In this work I deal with the project of an automated robotic bartender, whose task is to show model concepts such as virtual commissioning, digital factory or industry 4.0. The work resolves two parts (cells) for the overall construction. Individual cells are solved from the design and realization of the construction through the virtual verification of operation to the design and realization of the control itself for the given cells. The construction solution was created in SolidEdge ST10. Virtual verification will be solved in the Tecnomatix Process Simulate program and the implementation of PLC and HMI control by Siemens is programmed in the TIA Portal. Wiring diagrams were drawn in the student version of the EPLAN design environment. Other colleagues work on other parts of the barman project.

<p>Syftet med denna studie var att beskriva hur fysiskt aktiva personer som fått diagnosen TIA var. Frågeställningarna rörde vilka aktiviteter studiedeltagarna ägnade sig åt, hur de upplevde sin hälsa, begränsande faktorer, eventuell förändring av aktivitetsvanor, samt om deltagarna fått råd om fysisk aktivitet. Som metod valdes enkätundersökning och 195 enkäter skickades till personer som sökt Universitetssjukhuset Örebro 2007 och fått diagnosen TIA. Resultat: Svarsfrekvensen, efter externt och internt bortfall, blev 74 %. Mer än hälften av de 144 studiedeltagarna var fysiskt aktiva mindre än 30 minuter/dag. Den vanligaste aktiviteten var promenader, vilket 72 % ägnade sig åt. Yngre personer ägnade sig oftare åt tre eller fler aktiviteter jämfört med äldre personer. De deltagare som var regelbundet fysiskt aktiva skattade sin hälsa som god till utmärkt, medan de med stillasittande fritid skattade sin hälsa som någorlunda eller dålig. De mest begränsande faktorerna var sjukdom och smärta. Av studiedeltagarna uppgav 98 personer att de inte fått råd om fysisk aktivitet och hälften av deltagarna hade inte förändrat sina aktivitetsvanor. Slutsats: Studien visar att många personer som fått diagnosen TIA är fysiskt inaktiva. Begränsande faktorer, som, sjukdom, smärta och hög ålder, medför att råd om fysisk aktivitet bör vara individanpassade. Att ge råd om fysisk aktivitet på lämplig nivå, utifrån den enskilde personens förutsättningar är ett centralt kunskapsområde för sjukgymnaster. Därför bör dessa patienter ges möjlighet att träffa sjukgymnast.</p>

Close integration of front-end electronics and the transducer array within the catheter is critical for successful implementation of CMUT-based intravascular ultrasound (IVUS) imaging catheters to enable next generation imaging tools. Therefore, this research developed and implemented custom-designed electronic circuits and systems integrated with an IC compatible transducer technology for realization of miniature IVUS imaging catheters operating at 10-50 MHz frequency range. In one path of this research, an IC is custom designed in a 0.35-um CMOS process to monolithically integrate with a CMUT array (CMUT-on-CMOS) to realize a single-chip, highly-flexible, forward-looking (FL) IVUS imaging system. The amplifiers that are custom-designed achieved transducer thermal-mechanical noise dominated receive performance in a CMUT-on-CMOS implementation. In parallel to the FL-IVUS effort, for realization of a side-looking IVUS catheter based on an annular phased array, a dynamic receive beamformer IC is custom designed also in a 0.35-um CMOS process. Overall, the circuits and systems developed as part of this dissertation form a critical step in the translation of the research on CMUT-based IVUS catheters into real clinical applications for better management of coronary arterial diseases.

Cellular T-cell intracellular antigen-1 related protein (TIAR) binds to the 3' terminal stem-loop of the West Nile virus minus-strand RNA [WNV 3'(-) SL RNA]. TIAR binding sites were previously mapped on loop 1 (L1) and loop 2 (L2) of the 3' (-) SL RNA and mutations of these sites in a WNV infectious clone inhibited virus replication. In the present study, data from in vitro binding assays suggested that multiple TIAR proteins bind to each WNV 3′ (-) SL RNA in a positively cooperative manner. The tertiary structure of WNV 3′ (-) SL RNA was predicted and it was suggested that L2 forms an exposed loop while L1 forms an embedded loop. We propose that TIAR binds first to L2 and that this interaction facilitates the binding of a second TIAR molecule to L1. Data from in vitro assays also showed that TIAR binds specifically to the WNV 3' (-) SL RNA but not to the complementary WNV 5' (+) SL RNA and that the C-terminal prion domain of TIAR contributes to RNA binding specificity. Immunoprecipitation experiments indicated that TIAR interacts with the WNV 3' (-) SL RNA in cells. Colocalization of TIAR and viral dsRNA in the perinuclear region of WNV-infected cells was visualized using a proximity ligation assay. In WNV-infected, TIAR-overexpressing cells, increased extracellular virus yields, intracellular viral protein and RNA levels, and an increased ratio of viral plus-strand RNA to minus-strand RNA were observed. These data suggest that TIAR enhances WNV plus-strand RNA synthesis from the minus-strand template. WNV infections induce small TIAR foci formation in primate cells but not rodent cells. The TIAR foci are located in the perinuclear region and differ in size and location from arsenite-induced stress granules (SGs). However, the small TIAR foci contain many SG components, such as G3BP, PABP, and eIF3A, but not HuR. Arsenite-induced SG formation is still inhibited by WNV infection in these cells. eIF2a phosphorylation was observed in some infected cells that contained WNV-induced TIAR foci but viral NS3 protein accumulation was not inhibited. The data suggest that WNV-induced TIAR foci in primate cells are not canonical SGs.

Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Humanas, Departamento de História, 2008. / Submitted by Jaqueline Ferreira de Souza (jaquefs.braz@gmail.com) on 2009-09-21T17:45:04Z No. of bitstreams: 1 2008_MarceloRodriguesReis.pdf: 4252537 bytes, checksum: 3d766ec32f6811537c244e6b77b2fa3d (MD5) / Approved for entry into archive by Gomes Neide(nagomes2005@gmail.com) on 2010-05-21T14:30:05Z (GMT) No. of bitstreams: 1 2008_MarceloRodriguesReis.pdf: 4252537 bytes, checksum: 3d766ec32f6811537c244e6b77b2fa3d (MD5) / Made available in DSpace on 2010-05-21T14:30:05Z (GMT). No. of bitstreams: 1 2008_MarceloRodriguesReis.pdf: 4252537 bytes, checksum: 3d766ec32f6811537c244e6b77b2fa3d (MD5) Previous issue date: 2008-09 / O presente esforço intelectual se empenha em direcionar um olhar dedicado à história da líder religiosa da comunidade do Vale do Amanhecer: a médium que ficou nacionalmente conhecida como Tia Neiva. Migrante nordestina, Neiva Chaves Zelaya, após se estabelecer provisoriamente em muitas cidades em busca de estabilidade, em 1957, radica-se na Cidade Livre, Núcleo Bandeirante, e se envolve diretamente com os esforços que resultariam na edificação da nova capital federal. Informada pelas imagens de predestinação que qualificavam Brasília como uma Terra Prometida e dotada de vigorosa religiosidade, nesse período, dá início a sua vida mística, a sua trajetória hierofânica, na esteira da qual estabelece a Doutrina do Amanhecer. Diante desse objeto de estudo, nossa proposta se associa ao esforço de compreender como a imagem de Tia Neiva, por meio das representações a que deu vida e das que se viram consignadas por atores outros e permanecem a se constituir em torno de suas apresentações temporal e espiritual, autorizam a concepção, a solidificação e garantem a preservação de sua comunidade religiosa. Considerado, ainda, o centralismo carismático que fez perseverar a sua liderança, reconhecemos que a inspiração e a materialização dos saberes e dos fazeres religiosos que têm lugar na doutrina do Amanhecer passavam no mais das vezes pela enunciação de Tia Neiva ou então decorriam de sua legitimação. Isso porque atuava a Clarividente (como a nomeiam os entusiastas de suas revelações) na condição de canal de comunicação privilegiado com a dimensão transcendente, uma vez que se fazia reconhecer entre os da comunidade como detentora de poderes sobre-humanos. Temos, portanto, que a sistematização dos ritos, a narração dos mitos e a distribuição das competências de interação com a esfera espiritual, operações que no campo religioso, afiançamos, têm relevância ímpar, germinaram de sua palavra sagrada. __________________________________________________________________________________________ ABSTRACT / The present research focuses on the history of the religious leader of the community known as “Vale do Amanhecer”, the world famous medium Aunt Neiva. After dwelling temporarily in several different cities, searching for stability, the migrant from the north eastern region of the country, Neiva Chaves Zelaya, would get directly involved in the construction of the federal capital. Following the fore visions which showed Brasília as the promised land and endowed with vigorous religiosity, she started her mystical hierophantic trajectory establishing the Doctrine of “Amanhecer”. Face the study subject, our proposition consists of explaining how, the image built by Aunt Neiva, through the representations she developed and the ones consigned by other actors, perpetuates around its temporal and spiritual representations, authorizes the conceptions, solidify and grant the maintenance of the religious community. The consideration that the charismatic centralism contributed to maintain her leadership, confirms the recognition of the inspiration and materialization involved in the knowledge and the spiritual work, all dependent of her speech or her legitimating clairvoyance, that acted as a privileged communication channel with the transcending dimension, once she was recognized by the ones of the community as a vessel of super human powers. The findings points that the systematization of the rites, the narration of the myths and the distribution of competences concerning the interactions with the spiritual sphere, the operations that in the religious field, are supported as having strong relevance, germinated from her sacred words. __________________________________________________________________________________________ RÉSUMÉ / La présente recherche se concentre sur l'histoire du chef religieux de la communauté connue sous le nom de "Vale do Amanhecer", le célèbre moyen “Tia Neiva”. Après logement temporaire dans plusieurs différentes villes, à la recherche de la stabilité, les migrants de la région nord-est de la pays, Neiva Chaves Zelaya, seraient directement impliqués dans la construction du Fédéral Capital. A la suite de la vision avant Brasília, qui a montré que la terre promise et dotée de vigoureuse religiosité, elle a commencé sa trajectoire mystique hierophant instituant la Doctrine de "Amanhecer". Face sujet de l'étude, notre proposition consiste en expliquant comment, à l'image construit par la Tia Neiva, à travers les représentations elle a développé et ceux expédiés par d'autres acteurs, perpétue autour de son temporel et spirituel des représentations, autorise la conceptions, solidifier et accorder à l'entretien de la communauté religieuse. L'examen que le centralisme charismatique contribué à maintenir son leadership, confirme la reconnaissance de l'inspiration et la matérialisation impliqués dans la connaissance et le spirituel de travail, tous les dépendant de son discours ou sa légitimation clairvoyance, qui a agi comme un privilégié canal de communication avec la dimension transcendant, une fois qu'elle a été reconnue par ceux de la communauté comme un navire de super pouvoirs de l'homme. Les conclusions de points que la systématisation de la rites, le récit de mythes et de la répartition des compétences concernant la interactions avec la sphère spirituelle, les opérations que dans le domaine religieux, sont pris en charge comme ayant une forte pertinence, de son germé sacré mots.

Diploma thesis focuses on the topic of cleaning boilers in heating and power generation industry and automation of boiler cleaning process. There are summarized facts about cleaning devices, from which these systems consist of and as well as about support and control devices. Based on this facts, is developed control system and visualization interfaces with an emphasis on functionality into the system.

Syftet med denna studie var att beskriva hur fysiskt aktiva personer som fått diagnosen TIA var. Frågeställningarna rörde vilka aktiviteter studiedeltagarna ägnade sig åt, hur de upplevde sin hälsa, begränsande faktorer, eventuell förändring av aktivitetsvanor, samt om deltagarna fått råd om fysisk aktivitet. Som metod valdes enkätundersökning och 195 enkäter skickades till personer som sökt Universitetssjukhuset Örebro 2007 och fått diagnosen TIA. Resultat: Svarsfrekvensen, efter externt och internt bortfall, blev 74 %. Mer än hälften av de 144 studiedeltagarna var fysiskt aktiva mindre än 30 minuter/dag. Den vanligaste aktiviteten var promenader, vilket 72 % ägnade sig åt. Yngre personer ägnade sig oftare åt tre eller fler aktiviteter jämfört med äldre personer. De deltagare som var regelbundet fysiskt aktiva skattade sin hälsa som god till utmärkt, medan de med stillasittande fritid skattade sin hälsa som någorlunda eller dålig. De mest begränsande faktorerna var sjukdom och smärta. Av studiedeltagarna uppgav 98 personer att de inte fått råd om fysisk aktivitet och hälften av deltagarna hade inte förändrat sina aktivitetsvanor. Slutsats: Studien visar att många personer som fått diagnosen TIA är fysiskt inaktiva. Begränsande faktorer, som, sjukdom, smärta och hög ålder, medför att råd om fysisk aktivitet bör vara individanpassade. Att ge råd om fysisk aktivitet på lämplig nivå, utifrån den enskilde personens förutsättningar är ett centralt kunskapsområde för sjukgymnaster. Därför bör dessa patienter ges möjlighet att träffa sjukgymnast.

Abstract The purpose of the study was to explain the effects of risk factor targeted lifestyle counselling intervention on quality of lifestyle counselling and on adherence to lifestyle change in stroke patients. Content and characteristics of stroke patient counselling was described (I) with narrative literature review (n=33). Lifestyle habits of hospital-admitted stroke patients were described and explained (II) with cross-sectional design (n=150). Quasi-experimental, nonequivalent control group pretest-posttest design explained (III) the effects of lifestyle counselling intervention on working-age stroke patients’ adherence to lifestyle change (n=75/group). Cross-sectional, explorative between-groups prospective design explained (IV) associations between the quality of counselling and adherence to lifestyle change during the 12-month follow-up (n=98). The literature data was gathered from the databases and analysed with content analysis (I). The empirical data was collected with Lifestyle (II), Adherence to Lifestyle Change (III, IV) and Counselling Quality (IV) instruments. Descriptive statistics, factor analysis, cross-tabulation of variables, logistic regression, and ANCOVA were used for data analysis. Counselling was described with seven themes: information about the disease and concerns regarding stroke, aims of counselling, counselling methods, interaction as a method for counselling, stroke nurse as a counsellor, emotional support and decision making in patient care (I). Patients were overweight or obese (75%) and 86.7% had high waist circumference levels. They generally had rather unhealthy eating habits, were physically inactive and quite highly stressed, and 33.5% drank to excess every month or every week, and 32.9% were current smokers (II). After intervention the experimental group lost their weight at 3 and 6 months, reduced cigarette consumption at 3 months, and increased smoking cessation at 6 months. The experimental group received more support from nurses, family and friends (III). Lifestyle counselling quality was estimated rather good, with the exception of patient-centred counselling, and significantly better by the experimental group. Interactiveness, resources, and advantages of counselling were related to adherence variables (IV). Intervention had effects on lifestyle counselling quality and on adherence to lifestyle change in the short term. / Tiivistelmä Tutkimuksen tarkoituksena oli selittää aivoverenkiertohäiriöpotilaiden (AVH) riskitekijöihin kohdistuvan elintapaohjausintervention vaikutuksia elintapaohjauksen laatuun ja elintapamuutokseen sitoutumiseen. Ohjauksen sisältöä ja ominaispiirteitä kuvattiin (I) narratiivisen kirjallisuuskatsauksen avulla (n=33). AVH-potilaiden elintapoja (n=150) sairaalaan tulovaiheessa kuvattiin ja selitettiin (II) poikkileikkaustutkimuksella. Kvasikokeellinen tutkimus selitti (III) elintapaintervention vaikutuksia työikäisten AVH-potilaiden elintapamuutokseen sitoutumiseen (n=75/ryhmä). Ohjauksen laadun ja elintapamuutokseen sitoutumisen välistä yhteyttä 12 kuukauden seurannan aikana selitettiin (IV) poikkileikkaus- ja pitkittäistutkimuksen avulla (n=98). Kirjallisuuskatsauksen aineisto kerättiin tietokannoista ja analysoitiin sisällön analyysillä (I). Empiirinen data kerättiin elintapamittarilla (II), elintapamuutokseen sitoutumismittarilla (III, IV) ja ohjauksen laatu mittarilla (IV). Aineisto analysoitiin kuvailevin tilastollisin menetelmin, faktorianalyysillä, ristiintaulukoinnilla, logistisella regressiolla sekä varianssianalyysillä. Seitsemän teemaa kuvasi ohjausta: tieto sairaudesta ja siihen liittyvistä tekijöistä, ohjauksen tavoitteellisuus, ohjausmenetelmät, vuorovaikutus ohjausmenetelmänä, sairaanhoitaja ohjaajana, emotionaalinen tuki, sekä potilaan hoitoon liittyvä päätöksenteko (I). Potilaista 75% oli ylipainoisia tai lihavia ja suurella osalla vyötärönympärys oli liian suuri (86.7%). He söivät jokseenkin epäterveellisesti, liikkuivat liian vähän ja olivat stressaantuneita. Potilaista 33.5% joi humalahakuisesti kuukausittain tai joka viikko ja 32.9% tupakoi (II). Koeryhmän potilaiden paino laski kolmen ja kuuden kuukauden kuluttua kotiutumisesta. Savukkeiden määrä väheni kolmen kuukauden kuluttua kotiutumisesta ja tupakoinnin lopettaminen lisääntyi kuuden kuukauden kuluttua. Koeryhmän potilaat saivat enemmän tukea hoitajilta, perheeltä ja ystäviltä (III). Ohjauksen laatu arvioitiin hyväksi, poikkeuksena oli ohjauksen potilaskeskeisyys. Kokonaisuutena ohjauksen laatu arvioitiin paremmaksi koeryhmässä. Vuorovaikutus, resurssit ja ohjauksen vaikutukset olivat selkeimmin yhteydessä elintapamuutokseen sitoutumiseen (IV). Elintapainterventiolla oli vaikutusta elintapaohjauksen laatuun sekä elintapamuutokseen sitoutumiseen lyhyellä aikavälillä.

The thesis describes insurance, its main processes and support of the processes by SAP and TIA applications. The goal is to analyze and describe policy management and claims management processes, find out to what extent are these processes supported by TIA and SAP and compare the applications in conclusion. Description of the processes is based on author's working experience and experts' advices. The comparison of TIA and SAP applications is made according to ISO 9126 and other more specific criteria. Rating of the characteristics was made by TIA and SAP experts. Benefit of the thesis is description of support of main processes by SAP and TIA applications and its comparison.

The aim of this thesis is to create a custom application to simulate production lines. The first part explains the main reasons, benefits and current trends in the field of virtual commissioning and describes several simulation tools and engineering tools from Siemens. The second part is devoted to a detailed description of features, capabilities and application interface of the PLCSIM Advanced simulation tool. The third part is devoted to design and realization of the custom simulation application, which can be used for create conveyor lines and validate user PLC program in cooperation with PLCSIM Advanced tool. This simulator was created using Unity3D game engine and C# programming language. In the last part of the thesis, a simple simulation task is created in the simulator and is tested using PLC program and visualization created in the TIA Portal engineering framework.