Pyrimidine salvage pathways are essential to all cells. They provide a balance of RNA synthesis with the biosynthetic pathway in pyrimidine prototrophs and supply all the pyrimidine requirements in auxotrophs. While the pyrimidine biosynthetic pathway is found in almost all organisms and is nearly identical throughout nature, the salvage pathway often differs from species to species, with aspects of salvage seen in every organism. Thus significant taxonomic value may be ascribed to the salvage pathway. The pyrimidine salvage pathways were studied in 55 microorganisms. Nine different salvage motifs, grouped I-IX, were identified in this study based on the presence of different combinations of the following enzymes: cytidine deaminase (Cdd), cytosine deaminase (Cod), uridine phosphorylase (Udp), uracil phosphoribosyltransferase (Upp), uridine hydrolase (Udh), nucleoside hydrolase (Nuh), uridine/cytidine kinase (Udk), 5'-nucleotidase and CMP kinase (Cmk).

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Reuse of components as opposed to material recovery, recycling or disposal has been identified as one of the most efficient EOL strategies for products. The concept behind reuse is that some components and subassemblies have a design life that exceeds the life of the product itself. In order for reuse to be successfully implemented as an EOL strategy, a designer needs to incorporate into a product a philosophy of Design for Reuse (DfRe) at the early design stage. Reliable methods to assess the remaining life of used components based on a products usage life are also required. Furthermore, current industry practices and literature advocate that there is no methodology to decide which parameters need to be redesigned so as to change the life of a selected component to a desired level. The objective of this research is to develop a methodology to assess the reuse potential of product groups based on component failure mechanisms and their associated critical lifetime prediction design parameters. Utilising these clustered groups mathematical models were then developed to establish the useful life of the components for each clustered group. Finally, a means of equating useful life to design life was established and the relationship between, the failure mechanisms, critical lifetime prediction design parameters and design life were represented in graphical format. In order to achieve the proposed objective, Cluster analysis, in particular Group Technology (GT) and Hierarchical clustering were employed to group components with similar failure mechanisms. Following this, multiple linear regression was used to establish mathematical models based on condition monitoring data for each of the clustered groups and their related critical lifetime prediction design parameters. A sensitivity analysis was conducted using the mathematical models, in order to produce graphical relations between the useful life and design parameters of a product. The validity of the suggested methodology was tested on electric motors and a gearbox as both these components have demonstrated great reuse potential. The results demonstrate that the methodology can assist designers in estimating the design life and associated design parameters with great accuracy, and subsequently aiding in a stratagem for reuse.

This study compared the effects of fire severity and salvage logging on early successional vegetation in the mixedwood boreal forest upland of Saskatchewan. The effects of salvage logging on post-fire forest stands are poorly understood. Few studies have investigated the short-term effects of salvage logging on the regeneration of boreal plant species or the long-term impact on overall forest composition and diversity. This study examines salvage logged and wildfire leave stands across three burn severity classes (no burn, low/moderate burn, and high burn) over two time periods (1 year post-fire and 10 years post-fire). The results indicate that salvage logging has a significant impact on the early regeneration of burned mixedwood boreal plant communities with the effect still evident in forest stands ten years post-fire. Salvage logging has long-lasting residual effects on boreal forest plant community development. Salvage logging one year post-fire reduced the number, diversity, and abundance of species within each of the burn severities, creating a less abundant and simplified plant community. It was also shown that salvage logging one year post-fire tended to create more homogenous plant communities similar to those communities typical of areas of moderate burn severity, constraining the effects of burn severity and decreasing the range of the vegetation communities. These findings are less pronounced, but still evident, within salvage logged stands ten years post-fire as three regrowth cover types have developed, characterised by no disturbance, moderate disturbance either by fire or salvage logging, and severe disturbance. The convergence of plant community characteristics between burn severity classes across logging treatments suggests that the effects of salvage logging do not have long lasting effects within areas of high burn severity.

This study compared the effects of fire severity and salvage logging on early successional vegetation in the mixedwood boreal forest upland of Saskatchewan. The effects of salvage logging on post-fire forest stands are poorly understood. Few studies have investigated the short-term effects of salvage logging on the regeneration of boreal plant species or the long-term impact on overall forest composition and diversity. This study examines salvage logged and wildfire leave stands across three burn severity classes (no burn, low/moderate burn, and high burn) over two time periods (1 year post-fire and 10 years post-fire). The results indicate that salvage logging has a significant impact on the early regeneration of burned mixedwood boreal plant communities with the effect still evident in forest stands ten years post-fire. Salvage logging has long-lasting residual effects on boreal forest plant community development. Salvage logging one year post-fire reduced the number, diversity, and abundance of species within each of the burn severities, creating a less abundant and simplified plant community. It was also shown that salvage logging one year post-fire tended to create more homogenous plant communities similar to those communities typical of areas of moderate burn severity, constraining the effects of burn severity and decreasing the range of the vegetation communities. These findings are less pronounced, but still evident, within salvage logged stands ten years post-fire as three regrowth cover types have developed, characterised by no disturbance, moderate disturbance either by fire or salvage logging, and severe disturbance. The convergence of plant community characteristics between burn severity classes across logging treatments suggests that the effects of salvage logging do not have long lasting effects within areas of high burn severity.

Thesis (MA)--University of Montana, 2010. / Title from author supplied metadata. Includes bibliographical references.

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Hand dominance is the preferential use of one hand over the other for motor tasks. 90% of people are right-hand dominant, and the majority of injuries (acute and cumulative trauma) occur to the dominant limb, creating a double-impact injury whereby a person is left in a functional state of single-handedness and must rely on the less-dexterous, non-dominant hand. When loss of dominant hand function is permanent, a forced shift of dominance is termed injury-induced hand dominance transfer (I-IHDT). Military service members injured in combat operation may face I-IHDT following mutilating injuries (crush, avulsion, burn and blast wounds) that result in dominant limb amputation or limb salvage. Military occupational therapy practitioners utilize an intervention called Handwriting For Heroes to facilitate hand dominance transfer. This intervention trains the injured military member how to write again using the previously non-dominant hand. Efficacy and clinical effectiveness studies were needed to validate the use of this intervention. This dissertation contains three studies related to I-IHDT. One study measured handwriting performance in adults who previously (greater than 2 years ago) lost function of their dominant hands. Results verified that handwriting performance, when measured on two separate occasions (six-weeks apart) was similar (stable). A second study examined the efficacy of Handwriting For Heroes in non-impaired participants. Results demonstrated a positive effect on the variables that measured the written product: legibility, writing speed (letters-per-minute); as well as a positive effect on the variables that measured the writing process: kinematic and kinetic parameters. The final study examined the clinical effectiveness of Handwriting For Heroes in an injured military population. Results did not show as positive results as the efficacy study, despite similar compliance with the intervention. Specifically, non-impaired participants started with faster writing speeds in their non-dominant hands (higher letters-per-minute) and made more gains (wider ranges). The non-impaired participants also started with faster dexterity (betters scores on the Grooved Pegboard) but they made fewer gains than the injured service members (smaller ranges). Nevertheless, injured participants clearly made gains in all dependent variables thereby demonstrating clinical effectiveness of the intervention