av arbetet är utvecklingen av ett sätt att, som arkitekt, arbeta med storskaliga, komplexa och inter-beroende nätverk; hur sådana system kan kartläggas och förstås; samt hur det går att avgöra vart och hur interventioner passar in i “the wastescape”. För att förbättra “the wastescape”, interventioner måste medvetet och holistiskt adressera multipla skalor; nivåer av formell-informell; och faser i skräpets kretslopp. Studien innehåller ett stort nummer av möjliga interventioner. Några av dessa interventioner är ytterligare detaljerade för att visa på genomförbarhet; påverkan på “the wastescape”; och synergier gentemot andra interventioner i “the wastescape”.