Indiana University-Purdue University Indianapolis (IUPUI) / Colorectal cancer is the third most common type of cancer and the third most common cause of cancer-related mortality. There are three types of treatment available to patients, either individually or in combination. Treatments are radiation, chemotherapy, and surgery. In a Phase II clinical trial at IUSM, a multimodality approach was chosen. The patients with locally advanced rectal cancer received preoperative treatment with capecitabine and irinotecan (CPT-11) combination followed by chemoradiation with capecitabine and finally surgery to improve response and decrease local recurrence. Irinotecan and Capecitabine are both prodrugs activated in vivo to SN-38 and 5-FU, respectively. Identification of the molecular markers for 5-FU and Irinotecan efficacy and toxicity is important for the development of more efficient and less toxic treatment strategies for patients with colorectal cancer. The goal of this study was to determine the expression levels of the genes involved in activation and metabolism of capecitabine and irinotecan in pre and post treatment specimens from these patients. The genes quantitated by real-time PCR were carboxylesterase 1 and 2 (CES1 and CES2), thymidylate synthase (TS), β-glucoronidase (β-GUS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD) and topoisomerase I (Topo I). The UGT1A1*28 polymorphism in UDP glucuronosyltransferase 1 is associated with SN-38 toxicity. Therefore, the UGT1A1*28 polymorphism status in patients was determined by PCR-sequencing. Correlative analysis of gene expression and UGT1A1*28 mutation with clinical outcome in this Phase II study was completed.

No description available.

Shape memory alloys (SMAs) operating as solid-state actuators pose economic and environmental benefits to the aerospace industry due to their lightweight, compact design, which provides potential for reducing fuel emissions and overall operating cost in aeronautical equipment. Despite wide applicability, the implementation of SMA technology into aerospace-related actuator applications is hindered by harsh environmental conditions, which necessitate extremely high or low transformation temperatures. The versatility of the NiTi-based SMA system shows potential for meeting these demanding material constraints, since transformation temperatures in NiTi can be significantly raised or lowered with ternary alloying elements and/or Ni:Ti ratio adjustments. In this thesis, the expansive transformation capabilities of the NiTi-based SMA system are demonstrated with a low and high-temperature NiTi-based SMA; each encompassing different stages of the SMA development process. First, exploratory work on the NiTiSn SMA system is presented. The viability of NiTiSn alloys as low-temperature SMAs (LTSMAs) was investigated over the course of five alloy heats. The site preference of Sn in near-equiatomic NiTi was examined along with the effects of solution annealing, Ni:Ti ratio adjustments, and precipitation strengthening on the thermomechanical properties of NiTiSn LTSMAs. Second, the thermomechanical processability of NiTiHf high-temperature SMA (HTSMA) wires is presented. The evolution of various microstructural features (grain size reduction, oxide growth, and nano-precipitation) were observed at incremental stages of the hot rolling process and linked to the thermal and mechanical responses of respective HTSMA rods/wires. This work was carried out in an effort to optimize the rolling/drawing process for NiTiHf HTSMAs.

Une nouvelle stratégie pour la réalisation de matériaux d'électrodes, les NCIMs (Nano-Crystallite-Insertion-Materials) a été proposée. Les matériaux LixTiO2, LixSnO2 et LixWO3, ont été préparés sous forme de poudre en utilisant une voie originale (voie polymère). Ils présentent une texture nanocristalline, ce qui permet de disposer d'une surface électrochimiquement active importante sur laquelle les ions Li+ peuvent se greffer reversiblement.

科学研究費補助金 研究種目:試験研究 課題番号:61850069 研究代表者:日比野 倫夫 研究期間:1986-1987年度

No description available.

The IoT refers to the idea of internetworking physical devices, vehicles, buildings, and any other item embedded with the appropriate electronics, software, sensors, actuators, and network connectivity to allows them to interchange data and to provide highly effective new services. In this thesis we focus on the communications issues of the IoT in relation to mobility and we provide different solutions to alleviate the impact of these potential problems and to guarantee the information delivery in mobile scenarios. Our reference context is a Smart City where various mobile devices collaboratively participate, periodically sending information from their sensors. We assume that these services are located in platforms based in cloud infrastructures where the information is protected through the use of virtualisation ensuring their security and privacy. This thesis is structured into seven chapters. We first detail our objectives and identify the current problems we intend to address. Next, we provide a thorough review of the state of the art of all the areas involved in our work, highlighting how we improved the existing solutions with our research. The overall approach of the solutions we propose in this thesis use prototypes that encompasses and integrates different technologies and standards in a small infrastructure, using real devices in real scenarios with two of the most commonly used networks around the world: WiFi and 802.15.4 to efficiently solve the problems we originally identified. We focussed on protocols based on a producer/consumer paradigm, namely AMQP and particularly MQTT. We observed the behaviour of these protocols using in lab experiments and in external environments, using a mesh wireless network as the backbone network. Various issues raised by mobility were taken into consideration, and thus, we repeated the tests with different messages sizes and different inter-message periodicity, in order to model different possible applications. We also present a model for dimensioning the number of sources for mobile nodes and calculating the number of buffers required in the mobile node as a function of the number of sources and the size of the messages. We included a mechanism for avoiding data loss based on intermediate buffering adapted to the MQTT protocol that, in conjunction with the use of an alternative to the Network Manager in certain contexts, improves the connection establishment for wireless mobile clients. We also performed a detailed study of the jitter behaviour of a mobile node when transmitting messages with this proposal while moving through a real outdoor scenario. To emulate simple IoT networks we used the Cooja simulator to study and determine the effects on the probability of delivering messages when both publishers and subscribers were added to different scenarios. Finally we present an approach that combines the MQTT protocol with DTN which we specifically designed for constrained environments and guarantees that important information will never be lost. The advantage of our proposed solutions is that they make an IoT system more resilient to changes in the point of attachment of the mobile devices in an IoT network without requiring IoT application & service developers to explicitly consider this issue. Moreover, our solutions do not require additional support from the network through protocols such as MobileIP or LISP. We close the thesis by providing some conclusions, and identifying future lines of work which we unable to address here. / Internet de las cosas (IoT) se refiere a la idea de interconectar sensores, actuadores, dispositivos físicos, vehículos, edificios y cualquier elemento dotado de la electrónica, así como del software y de la conectividad de red que los hace capaces de intercambiar datos para proporcionar servicios altamente efectivos. En esta tesis nos centramos en temas relacionados con la comunicación de sistemas IoT, específicamente en situaciones de movilidad y en los problemas que esto conlleva. Con este fin ofrecemos diferentes soluciones que alivian su impacto y garantizan la entrega de información en estas situaciones. El contexto de referencia es una ciudad inteligente donde varios dispositivos móviles participan de forma colaborativa enviando periódicamente información desde sus sensores hacia servicios ubicados en plataformas en la nube (cloud computing) donde mediante el uso de virtualización, la información está protegida garantizando su seguridad y privacidad. Las soluciones propuestas en esta tesis se enfocan en probar sobre una pequeña infraestructura un prototipo que abarca e integra diferentes tecnologías y estándares para resolver eficientemente los problemas previamente identificados. Hemos enfocado nuestro esfuerzo en el uso de dispositivos sobre escenarios reales con dos de las redes más extendidas en todo el mundo: WiFi y enlaces 802.15.4. Nos enfocamos en protocolos que ofrecen el paradigma productor/consumidor como el protocolo avanzado de colas de mensajes (AMQP) y particularmente el protocolo de transporte de mensajes telemétricos (MQTT), observamos su comportamiento a través de experimentos en laboratorio y en pruebas al aire libre, repitiendo las pruebas con diferentes tamaños de mensajes y diferente periodicidad entre mensajes. Para modelar las diferentes posibles aplicaciones de la propuesta, se tomaron en consideración varias cuestiones planteadas por la movilidad, resultando en un modelo para dimensionar eficientemente el número de fuentes para un nodo móvil y para calcular el tamaño requerido del buffer, en función del número de fuentes y del tamaño de los mensajes. Proponemos un mecanismo adaptado al protocolo MQTT que evita la pérdida de datos en clientes móviles, basado en un buffer intermedio entre la producción y publicación de mensajes que, en conjunto con el uso de una alternativa al gestor de conexiones inalámbricas "Network Manager", en ciertos contextos mejora el establecimiento de las conexiones. Para la evaluación de esta propuesta se presenta un estudio detallado de un nodo móvil que se mueve en un escenario real al aire libre, donde estudiamos el comportamiento del jitter y la transmisión de mensajes. Además, hemos utilizado emuladores de redes IoT para estudiar y determinar los efectos sobre la probabilidad de entrega de mensajes, cuando se agregan tanto publicadores como suscriptores a diferentes escenarios. Finalmente, se presenta una solución totalmente orientada a entornos con dispositivos de recursos limitados que combina los protocolos MQTT con redes tolerantes a retardos (DTN) para garantizar la entrega de información. La ventaja de las soluciones que proponemos reside en el hecho de que los sistemas IoT se vuelven resilientes a la movilidad y a los cambios de punto de acceso, permitiendo así que los desarrolladores creen fácilmente aplicaciones y servicios IoT evitando considerar estos problema. Otra ventaja de nuestras soluciones es que no necesitan soporte adicional de la red como sucede con protocolos como MobileIP o el protocolo que separa el identificador del localizador (LISP). Se destaca cómo hemos mejorado las soluciones existentes hasta el momento de la escritura de esta disertación, y se identifican futuras líneas de actuación que no han sido contempladas. / Internet de les coses (IoT) es refereix a la idea d'interconnectar sensors, actuadors, dispositius físics, vehicles, edificis i qualsevol element dotat de l'electrònica, així com del programari i de la connectivitat de xarxa que els fa capaces d'intercanviar dades per proporcionar serveis altament efectius. En aquesta tesi ens centrem en temes relacionats amb la comunicació de sistemes IoT, específicament en situacions de mobilitat i en els problemes que això comporta. A aquest efecte oferim diferents solucions que alleugeren el seu impacte i garanteixen el lliurament d'informació en aquestes situacions. El context de referència és una ciutat intel·ligent on diversos dispositius mòbils participen de forma col·laborativa enviant periòdicament informació des dels seus sensors cap a serveis situats en plataformes en el núvol (cloud computing) on mitjançant l'ús de virtualització, la informació està protegida garantint la seva seguretat i privadesa. Les solucions proposades en aquesta tesi s'enfoquen a provar sobre una xicoteta infraestructura un prototip que abasta i integra diferents tecnologies i estàndards per a resoldre eficientment els problemes prèviament identificats. Hem enfocat el nostre esforç en l'ús de dispositius sobre escenaris reals amb dos de les xarxes més esteses a tot el món: WiFi i enllaços 802.15.4. Ens enfoquem en protocols que ofereixen el paradigma productor/consumidor com el protocol avançat de cues de missatges (AMQP) i particularment el protocol de transport de missatges telemètrics (MQTT), observem el seu comportament a través d'experiments en laboratori i en proves a l'aire lliure, repetint les proves amb diferents grandàries de missatges i diferent periodicitat entre missatges. Per a modelar les diferents possibles aplicacions de la proposta, es van prendre en consideració diverses qüestions plantejades per la mobilitat, resultant en un model per a dimensionar eficientment el nombre de fonts per a un node mòbil i per a calcular la grandària requerida del buffer, en funció del nombre de fonts i de la grandària dels missatges. Proposem un mecanisme adaptat al protocol MQTT que evita la pèrdua de dades per a clients mòbils, basat en un buffer intermedi entre la producció i publicació de missatges que en conjunt amb l'ús d'una alternativa al gestor de connexions sense fils "Network Manager'', en certs contextos millora l'establiment de les connexions. Per a l'avaluació d'aquesta proposta es presenta un estudi detallat d'un node mòbil que es mou en un escenari real a l'aire lliure, on estudiem el comportament del jitter i la transmissió de missatges. A més, hem utilitzat emuladors de xarxes IoT per a estudiar i determinar els efectes sobre la probabilitat de lliurament de missatges, quan s'agreguen tant publicadors com subscriptors a diferents escenaris. Finalment, es presenta una solució totalment orientada a entorns amb dispositius de recursos limitats que combina els protocols MQTT amb xarxes tolerants a retards (DTN) per a garantir el lliurament d'informació. L'avantatge de les solucions que proposem resideix en el fet que els sistemes IoT es tornen resilients a la mobilitat i als canvis de punt d'accés, permetent així que els desenvolupadors creuen fàcilment aplicacions i serveis IoT evitant considerar aquests problema. Un altre avantatge de les nostres solucions és que no necessiten suport addicional de la xarxa com succeeix amb protocols com MobileIP o el protocol que separa l'identificador del localitzador (LISP). Es destaca com hem millorat les solucions existents fins al moment de l'escriptura d'aquesta dissertació, i s'identifican futures línies d'actuació que no han sigut contemplades. / Luzuriaga Quichimbo, JE. (2017). Managing Mobility for Distributed Smart Cities Services [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/84744

[pt] A Marinha do Brasil presta o seu apoio logístico em cenários, por vezes, inóspitos, a partir de uma rede logística que, na sua origem, formou-se com base em conceitos e necessidades operativas, podendo também conviver com ineficiências e acomodações pela falta de concorrentes. Em 2008, fruto de uma decisão política e estratégica, dentro do contexto das relações internacionais no qual o Brasil está inserido, iniciou-se o processo de aquisição de novos submarinos convencionais (S-BR) e o apoio à elaboração do projeto e construção de um submarino nuclear (SN-BR), que se constitui no mais complexo e significativo projeto conduzido pela Marinha nos últimos tempos. Não obstante a importância desse projeto, estaria a cadeia de suprimento de sobressalentes (CSS) da Marinha pronta para prestar o devido apoio logístico ao novo meio operativo? O atual desenho de rede da Marinha atende as necessidades deste apoio? Qual o atual estágio de desenvolvimento da CSS e como promover uma maior integração dessa rede, com vistas a um melhor gerenciamento? Em meio a poucos estudos sobre o assunto e uma significativa carência de informações, o presente trabalho apresenta respostas a essas e outras questões correlatas, que se mostram cada vez mais prementes, diante da previsão de início dos testes de mar do primeiro submarino já 2017. Indubitavelmente, a Marinha é reconhecida pela sua grande capacidade de organização e pelo comprometimento de seus profissionais, mas serão necessárias algumas ações a mais para vencer este enorme desafio logístico. / [en] The Brazilian Navy provides logistics support in areas, sometimes inhospitable, using a logistics network that, in its origin, was formed on the basis of military concepts and needs, and, sometimes coexisting with inefficiencies and without competitors. In 2008, the result of a political and strategic decision, in a context of international relations in which Brazil is inserted, began the process of acquiring new Brazilian hunter-killer Submarine (SSK) and the support for design and construction of the Brazilian Nuclear-Powered Attack Submarine (SSN), which constitutes the most complex and significant Navy project in recent times. Despite the importance of this project, the Navy spare parts supply chain (SSC) would able to provide the appropriate logistics support for the new submarines? The current Navy network design meets the needs of this support? What is the current development stage of SSC and how to upgrade the integration of this network for improve the SCM? Few studies about this subject exist and a significant lack of information, therefore, this presents answers to these and other related issues that are becoming increasingly pressing, given the early prediction of sea tests of the first SSK submarine in 2017. Undoubtedly, the Navy is known to be a great organizational due to her organizational skills and the commitment of its seamen, but this project will require a little more to overcome this huge logistical challenge.

科学研究費補助金 研究種目:試験研究 課題番号:63850078 研究代表者:日比野 倫夫 研究期間:1988-1989年度

科学研究費補助金 研究種目:一般研究(A) 課題番号:62420021 研究代表者:日比野 倫夫 研究期間:1987-1989年度