International Telemetering Conference Proceedings / October 18-21, 2004 / Town & Country Resort, San Diego, California / Packetizing data for transport over a networked system corrupts embedded information such as absolute and relative timing from the data. Without this information, it is difficult to reproduce the data with its original timing restored. Absolute timing is the time between data points within a given channel of data. Relative timing is the time relationship between data points from two or more channels of data. Having this restored timing allows the use of existing equipment for analysis and eliminates the need for expensive custom designed equipment to analyze the recovered data. Using a packetizing solution that transports information about the data stream and transport packets that are broken up by system wide timing allows us to accomplish this.

No description available.

<p>To ensure genomic integrity, the genome must be accurately duplicated once and only once per cell division. DNA replication is tightly regulated by replication licensing mechanisms which ensure that origins only initiate replication once per cell cycle. Disruption of replication licensing mechanisms may lead to re-replication and genomic instability. </p><p>DNA licensing involves two steps including the assembly of the pre-replicative compelx at origins in G1 and the activation of pre-RC in S-phase. Cdt1, also known as Double-parked (Dup) in <italic> Drosophila Menalogaster </italic>, is a key regulator of the assembly of pre-RC and its activity is strictly limited to G1 by multiple mechanisms including Cul4<super>Ddb1</super> mediated proteolysis and inhibitory binding by geminin. Previous studies have indicated that when the balance between Cdt1 and geminin is disrupted, re-replication occurs but the genome is only partially re-replicated. The exact sequences that are re-replicated and the mechanisms contributing to partial re-replication are unknown. To address these two questions, I assayed the genomic consequences of deregulating the replication licensing mechanisms by either RNAi depletion of geminin or Dup over-expression in cultured Drosophila Kc167 cells. In agreement with previously reported re-replication studies, I found that not all sequences were sensitive to geminin depletion or Dup over-expression. Microarray analysis and quantitative PCR revealed that heterochromatic sequences were preferentially re-replicated when Dup was deregulated either by geminin depletion or Dup over-expression. The preferential re-activation of heterochromatic replication origins was unexpected because these origins are typically the last sequences to be duplicated during normal S-phase. </p><p>In the case of geminin depletion, immunofluorescence studies indicated that the re-replication of heterochromatin was regulated not at the level of pre-RC activation, but rather due to the restricted formation of the pre-RC to the heterochromatin. Unlike the global assembly of the pre-RC that occurs throughout the genome in G1, in the absence of geminin, limited pre-RC assembly was restricted to the heterochromatin. Elevated cyclin A-CDK activity during S-phase could be one mechanism that prevents pre-RC reassembly at euchromatin when geminin is absent. These results suggest that there are chromatin and cell cycle specific controls that regulate the re-assembly of the pre-RC outside of G1.</p><p>In contrast to the specific re-replication of heterochromatin when geminin is absent, re-replication induced by Dup over-expression is not restricted to heterochromatin but rather includes re-activation of origins throughout the genome, although there is a slight preference for heterochromatin when re-replication is initiated. Surprisingly, Dup over-expression in G2 arrested cells result in a complete endoreduplication. In contrast to the ordered replication of euchromatin and heterochromatin during early and late S-phase respectively, endoreduplication induced by Dup over-expression does not exhibit any temporal order of replication initiation from these two types of chromatin, suggesting replication timing program may be uncoupled from local chromatin environment. Taken together, these findings suggest that the maintenance of proper levels of Dup protein is critical for genome integrity.</p> / Dissertation

In this thesis, we describe how to use UML sequence diagrams with MARTE timing constraints to specify entirely the behavior of component-based systems while abstracting as much as possible the functional roles of components composing it. We have shown how to conduct compositional analysis of such specifications. For this, we have defined operational semantics to sequence diagrams by translating them into TIOSTS which are symbolic automata with timing constraints. We have used symbolic execution techniques to compute possible executions of the system in the form of a symbolic tree. We have defined projection mechanisms to extract the execution tree associated with any distinguished component. The resulting projected tree characterizes the possible behaviors of the component with respect to the context of the whole system specification. As such, it represents a constraint to be satisfied by the component and it can be used as a correctness reference to validate the system in a compositional manner. For that purpose, we have grounded our validation framework on testing techniques. We have presented compositional results relating the correctness of a system to the correctness of components. Based on these results, we have defined an incremental approach for testing from sequence diagrams.

<p>A payment scheme specifies when payments are made between firms in a supply chain. It has direct implications on how supply chain inventory is financed and managed. Longer supply chains due to globalization and the recent credit crisis have increased the pressure to make financing the supply chain more efficient. It was recently reported that 81% of UK firms say that market conditions have brought procurement and finance strategies in closer alignment. Meanwhile, information technology platform advancements provide opportunity for increased variety of payment schemes. It is therefore important to understand how different payment schemes should be captured in inventory decisions. This dissertation examines the impact of supply chain finance (the set of financial payment transactions that are triggered by supply chain events) on inventory management from both normative and behavioral perspectives. </p><p>We seek to address the following questions. From a normative perspective: How does the optimal inventory policy depend on the supply chain financing structure? What is the right inventory financing scheme for a supply chain? From a behavioral perspective: How do real managers psychologically process payments when making inventory decisions, and how are they affected by the supply chain financing scheme? The results are reported in three chapters, described below.</p><p>In the first chapter, "Payment schemes and the financed inventory," we present a model of payment schemes in an echelon supply chain. A payment scheme specifies when payments are made between firms. Standard inventory decision models make strict assumptions about the payment scheme in order to avoid explicitly tracking financial flows. These assumptions, however, often do not hold in practice. We show that these assumptions can be relaxed. In particular, we introduce a model that allows us to track the financial flow of inventory models depending on the inventory policy and the payment scheme. We also define two new measures - financed inventory and margin backorders. These new measures allow us to leverage the structure of the payment scheme to define an equivalent problem that does not have to explicitly track financial flows. We apply this method to the base stock model and economic order quantity model to demonstrate the sensitivity of the optimal inventory policy to the payment scheme. Our results provide simple closed-form formulas for inventory managers and also sheds light on what is the right payment scheme for a supply chain.</p><p>The second chapter, "The effect of payment schemes on inventory decisions: The role of mental accounting," focuses on managerial behavior: how do manager's mentally process and evaluate payments when making an inventory decision? Keeping the net profit structure constant, we study how the payment scheme affects inventory decisions in the newsvendor problem. Specifically, we examine three payment schemes which can be interpreted as the inventory order being financed 1) by the newsvendor herself, 2) by the supplier, and 3) by the customer. We find in laboratory experiments that the order quantities may be higher or lower than the expected profit-maximizing solution depending on the payment scheme. Specifically, the order quantity under newsvendor own financing is greater than that under supplier financing, which is, in turn, greater than the order quantity under customer financing. This observed behavior biases orders in the opposite direction as what a regular or hyperbolic time-discounted utility model would predict, and cannot be explained by loss aversion models. Instead, the findings are consistent with a model that underweights the order-time payments, which is consistent with the "prospective accounting" assumption in the mental accounting literature. A second study shows the results hold even if all actual payments are conducted at the same time, suggesting that the framing of the payment scheme is sufficient to induce mental accounting of payments at different times. We further validate the robustness of our model under different profit-margin conditions. Our findings contribute to the understanding of the psychological processes involved in newsvendor decisions and have implications for supply chain financing practices and supply chain contract design.</p><p>The third chapter, "Reference prices and transaction utility in inventory decisions," studies another aspect of mental accounting in inventory decisions - the phenomenon that individuals often view a price as relative to other prices when making an evaluation. We present a descriptive model of the effects of reference prices and transaction utility in a newsvendor setting. The model predicts that an individual's order is irrationally increasing in past purchasing costs, decreasing in past selling prices, and decreasing in the proportion of high profit margin to low profit margin products in the decision portfolio. Three laboratory experiments support the model's predictions. These results suggest that managerial supervision and/or intervention are most valuable after a sudden increase or decrease in the cost or price of a product, or for a product that differs significantly in profit margin from other products in the category. We further extend the study to a supply chain setting. We show analytically that the supplier's optimal wholesale price is lower when the newsvendor is subject to reference effects compared to when the newsvendor is rational, and that the supplier's optimal retail price may be higher or lower depending on whether the reference effect is stronger for the newsvendor or for customers. Finally, we show that supply chains may suffer from a behavioral inefficiency we call a behavioral price whip: an increase in the transfer price between two nodes may influence the upstream node to order more than is rational while the downstream node demands less than is rational. These results suggest that suppliers should carefully evaluate the reference effect on both customers and retailers, and that everyday low pricing has a behavioral benefit over high-low pricing.</p> / Dissertation

The human sense of touch integrates feedback from a multitude of touch receptors, but how this information is represented in the neural responses such that it can be extracted quickly and reliably is still largely an open question. At the same time, dexterous robots equipped with touch sensors are becoming more common, necessitating better methods for representing sequentially updated information and new control strategies that aid in extracting relevant features for object manipulation from the data. This thesis uses information theoretic methods for two main aims: First, the neural code for tactile processing in humans is analyzed with respect to how much information is transmitted about tactile features. Second, machine learning approaches are used in order to influence both what data is gathered by a robot and how it is represented by maximizing information theoretic quantities. The first part of this thesis contains an information theoretic analysis of data recorded from primary tactile neurons in the human peripheral somatosensory system. We examine the differences in information content of two coding schemes, namely spike timing and spike counts, along with their spatial and temporal characteristics. It is found that estimates of the neurons’ information content based on the precise timing of spikes are considerably larger than for spikes counts. Moreover, the information estimated based on the timing of the very first elicited spike is at least as high as that provided by spike counts, but in many cases considerably higher. This suggests that first spike latencies can serve as a powerful mechanism to transmit information quickly. However, in natural object manipulation tasks, different tactile impressions follow each other quickly, so we asked whether the hysteretic properties of the human fingertip affect neural responses and information transmission. We find that past stimuli affect both the precise timing of spikes and spike counts of peripheral tactile neurons, resulting in increased neural noise and decreased information about ongoing stimuli. Interestingly, the first spike latencies of a subset of afferents convey information primarily about past stimulation, hinting at a mechanism to resolve ambiguity resulting from mechanical skin properties. The second part of this thesis focuses on using machine learning approaches in a robotics context in order to influence both what data is gathered and how it is represented by maximizing information theoretic quantities. During robotic object manipulation, often not all relevant object features are known, but have to be acquired from sensor data. Touch is an inherently active process and the question arises of how to best control the robot’s movements so as to maximize incoming information about the features of interest. To this end, we develop a framework that uses active learning to help with the sequential gathering of data samples by finding highly informative actions. The viability of this approach is demonstrated on a robotic hand-arm setup, where the task involves shaking bottles of different liquids in order to determine the liquid’s viscosity from tactile feedback only. The shaking frequency and the rotation angle of shaking are optimized online. Additionally, we consider the problem of how to better represent complex probability distributions that are sequentially updated, as approaches for minimizing uncertainty depend on an accurate representation of that uncertainty. A mixture of Gaussians representation is proposed and optimized using a deterministic sampling approach. We show how our method improves on similar approaches and demonstrate its usefulness in active learning scenarios. The results presented in this thesis highlight how information theory can provide a principled approach for both investigating how much information is contained in sensory data and suggesting ways for optimization, either by using better representations or actively influencing the environment.

This thesis examines capital structure theories and debt level determinants to develop a better understanding, and to establish the most appropriate theory to explain the behaviour of firms‟ debt and equity choices. It tests three major capital structure theories (e.g. the trade-off, pecking order and market timing theories) using static and dynamic statistical models and 13 capital structure determinants, based on three major capital structure theories. The study uses 4,598 sample companies from 11 countries and 27 industries over a 20 year period. This method provides a clear insight into firms‟ debt and equity choice behaviours. The static trade-off theory is tested by first searching for similarities and differences between industries, countries and time periods and, second, by observing whether firms change their capital structures towards optimal levels and whether the coefficient signs are the same as the predictions. The "stock price effect‟ on debt levels is used to examine the pecking order and market timing theories. The pecking order theory is likewise tested by confirming whether firms issue debt when they face a financial deficit. Furthermore, these theories are tested using cluster analyses. The sample examines 11 different characteristics, which include firm size, debt level, and bankruptcy probability. As each characteristic is related to one or more capital structure theories, the most appropriate theory can be derived, based on such characteristics. There are five main findings. First, firms which are financial stable issue relatively more debt. Second, they have a preference for moderate debt levels and thus limit their bankruptcy probability. They also try to exploit opportunities from overestimated stock price by issuing stocks to increase cash inflows. Third, the effects from bankruptcy costs are greater than transaction costs in terms of capital structure adjustment. Fourth, during the sample period, firms continuously decrease leverage levels. Fifth, firms‟ characteristics and macro-economic factors affect their capital structure. There are three main conclusions. First, the behaviour of firms appears generally aligned with the trade-off theory, although the pecking order and market timing theories also partially explain the equity issuance condition. Second, the "equity and debt choice modes‟ can likewise be explained by the use of a theoretically combined approach, using the three major capital structure theories. In this approach, firms increase their value by both increasing debt for tax benefits and low adverse selection costs, and by issuing equity when the stock price is high. Third, this second conclusion implies that the trade-off, pecking order and market timing theories can be combined on the assumption that firms maximise their values under conditions of the existence of asymmetric information, tax shields and bankruptcy probability.

L’observation d’un modèle pratiquant une habileté motrice promeut l’apprentissage de l’habileté en question. Toutefois, peu de chercheurs se sont attardés à étudier les caractéristiques d’un bon modèle et à mettre en évidence les conditions d’observation pouvant optimiser l’apprentissage. Dans les trois études composant cette thèse, nous avons examiné les effets du niveau d’habileté du modèle, de la latéralité du modèle, du point de vue auquel l’observateur est placé, et du mode de présentation de l’information sur l’apprentissage d’une tâche de timing séquentielle composée de quatre segments. Dans la première expérience de la première étude, les participants observaient soit un novice, soit un expert, soit un novice et un expert. Les résultats des tests de rétention et de transfert ont révélé que l’observation d’un novice était moins bénéfique pour l’apprentissage que le fait d’observer un expert ou une combinaison des deux (condition mixte). Par ailleurs, il semblerait que l’observation combinée de modèles novice et expert induise un mouvement plus stable et une meilleure généralisation du timing relatif imposé comparativement aux deux autres conditions. Dans la seconde expérience, nous voulions déterminer si un certain type de performance chez un novice (très variable, avec ou sans amélioration de la performance) dans l’observation d’une condition mixte amenait un meilleur apprentissage de la tâche. Aucune différence significative n’a été observée entre les différents types de modèle novices employés dans l’observation de la condition mixte. Ces résultats suggèrent qu’une observation mixte fournit une représentation précise de ce qu’il faut faire (modèle expert) et que l’apprentissage est d’autant plus amélioré lorsque l’apprenant peut contraster cela avec la performance de modèles ayant moins de succès. Dans notre seconde étude, des participants droitiers devaient observer un modèle à la première ou à la troisième personne. L’observation d’un modèle utilisant la même main préférentielle que soi induit un meilleur apprentissage de la tâche que l’observation d’un modèle dont la dominance latérale est opposée à la sienne, et ce, quel que soit l’angle d’observation. Ce résultat suggère que le réseau d’observation de l’action (AON) est plus sensible à la latéralité du modèle qu’à l’angle de vue de l’observateur. Ainsi, le réseau d’observation de l’action semble lié à des régions sensorimotrices du cerveau qui simulent la programmation motrice comme si le mouvement observé était réalisé par sa propre main dominante. Pour finir, dans la troisième étude, nous nous sommes intéressés à déterminer si le mode de présentation (en direct ou en vidéo) influait sur l’apprentissage par observation et si cet effet est modulé par le point de vue de l’observateur (première ou troisième personne). Pour cela, les participants observaient soit un modèle en direct soit une présentation vidéo du modèle et ceci avec une vue soit à la première soit à la troisième personne. Nos résultats ont révélé que l’observation ne diffère pas significativement selon le type de présentation utilisée ou le point de vue auquel l’observateur est placé. Ces résultats sont contraires aux prédictions découlant des études d’imagerie cérébrale ayant montré une activation plus importante du cortex sensorimoteur lors d’une observation en direct comparée à une observation vidéo et de la première personne comparée à la troisième personne. Dans l’ensemble, nos résultats indiquent que le niveau d’habileté du modèle et sa latéralité sont des déterminants importants de l’apprentissage par observation alors que le point de vue de l’observateur et le moyen de présentation n’ont pas d’effets significatifs sur l’apprentissage d’une tâche motrice. De plus, nos résultats suggèrent que la plus grande activation du réseau d’observation de l’action révélée par les études en imagerie mentale durant l’observation d’une action n’induit pas nécessairement un meilleur apprentissage de la tâche. / Observation of a model practicing a motor skill has been shown to promote the learning of that skill. However, relatively little is known regarding the attributes of a good model and the conditions of observation that can optimize learning. In the three studies reported in this thesis, we investigated the effects of the model’s skill level, the model’s handedness, the observation perspective, and the medium of presentation on the learning of a sequential, four-segmented timing task. In the first experiment of the first study, we had participants observe a novice, an expert, or a combination of both novice and expert models (i.e., mixed model). The results of the retention/transfer tests revealed that observation of the novice model was not as effective for the learning of the task as observation of the expert and mixed models. Importantly, a mixed schedule of novice and expert observation resulted in more stable movement time and better generalization of the imposed relative timing pattern than observation of either a novice or an expert model. In the second experiment, we wanted to determine whether a certain type of novice performance (highly variable, with or without performance improvement) in a mixed observation schedule results in better learning of the task. No significant differences were revealed with respect to the type of novice model used in a mixed schedule of observation. These results suggest that mixed observation provides an accurate template of what to do (expert observation), which is enhanced when it can be contrasted with the performance of less successful models. In our second study, right-handed participants were asked to observe, from a first-person or a third-person perspective, a right-handed (i.e., same-handed) or left-handed (i.e., opposite-handed) model performing the experimental task. Observation of the same-handed model resulted in better learning of the task than did observation of the opposite-handed model, regardless of the observation perspective. This suggests that the action observation network (AON) is more sensitive to the model’s handedness than to the observer’s viewpoint. Thus, the AON seems to be linked to sensorimotor regions of the brain that simulate motor programming as though the observed movement was performed with one’s own dominant hand. Finally, in the third study, we were interested to determine whether the medium of presentation (live vs. video) affects observational learning and whether this effect would be mediated by the observer’s viewpoint (1st vs. 3rd person). In that regard, participants observed a live model or a video presentation of the model from a first- or third-person perspective. Our results revealed that observation did not differ significantly as a function of the media or the perspective of observation. These results are inconsistent with the predictions of brain imaging studies that show a larger activation of the sensorimotor cortex during live observation compared with video observation and from a first-person compared with the third-person perspective. Taken together, our results indicate that the model’s skill level and handedness are important determinants of observational learning, whereas the observer’s viewpoint and the medium of observation had no significant impact on motor task learning. In addition, our results suggest that the larger activation of AON revealed in brain imaging studies during action observation does not necessarily result in or indicate better learning of the task.

I mitt arbete undersöker jag vikten av timing i det vi gör som musiker när vi spelar. Genom min analys av Douze Études 1, med både egen övning och digitala verktyg, har jag kommit fram till hur timing kan skapa olika sound. Mitt arbete kommer täcka olika metoder av övning med digitala verktyg. Första delen av arbetet är en formanalys av etyden, då jag kommer gå igenom olika delar i stycket för att få en grundläggande översikt. Därefter går jag igenom min övningsprocess där jag detaljerat beskriver de problem som jag har stött på. Avslutningsvis dedicerar jag ett kapitel om övning med digitala verktyg där jag även kommer att ta upp logistiken och mentaliteten bakom övningen. / <p>Inspelning av Delécluse Étude 1 skedde separat och därav kommer som en separat inspelning.</p><p>Examenskonserten ägde rum på Kungliga Musikhögskolan, Svarta Lådan den 26e maj 2017.</p><p>Program:</p><p>Twine - Rolf Wallin, för marimba och xylofon</p><p>Rollercoaster - Daniel Berg, Yaroslav Polikarpov, för vibrafon och marimba (uruppförande)</p><p>Blues for Gilbert - Mark Glentworth, solo stycke för vibrafon</p><p>Dancing Stars - George Hamilton Green (arr. av Jerker Johansson), för solo xylofon tillsammans med två marimbor.</p><p></p><p>Medverkande:</p><p>Aleksander Ullriksen, Maarja Nuut, Daniel Berg, Rikard Markstedt, Kristoffer Linder</p>

Inspired by Lin and Huang’s (2009) rhythmic study of Chinese dialects, this study examines speech rhythm of 21 Chinese dialects from three perspectives, timing, melody, and phonological structure. The 21 dialects belong to four major groups of Chinese and their respective sub-groups. The four major groups are Mandarin, Wu, Min, and Cantonese. Nine duration-based and four pitch-based metrics are used to quantify timing and melody, respectively. Four phonological structure-based metrics are used to explore the relationships between syllable structure and timing and between tone structure and melody. All the metrics are paired up according to five categories, duration-only, pitch-only, duration-pitch, duration-syllable, pitch-tone, and each pair is subject to a correlation analysis. Then timing and melody patterns of the Chinese dialects are determined by correlation patterns of relevant metric pairs. The main findings of this study are as follows: 1) Timing and melody patterns of the Chinese dialects are far from homogenous across major groups and melody patterns are more distinct than timing patterns; 2) No single metric pair is able to quantify speech rhythm consistently for all the Chinese dialects; nonetheless, pitch-based metric pairs fare better than duration-based ones; 3) Syllable-timedness and melodiousness are correlated positively for all the major groups except for Wu; 4) Phonological structure plays little role in shaping timing and melody patterns of most Chinese dialects. The above findings are both expected and unexpected. They are expected in the sense that rhythmic perception invovles multiple acoustic cues, so it comes as no surprise that not all rhythmic metrics are successful in quantifying Chinese rhythm. They are unexpected for the reason that all the metrics are developed based more or less on phonological structure, yet the rhythmic patterns they reveal do not correspond to the structure affinity or group membership of the Chinese dialects. Overall, the findings suggest that pitch is a more import cue than duration to Chinese rhythm. As the first study of Chinese rhythm across multiple dialects and from different perspectives, this study not only lays a methodological foundation for future research but also contributes to our in-depth understanding of Chinese dialects. / Graduate / 0290 / yali@uvic.ca