Thèse (M.Ps.)--Université Laval, 2004. / Bibliogr.: f. 45-52. Publié aussi en version électronique.

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Yes / The difference between Apolipoprotein E ε4 carriers and non-carriers in response to single exercise sessions was tested. Stroop and Posner tasks were administered to young untrained women immediately after walking sessions or moderately heavy exercise. Exercise had a significantly more profound impact on the Stroop effect than on the Posner effect, suggesting selective involvement of prefrontal function. A significant genotype-by-exercise interaction indicated differences in response to exercise between ε4 carriers and non-carriers. Carriers showed facilitation triggered by exercise. The transient executive down-regulation was construed as due to exercise-dependent hypofrontality. The facilitation observed in carriers was interpreted as better management of prefrontal metabolic resources, and explained within the antagonistic pleiotropy hypothesis framework. The findings have implications for the interpretation of differences between ε4 carriers and non-carriers in the benefits triggered by long-term exercise that might depend, at least partially, on mechanisms of metabolic response to physical activity. / Partially supported by a University of Hull Faculty of Science scholarship to MDM and by funding from MIUR and FP7 VPH-DARE to AV.

This study examined the utility of the Trail Making Test Quotient (Trails B/ Trails A) in assessing executive functioning relative to that of common tests of executive function such as the Wisconsin Card Sorting Test, Category Test, and the Stroop Test. The purpose of the current study was to investigate the relationship of the Trail Making Test Quotient (Trails B/ Trails A) with other common tests of executive functioning (i.e., Wisconsin Card Sorting Test, Stroop, Category Test) to determine whether these tests are measuring similar domains of functioning or whether Trail Making Test Quotient (Trails B/ Trails A) offers a more pure measure of executive functioning over and beyond that of Trail Making Test B alone or the difference score, Trail Making Test (Trails B- Trails A). A series of partial correlations were conducted involving the Trail Making Test scores (Quotient, Difference, and B [Raw]), and the scores of the executive functioning measures (Wisconsin Card Sorting Test, Category Test, and Stroop), controlling for age, education, and gender. Trails Quotient, Trails B Raw, and Trails Difference were found to significantly negatively correlate with WCST Total # of Categories. Only Trails B Raw and Trails Difference were found to significantly positively correlate with WCST Perseverative Responses and Category Error. None of the Trail Making Test measures used in this study were found to significantly correlate Stroop Interference. Correlation coefficients were compared to determine the strength of Trails Quotient's relationship with the aforementioned executive functioning measures relative to that of Trails Difference and Trails B Raw. Contrary to the hypotheses of the current study, the Trails Quotient demonstrated a significantly weaker correlation with WCST Total # of Categories, WCST Perseverative Responses, and Category Error than that of Trails Difference and Trails B Raw. Additionally, there were no significant differences in the correlation coefficients of Trails Quotient, Trails Difference, and Trails B Raw with Stroop Interference. However, upon further investigation using exploratory factor analyses, it was discovered that Trails Quotient may have represented a particular component of executive functioning more so than the Trails Difference and Trails B Raw. The results suggest that Trails Quotient offers a unique estimate of executive skill specific to cognitive organization, whereas Trails B Raw and Trails Difference represent multiple executive domains including regulatory and organizational abilities. Clinical practice will benefit from the current study's findings in that assessment of complex executive functioning will be more precise. Future research is needed to determine the utility of the Trails Quotient in identifying specific types and locations of brain injury. Assessment of specific impaired frontal skills common to degenerative dementias and traumatic brain injury may be possible with the use of Trails Quotient contingent upon further research. Future research into the domains of executive functioning and the Trail Making Test should focus on specific skills within regulatory and organizational components, and the development of normative data for Trails Quotient.

Induktion präfrontaler Dysfunktion bei gesunden Probanden durch inhibitorische TMS: Eine NIRS-Messung / Induction of a prefrontal dysfunction on healthy subjects with inhibitory TMS: a near-infrared spectroscopy (NIRS) study

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Mental disorders have an important socio-economic impact on the world. Among the different types of mental disorders, anxiety ones are among the most prevalent, being that social anxiety disorder (SAD) stands out as one of the most limiting anxiety disorders for individuals and is associated with poor academic performance, which directly impacts university students. In addition, your treatment is still a challenge. Alternative treatments considered effective, such as meditation, are often inaccessible to lots of people, especially for students. An interesting alternative came in the attempt to resolve this issue, the Natural Stress Relief (NSR) meditation, via a simple and self-administered program, in a more accessible way. Therefore, the aims of this study were to evaluate the effect of NSR meditation on anxiety of university students with SAD. For that, we selected university students of both sexes, diagnosed with SAD by SPIN. The volunteers were allocated to one of two groups: NSR (n = 18) or Waiting list (n = 18). NSR group individuals performed two sessions per day of NSR meditation (15 min per session) during four weeks, in which first and last sessions were performed in the Laboratório de Fisiologia do Comportamento. Individuals belonging waiting list group did not practice any technique. All volunteers had their general symptoms of anxiety and social anxiety symptoms assessed by the hospital scale of anxiety and depression (HADS-A) and SPIN, respectively. Levels of state anxiety were also evaluated by the numerical tension scale (NTS), the state-trait anxiety inventory (STAI), and physiological indicators records (electromyographic gastrocnemius muscle activity, heart rate, temperature of extremity and skin conductance); and trait anxiety levels were assessed by the trait subscale of the STAI. In addition, One day after last session, volunteers were individually submitted to a social anxiety induction test. Data were analyzed by means of appropriate statistical tests. The results showed that the practice of NSR meditation reduced trait anxiety levels after four weeks (STAI-T); reduced weekly general anxiety symptoms (HADS-A) and social anxiety symptoms (SPIN); and reduced subjective levels of state anxiety (STAI-S and NTS) after the first and last session, but no changes were observed in the physiological indicators of anxiety. In addition, data analysis revealed that four weeks of meditative practice were not sufficient to prevent changes in levels of state anxiety (STAI-S, NTS and physiological indicators) elicited by a social anxiety induction test. At the end of the fourth week, most of NSR group volunteers were classified as presenting normal anxiety symptoms and were no longer categorized as presenting with SAD. Finally, this study showed the anxiolytic effect of NSR meditation in university students diagnosed with SAD according to SPIN. / Os transtornos mentais causam um importante impacto sócio-econômico no mundo. Dentre os diferentes tipos de transtornos mentais, os de ansiedade estão entre os mais prevalentes, sendo que o transtorno de ansiedade social (TAS) se destaca como um dos transtornos ansiosos mais limitantes para os indivíduos, sendo associado também a um baixo desempenho acadêmico, o qual impacta diretamente os estudantes universitários. Além disso, seu tratamento ainda é um desafio. Tratamentos alternativos considerados eficazes como a meditação são, muitas vezes, de difícil acesso para a população geral, em especial, para os estudantes. Na tentativa de resolver essa questão, surgiu a meditação Natural Stress Relief (NSR) como uma interessante alternativa, pois pode ser aprendida por um método simples, autoexplicativo e de baixo custo. Sendo assim, o objetivo do presente estudo foi avaliar o efeito da meditação NSR na ansiedade de estudantes universitários com TAS. Para tanto, foram selecionados estudantes universitários, de ambos os sexos, diagnosticados com TAS pelo inventário de fobia social (SPIN). Os voluntários foram alocados em um dos dois grupos: NSR (n = 18) ou Espera (n = 18). Os indivíduos do grupo NSR realizaram duas sessões por dia da meditação NSR (15 min por sessão), durante quatro semanas, sendo que a primeira e a última sessões foram realizadas no Laboratório de Fisiologia do Comportamento. Os indivíduos pertencentes ao grupo Espera não praticaram técnica alguma, mas realizaram os mesmos procedimentos que o grupo NSR. Todos os voluntários tiveram seus sintomas gerais de ansiedade e de ansiedade social avaliados a partir da escala hospitalar de ansiedade e depressão (HADS-A) e do SPIN, respectivamente. Também foram avaliados os níveis de ansiedade-estado a partir da escala numérica de tensão (ENT), do inventário de ansiedade traço/estado (IDATE) e de registros de indicadores fisiológicos (atividade eletromiográfica do músculo gastrocnêmio, frequência cardíaca, temperatura de extremidade e condutância da pele); e os níveis de ansiedade-traço a partir da subescala traço do IDATE. Além disso, no dia seguinte à última sessão, os voluntários foram individualmente submetidos a um teste de indução de ansiedade social. Os dados obtidos foram analisados por meio de testes estatísticos apropriados, sendo que os resultados mostraram que a prática da meditação NSR reduziu os níveis de ansiedade-traço após quatro semanas (IDATE-T); reduziu semanalmente os sintomas gerais de ansiedade (HADS-A) e os sintomas de ansiedade social (SPIN); e reduziu os níveis subjetivos de ansiedade-estado (IDATE-E e ENT) após a primeira e última sessão, no entanto, não foram observadas mudanças nos indicadores fisiológicos de ansiedade-estado. Além disso, a análise dos dados revelou que quatro semanas de prática meditativa não foram suficientes para prevenir as alterações nos níveis de ansiedade-estado (IDATE-E, ENT, indicadores fisiológicos) eliciadas por um teste de indução de ansiedade social. E ao final da quarta semana, a maioria dos voluntários do grupo NSR passaram a ser classificados como apresentando sintomas normais de ansiedade e deixaram de ser categorizados como apresentando o TAS. Por fim, este estudo mostrou o efeito ansiolítico da meditação NSR em estudantes universitários com diagnóstico do TAS de acordo com o SPIN.

INTRODUÇÃO: O envelhecimento está associado, muitas vezes, a um declínio cognitivo frequentemente negligenciado, especialmente quando em formas brandas e/ou iniciais, com importante repercussão na vida das pessoas. Tais declínios podem regredir para a normalidade, estabilizar ou mesmo evoluir para quadro demenciais. O comprometimento cognitivo leve (CCL) é uma síndrome clínica de associada a um risco aumentado de demência, podendo ter várias etiologias e patologias. Até o momento, não existe ainda uma abordagem terapêutica, deixando uma lacuna no arsenal terapêutico tanto do especialista quanto do clínico geral. A estimulação magnética transcraniana é uma técnica não invasiva e promissora. Tem potencial para melhorar a memória e a cognição de idosos ativando redes neurais. OBJETIVOS: Este trabalho visa verificar os efeitos da estimulação magnética transcraniana repetitiva (EMTr) de alta frequência primeiramente sobre a memória e, secundariamente, sobre a cognição global de idosos com CCL. MÉTODOS: Trata-se de um estudo duplo cego, randomizado sham-controlado. Foram estimulados 32 idosos com idades entre 60-74 anos, totalmente independentes para as atividades instrumentais de vida diária (AIVDs), com queixas subjetivas de memória e evidência de algum prejuízo na avaliação neuropsicológica, caracterizando CCL. Os participantes foram divididos em dois grupos: (I) EMTr ativa (n=15) e (II) EMTr sham (n=17). O grupo ativo recebeu 10 sessões de EMTr a 10Hz (110% do limiar motor e 2.000 pulsos por sessão) sobre o córtex pré-frontal dorso lateral esquerdo.Foi utilizada uma bobina inativa (sham) para o grupo placebo. As baterias neuropsicológicas foram realizadas nos três tempos: antes (T0), logo após (T1) e um mês após (T2) a EMTr. RESULTADOS: Dos 109 pacientes triados, 36 foram elegíveis para o estudo. Houve 4 desistências, e 32 finalizaram o estudo. Os dados demográficos foram homogêneos. Os escores dos testes foram ajustados para a idade e escolaridade. O ponto de corte do Escore Isquêmico de Hachinski foi <=4. A medida de desfecho primário foi o teste ecológico Rivermead Behavioural Memory (RBMT) devido a sua alta capacidade de predizer problemas de memória diárias. As variáveis contínuas foaram avaliadas pelo teste t de Student. Análise de variância para medidas repetidas (ANOVA) foi utilizada para comparar as medidas de variáveis quantitativas ao longo dos instantes de medição. Houve interação (efeito de grupo) a favor do grupo ativo nas variáveis Rivermead Behavioural Memory Test (p=0,042) e teste de Stroop (retângulos) (p=0,044) em T0-T1; dígitos ordem direta (p=0,041) e trilhas B em T1-T2 (p=0,032). Houve interação no teste de memória lógica tardia em T0-T1 e T0-T2 (p=0,044 e 0,005, respectivamente) a favor do grupo sham; porém, o desfecho foi igual em T2 em ambos os grupos. Não houve interação no IQCODE e na escala de Bayer de funcionalidade. Os resultados mostram melhora significativa, a um nível de 5% de significância, na memória do dia a dia, da atenção e de função executiva dos idosos que se submeteram à EMTr de alta frequência, sugerindo seu potencial terapêutico no CCL. Trial registration: clinicaltrials.gov Identifier: NCT01292382. / BACKGROUND: Aging maybe associated with a cognitive decline often overlooked, especially in milder forms, with significant impact on people\'s lives. Such declines may regress to normal, or even stabilize, or progress to dementia. Mild cognitive impairment (MCI) is a clinical syndrome associated with an increased risk of dementia and may have different etiologies and pathologies. To date, there is still not a therapeutic approach, leaving a gap in the therapeutic armamentarium of both expert as the general practitioner. Transcranial magnetic stimulation is a promising and noninvasive technique with potential to improve memory and cognition in elderly by activating neural networks. OBJECTIVES: This study aims to assess the effects of high frequency repetitive transcranial magnetic stimulation (rTMS) primarily on memory and secondarily on global cognition in elderly people with MCI. METHODS: Double blind, randomized sham-controlled trial. Were stimulated 32 eldrely aged 60-74 years, totally independent for instrumental activities of daily living (IADL) with subjective memory complaints and evidence of some impairment in neuropsychological assessment, characterizing MCI. Subjects were divided into two groups: (I) active rTMS (n=15) and (II) rTMS sham (n=17). The active group received 10 sessions of 10 Hz rTMS (110% of motor threshold and 2000 pulses per session) over left dorsolateral prefrontal cortex. We used a inactive coil (sham) for the placebo group. The neuropsychological assessment were conducted in three stages: before (T0), immediately after (T1) and one month after (T2) rTMS. RESULTS: Of 109 patients screened, 36 were eligible for the study. There were 4 dropouts, and 32 completed the study. Demographic data were homogeneous. The test scores were adjusted for age and education. All subjects presented a cut-off score <=4 for the Hachinski Ischaemic Score. Continuous variables were evaluated by Student t test. Repeated measures of anayses of variance (ANOVA) were used to compare measures of quantitative variables along time. The primary outcome measure was a positive response on the ecological tool Rivermead Behavioural Memory Test (RBMT) because of its capacity to predict everyday memory problems. There was interaction (group effect) in favor of the active group over the variables RBMT (p=0.042) and Stroop test (colored rectangles) (p=0.044) at T0-T1; digit span direct order (p=0.041) and trail making B, T1-T2 (p=0.032). There was interaction in late logic memory test at T0-T1 and T0-T2 (p=0.044 and 0.005, respectively) for the sham group, but the outcome was the same in both groups at T2. There were no significant interaction at IQCODE and Bayer ADL Scale. The results present significant improvement, at a 5% level of significance, in everyday memory, attention and executive function of the elderly who underwent to high-frequency rTMS, suggesting its therapeutic potential in MCI. Trial registration: clinicaltrials.gov Identifier: NCT01292382.

Hälso- och sjukvården befinner sig under ett allt större tryck av patienter som söker hjälp på grund av utmattningssyndrom. Kognitiva nedsättningar är en kärnkomponent i utmattningssyndrom och effektiva och korta screeninginstrument för att upptäcka dessa behövs för identifiera tillståndet tidigt. Syftet med föreliggande studie var att utveckla ett modifierat Symbol Digit Modalities Test. De totalt 90 deltagarna bestående av studenter delades in i två grupper efter självskattad utmattning. Tjugofyra individer identifierades i gruppen med låg utmattning och trettiofyra i gruppen med hög utmattning. De två grupperna jämfördes med prestation på testet. Testet bestod av tre block bestående av symboler, neutrala ord och hotfulla ord och vardera blocks testtid var 90 sekunder. Resultatet visade inga signifikanta skillnader mellan låg och hög utmattningsgrupp och prestation på testet. Däremot fanns signifikanta skillnader mellan blocken när samtliga deltagares prestation jämfördes. Det modifierade testet lyckas inte att differentiera mellan deltagare med låg och hög utmattning. Resultatet som visade att det fanns skillnader mellan blocken är intressant och visar på att det kan finnas en effekt av uppmärksamhetsvridning som framtida forskning kan bygga vidare på. / The Swedish healthcare system is under increasing pressure from patients seeking help due to fatigue syndrome. Cognitive impairments are a core symptom of the syndrome; effective screening tools to detect cognitive impairment related to fatigue are warranted to identify the condition. The aim of the present study was to develop a modified Symbol Digit Modalities. A total of 90 participants consisting of undergraduate students were divided into two groups after self-assessed fatigue. Twenty-four individuals were identified in the low fatigue group and thirty-four in the high fatigue group. The two groups’ test performance were compared. The test consisted of three blocks consisting of symbols, neutral words, and threat words; the duration of each test block was 90 seconds. The results showed no significant differences between low and high fatigue in terms of performance on the tests. However, there were significant differences across the blocks when comparing all participants' performance. The modified test failed to differentiate between low and high fatigue participants. The result indicating significant differences across the blocks is interesting and shows that there may be an effect of attentional bias that future research can build upon.

INTRODUÇÃO: O envelhecimento está associado, muitas vezes, a um declínio cognitivo frequentemente negligenciado, especialmente quando em formas brandas e/ou iniciais, com importante repercussão na vida das pessoas. Tais declínios podem regredir para a normalidade, estabilizar ou mesmo evoluir para quadro demenciais. O comprometimento cognitivo leve (CCL) é uma síndrome clínica de associada a um risco aumentado de demência, podendo ter várias etiologias e patologias. Até o momento, não existe ainda uma abordagem terapêutica, deixando uma lacuna no arsenal terapêutico tanto do especialista quanto do clínico geral. A estimulação magnética transcraniana é uma técnica não invasiva e promissora. Tem potencial para melhorar a memória e a cognição de idosos ativando redes neurais. OBJETIVOS: Este trabalho visa verificar os efeitos da estimulação magnética transcraniana repetitiva (EMTr) de alta frequência primeiramente sobre a memória e, secundariamente, sobre a cognição global de idosos com CCL. MÉTODOS: Trata-se de um estudo duplo cego, randomizado sham-controlado. Foram estimulados 32 idosos com idades entre 60-74 anos, totalmente independentes para as atividades instrumentais de vida diária (AIVDs), com queixas subjetivas de memória e evidência de algum prejuízo na avaliação neuropsicológica, caracterizando CCL. Os participantes foram divididos em dois grupos: (I) EMTr ativa (n=15) e (II) EMTr sham (n=17). O grupo ativo recebeu 10 sessões de EMTr a 10Hz (110% do limiar motor e 2.000 pulsos por sessão) sobre o córtex pré-frontal dorso lateral esquerdo.Foi utilizada uma bobina inativa (sham) para o grupo placebo. As baterias neuropsicológicas foram realizadas nos três tempos: antes (T0), logo após (T1) e um mês após (T2) a EMTr. RESULTADOS: Dos 109 pacientes triados, 36 foram elegíveis para o estudo. Houve 4 desistências, e 32 finalizaram o estudo. Os dados demográficos foram homogêneos. Os escores dos testes foram ajustados para a idade e escolaridade. O ponto de corte do Escore Isquêmico de Hachinski foi <=4. A medida de desfecho primário foi o teste ecológico Rivermead Behavioural Memory (RBMT) devido a sua alta capacidade de predizer problemas de memória diárias. As variáveis contínuas foaram avaliadas pelo teste t de Student. Análise de variância para medidas repetidas (ANOVA) foi utilizada para comparar as medidas de variáveis quantitativas ao longo dos instantes de medição. Houve interação (efeito de grupo) a favor do grupo ativo nas variáveis Rivermead Behavioural Memory Test (p=0,042) e teste de Stroop (retângulos) (p=0,044) em T0-T1; dígitos ordem direta (p=0,041) e trilhas B em T1-T2 (p=0,032). Houve interação no teste de memória lógica tardia em T0-T1 e T0-T2 (p=0,044 e 0,005, respectivamente) a favor do grupo sham; porém, o desfecho foi igual em T2 em ambos os grupos. Não houve interação no IQCODE e na escala de Bayer de funcionalidade. Os resultados mostram melhora significativa, a um nível de 5% de significância, na memória do dia a dia, da atenção e de função executiva dos idosos que se submeteram à EMTr de alta frequência, sugerindo seu potencial terapêutico no CCL. Trial registration: clinicaltrials.gov Identifier: NCT01292382. / BACKGROUND: Aging maybe associated with a cognitive decline often overlooked, especially in milder forms, with significant impact on people\'s lives. Such declines may regress to normal, or even stabilize, or progress to dementia. Mild cognitive impairment (MCI) is a clinical syndrome associated with an increased risk of dementia and may have different etiologies and pathologies. To date, there is still not a therapeutic approach, leaving a gap in the therapeutic armamentarium of both expert as the general practitioner. Transcranial magnetic stimulation is a promising and noninvasive technique with potential to improve memory and cognition in elderly by activating neural networks. OBJECTIVES: This study aims to assess the effects of high frequency repetitive transcranial magnetic stimulation (rTMS) primarily on memory and secondarily on global cognition in elderly people with MCI. METHODS: Double blind, randomized sham-controlled trial. Were stimulated 32 eldrely aged 60-74 years, totally independent for instrumental activities of daily living (IADL) with subjective memory complaints and evidence of some impairment in neuropsychological assessment, characterizing MCI. Subjects were divided into two groups: (I) active rTMS (n=15) and (II) rTMS sham (n=17). The active group received 10 sessions of 10 Hz rTMS (110% of motor threshold and 2000 pulses per session) over left dorsolateral prefrontal cortex. We used a inactive coil (sham) for the placebo group. The neuropsychological assessment were conducted in three stages: before (T0), immediately after (T1) and one month after (T2) rTMS. RESULTS: Of 109 patients screened, 36 were eligible for the study. There were 4 dropouts, and 32 completed the study. Demographic data were homogeneous. The test scores were adjusted for age and education. All subjects presented a cut-off score <=4 for the Hachinski Ischaemic Score. Continuous variables were evaluated by Student t test. Repeated measures of anayses of variance (ANOVA) were used to compare measures of quantitative variables along time. The primary outcome measure was a positive response on the ecological tool Rivermead Behavioural Memory Test (RBMT) because of its capacity to predict everyday memory problems. There was interaction (group effect) in favor of the active group over the variables RBMT (p=0.042) and Stroop test (colored rectangles) (p=0.044) at T0-T1; digit span direct order (p=0.041) and trail making B, T1-T2 (p=0.032). There was interaction in late logic memory test at T0-T1 and T0-T2 (p=0.044 and 0.005, respectively) for the sham group, but the outcome was the same in both groups at T2. There were no significant interaction at IQCODE and Bayer ADL Scale. The results present significant improvement, at a 5% level of significance, in everyday memory, attention and executive function of the elderly who underwent to high-frequency rTMS, suggesting its therapeutic potential in MCI. Trial registration: clinicaltrials.gov Identifier: NCT01292382.

Cognitive function disorders have an enormous impact on the life quality of a patient, his or her family and close people. It influences the patient's job, social interaction and independence. This diploma thesis focuses on the possibility of improving cognitive functions concerning multiple sclerosis with the help of facilitation physiotherapy. Twelve disordered volunteers participated a two-month physiotherapeutic programme (motor programs activating therapy), for 1 hour, twice per week. Before the beginning and after the end of the therapeutic programme an examination by a clinic test PASAT and the monitoring of functional magnetic resonance was done. The results of functional magnetic resonance were further compared with the results of group of healthy volunteers. Concerning clinic test, the results of the disordered patients have improved after the therapy. In functional magnetic resonance statistics the earlier start and change of a curve progress of brain activation was discovered, which portrays improving speed of processing information at multiple sclerosis disordered.