Denna uppsats syfte är att undersöka de långsiktiga konsekvenserna för bibliotekari-ernas dagliga arbete, utifrån ett kommunöverskridande projekt rörande digitala sam-arbeten. Detta kan ge en större kunskap om både möjligheter, nackdelar och, i för-längningen, vilken kompetens som dagens samhälle kräver av bibliotekarierna. Det projekt som undersökningen är baserad på går under namnet V8 och består av ett samarbete mellan åtta kommuners folkbibliotek i Västerbottens inland.För att kunna uppfylla detta syfte består uppsatsen av en kvalitativ intervjustudie med bibliotekariers upplevelser av ett avslutat kommunalt överskridande samarbetsprojekt (V8) i fokus, där jag försökt se vilken påverkan projektet haft på bibliotekariernas dagliga arbete. Undersökningen har framför allt koncentrats till att behandla följande områden: 1. Kundanvändandet av hemsidan, katalog och databaser, 2. Bibliotekens gemensamma regler och tjänster samt 3. Ut- och fortbildning för personalen. Huvud-områden i V8 projektet.Ett tydligt resultat visar på att tekniken i allt större grad står i fokus för bibliotekarier-nas dagliga arbetsuppgifter, bland annat i form av arbete med webbsidor, internetba-serad kundkontakt och både databas- och kataloghantering. Ett annat relevant resul-tat som framkommer i undersökningen är att ut- och fortbildning har ökat som effekt av samarbetsprojektet. Slutligen framkom det att projektet även resulterat i en större gemenskap mellan de inblandade biblioteken, vilket skapat en större känsla av sä-kerhet som även gett en större gemensam kunskaps- och inspirationsbas.De slutsatser som kan dras av undersökningen är, för det första, att det krävs en allt större teknisk kompetens hos bibliotekarierna, då allt mer arbete stammar från inter-netbaserade tjänster och att allt mer service sker digitalt. För det andra, har det i just detta fall, blivit en markant förbättring gällande ut- och fortbildningsmöjligheter, vilket också kan anses spegla den allt större efterfrågan på teknisk kunnig personal. För det tredje förefaller det som så att ett bibliotek som är del i ett större samarbete även får en större trygghet och en bredare kunskaps- och inspirationsbas. I förlängningen leder allt detta till en bättre och mer kompetent biblioteksverksamhet samt indikation-er på att samverkan mellan bibliotek på en nationell nivå kan vara av yttersta vikt för att biblioteken skall kunna inta en position bland de viktigaste och mest inflytelserika institutionerna i det nya århundradet.

Latest trend in multi core architectures is to integrate heterogeneouscores on a single chip in order to achieve task and threadlevel parallelism, high performance and energy efficiency. Someexamples of heterogeneous multi cores processors include (Tegraby NVIDIA,Cell by IBM and Fusion by AMD). The goal of this thesis work is to design a heterogeneous (2x2)network on chip which can run different tasks in parallel on allthe four cores in the network. Development steps of heterogeneousnetwork on chip include integration of Leon3 -a soft core processorby AeroFlex Gaisler which conforms with IEEE 1754 (SPARCV8) architecture- at one of the nodes of a homogeneous networkon chip incorporating four NiosII/s cores -soft core processor byAltera.This integration involves replacing a NiosII/s processor fromone of the four nodes of the homogeneous network by Leon3 processor.To translate the signals between the resource to networkinterface of the node and the Leon3 processor an AMBA bus1 toAvalon bus2 signal translation wrapper was designed. All processorsin the network on chip communicate by message passing interface.To exploit the potential of heterogeneous network on chipthree applications including sparse LU factorization, nqueens andFibonacci numbers calculation were run on it. These applicationwere run on Leon3 SPARC which generated a number of tasks thatcan run in parallel on all cores of the network simultaneously. Thisparallel execution of nqueens and fibonacci numbers calculationhas resulted in speed up as compared to the serial execution ofthese applications on Leon3 SPARC only. Because of the limitedsize of the on chip memory available for the Leon3 processor, itwas not possible to run sparse LU factorization for bigger matrixsizes and this constraint has resulted in no speed up in case ofsparse LU factorization.

This bachelor thesis explores the work among the ”V8-libraries”, with focus on the librarians that works within the collaboration to see how it’s perceived. The questions asked are: How does the communication between the libraries work? How does the leadership look like? What benefits and what challenges does the collaboration come with? For the theoretical framework, Jennifer Rowleys theory of innovation collaboration strategies for libraries has been used. The method has been qualitative interviews with three informants that works within the collaboration. The study’s conclusion is that the V8-libraries have great communication and a leadership that serves the needs of the collaboration. The two biggest benefit is for the users of the libraries since they receive a greater range of books and other media, and also for the librarians since the collaboration makes bigger staff with bigger competence. The big challenge in the collaboration is the great distances between the libraries since the librarians wish to visit each other more often to discuss greater innovations between them.

An engine heater is used to warm engine cooling fluid in an engine. This specific case pertains to the engine warmers found in the V8 engines of Scania trucks. The purpose of this study is to make the product development more effective by optimizing the cooperation with suppliers. This is achieved by lowering the costs and development time of the product development. The form and extent to which the supplier is involved can vary, depending on whether or not they are to be fully, partially, or not at all involved in the project. The problem is how a recommendation for collaboration should look like. In order to understand how these recommendations should look, one needs to know which variables affect the cooperation between the company and the supplier. This is done to give a recommendation for how the cooperation with the supplier should be, in order to achieve an effective product development (PD) and high product performance. Through research in the form of written literature, a comparison could be made between the different theories of the PD-process and the cooperation and involvement of the supplier in a company’s PD process, with the company’s actual PD process, but also the cooperation levels with the suppliers in the NPD (New Product Development). This was done to identify which variables influence the cooperation between the company and the supplier, and to find out in what phase of a company’s NPD a supplier should be involved. The results showed that the company had not applied a common development relationship. This meant that it had not made use of organizational enablers (Garengo & Panizzolo, 2013), only technological and methodological enablers. The company's communication channels had not included face-to-face meetings, with communication primarily taking place through email or phone calls. This low level of communication has resulted in a low exchange of knowledge (Thomas, 2013), which affected the NPD efficiency in the form of delays to the project plan. The company had not applied the theory of not trusting “the trust” towards the supplier (Garengo & Panizzolo, 2013) nor kept a constant level of formal control. A case study about the development of engine heaters has also been made. This study has had certain specifications put up as boundaries for the work, such as that the engine heater should be designed in a way that it meets certain demands from the company and the customers. In this case our customers are the assemblers from the production and aftermarket. It should be designed as simply as possible, and be able to function in the most unclean environments, with dust, water, mud and oil. The main principle is to replace the current engine heater that is included in the V8 engines of today, with one that has a new design and takes mount ability, demount ability, quality, and production costs into account, and is backward compatible. The thesis has taken the production development method, from the book "Product Design and development" (Garengo & Panizzolo, 2013) into account in the development of engine heaters. Although it does differ on certain points, such as having the project leader in charge of the time management for the development of entire v8 engines. 3 (80) According to the conclusion, when involved in NPD, the company should apply a constant level of formal control for the supplier during the cooperation - and not just during the serial production (Garengo & Panizzolo, 2013) - and also not trust “trust” towards the supplier and informal controls. The company should use face to face meetings as a preferred communication channel (Garengo & Panizzolo, 2013) in order to achieve NPD (New Product Development) high media richness (high knowledge exchange). When NPD is used for complex products, or has a short project period, the company should involve the supplier at an early phase of the NPD process (Zhao, Cavugsil, & Cavusgil, 2014, for an effective project quality regarding the production speed to the market. An organisational enabler, with the help of a guest engineer or a site engineer (Garengo & Panizzolo, 2013, should also be applied. However, when it comes to new products of great importance the company should avoid involving the supplier for the NPD process (Zhao, Cavugsil, & Cavusgil, 2014) and instead only use technological based integration in a late phase of the process, such as the phase where only technological enablers are used (Garengo & Panizzolo, 2013). / En motorvärmare är en värmare för kylvätska till motorer. Dessa finns i fordon och i detta fall riktas det till motorvärmare i v8 motorer som finns i Företagets lastbilar. Syftet med detta examensarbete är att effektivisera produktutvecklingen genom att optimera samarbetsformerna med leverantörer. Detta sker genom att sänka produktutvecklingens kostnader och utvecklingstid. Samarbetsformen av leverantör kan variera under produktutvecklingen. Beroende på om de skall vara delaktiga i projektet helt och hållet, delvis eller inget. Problemet är hur en rekommendation för samverkan ska se ut. För att kunna ta reda på detta så behöver man veta vilka variabler som påverkar samarbetet mellan företag och leverantör. Detta görs för att kunna ge en rekommendation om det bästa möjliga sättet för vilket ett samarbete med en leverantör bör ske för att uppnå en effektiv produktutveckling (PU) och hög produktprestanda. Via forskning i form av läsning av böcker och artiklar kunde en jämförelse göras mellan de olika teorierna om PU-processen och samarbete & involvering av leverantör i ett företags PUprocess, med företagets verkliga PU-process och dess samarbete & involvering av leverantören i ny produktutveckling (NPU). Detta har gjorts för att ta reda på vilka variabler som har påverkat och påverkar samarbetet mellan företag och leverantör, och för att ta reda på under vilken fas i företagets NPU en leverantör bör bli involverad. Resultatet visade att företaget inte har tillämpat en gemensam utvecklingsrelation, detta innebär att man inte använt sig utav organisatoriska möjliggörare (Garengo & Panizzolo, 2013) utan endast teknologiska och metodologiska möjliggörare. Företagets kommunikationskanal har inte tillämpats genom face to face möten, utan kommunikationen har främst skett genom email eller telefonsamtal. Denna låga kommunikationskanal har resulterat i ett lågt kunskapsutbyte (Thomas, 2013) vilket har påverkat NPU-effektiviteten i form av förseningar av projektplan. Man har inte heller tillämpat att inte lita på tillit gentemot leverantören (Smets, Oorschot, & Langerak, 2013) och inte hållit en konstant nivå av formell kontroll. Det har även gjorts en fallstudie om utvecklingen av motorvärmare. Denna fallstudie gjordes och tillämpades för att kunna gå igenom hela företagets verkliga NPU-process steg för steg, och därefter studera hur samarbetet har varit mellan förtaget och leverantören. Denna studie har haft vissa specifikationer som har satt gränser för arbetet, bl.a. ska motorvärmaren designas så att den uppfyller vissa krav och kundernas krav. Huvudprincipen är att ersätta den nuvarande motorvärmaren som ingår i dagens V8 motorer med en som har en ny design som tar hänsyn till monterbarhet, demonterbarhet, kvalitet, tillverkningskostnad och är bakåtkompatibel. Examensarbetet har tagit hänsyn till produktutvecklingsmetoden från boken ”Product Design and Development” (Ulrich & Eppinger, 2012) vid utvecklingen av motorvärmare. Detta har skett med undantag för vissa punkter som t.ex. hur tidsplaneringen för projektet tagits fram, vilket bestäms av projektledaren som lägger fram tidsplaneringen för utvecklingen av hela v8 motor. Enligt slutsatsen så bör företaget vid NPU tillämpa en konstant nivå av formell kontroll vid samarbete med leverantören vid utvecklingsfasen och inte enbart vid serieproduktion (Smets, Oorschot, & Langerak, 2013), samt att inte lita på tillit gentemot leverantören. Företaget bör 5 (80) även använda face to face möten som kommunikationskanal för att åstadkomma hög informationsutbyte (Thomas, 2013). Vid NPU med en komplex produkt eller vid kort projekttid så bör företaget involvera leverantörer vid tidig fas av NPU-process (Zhao, Cavugsil, & Cavusgil, 2014), för en effektiv projektkvalitet gällande produktsnabbhet till marknad. Samt att tillämpa organisatorisk möjliggörare med hjälp av gästingenjör eller platsingenjör (Garengo & Panizzolo, 2013). Däremot vid en ny produktnyhet som är väldigt viktig för företaget så bör företaget undvika att involvera leverantörer vid NPU-process (Zhao, Cavugsil, & Cavusgil, 2014) genom att använda sig av istället enbart teknologisk utvecklingsrelation i en sen fas av processen (Garengo & Panizzolo, 2013). / NCG projekt

Atopic Dermatitis (AD) is a common chronic relapsing inflammatory skin disease affecting 15 - 20% of children and 2 - 10% of adults worldwide, with significant morbidity. A hallmark of AD is disruption of the critical barrier function of upper epidermal layers, causatively linked to environmental stimuli, genetics and infections. Another typical feature of AD is skin infections, especially from Staphylococcus aureus (S. aureus), which closely relates with the disease severity. Although not a normal flora, S. aureus is found on 75-100% of AD lesions (< 30% on healthy skin). S. aureus secrete a range of virulence factors, including extracellular toxins and proteases which contribute to disease pathogenesis. S. aureus serine protease A (SspA/V8) is a well-characterised extracellular protease widely expressed among different S. aureus strains. The pathogenic effect of V8 protease has been demonstrated in vivo, damaging murine skin integrity via effects on the stratum corneum (SC), but the targets for this V8-mediated damage remains unclear. The capacity of proteases to induce barrier dysfunction has been proposed as a key driving force in the initiation and exacerbation of AD. Thus, understanding the host factors that maintain barrier function is a priority in developing novel therapeutic approaches. This thesis therefore aimed at detecting host factors which can combat the barrier dysfunction caused by pathogenic proteases, assessing their relevance in vitro and ex vivo and elucidating the underlying mechanisms. Firstly, an in vitro skin barrier integrity model was developed, using both immortalized and primary keratinocytes, to evaluate the barrier damage mediated by pathogenic proteases. The results revealed that S. aureus protease SspA/V8 is the dominant secreted factor (in laboratory and AD clinical strains of S. aureus) inducing barrier integrity impairment. In addition, studies demonstrated that V8 protease itself was sufficient to induce barrier disruption, and this phenotype was not dependent on cell death, but rather on breaking down of cell-cell junctions. Key tight junction proteins including claudin-1 and occludin were found to be degraded by V8 protease. Next, a wide range of host and bacterial factors were investigated to determine whether they could promote protection of keratinocytes against V8 damage. Several factors, including IL-1β, TNF-α, heat-killed Staphylococcus epidermidis (which is the main skin normal flora), were found to induce protection against V8 protease, with IL-1β having the strongest effect. In addition, data indicated that this IL-1β-mediated protection was independent of effects on claudin-1 but occurred via secretion of a transferrable host factor. Induction of keratinocyte expression of the antimicrobial/host defence peptide human beta-defensin 2 (hBD2) was found to be the mechanism underpinning this IL-1β- induced protective effect. Endogenous hBD2 expression was required and sufficient for protection against V8 protease-mediated integrity damage, and exogenous application of hBD2 was also protective. An ex vivo model using human skin tissue was also established to address this novel function of hBD2, and preliminary data indicated that exogenous hBD2 protected against V8-mediated damage in this system. Overall, my data reveal a novel function for the antimicrobial/host defence peptide hBD2. This modulatory property of hBD2, independent of its antibacterial effects, gives new significance to the defective induction of hBD2 in the barrier-defective skin lesions of AD and indicates therapeutic potential to prevent S. aureus-mediated aggravation of skin barrier dysfunction in AD.

One of the latest tools in the strive troughwards a fast and secure Web is called WebAssembly. It is a low-level, assembly-like language that can run in the browser alongside JavaScript. WebAssembly is designed to load fast and aims to execute at near-native speed. Being a compilation target for system languages like C, C++, and Rust, WebAssembly is not very accessible from a Web developer perspective. This project explores ways to generate WebAssembly directly from JavaScript code, in order to lower the learning curve, and allow for a more widespread adoption of WebAssembly. This has resulted in a utility tool called Esmbly, which can turn simple JavaScript programs into WebAssembly binaries by collecting and utilizing type information from various flavours of statically typed JavaScript.

This thesis deals with the design of a crankshaft for a high power racing engine using modern technology. It covers all of the steps from a brief research, design, torsional vibration analysis to fatigue calculation using FEA and MBS models.

Master´s thesis is considered with design and construction of V8 combustion engine with small size and low mass of its body. In the construction were used mass-produced components from the other engines. From every component was generated a 3D model in computer program Pro/Engineer, new necessary parts were made in the same program and put together to assembly. Main part of the construction was to design a new crankshaft, a crankcase and an engine lubricating system. The crankshaft was subjected computing analysis in program Pro/Mechanica, using FEM.

The need for products has increased during the last few years, this high demand needs to bemet with higher means of production. The use of neural networks can be the key to increasedproduction without having to compromise product quality or human workers well being. This thesislooks into the concept of reliable architectures in convolutional neural networks and how they canbe implemented. The neural networks are trained to recognize the features in images to identifycertain objects, these recognition is then compared to other models to see which of them had the bestprediction. Using multiple models creates a reliable architecture from which results can be produced,these results can then be used in combinations with algorithms to improve prediction certainty. Theaim of implementing the networks with these algorithms are to improve the results without havingto change the networks configurations.

Background: In recent years, computer vision has undergone significant advancements, revolutionizing fields such as robotics, augmented reality, and autonomoussystems. Key to this transformation is Simultaneous Localization and Mapping(SLAM), a fundamental technology that allows machines to navigate and interactintelligently with their surroundings. Challenges persist in harmonizing spatial andsemantic understanding, as conventional methods often treat these tasks separately,limiting comprehensive evaluations with shared datasets. As applications continueto evolve, the demand for accurate and efficient image segmentation ground truthbecomes paramount. Manual annotation, a traditional approach, proves to be bothcostly and resource-intensive, hindering the scalability of computer vision systems.This thesis addresses the urgent need for a cost-effective and scalable solution byfocusing on the creation of accurate and efficient image segmentation ground truth,bridging the gap between spatial and semantic tasks. Objective: This thesis addresses the challenge of creating an efficient image segmentation ground truth to complement datasets with spatial ground truth. Theprimary objective is to reduce the time and effort taken for annotation of datasets. Method: Our methodology adopts a systematic approach to evaluate and combineexisting annotation techniques, focusing on precise object detection and robust segmentation. By merging these approaches, we aim to enhance annotation accuracywhile streamlining the annotation process. This approach is systematically appliedand evaluated across multiple datasets, including the NYU V2 dataset(consists ofover 1449 images), ARID(real-world sequential dataset), and Italian flats(sequentialdataset created in blender). Results: The developed pipeline demonstrates promising outcomes, showcasing asubstantial reduction in annotation time compared to manual annotation, thereby addressing the challenges posed by the cost and resource intensiveness of the traditionalapproach. We observe that although not initially optimized for SLAM datasets, thepipeline performs exceptionally well on both ARID and Italian flats datasets, highlighting its adaptability to real-world scenarios. Conclusion: In conclusion, this research introduces an innovative annotation pipeline,offering a systematic and efficient approach to annotation. It tries to bridge the gapbetween spatial and semantic tasks, addressing the pressing need for comprehensiveannotation tools in this domain.