- About
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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 31 to 40 of 62 (0.017 seconds)| 31 |
On the mechanisms governing plasma membrane organization - a STED-FCS investigationMachado Andrade, Débora 06 January 2014 (has links)
No description available.
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Development of Nanobodies to Image Synaptic Proteins in Super-Resolution MicroscopyMaidorn, Manuel 15 November 2017 (has links)
No description available.
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Molecular physiology of synaptic sound encoding at the first auditory synapseKrinner, Stefanie 22 November 2017 (has links)
No description available.
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Tomographic STED MicroscopyKrüger, Jennifer-Rose 22 February 2017 (has links)
No description available.
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Empirical Optimal Transport on Discrete Spaces: Limit Theorems, Distributional Bounds and ApplicationsTameling, Carla 11 December 2018 (has links)
No description available.
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Analyse von zehn synaptischen Proteinen in Ratten-Hirnschnitten mittels STED-Mikroskopie zeigt geringfügige Unterschiede zwischen Hirnarealen in Bezug auf Quantität und Lokalisation / Analysis of ten synaptic proteins in rat brain slices via STED microscopy shows slight differences between brain areas regarding quantity and localisationSchubert, Konstantin 31 December 1100 (has links)
No description available.
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Engineering of a NIR fluorescent protein for live-cell nanoscopyHabenstein, Florian 01 September 2021 (has links)
No description available.
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DEVELOPMENT OF A RAPID, CONTINUOUS 3D NANOPRINTING SYSTEM BASED ON MULTIPHOTON ABSORPTIONPaul Somers (13949883) 13 October 2022 (has links)
<p> 3D printing has established itself as a critical tool for manufacturing in all areas. It has evolved from a purely rapid prototyping technique into a feasible process for large-scale processing. A wide variety of 3D printing processes exist across an extreme range of size, from meters to nanometers. Much of the current technological advances come from pushing fabrication techniques to smaller and smaller scales. For 3D printing this has led to the rise of two-photon polymerization, a direct laser writing process with submicron structuring capabilities. Two-photon polymerization has proven its worth as a nanoscale 3D fabrication technique but is often considered slow and expensive, two undesirable qualities for high throughput manufacturing. Parallelization methods such as projection lithography are potential solutions to increasing the throughput capabilities of two-photon polymerization 3D printing. Additionally, the drive for further reducing the print size has inspired printing resolution enhancing strategies in two-photon polymerization printing by processes such as stimulated emission depletion (STED) and other STED-inspired pathways. This work will explore avenues for improving two-photon polymerization printing throughput and resolution.</p>
<p> First, a two-photon polymerization printing system is constructed with a secondary laser for controlling polymerization inhibition. Through a STED process, a 65 nm wide printed line feature was achieved. Alongside this, a characterization and verification methodology for choosing new photoinitiator molecules for similar inhibition lithography processes is presented. Through implementation of tests such as Z-scan, fluorescence depletion, ultrafast transient spectroscopy and UV-Vis absorption and fluorescence measurements a promising new photoinitiator with 5-factor improvement in printing efficiency is found. </p>
<p> Second, a projection lithography scheme is developed for rapid two-photon 3D printing. A digital micro-mirror device (DMD) is utilized for dynamic pattern generation and the effects of its dispersion properties are considered. Through a spatiotemporal focusing process, continuous 3D printing is achieved at vertical prints speeds of 1 mm s-1. Simulations performed representing this rapid printing process indicate a ~1 µm layer print feature size for large areas of exposure. Comparably, a printed vertical feature size of ~ 1 µm was achieved. Lateral feature sizes ~200 nm were also demonstrated in fabrication. A variety of complex 3D structures are printed for demonstration of the spatiotemporal focusing projection lithography process including millimeter scale objects with micrometer scale 3D features.</p>
<p> Finally, resolution enhancing strategies are implemented into the continuous, projection two-photon lithography technique. An investigation of the inhibition properties of a variety of photoinitiator systems for inhibiting polymerization achieved with low repetition rate laser exposure is presented. A planar polymerization inhibiting region is generated by creating a light sheet propagating perpendicularly to the projection printing plane. </p>
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Functional Insights into Novel Roles for Gap Junction Protein-Protein Interaction Networks in Liver and BrainFowler, Stephanie January 2017 (has links)
Gap junctions are highly-conserved communicating junctions composed of the connexin family of proteins. In addition to this channel function, gap junctions mediate adhesive contacts at extracellular domains, and are host to a variety of signalling metabolites at intracellular surfaces. In this thesis, I explore the emerging theme of the connexin interactome. Starting with a non-biased proteomic approach, I identified
endogenous protein interactions with the predominant liver and oligodendrocyte connexin, connexin32 (Cx32). Here, I identified novel mitochondrial protein interactions suggesting that Cx32 might localize to mitochondrial membranes, as has been reported for cardiac Cx43. Following proteomic quantitation of WT and Cx32 KO membranes, I determined that loss of Cx32 specifically induces mitochondrial protein expression. Bioenergetic analysis of isolated mitochondria then confirmed that oxygen consumption and rates of reactive oxygen species (ROS) generation were elevated in Cx32 KO mitochondria. In addition to novel intracellular connexin protein interactions, we hypothesized that connexin-mediated glial cell:cell interactions were responsible for mediating fate decisions in the complex hippocampal neurogenic niche environment. We identified that Cx32-mediated glial cell:cell interactions exert significant proliferative and fate specifying pressures on hippocampal progenitor cell types, wherein the loss of Cx32 enables improved histological and functional regeneration following excitotoxic injury. Together, this thesis identifies novel connexin-mediated signalling pathways that provide mechanistic insight into both intracellular and extracellular interactomedependent functions for Cx32, and outlines a potentially transformative avenue for brain repair.
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Fast STED Microscopy / Schnelle STED-MikroskopieLauterbach, Marcel 15 December 2009 (has links)
No description available.
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