大动脉闭塞性疾病是脑卒中常见病因，包括颅内外狭窄性血管病变。本研究旨在分析卒中患者颅内外大动脉狭窄斑块的血管造影特征以及相关治疗方案。进一步了解颅内斑块的形态学变化，以及颅外大动脉狭窄的血管造影特征和侧枝循环状态，对于研究其发病机制及临床治疗有指导意义。 / 研究目的 / 研究1：通过前瞻性纵向研究，利用三维旋转血管造影（3D-RA），探讨颅内斑块形态学变化。 / 研究2：通过病例对照研究分析症状性放射性闭塞性血管病变(ORV)的血管造影特征及侧枝循环状态。 / 研究3：通过病例对照研究分析放射性血管病变（RIV）患者进行颈动脉支架治疗（CAS）后血管造影特征及临床预后。 / 研究方法 / 研究1：24例颅内重度狭窄(>70%)的急性缺血性卒中患者，严格控制其危险因素，应用3D-RA研究其发病时及12个月后颅内斑块的形态学变化。 / 研究2：分析96例ORV以及115例非放疗所致严重颈动脉狭窄（>70%）的缺血性卒中患者血管造影特点，比较其病变分布，形态学改变及侧枝循环状态。 / 研究3：比较63例ORV以及87例动脉粥样硬化性颈动脉狭窄的卒中患者的血管造影及预后。主要终点事件包括短暂性脑缺血发作，卒中和死亡。次要终点事件为24个月时支架内再狭窄。 / 结果 / 研究1：颅内动脉粥样硬化性斑块的厚长比不能预测其稳定性。12个月的血管造影提示：13例（50%)斑块逆转；10例（38.5%)斑块无明显变化；3例（11.5%)斑块进展。 / 研究2：ORV更多累及颈总动脉，多见双侧颈动脉受累（54% vs 22%)或出现闭塞（30% vs 9%），常见椎动脉受累(28% vs 14%)（均P<0.05）。ORV常见代偿性软脑膜动脉、前后交通动脉开放，及逆向眼动脉血流。 / 研究3：两组间围手术期并发症，长期生存率和卒中复发率无统计学差异。 / 结论 / 研究1：3D-RA可评价颅内斑块形态学变化；颅内光滑斑块亦可为易损斑块。严格控制危险因素可能逆转斑块。 / 研究2： ORV患者更多见颈动脉及椎基底动脉狭窄-闭塞性病变，并伴随侧枝循环开放。侧枝循环代偿功能减退可能诱导ORV患者发生卒中。 / 研究3：RIV患者与对照组相比，CAS的耐受性和临床预后无明显差异。 / Large artery occlusive disease, encompassing stenosis in intracranial and extracranial vasculature, is the most common stroke subtype worldwide. In this thesis, we aimed to investigate angiographic plaque morphology and treatments in stroke patients attributed to intracranial and/or extracranial stenosis. A better understanding of intracranial plaque morphology, angiographic characteristics and collateral circulations of extracranial occlusive vasculopathy may help clarify pathogenesis and formulate treatment. / Objectives / Study 1: In this prospective longitudinal study, we investigated the intracranial plaque morphology of acute stroke patients by three-dimensional rotational angiography (3D-RA). / Study 2: We aimed to delineate the angiographic attributes and collateral circulations in symptomatic occlusive radiation vasculopathy (ORV) patients by a case-controlled study. / Study 3: We investigated the angiographic and clinical outcome of carotid artery stenting (CAS) in stroke patients attributed to ORV. / Methods / Study 1: Twenty-four patients with acute strokes attributed to a >70% intracranial stenosis were recruited to undergo 3D-RA at baseline and in 12 months after an intensive control of atherosclerotic risks. We described the degree of stenosis and morphology that might be associated with plaque vulnerability. / Study 2: We performed digital subtraction angiograms (DSA) in 96 patients who had first-ever ischemic strokes attributed to ORV, and 115 referent patients who had no radiotherapy (RT) but symptomatic high-grade (>70%) atherosclerotic carotid stenoses. We compared the lesions’ distribution, morphology, and the resultant alteration of collateral flows in both patient groups. / Study 3: We compared the angiographic and clinical outcome of CAS in 63 symtomatic ORV patients and 87 patients with spontaneous atheromatous carotid stenoses. Primary end-points were transient ischemic attack, stroke and death of all causes. Secondary end-point was instent restenosis in 24 months. / Results / Study 1: Inracranial atherosclerotic plaque is a dynamic lesion.Thickness-to-length ratio may not indicate plaque vulnerability. In 12-month angiogram, 13 patients (50%) had plaque regression, 10 (38.5%) had static plaque, and 3 (11.5%) had plaque progression. / Study 2: Compared with spontaneous atheromatous carotid disease, ORV lesions diffusely involved common carotid artery, and were more frequently bilateral (54% vs 22%), associated with complete occlusion in one or both carotid arteries (30% vs 9%), vertebral artery steno-occlusions (27% vs 14%) (all p<0.05). ORV patients showed more established collateral circulations through leptomeningeal arteries, anterior communicating artery, posterior communicating artery and retrograde flow in ophthalmic artery. / Study 3: We found no significant differences in the frequency of periprocedural complications, the rates of patient survival and stroke recurrence between ORV and control groups. / Conclusions / Study 1: Evaluation of intracranial plaque morphology is feasible with 3D-RA. Smooth plaques might also be vulnerable in intracranial vasculature. Intensive risk factor control may halt progression of intracranial plaques. / Study 2: ORV patients had more steno-occlusions over carotid and vertebral arteries amid mature collateral circulations at initial stroke presentation. Decompensation of collateral flows may precipitate stroke in ORV. / Study 3: The durability and clinical outcome of CAS in ORV patients were comparable to those in patients with spontaneous atherosclerotic carotid stenosis. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Zou, Xinying. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2012. / Includes bibliographical references (leaves 101-119). / Abstract also in Chinese. / ABSTRACT --- p.i / 摘要 --- p.vi / DECLARATION OF ORIGINALITY --- p.ix / ACKNOWLEDGEMENTS --- p.x / PUBLICATIONS AND PRESENTATIONS --- p.xii / LIST OF ABBREVIATIONS --- p.xiv / LIST OF TABLES --- p.xvii / LIST OF FIGURES --- p.xviii / TABLE OF CONTENTS --- p.xx / Chapter CHAPTER 1 --- INTRODUCTION AND LITERATURE REVIEW --- p.1 / Chapter 1.1 --- An overview of large artery occlusive disease in ischemic stroke --- p.1 / Chapter 1.2 --- Vulnerable plaque and plaque morphology in ischemic stroke --- p.3 / Chapter 1.2.1 --- Definition of vulnerable plaque and plaque morphology --- p.4 / Chapter 1.2.2 --- Imaging of vulnerable plaques --- p.5 / Chapter 1.2.3 --- Factors affecting plaque stability or arterial luminal narrowing --- p.7 / Chapter 1.2.3.1 --- Stenosis severity --- p.7 / Chapter 1.2.3.2 --- Thickness and length of plaque --- p.8 / Chapter 1.2.3.3 --- Mechanical stress, shear stress and hemodynamics on plaque stability --- p.9 / Chapter 1.2.3.4 --- Plaque eccentricity --- p.10 / Chapter 1.2.3.5 --- Plaque surface morphology --- p.11 / Chapter 1.2.4 --- Morphological characteristics of symptomatic plaque --- p.11 / Chapter 1.2.4.1 --- Carotid plaque morphology --- p.11 / Chapter 1.2.4.2 --- Intracranial plaque morphology --- p.12 / Chapter 1.2.5 --- Treatment of vulnerable intracranial stenosis --- p.12 / Chapter 1.3 --- Occlusive radiation vasculopathy (ORV) --- p.13 / Chapter 1.3.1 --- Epidemiology of ORV --- p.13 / Chapter 1.3.2 --- Pathogenesis and Pathophysiology of ORV --- p.14 / Chapter 1.3.3 --- Imaging and angiographic characteristics of ORV --- p.16 / Chapter 1.3.4 --- Collateralization in ORV --- p.18 / Chapter 1.3.5 --- Angioplasty and stenting for ORV --- p.19 / Chapter CHAPTER 2 --- OBJECTIVES --- p.22 / Chapter CHAPTER 3 --- RECRUITMENT OF STUDY PARTICIPANTS --- p.24 / Chapter CHAPTER 4 --- REGRESSION OF SYMPTOMATIC INTRACRANIAL PLAQUE BY INTENSIVE RISK FACTOR CONTROL: A LONGITUDIANL STUDY ON PLAQUE MORPHOLOGY BY 3D-ROTATIONAL ANGIOGRAPHY --- p.28 / Chapter 4.1. --- Background and objectives --- p.28 / Chapter 4.2 --- Methods --- p.32 / Chapter 4.2.1 --- Participants --- p.32 / Chapter 4.2.2 --- Risk factors and intensive control --- p.33 / Chapter 4.2.3 --- Evaluation of intracranial stenosis --- p.33 / Chapter 4.2.3.1 --- DSA and 3D-RA protocol --- p.33 / Chapter 4.2.3.2 --- Severity of stenosis --- p.34 / Chapter 4.2.3.3 --- Analysis of morphological characteristics on 3D-RA --- p.34 / Chapter 4.2.3.4 --- Plaque regression --- p.35 / Chapter 4.2.4 --- Statistical analysis --- p.36 / Chapter 4.3 --- Results --- p.36 / Chapter 4.4 --- Discussion --- p.54 / Chapter CHAPTER 5 --- ANGIOGRAPHY DISTINCTIONS AND COLLATERALIZATION IN SYMPTOMATIC CRANIO-CERVICAL OCCLUSIVE RADIATION VASCULOPATHY: A CASE-REFERENT STUDY --- p.58 / Chapter 5.1 --- Background and objectives --- p.58 / Chapter 5.2 --- Methods --- p.59 / Chapter 5.2.1 --- ORV and referent patients --- p.60 / Chapter 5.2.2 --- Evaluation of vascular lesions and collateral status --- p.61 / Chapter 5.2.3 --- Statistical analysis --- p.64 / Chapter 5.3 --- Results --- p.64 / Chapter 5.4 --- Discussion --- p.81 / Chapter CHAPTER 6 --- SAFETY AND CLINICAL OUTCOME OF CAROTID ARTERY STENTING IN STROKE PATIENTS WITH OCCLUSIVE RADIATION VASCULOPATHY --- p.86 / Chapter 6.1. --- Background and objectives --- p.86 / Chapter 6.2 --- Methods --- p.87 / Chapter 6.2.1 --- Participants --- p.87 / Chapter 6.2.2 --- Baseline clinical assessment --- p.87 / Chapter 6.2.3 --- Carotid artery stenting (CAS) --- p.88 / Chapter 6.2.4 --- Follow-up and end-points --- p.89 / Chapter 6.2.5 --- Statistical analysis --- p.89 / Chapter 6.3. --- Results --- p.90 / Chapter 6.4. --- Discussion --- p.96 / Chapter CHAPTER 7 --- CONCLUSIONS --- p.98 / REFERENCES --- p.101

Lu, Jinyan. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 75-86). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese; some appendixes in Chinese.

Introdução: Muitos pacientes acometidos por acidente vascular cerebral (AVC) sofrem sequelas motoras e cognitivas permanentes, as quais promovem maior risco de quedas que constitui a complicação mais frequente nesse grupo de pacientes. Dessa forma, a identificação dos fatores que predispõem a quedas em pacientes após AVC se faz necessária para a elaboração de estratégias de prevenção dos fatores modificáveis a fim de evitar suas consequências, melhorar prognóstico funcional, expectativa e qualidade de vida desta enorme população. Objetivos: O objetivo primário deste estudo foi analisar os fatores preditivos de quedas em uma amostra de pacientes acometidos por AVC atendidos em um hospital de referência de Ribeirão Preto e incluídos no Registro de AVC de Ribeirão Preto (REAVER), no período de seis meses após o AVC. Os objetivos secundários foram analisar a frequência relativa de quedas nos 6 primeiro meses após o AVC; analisar as características da ocorrência de quedas ocorridas nos 6 primeiros meses após o AVC; analisar as características clínicas, funcionais e processos de reabilitação em pacientes caidores e não-caidores da amostra estudada. Metodologia: Foram incluídos todos os pacientes com diagnóstico de AVC isquêmico ou hemorrágico internados na Unidade de Emergência do HCFMRP-USP no período de setembro de 2015 a março de 2016 com Escala de Rankin modificado prévia menor que 1. De forma retrospectiva, foram coletadas variáveis do REAVER referentes aos dados pessoais, doenças associadas, déficits neurológicos, funcionalidade, estado cognitivo e reabilitação. De forma prospectiva após 6 meses do AVC, coletamos por meio de contato telefônico informações sobre uso de medicações que afetam o sistema nervoso central, presença de parkinsonismo, demência após AVC, sintomas de tontura e desequilíbrio, déficit visual, além da ocorrência, número, local e circunstâncias em que as quedas ocorreram neste período. Resultados: Foram investigados 304 e incluídos 129 pacientes no estudo, com uma prevalência de 31 quedas que ocorreram em 24% da amostra. Os locais mais frequentes de queda foram nas proximidades do quarto do paciente no período de maior atividade (manhã e tarde). A maior parte das quedas ocorreram entre 3 a 6 meses após o evento. As principais atividades envolvidas foram a deambulação e transferências. Encontramos associação positiva entre ocorrência de quedas e os seguintes fatores: déficit visual antes do AVC (p=0,02), síndrome demencial após AVC (p=0,01), uso de inibidores da acetilcolinesterase (p=0,01), parkinsonismo (p =0,01), sintomas de tontura e desequilíbrio após o AVC (p<0,001) e Escala Modificada de Rankin em 3 meses após o AVC (p=0,007). A análise de regressão logística evidenciou que a presença de desequilíbrio postural ou tonturas são fatores preditivos independentes para quedas na amostra estudada. Conclusões: As quedas são um problema frequente em pacientes que sofreram AVC e sua ocorrência é maior nos períodos de atividade do paciente e em atividades simples como deambulação e transferências. Alterações do equilíbrio postural consolida-se como fator preditivo independente de quedas após o AVC / Introduction: Many patients affected by stroke suffer from permanent motor and cognitive deficits, which lead to greater risk of falls that constitutes the most frequent complication in this group of patients. Thus, the identification of the factors that predict falls in patients after stroke is necessary for the elaboration of prevention strategies to avoid falls\' consequences, increasing functional prognosis, expectancy and quality of life in this huge population. Objectives: The primary goal of the study was to analyze the fall predictor factors in a sample of stroke patients included in the Stroke Register of Ribeirão Preto (REAVER) in a period of six months after stroke. The secondary goals were to analyze the relative frequency of falls in the first six months after stroke; to analyze the characteristics of fall occurrence in the first six months after stroke; to investigate the rehabilitation processes, clinical and functional characteristics in faller and non-faller patients in this sample. Methodology: We included all stroke patients with ischemic and hemorrhagic strokes admitted to the Emergency U nit of the HCFMRP-USP, between 2015 September and 2016 March, with previous Modified Rankin Scale (mRS) less than 1. We did a retrospective collection of data from REAVER related to personal data, concomitant diseases, neurologic deficits, functionality, cognitive assessment, and rehabilitation. After six months of the stroke ictus, we did a prospective investigation by phone regarding the use of medications that affect central nervous system, parkinsonism and dementia before stroke, vertigo, imbalance, and visual deficit after stroke, in addition to the occurrence, number, location and circumstances of falls in six months period after stroke. Results: We investigated 304 patients and 129 were included in the study, with a prevalence of 31 falls that occurred in 24% of the study sample. The most frequent locations of falls were next to the patient\'s bedroom and in the period of more activity (morning and afternoon). Most of the falls occurred between 3 to 6 months after the stroke. The main activities related to the falls were gait and transfer. We found positive association between the occurrence of falls and the following factors: visual deficits before stroke (p=0,02), dementia after stroke (p=0,01), use of acetylcholinesterase inhibitors (p=0,01), parkinsonism (p=0,01), vertigo and imbalance after stroke (p<0,001) and mRS 3 months after stroke (p=0,007). The logistic regression analysis showed that vertigo and imbalance are independent predictive factors for falls in this study. Conclusions: Falls are frequent after stroke. Their occurrence is greater in the periods of more activity and in simple activities like gait and transfer. Disturbance of postural balance is consolidated as an independent risk factor for falls

Li Huan. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2001. / Includes bibliographical references (p. 285-306). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web.

Introdução: O AVC (acidente vascular cerebral) é uma das mais importantes causas de alterações neuropsicológicas. Uma avaliação cognitiva inicial realizada por telefone implicaria em um diagnóstico mais precoce de prejuízo cognitivo e demência, reduzindo custos e tempo. Objetivo: Examinar as propriedades psicométricas da versão brasileira da Entrevista Telefônica para Avaliação do Estado Cognitivo - Modificada (TICS-M) em pacientes pós-AVC. Métodos: Previamente à validação da TICS-M em indivíduos acometidos por AVC, foi realizada tradução para o Português do Brasil e adaptação transcultural da versão original da TICS-M em uma amostra de 30 sujeitos não clínicos. Após esta fase, um subgrupo de 61 pacientes com AVC, participantes do Estudo da Mortalidade e Morbidade do AVC (EMMA) que ocorre no Hospital Universitário da Universidade de São Paulo, foram convidados a participar da validação da TICS-M, seis meses após o evento agudo. A TICS-M foi aplicada em três momentos: avaliação inicial (entrevista presencial), uma e duas semanas após a primeira avaliação. Na avaliação inicial, além da TICS-M, questionários adicionais foram aplicados para avaliar a cognição: MoCA (Montreal Cognitive Assessment), MEEM (Mini Exame do Estado Mental); e para a depressão, HDRS (Hamilton Depression Rating Scale). Todos os questionários foram aplicados por duas entrevistadoras treinadas para o estudo. A confiabilidade intra-observador da TICS-M foi testada através dos coeficientes de Pearson, Intraclasse e alfa de Cronbach. As características internas do TICS-M também foram avaliadas através de uma análise exploratória utilizando o método Análise de Componentes Principais. A validade discriminatória do instrumento para rastreamento de demência pós-AVC foi avaliada em comparação a MEEM pela análise da área sob a curva (AUC) determinada pela curva ROC. Foram calculadas sensibilidade e especificidade para o ponto de corte ideal para rastrear demência. Resultados: De maneira geral, a TICS-M traduzida para o português apresentou um bom entendimento dos itens na mostra de indivíduos não clínicos. Foi observada uma frequência de 23% sugestiva de demência pós-AVC. O nível de escolaridade esteve positivamente associado ao estado demencial rastreado pelo MEEM. O estado depressivo assim como outras características de base não se associou à demência sugerida pelo MEEM. A confiabilidade teste-reteste intra-observador revelou taxas quase totais nos três momentos avaliados (Pearson Coeficiente > 0,85, Coeficientes de Correlação Intraclasse > 0,85 e Coeficiente alfa de Cronbach: 0,96). A análise fatorial determinou três domínios: memória de trabalho e atenção; memória recente e de evocação e orientação. A área sob a curva (AUC) determinada para a TICS-M em comparação com MEEM foi de 0,89 (intervalo de confiança 95%: 0,80-0,98). O ponto de corte sugerido para TICS-M foi de 14 pontos (escala de 0-39 pontos) para rastrear demência com sensibilidade de 91,5% e especificidade de 71,4%. Resultados semelhantes foram observadas com o MoCA. Conclusão: A versão brasileira da TICS-M sugere ser um instrumento de pesquisa útil e confiável para rastrear demência em pacientes pós-AVC / Introduction: Stroke is one most important cause of neuropsychological disorders. An initial cognitive assessment performed by telephone resulting in an early diagnosis of cognitive impairment and dementia, reducing costs and time. Objective: To examine the psychometric properties of the Brazilian version of the Modified Telephone Interview for Cognitive Status Assessment (TICS-M) for assessment of dementia in post-stroke patients. Methods: Prior to validation of TICS-M in post-stroke patients, translation was performed for the Brazilian-Portuguese and cross-cultural adaptation of the original version of TICS-M in a non-clinical sample of 30 subjects. After this phase, 61 stroke patients enrolled in the Stroke Mortality and Morbidity Study (The EMMA study) that occurs at the University Hospital of the University of São Paulo, were invited to participate in this sub-study to validate the TICS-M six months after the acute event. The TICS-M was applied in three moments: first evaluation (personal interview), one and two weeks after of the first evaluation. At the first evaluation, beyond the TICS-M, additional questionnaires were applied to assess cognition: MoCA (Montreal Cognitive Assessment), MMSE (Mini-Mental Status Examination), and for depression, HDRS (Hamilton Depression Rating Scale). All questionnaires were administered by two trained interviewers for the study. Reliability of the TICS-M was tested by intra-observer rates using Pearson, Intraclass and Cronbach´s alpha coefficients. The internal characteristics of TICS-M were also evaluated by an exploratory analysis using Principal Component Analysis. The discrimination validity of the instrument to assess dementia was evaluated by comparison to the MMSE analysis of the area under the curve (AUC) determined by the ROC curve. Sensitivity and specificity for the ideal cutoff to assess dementia were calculated. Results: In general, the TICS-M translated into Portuguese version showed a good understanding of the items in non-clinical individuals. A frequency of 23% suggestive of post-stroke dementia was observed. The level of education was positively associated with dementia status assessed by MMSE. The depressive status, as well as, other baseline characteristics was not associated with dementia suggested by MMSE. Test-retest reliability intra-observer revealed almost total rates in the three evaluation moments (Pearson coefficient > 0.85, Intraclass Correlation Coefficient > 0.85 and Cronbach\'s alpha coefficient: 0.96). The factorial analysis determined three domains: working memory and attention, recent and recall memory and orientation. The area under the curve (AUC) determined by TICS-M compared to MMSE was 0.89 (95% confidence interval: 0.80-0.98). The cutoff suggested for TICS-M was equal or greater than 14 points (range 0-39 points) to assess dementia (91.5% sensitivity, 71.4 % specificity). Similar results were observed with the MoCA. Conclusion: The Brazilian version of TICSM suggests being a useful and reliable research instrument to evaluate dementia in poststroke patients in epidemiological studies

Introdução: O AVC (acidente vascular cerebral) é uma das mais importantes causas de alterações neuropsicológicas. Uma avaliação cognitiva inicial realizada por telefone implicaria em um diagnóstico mais precoce de prejuízo cognitivo e demência, reduzindo custos e tempo. Objetivo: Examinar as propriedades psicométricas da versão brasileira da Entrevista Telefônica para Avaliação do Estado Cognitivo - Modificada (TICS-M) em pacientes pós-AVC. Métodos: Previamente à validação da TICS-M em indivíduos acometidos por AVC, foi realizada tradução para o Português do Brasil e adaptação transcultural da versão original da TICS-M em uma amostra de 30 sujeitos não clínicos. Após esta fase, um subgrupo de 61 pacientes com AVC, participantes do Estudo da Mortalidade e Morbidade do AVC (EMMA) que ocorre no Hospital Universitário da Universidade de São Paulo, foram convidados a participar da validação da TICS-M, seis meses após o evento agudo. A TICS-M foi aplicada em três momentos: avaliação inicial (entrevista presencial), uma e duas semanas após a primeira avaliação. Na avaliação inicial, além da TICS-M, questionários adicionais foram aplicados para avaliar a cognição: MoCA (Montreal Cognitive Assessment), MEEM (Mini Exame do Estado Mental); e para a depressão, HDRS (Hamilton Depression Rating Scale). Todos os questionários foram aplicados por duas entrevistadoras treinadas para o estudo. A confiabilidade intra-observador da TICS-M foi testada através dos coeficientes de Pearson, Intraclasse e alfa de Cronbach. As características internas do TICS-M também foram avaliadas através de uma análise exploratória utilizando o método Análise de Componentes Principais. A validade discriminatória do instrumento para rastreamento de demência pós-AVC foi avaliada em comparação a MEEM pela análise da área sob a curva (AUC) determinada pela curva ROC. Foram calculadas sensibilidade e especificidade para o ponto de corte ideal para rastrear demência. Resultados: De maneira geral, a TICS-M traduzida para o português apresentou um bom entendimento dos itens na mostra de indivíduos não clínicos. Foi observada uma frequência de 23% sugestiva de demência pós-AVC. O nível de escolaridade esteve positivamente associado ao estado demencial rastreado pelo MEEM. O estado depressivo assim como outras características de base não se associou à demência sugerida pelo MEEM. A confiabilidade teste-reteste intra-observador revelou taxas quase totais nos três momentos avaliados (Pearson Coeficiente > 0,85, Coeficientes de Correlação Intraclasse > 0,85 e Coeficiente alfa de Cronbach: 0,96). A análise fatorial determinou três domínios: memória de trabalho e atenção; memória recente e de evocação e orientação. A área sob a curva (AUC) determinada para a TICS-M em comparação com MEEM foi de 0,89 (intervalo de confiança 95%: 0,80-0,98). O ponto de corte sugerido para TICS-M foi de 14 pontos (escala de 0-39 pontos) para rastrear demência com sensibilidade de 91,5% e especificidade de 71,4%. Resultados semelhantes foram observadas com o MoCA. Conclusão: A versão brasileira da TICS-M sugere ser um instrumento de pesquisa útil e confiável para rastrear demência em pacientes pós-AVC / Introduction: Stroke is one most important cause of neuropsychological disorders. An initial cognitive assessment performed by telephone resulting in an early diagnosis of cognitive impairment and dementia, reducing costs and time. Objective: To examine the psychometric properties of the Brazilian version of the Modified Telephone Interview for Cognitive Status Assessment (TICS-M) for assessment of dementia in post-stroke patients. Methods: Prior to validation of TICS-M in post-stroke patients, translation was performed for the Brazilian-Portuguese and cross-cultural adaptation of the original version of TICS-M in a non-clinical sample of 30 subjects. After this phase, 61 stroke patients enrolled in the Stroke Mortality and Morbidity Study (The EMMA study) that occurs at the University Hospital of the University of São Paulo, were invited to participate in this sub-study to validate the TICS-M six months after the acute event. The TICS-M was applied in three moments: first evaluation (personal interview), one and two weeks after of the first evaluation. At the first evaluation, beyond the TICS-M, additional questionnaires were applied to assess cognition: MoCA (Montreal Cognitive Assessment), MMSE (Mini-Mental Status Examination), and for depression, HDRS (Hamilton Depression Rating Scale). All questionnaires were administered by two trained interviewers for the study. Reliability of the TICS-M was tested by intra-observer rates using Pearson, Intraclass and Cronbach´s alpha coefficients. The internal characteristics of TICS-M were also evaluated by an exploratory analysis using Principal Component Analysis. The discrimination validity of the instrument to assess dementia was evaluated by comparison to the MMSE analysis of the area under the curve (AUC) determined by the ROC curve. Sensitivity and specificity for the ideal cutoff to assess dementia were calculated. Results: In general, the TICS-M translated into Portuguese version showed a good understanding of the items in non-clinical individuals. A frequency of 23% suggestive of post-stroke dementia was observed. The level of education was positively associated with dementia status assessed by MMSE. The depressive status, as well as, other baseline characteristics was not associated with dementia suggested by MMSE. Test-retest reliability intra-observer revealed almost total rates in the three evaluation moments (Pearson coefficient > 0.85, Intraclass Correlation Coefficient > 0.85 and Cronbach\'s alpha coefficient: 0.96). The factorial analysis determined three domains: working memory and attention, recent and recall memory and orientation. The area under the curve (AUC) determined by TICS-M compared to MMSE was 0.89 (95% confidence interval: 0.80-0.98). The cutoff suggested for TICS-M was equal or greater than 14 points (range 0-39 points) to assess dementia (91.5% sensitivity, 71.4 % specificity). Similar results were observed with the MoCA. Conclusion: The Brazilian version of TICSM suggests being a useful and reliable research instrument to evaluate dementia in poststroke patients in epidemiological studies