Submitted by SBI Biblioteca Digital (sbi.bibliotecadigital@puc-campinas.edu.br) on 2018-04-10T16:53:27Z No. of bitstreams: 1 RAFAEL AUGUSTO SILVA FERREIRA.pdf: 10632319 bytes, checksum: a0858d381a6c0ac981ac41aa23454ed9 (MD5) / Made available in DSpace on 2018-04-10T16:53:27Z (GMT). No. of bitstreams: 1 RAFAEL AUGUSTO SILVA FERREIRA.pdf: 10632319 bytes, checksum: a0858d381a6c0ac981ac41aa23454ed9 (MD5) Previous issue date: 2017-12-12 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / This dissertation aims to understand the process of forming the urban network of a portion of Rio Pardo?s hinterland, related to the formation of the frontiers between the Captaincies and later Provinces of S?o Paulo and Minas Gerais, from the foundation of the parish of Nossa Senhora da Concei??o of Bom Sucesso do Rio Pardo, in the middle of the eighteenth century. The temporal clipping extends until the formation of the first two religious patrimonies dismembered of its territory: Espirito Santo do Rio do Peixe (1834) and S?o Jos? do Rio Pardo (1865), covered by the clipping from 1775 to 1865. However, to demonstrate the formation of this urban network, we retreat in time to the first decades of the eighteenth century demonstrating the formation of the Caminhos dos Goiases and its function in structuring a network of landings, settlements and parishes highlighting the land aspects of the different forms of occupation of the territory. For this objective, the method used was the work on primary sources (textual and historical cartography), spatialized in cartographic and georeferenced bases. Methodologically, the research is located in the disciplinary field of Historical Urbanization, using concepts of Geography and Urban Morphology as theoretical-methodological contributions to the understanding of the spatial dimension of primary sources. Through in-depth examination of arid primary documentation (Ma?os de Popula??o, Sesmarias e Registros Paroquiais de Terras) we can advance the understanding of the formation of this territory from the comparison of the results with the bibliography established for this research. By spatializing the urban network in formation, we reveal new nuances of the occupation of the Sert?o do Rio Pardo, giving life to the actors involved in this process, representatives of an agrarian oligarchy in the nineteenth century. / Essa disserta??o objetiva compreender o processo de forma??o da rede urbana de uma parcela do Sert?o do Rio Pardo, relacionada com a forma??o da fronteira entre as Capitanias e depois Prov?ncias de S?o Paulo e Minas Gerais, a partir da funda??o da freguesia de Nossa Senhora da Concei??o do Bom Sucesso do Rio Pardo, em meados do s?culo XVIII. O recorte temporal estende-se at? a forma??o dos dois primeiros patrim?nios religiosos desmembrados de seu territ?rio: Esp?rito Santo do Rio do Peixe (1834) e S?o Jos? do Rio Pardo (1865), abarcado pelo recorte de 1775 a 1865. Contudo, para demostrar a forma??o dessa rede urbana, recuamos no tempo at? as primeiras d?cadas do s?culo XVIII demonstrando a forma??o do Caminho dos Goiases e seu papel na estrutura??o de uma rede de pousos, povoados e freguesias destacando os aspectos fundi?rios das diferentes formas de ocupa??o do territ?rio. Para tanto, o m?todo empregado foi o trabalho sobre fontes prim?rias (textuais e cartografia hist?rica), espacializadas em bases cartogr?ficas e georreferenciadas. Metodologicamente, a pesquisa situa-se no campo disciplinar da Hist?rica da Urbaniza??o, utilizando conceitos da Geografia e da Morfologia Urbana como aportes te?rico-metodol?gicos para a compreens?o da dimens?o espacial das fontes prim?rias. Atrav?s do exame aprofundado de ?rida documenta??o prim?ria (Ma?os de Popula??o, Sesmarias e Registro Paroquial de Terras) podemos avan?ar na compreens?o da forma??o desse territ?rio a partir da confronta??o dos resultados com a bibliografia estabelecida para essa pesquisa. Ao espacializar a rede urbana em forma??o, revelamos novas nuances da ocupa??o do Sert?o do Rio Pardo, dando vida aos atores envolvidos nesse processo, representantes de uma oligarquia agr?ria atuante no s?culo XIX.

Obsessive–compulsive disorder (OCD) is a psychiatric condition that is characterized by two main symptom cohorts, namely recurrent inappropriate thoughts (obsessions) and seemingly purposeless repetitive motor actions (compulsions). In 70% of cases, the condition only re–sponds to chronic, but not sub–chronic, high dose treatment with the selective serotonin reup–take inhibitors (SSRIs), such as fluoxetine and escitalopram. This indicates a role for hyposero–tonergic functioning in the primary brain areas involved in OCD, namely the components of the cortico–striatal–thalamic–cortical (CSTC) circuit which include the prefrontal cortex, the basal ganglia, and the thalamus. A number of studies have demonstrated a lower serotonin trans–porter (SERT) availability in OCD patients compared with healthy controls, supporting the hy–pothesis of a hyposerotonergic state in OCD. The current study focuses on the validation of the deer mouse (Peromyscus maniculatus bairdii) model of OCD and builds on previous work done in our laboratory. Deer mice that are bred and housed in confinement naturally develop two main forms of stereotypical behaviour, namely vertical jumping and pattern running. Furthermore, these behaviours can be catego–rized into various levels of severity, namely high (HSB), low (LSB) and non–stereotypic (NSB) cohorts. The seemingly purposeless and repetitive nature of these behaviours mimics the com–pulsions that characterize human OCD and constitutes the basis for the face validity of the model. However, although these two forms of stereotypy seem equally repetitive and persis–tent, stereotypical pattern runners do not complete the required number of cage revolutions per 30 minutes compared to the amount of jumps executed by stereotypical vertical jumpers. As only one set of criteria for the appraisal of the different topographies of deer mouse stereotypy has been applied in previous studies, the matter of whether pattern runners do in fact generate stereotypical behaviour of the same persistent and severe nature as opposed to the behaviour expressed by vertical jumpers, is problematic. Therefore, the first objective of the current study was to develop a new classification system for the appraisal of the different forms of behavioural topographies of deer mice and subse–quently to evaluate whether pattern runners can indeed be categorized into non–, low– and high stereotypical cohorts. After an eight–week behavioural assessment period, deer mice express–ing the two different behavioural topographies could be classified into non–, low– and high stereotypical cohorts (NSB, LSB, and HSB respectively), applying different criteria for each be–havioural topography. Based on the weekly mean stereotypy count generated during three 30–minute intervals of highest stereotypical behaviour over the course of a 12–hour assessment period, HSB pattern runners were found to execute on average 296 cage revolutions per 30 minutes, while HSB vertical jumpers executed an average of 3063 jumps per 30 minutes. This discrepancy between the generated numbers of the different topographies of stereotypy indi–cates that one classification system for the appraisal of both behavioural topographies is indeed inappropriate, and hence requires re–evaluation and validation. As patients with OCD present with a lower central SERT availability compared to healthy controls, the second objective of the study was to determine whether a decrease in SERT den–sity could be demonstrated in HSB animals compared to the NSB and LSB controls. After eight weeks of behavioural assessment, animals were sacrificed and frontal–cortical and striatal SERT binding was performed. HSB deer mice presented with significantly lower striatal, but not fron–tal–cortical SERT availability compared to the [NSB/LSB] control animals (p = 0.0009). As far as it concerns a lower SERT availability in HSB animals and involvement of the CSTC circuitry, this data is congruent with that demonstrated in human OCD and strengthens the construct validity of the model. Although previous studies undertaken in our laboratory demonstrated that deer mouse stereotypy is attenuated after chronic (21–day) fluoxetine administration, OCD only responds to chronic, but not sub–chronic treatment with the SSRIs. The lack of response of deer mouse stereotypy to sub–chronic treatment has not been established and therefore the third study ob–jective was to assess the behavioural effects of sub–chronic (7–day) and chronic (28–day) SSRI treatment on expression of deer mouse stereotypy. Chronic, but not sub–chronic treatment with oral escitalopram (50 mg/kg/day) significantly increased the number of intervals over a 12–hour assessment period during which no stereotypical behaviour were expressed by HSB deer mice (p = 0.0241) and decreased the number of intervals during which high–stereotypical be–haviour were executed (p = 0.0054). Neither chronic, nor sub–chronic treatment significantly affected the behaviour of animals in the [NSB/LSB] cohort. The fact that the model demon–strates a lack of response to sub–chronic treatment with high dose SSRIs, positively contributes to the predictive validity of the deer mouse model of OCD. The results from the current study therefore strengthens the construct and predictive valid–ity of the deer mouse model of OCD and confirm the model’s status as a prominent animal model of OCD. Not only is hyposerotonergic functioning in the CSTC circuitry implicated in the behaviour of HSB animals, but the model also demonstrates selective response to chronic SSRI–treatment - two core characteristics of human OCD. / Thesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2012.

Obsessive–compulsive disorder (OCD) is a psychiatric condition that is characterized by two main symptom cohorts, namely recurrent inappropriate thoughts (obsessions) and seemingly purposeless repetitive motor actions (compulsions). In 70% of cases, the condition only re–sponds to chronic, but not sub–chronic, high dose treatment with the selective serotonin reup–take inhibitors (SSRIs), such as fluoxetine and escitalopram. This indicates a role for hyposero–tonergic functioning in the primary brain areas involved in OCD, namely the components of the cortico–striatal–thalamic–cortical (CSTC) circuit which include the prefrontal cortex, the basal ganglia, and the thalamus. A number of studies have demonstrated a lower serotonin trans–porter (SERT) availability in OCD patients compared with healthy controls, supporting the hy–pothesis of a hyposerotonergic state in OCD. The current study focuses on the validation of the deer mouse (Peromyscus maniculatus bairdii) model of OCD and builds on previous work done in our laboratory. Deer mice that are bred and housed in confinement naturally develop two main forms of stereotypical behaviour, namely vertical jumping and pattern running. Furthermore, these behaviours can be catego–rized into various levels of severity, namely high (HSB), low (LSB) and non–stereotypic (NSB) cohorts. The seemingly purposeless and repetitive nature of these behaviours mimics the com–pulsions that characterize human OCD and constitutes the basis for the face validity of the model. However, although these two forms of stereotypy seem equally repetitive and persis–tent, stereotypical pattern runners do not complete the required number of cage revolutions per 30 minutes compared to the amount of jumps executed by stereotypical vertical jumpers. As only one set of criteria for the appraisal of the different topographies of deer mouse stereotypy has been applied in previous studies, the matter of whether pattern runners do in fact generate stereotypical behaviour of the same persistent and severe nature as opposed to the behaviour expressed by vertical jumpers, is problematic. Therefore, the first objective of the current study was to develop a new classification system for the appraisal of the different forms of behavioural topographies of deer mice and subse–quently to evaluate whether pattern runners can indeed be categorized into non–, low– and high stereotypical cohorts. After an eight–week behavioural assessment period, deer mice express–ing the two different behavioural topographies could be classified into non–, low– and high stereotypical cohorts (NSB, LSB, and HSB respectively), applying different criteria for each be–havioural topography. Based on the weekly mean stereotypy count generated during three 30–minute intervals of highest stereotypical behaviour over the course of a 12–hour assessment period, HSB pattern runners were found to execute on average 296 cage revolutions per 30 minutes, while HSB vertical jumpers executed an average of 3063 jumps per 30 minutes. This discrepancy between the generated numbers of the different topographies of stereotypy indi–cates that one classification system for the appraisal of both behavioural topographies is indeed inappropriate, and hence requires re–evaluation and validation. As patients with OCD present with a lower central SERT availability compared to healthy controls, the second objective of the study was to determine whether a decrease in SERT den–sity could be demonstrated in HSB animals compared to the NSB and LSB controls. After eight weeks of behavioural assessment, animals were sacrificed and frontal–cortical and striatal SERT binding was performed. HSB deer mice presented with significantly lower striatal, but not fron–tal–cortical SERT availability compared to the [NSB/LSB] control animals (p = 0.0009). As far as it concerns a lower SERT availability in HSB animals and involvement of the CSTC circuitry, this data is congruent with that demonstrated in human OCD and strengthens the construct validity of the model. Although previous studies undertaken in our laboratory demonstrated that deer mouse stereotypy is attenuated after chronic (21–day) fluoxetine administration, OCD only responds to chronic, but not sub–chronic treatment with the SSRIs. The lack of response of deer mouse stereotypy to sub–chronic treatment has not been established and therefore the third study ob–jective was to assess the behavioural effects of sub–chronic (7–day) and chronic (28–day) SSRI treatment on expression of deer mouse stereotypy. Chronic, but not sub–chronic treatment with oral escitalopram (50 mg/kg/day) significantly increased the number of intervals over a 12–hour assessment period during which no stereotypical behaviour were expressed by HSB deer mice (p = 0.0241) and decreased the number of intervals during which high–stereotypical be–haviour were executed (p = 0.0054). Neither chronic, nor sub–chronic treatment significantly affected the behaviour of animals in the [NSB/LSB] cohort. The fact that the model demon–strates a lack of response to sub–chronic treatment with high dose SSRIs, positively contributes to the predictive validity of the deer mouse model of OCD. The results from the current study therefore strengthens the construct and predictive valid–ity of the deer mouse model of OCD and confirm the model’s status as a prominent animal model of OCD. Not only is hyposerotonergic functioning in the CSTC circuitry implicated in the behaviour of HSB animals, but the model also demonstrates selective response to chronic SSRI–treatment - two core characteristics of human OCD. / Thesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2012.

Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-07-26T19:01:24Z No. of bitstreams: 1 2015 - Thais Dias Luz Borges Santos.pdf: 1934931 bytes, checksum: 28e3fad5670af91cb1f6d74c40b37345 (MD5) / Made available in DSpace on 2017-07-26T19:01:24Z (GMT). No. of bitstreams: 1 2015 - Thais Dias Luz Borges Santos.pdf: 1934931 bytes, checksum: 28e3fad5670af91cb1f6d74c40b37345 (MD5) Previous issue date: 2015-03-31 / CNPq / This dissertation wants to contribute with the knowledge related to the way of life in the Sert?o of Northern Minas Gerais, bathed by the S?o Francisco River. It specifically this place we call Sert?o, their economic and social characteristics, as well as the strategies of its residents to stay at this place despite the difficulties of playing their way of life. Addresses also the question of the relevance of social programs in this process, notably the Family Grant Program. Uses elements of analysis of Jo?o Guimar?es Rosa literature related to this Sert?o of Rio S?o Francisco and the case of the Rural Sagrada Fam?lia Subdivision comes up to exemplify what permanence strategies, economic, cultural ties with the place and as forms of social recognition of the individuals in your group. / Esta disserta??o de mestrado visa contribuir para o conhecimento relacionado ao modo de vida no Sert?o do Norte de Minas Gerais banhado pelo Rio S?o Francisco. Trata especificamente desse lugar a que denominamos Sert?o, suas caracter?sticas econ?micas, sociais e culturais, bem como as estrat?gias de perman?ncia e reprodu??o social de seus moradores nesse lugar-sert?o, apesar das dificuldades de reprodu??o de seu modo de vida. Aborda, igualmente, a quest?o da relev?ncia dos programas sociais nesse processo, notadamente, o Programa Bolsa Fam?lia. Recorre a elementos de an?lise da literatura de Jo?o Guimar?es Rosa relacionado a esse Sert?o do Rio S?o Francisco e o caso do Bairro Rural Sagrada Fam?lia vem ? tona para exemplificar quais as estrat?gias de perman?ncia, as quest?es econ?micas, os v?nculos culturais com o lugar, bem como as formas de reconhecimento social dos indiv?duos em seu grupo.

[EN] ABSTRACT This work aims to compile and to study school buildings which were designed and constructed in Valencia and its province, between the year 1920 and 1939. The period begins in 1920 when the Oficina Técnica de Construcción de Escuelas was founded, given that this measure -together with others of the same moment- supposed a very important change in the mechanisms that the State arranged for the construction of school buildings. The temporary period of this study finishes in 1939, moment in which Spanish II Republic falls. The present work raises five thematic core issues (nudos temáticos) able to establish a framework capable to centering the context from where the school production was developed The second part of this work consists on the specific study of all the schools compiled in Valencia, by means of a systematic analysis, which uses defined variables distilled from the above mentioned core issues. This analysis will allow us to explain some circumstances in a relatively trustworthy way, that is to say we will be able to extract founded conclusions. To be able to study the school buildings in Valencia and to understand the school buildings production in our environment, there has been compiled a great quantity of information about the school buildings designed and constructed, gathered in four annexes in this work. / [ES] RESUMEN Este estudio se plantea como objetivo la recopilación y estudio de los grupos escolares proyectados y construidos en Valencia y su provincia, entre los años 1920 y 1939. El ámbito temporal se inicia en 1920 con la creación de la Oficina Técnica de Construcción de Escuelas, puesto que esta medida junto con otras del mismo momento, suponen un cambio muy importante en los mecanismos que el Estado dispone para la construcción de edificios escolares. El periodo temporal de estudio finaliza en 1939, momento en que cae la II República El estudio plantea cinco nudos temáticos que establecen una trama capaz de centrar el contexto sobre el que se desarrolló la producción escolar. La segunda parte de este trabajo consiste en el estudio específico de todas las escuelas recopiladas en Valencia, mediante un análisis sistemático, destilado de los nudos temáticos a través de las variables definidas. El análisis nos permitirá explicar algunas circunstancias de una manera relativamente fiable, es decir extraeremos conclusiones fundadas. Para poder realizar el estudio de las escuelas en Valencia y entender la producción escolar en nuestro entorno, se ha recopilado una gran cantidad de información sobre los edificios escolares proyectados y construidos, recogida en los cuatro anexos de este trabajo. / [CA] RESUM Aquest treball es planteja com a objectiu la recopilació i estudi dels grups escolars projectats i construïts a València i la seua província, entre els anys 1920 i 1939. El període temporal s'inicia en 1920 amb la creació de la Oficina Técnica de Construcción de Escuelas, ja que aquesta mesura juntament amb unes altres del mateix moment, suposen un canvi molt important en els mecanismes que l'Estat disposa per a la construcció d'edificis escolars. El estudi finalitza en 1939, moment en què cau la II República. El treball planteja cinc nusos temàtics que estableixen una trama capaç de centrar el context sobre el qual es va desenvolupar la producció escolar. La segona part d'aquest treball consisteix en l'estudi específic de totes les escoles recopilades a València, mitjançant una anàlisi sistemàtica, destil¿lat dels nusos temàtics a través de les variables definides. L'anàlisi ens permetrà explicar algunes circumstàncies d'una manera relativament fiable, és a dir extraurem conclusions fonamentades. Per a poder realitzar l'estudi de les escoles a València i entendre la producció escolar en el nostre entorn, s'ha recopilat una gran quantitat d'informació sobre els edificis escolars projectats i construïts, recollida en els quatre annexos d'aquest treball. / Gómez Alfonso, CJ. (2016). CONSTRUCCIONES ESCOLARES EN VALENCIA. 1920-1939 [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/62170