Para compreensão da biologia dos tumores adrenocorticais são utilizados marcadores moleculares que em geral são genes reguladores do ciclo celular. AP-1 é um fator dimérico composto principalmente pelas proteínas JUN (JUN, JUNB e JUND) e FOS. Nesse projeto tivemos como hipótese que as proteínas da família JUN, se correlacionam com proteínas reguladoras do ciclo celular em tumores adrenocorticais, e poderiam ser utilizados no diagnóstico e prognóstico desse tipo de tumor. O objetivo foi analisar o padrão de expressão gênica e proteica (PCR e Immunobloting). A análise por PCR Array em culturas de células de tumores adrenais, mostrou que os genes da família JUN e o gene FOS estão pouco expressos nessas culturas, o que foi confirmado em ensaios de qPCR. Não foi possível determinar um padrão de expressão que diferenciasse os tipos de culturas celulares estudados, ou mesmo tumores adultos e pediátricos. Os tratamentos com ACTH aumentam a expressão da proteina JUN e JUNB, e podem ter certa importância em tumores responsivos à esse hormônio, que merecem análises futuras. / In order to have a better comprehension of adrenocortical tumor biology, molecular markers are utillized because they are in general cell cycle regulators. AP-1 is a dimeric factor, compound mainly by JUN (JUN, JUNB, JUND) and FOS proteins. In the present study, our hypothesis is that JUN proteins are correlated with others cell cycle regulatory proteins and could be utilized as a prognose and diagnostic predictor for adrenocortical tumors. To confirm our hypothesi the aim was genic and protein profile analyzes (PCR and Immunobloting). The PCR Array analysis showed that JUN and FOS gene expression were down regulated in these adrenocortical tumors cells which were confirmed through qPCR analysis. The genes expression analysis wasn´t able to stablish a standard of expression between the studied cell cultures or even between adults and pediatric tumors. The ACTH treatments increased JUN and JUNB proteins that may have some significance in responsive tumors to this hormone, and deserve further analysis.

The purpose of this report is to give teachers of AP Statistics a way to enrich student learning with an engaging, rigorous and relevant project. The report details the reasons necessary for student-based learning, along with examples in which projects in classrooms were successful. The project is centered on categorical data analysis involving tests of proportions, chi-squared distributions and confidence intervals. There are supplemental worksheets provided with the intent of showing students the relevance and applications of what they are learning to actual studies. Finally, a rubric is provided for students to align and focus their projects as well as for teachers to assess student learning. / text

published_or_final_version / Urban Planning / Master / Master of Science in Urban Planning

No description available.

Made available in DSpace on 2015-04-17T14:55:30Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 3151049 bytes, checksum: bf8a1ed91961b25d4cd47478b3320588 (MD5) Previous issue date: 2013-09-13 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / Freshwater stingrays of the Potamotrygonidae family are restricted to South America, where they occur in the main river systems. This is the only group within Elasmobranchs that is exclusive to freshwater, thus, presenting morphological and physiological adaptations to this particular environment. In some regions these animals usually have a strong presence in the lifestyle of riparian populations, because of their high potential for accidents with humans. The present study was conducted at the Parazinho Biological Reserve, an island in the archipelago of Bailique, Macapá (AP), located at the mouth of the Amazon River. The study evaluated the composition and structure of freshwater stingray species by determining the taxocenose population contingent and understanding their biological and ecological characteristics such as feeding habits, reproduction, movement, and morphological features. Additionally, their spatial habitat patterns on the island were examined. Samplings were performed bimonthly between March 2011 and January 2013. Longlines, fishnets and spears were used to capture specimens. All specimens collected in the first year were measured and marked with an implanted microchip and subsequently released. In the second year, the captured stingrays were preserved and dissected to analyze their gonads and digestive tracts. A total of 223 animals were caught during the 82 days of sampling, corresponding to 208 different specimens of stingrays. Eight species were identified: Paratrygon aiereba, Potamotrygon motoro, P orbignyi, P. scobina, P. constellata, P. cf. dumerilii, Potamotrygon sp., and Potamotrygon sp. 1. Discriminant analysis between the ratio of the disk width and morphometric data of the most representative species (Potamotrygon cf. dumerilii, P. motoro, P. orbignyi, P. scobina, and Potamotrygon sp. 1) revealed dimensional differences among species, although these did not reach significant levels in most cases. The population study revealed that the distribution of stingrays by gender was homogeneous, and no habitat preference by species was observed along the island. Weight length relationship analysis showed that males and females have different growth patterns; however, the differences were small and not significant (α = 0.05). The analysis of 95 stomachs confirmed predatory activity. The main food source consisted of invertebrates, predominantly crustaceans, mollusks, insects and annelids. The analysis also revealed differences in the consumption of prey throughout the year and among species. It was observed that freshwater stingrays are specialist fish with low niche width, indicating overlaps between spatial movements and dietary patterns based on the availability of food resources in the environment. The animals reproduced throughout the year, following alternate reproductive periods. The observed overlap of reproductive periods among species is indicative of possible hybridization. The study also showed that freshwater stingrays are conservative with regard to site utilization. / As raias de água doce da família Potamotrygonidae são restritas à América do Sul, onde ocorrem nos principais sistemas fluviais. É o único grupo de Elasmobrânquios exclusivo do meio dulcícola, possuindo especializações morfológicas e fisiológicas para a vida neste tipo de ambiente. Em algumas regiões esses animais costumam marcar forte presença no modo de vida das populações ribeirinhas, devido ao elevado potencial de acidentes que representam. O presente trabalho foi desenvolvido na Reserva Biológica do Parazinho, uma ilha do Arquipélago do Bailique, Macapá (AP), localizada na região da foz do rio Amazonas. Teve como objetivo estudar a composição de espécies de raias de água doce, determinando o contingente populacional da taxocenose e conhecendo características biológicas e ecológicas das espécies quanto à sua alimentação, reprodução, movimentação e morfologia. Além disso, buscou-se descrever os padrões de ocupação espacial da ilha pelas espécies. As amostragens aconteceram em regime bimestral de março de 2011 a janeiro de 2013. Para a captura foram utilizados espinhéis, tarrafas, zagaias e tapagem em diferentes momentos da amostragem. No primeiro ano, as raias capturadas eram marcadas com microchips e soltas, após terem sido registradas algumas de suas medidas corporais. Nas coletas subsequentes, as raias recapturadas eram novamente medidas e soltas. No segundo ano, as raias capturadas eram sacrificadas e dissecadas para análise de suas gônadas e aparelhos digestivos. Durante as amostragens eram tomados dados ambientais acerca da qualidade de água. Foram efetuadas 223 capturas, correspondendo a 208 espécimes diferentes de raias durante 82 dias de amostragem. Foram identificadas oito espécies: Paratrygon aiereba, Potamotrygon motoro, P orbignyi, P. scobina, P. constellata, P. cf. dumerilii, Potamotrygon sp. e Potamotrygon sp 1. A análise discriminante entre a proporção da largura do disco e dados morfométricos das espécies mais representativas (Potamotrygon cf, dumerilii, P. motoro, P. orbignyi, P. scobina e P. sp1) revelou diferenças dimensionais entre as espécies, embora na maioria dos casos não alcançassem níveis significativos. O estudo populacional revelou que a distribuição das raias por sexo foi homogênea e não houve preferência de ocupação das espécies ao longo da ilha. A análise da relação peso comprimento mostrou que machos e fêmeas apresentam alguma diferença no tipo de crescimento, porém, essas diferenças foram pequenas e não significativas (α=0,05). A análise de 70 estômagos confirmou hábitos alimentares predadores, tendo como principais recursos invertebrados, predominantemente crustáceos, moluscos, insetos e anelídeos, revelando também alguma diferença no consumo dos itens ao longo do ano e entre as espécies. Observou-se que raias são peixes especialistas com baixa largura de nicho, revelando algum grau de sobreposição espacial e de dieta de acordo com a disponibilidade do recurso alimentar no ambiente. As raias reproduziram-se durante todo o ano, com as espécies alternando seus períodos reprodutivos, com alguma sobreposição de períodos entre espécies, o que pode indicar a possibilidade de hibridização. Verificou-se ainda que os indivíduos são conservadores quanto aos sítios utilizados.

HTLV-1, un rétrovirus endémique des Antilles-Guyane qui infecte plus de 10 millions de personnes dans le monde, est l’agent étiologique de l’ATL, une leucémie agressive des lymphocytes T CD4+ résistante aux traitements conventionnels actuels. Le rôle émergent des miARN dans la leucémogénèse et la résistance aux chimiothérapies a soulevé des interrogations quant à leurs rôles dans le développement de l’ATL. Les miARN sont de petits ARN non codant qui régulent l’expression génique. Récemment leur altération durant le cycle de vie du HTLV-1 a été mise en lumière. Une des caractéristiques de l’émergence de l’ATL est la perte d’expression des protéines virales codées par le promoteur en amont du génome proviral (LTR5’), à l’exception d’hbz dont l’expression est initiée dans le promoteur en aval du génome proviral (LTR3’). Dans une première étude, nous démontrons, dans un modèle mimant la cellule ATL, qu’HBZ module sa propre transcription à travers une boucle de rétrocontrôle qui implique une coopération avec le facteur de transcription de la famille AP-1 JunD. Nous montrons que l’expression d’HBZ induit des caractéristiques phénotypiques de fibroblastes transformés. Nous avons, ensuite, analysé l’effet d’HBZ sur les miARN dans les cellules ATL et montré qu’il induit une diminution des miARN cellulaires via l’inhibition d’un acteur clé de la maturation, Dicer. En accord avec notre première étude, nous montrons que l’induction d’HBZ dans les CD4+ de patients ATL corrèle avec une augmentation de la charge provirale (CPV) et donc l’évolution de l’ATL. Le traitement de ces cellules au VPA inhibe l’expression d’hbz, restaure celle de dicer et inverse la CPV et donc la prolifération des cellules malignes ex vivo. / HTLV-1, a retrovirus endemic of Antilles-Guyana that infects more than 10 million people worldwide, is the etiological agent of ATL, an aggressive leukemia of CD4+ T lymphocytes resistant in currents treatments. The emerging role of miRNA in leukemogenesis and chemoresistance has risen questioning about their role in ATL development. MiRNAs are a class of non-coding RNAs that regulate gene expression. Involvement of their alteration in the HTLV-1 life cycle has recently come to light. One of the hallmarks of progression toward ATL is the emergence of LTR5’-deficient provirus and thereby eliminating the expression of all viral proteins on the sense strands in these cells, with the exception of the hbz gene regulated by an independent promoter in the 3’LTR. In a first study, using a provirus with the 5’LTR deleted, we found that HBZ modulates its own expression through a positive-feedback loop that involves cooperation with AP-1 transcription factor JunD. We also found that hbz-expressing fibroblasts displayed of a transformed phenotype. Then, we analyzed the effect of HBZ on miRNA expression in ATL patients and report that hbz reduce significantly expression of cellular miRNAs via inhibition of an enzyme essential for maturation, Dicer1. In agreement with our previous study, we show that hbz expression in ATL samples correlates with HTLV-1–provirus load (CPV) and consequently progression of the pathology. VPA treatment of these cells inhibits hbz expression, restores Dicer expression, and inverts the proviral charge thereby reducing cellular proliferation of malignant cells.

SCHEIBE, Roberta. Tempos de chorar e de sorrir no espaço da morada: um estudo socioantropológico de mulheres resistentes marcadas pela tragédia em Macapá-AP. 2016. 382f. – Tese (Doutorado) – Universidade Federal do Ceará, Programa de Pós-graduação em Sociologia, Fortaleza (CE), 2016. / Submitted by Márcia Araújo (marcia_m_bezerra@yahoo.com.br) on 2017-02-01T12:19:15Z No. of bitstreams: 1 2016_tese_rscheibe.pdf: 9715359 bytes, checksum: c7047803fb882cdfdc8934c5ac92306d (MD5) / Approved for entry into archive by Márcia Araújo (marcia_m_bezerra@yahoo.com.br) on 2017-02-01T12:19:51Z (GMT) No. of bitstreams: 1 2016_tese_rscheibe.pdf: 9715359 bytes, checksum: c7047803fb882cdfdc8934c5ac92306d (MD5) / Made available in DSpace on 2017-02-01T12:19:51Z (GMT). No. of bitstreams: 1 2016_tese_rscheibe.pdf: 9715359 bytes, checksum: c7047803fb882cdfdc8934c5ac92306d (MD5) Previous issue date: 2016 / This thesis offers a description and analysis of how four women experienced a major fire that occurred at Baixada do Perpétuo Socorro, an occupied neighborhood in Macapá, Amapá, in October 2013. These women are a part of the 250 families that witnessed the event. This social space was officially considered an environmental preservation area by the government and, therefore, unsuitable for housing. This critical event brought them pain, social suffering, humiliation and a new home far from their day-to-day routine that did not take into consideration their wishes and personal needs. This paper discusses how these four women describe this transient period starting with the loss of their homes, then their dignity, to how they had to reconfigure their everyday life in a new dwelling place, the government housing complex called Master Oscar Santos. The problematization in this work focus on the notion of person and subjective constructs in the social context of moving from home to another place; also in these women’s notion of self as they readjusted their attachments and sense of belonging to a new environment by practicing their day to day routines utilizing resistances, tactics, and micro-relationships in their transitory social spaces until they received their own home granted by the State, which were located far away from the place where these women felt comfortable and capable of using their agency. The ethnographic concepts that support these considerations are the practice of everyday life, tactics and resistances. Such concepts serve as basis to social suffering using such native categories as shack, home, baixada (pile dwellings), government housing and humiliation. The authors who inspired this discussion are Veena Das, Michel Foucault and Michel De Certeau, among others. The problematization of women is performed using methods proposed by Marilyn Strathern, whose work with women deals with categories which are not based on gender identity but in the physical female and male form. The method is sustained by ethnographic fieldwork and relies on intellectual and ethnobiographic tools proposed by Marco Antonio Gonçalves, Roberto Marques and Vania Cardoso, among others, where the individuals are subjectified and the sociocultural reality is perceived by the experience of characters that construct their own narrative as they practice the notion of self. / Esta tese propõe uma descrição e análise dos modos como quatro mulheres, pertencentes ao universo de 250 famílias, vivenciaram o evento crítico do incêndio da Baixada Perpétuo Socorro, em Macapá-AP, em outubro de 2013. Este espaço social ocupado era considerado pelo poder público como oficialmente impróprio para moradia e área de preservação ambiental. O evento crítico lhes trouxe dor, sofrimento social, humilhação e um novo lar distante de seu cotidiano e de suas vontades e escolhas pessoais. Este trabalho tem como problematização a questão do lugar de pessoa e das suas subjetividades e pretende discutir como estas quatro mulheres relatam este período de transitoriedade, a partir da perda de suas casas, de sua dignidade, e de como reconfiguraram o seu cotidiano no novo lugar de morada, o conjunto habitacional Mestre Oscar Santos. O trabalho detém-se nas maneiras como estas mulheres reconfiguram pertencimentos, práticas cotidianas através de resistências, táticas e micro-relações nos novos espaços de trânsito destas famílias. Inclusive em moradias provisórias até chegar à casa própria concedida pelo Estado, distante de toda sua história e agenciamentos de desejo. As noções etnográficas que embasam esta reflexão são de práticas cotidianas, táticas e resistências, aportadas por sofrimentos sociais, praticadas nas categorias nativas de barraco, casa, baixada, conjunto habitacional e humilhação. Os autores que inspiram esta discussão são Veena Das, Michel Foucault e Michel De Certeau, entre outros. A problematização com mulheres se dá nos sentidos propostos por Marilyn Strathern, cujo trabalho com mulheres refere-se a categoria, não no que diz respeito à identidade de gênero, e sim nas formas de usos de imagens do feminino e do masculino. O método está sustentando por trabalho de campo etnográfico e se apoia na ferramenta intelectual da etnobiografia, proposta por Marco Antonio Gonçalves, Roberto Marques e Vânia Cardoso, entre outros, onde os sujeitos são subjetivados e a realidade sociocultural é apreendida pela experiência de pessoas personagens que constroem a sua narrativa como prática de si.

Para compreensão da biologia dos tumores adrenocorticais são utilizados marcadores moleculares que em geral são genes reguladores do ciclo celular. AP-1 é um fator dimérico composto principalmente pelas proteínas JUN (JUN, JUNB e JUND) e FOS. Nesse projeto tivemos como hipótese que as proteínas da família JUN, se correlacionam com proteínas reguladoras do ciclo celular em tumores adrenocorticais, e poderiam ser utilizados no diagnóstico e prognóstico desse tipo de tumor. O objetivo foi analisar o padrão de expressão gênica e proteica (PCR e Immunobloting). A análise por PCR Array em culturas de células de tumores adrenais, mostrou que os genes da família JUN e o gene FOS estão pouco expressos nessas culturas, o que foi confirmado em ensaios de qPCR. Não foi possível determinar um padrão de expressão que diferenciasse os tipos de culturas celulares estudados, ou mesmo tumores adultos e pediátricos. Os tratamentos com ACTH aumentam a expressão da proteina JUN e JUNB, e podem ter certa importância em tumores responsivos à esse hormônio, que merecem análises futuras. / In order to have a better comprehension of adrenocortical tumor biology, molecular markers are utillized because they are in general cell cycle regulators. AP-1 is a dimeric factor, compound mainly by JUN (JUN, JUNB, JUND) and FOS proteins. In the present study, our hypothesis is that JUN proteins are correlated with others cell cycle regulatory proteins and could be utilized as a prognose and diagnostic predictor for adrenocortical tumors. To confirm our hypothesi the aim was genic and protein profile analyzes (PCR and Immunobloting). The PCR Array analysis showed that JUN and FOS gene expression were down regulated in these adrenocortical tumors cells which were confirmed through qPCR analysis. The genes expression analysis wasn´t able to stablish a standard of expression between the studied cell cultures or even between adults and pediatric tumors. The ACTH treatments increased JUN and JUNB proteins that may have some significance in responsive tumors to this hormone, and deserve further analysis.

Fra-1 appartient à la famille des facteurs de transcription AP-1. Son expression est particulièrement élevée dans les cellules de cancer du sein qui n'expriment pas le récepteur aux œstrogènes (RE-), c'est-à-dire les cellules les plus agressives. L'inhibition de Fra-1 dans ces cellules entraîne une diminution de la motilité, de l'invasion et de la prolifération, mais elle entraîne aussi de profonds changements de morphologie. Les cellules RE-, qui présentent un phénotype mésenchymateux s'arrondissent et établissent un plus grand nombre de contacts cellule-cellule après l'inhibition de Fra-1. Dans les cellules RE-, la β-caténine est localisée au noyau ou dans le cytoplasme, ce qui est un marqueur de mauvais pronostic. Au cours de cette thèse, j'ai montré que Fra-1 régule la localisation nucléaire de la β-caténine et ainsi régule son activité transcriptionelle en agissant très tardivement sur la voie Wnt. J'ai également mis en évidence une interaction physique directe entre Fra-1 et la β-caténine qui pourrait être responsable de cet effet. De plus, l'analyse de microarrays par RT-QPCR a révélé la régulation d'autres gènes comme la mœsine, la fibronectine et l'extracellular matrix protein 1, qui pourraient également jouer un rôle dans la régulation de l'agressivité tumorale par Fra-1. Par ailleurs, Fra-1 est une protéine instable et nous avons montré qu'elle est phosphorylée et stabilisée par PKCθ. Fra-1 est d'ailleurs nécessaire à l'effet de la kinase sur la motilité cellulaire. / Fra-1 is a member of the AP-1 transcription factor family. It is aberrantly expressed in breast cancer cells lacking Estrogen Receptor (ER-) expression, which are the most aggressive ones. Fra-1 inhibition in these cells leads to a decreased in motility, invasion and proliferation, but also to deep morphologic changes. ER- cells, which present a mesenchymal phenotype, become rounder and establish a greater number of cell-cell contacts after Fra-1 inhibition. In ER- cells, β-catenin is nuclear or cytoplasmic, which is considering as a poor prognosis marker. During this PhD, I demonstrate that Fra-1, which acts very downstream in the Wnt/β-catenin signaling pathway, regulates the nuclear localization of β-catenin leading to up-regulation transcriptional activity of β-catenin. I also found that Fra-1 directly interacts with β-catenin. In addition, RT-QPCR microarrays analysis has revealed the regulation of other genes such as mœsin, fibronectin and extracellular matrix protein 1, which might also take part in the tumoral aggressiveness regulated by Fra-1. Moreover, we show that Fra-1, which is an unstable protein, is phosphorylated and stabilized by PKCθ. Furthermore, Fra-1 is necessary to mediate the kinase effect on cell motility.

Die Studie definiert und analysiert Kanywood-Videofilme kritisch, wobei ein besonderer Schwerpunkt auf Quellen der mündlichen Literatur und Performancepraxis liegt. Per Definition steht Kanywood sowohl für Filmindustrie als auch für in Nordnigeria produzierten Videofilme. Die Studie hält an "Kanywood" als dem für die Branche geprägten Label fest. Der Literaturüberblick zeigt, dass die Aneignung von Bollywood-Filmmustern durch Kanywood-Filmemacher übermäßig untersucht wurde. Bisherige Untersuchungen im Bereich des re-enactment oraler Hausa-Performance in Kanywood-Videofilmen sind hingegen unzureichend. Die vorliegende Studie füllt mit ihrer Untersuchung der Transformation der Hausa-Kultur im Medium Film aufgrund der Globalisierung und im Kontext traditioneller Performance-Künste diese Lücke, und fügt so den bestehenden Arbeiten über Kanywood eine innovative Forschungsperspektive hinzu. Im theoretischen Rahmen von Performance Studies und mit der gründlichen Analyse eines ausgewählten Korpus zeigt die Studie, wie der Videofilm als Medium wichtiger sozialer und kultureller Veränderungen gesehen wird. Er ist nicht nur ein Gegenstand anhand dessen die Erforschung des Konzepts einer transzendierenden Globalisierung möglich ist, sondern auch ein Weg, um zu verstehen, wie die Gesellschaft sich unter bestimmten sich wandelnden Umständen verändert. Während die allgemein zugrunde liegende Frage lautet, ob Kultur statisch ist oder nicht, verhandelt die Studie dabei die spezifischen Fragen, inwiefern Performances während des Filmemachens neu inszeniert und neu gerahmt werden, und inwieweit traditionell kodierte Performance-Ereignisse im Videofilm verändert, subvertiert und/oder bereichert werden. Die Studie empfiehlt die Ästhetik von Filmsprache als ein Gebiet weiterführender Forschung, stellt heraus, dass Imitation, Adaptation und Aneignung zirkulierender künstlerischer Formen ein globale Phänomene sind, die auf Intertextualität beruhen, erklärt, dass Kultur nicht statisch, sondern dynamisch ist, und kommt zu dem Schluss, dass es angemessener ist, Videofilme und Filmemacher durch das Paradigma der kulturellen Hybridität und Modernisierung zu betrachten, da sie die kulturelle Verschiebung, Transformation und Veränderung im Zeitalter der Globalisierung fördern. / The study identifies and critically analyses Kanywood video films with particular emphasis on sources in oral literature and performance practices. By way of definition, Kanywood stands for both the film industry and video films produced in northern Nigeria. The study sticks to “Kanywood” as the label coined for the industry. However, “Kannywood” with the consonant cluster, as in Hollywood, Bollywood and Nollywood is a variant label, which some scholars have adopted. The study forgrounds that Kanywood filmmakers' appropriation of Bollywood have been excessively explored. But investigations in the area of re-enactment of performance in Kanywood video films are conceivably insufficiently undertaken. Therefore, the distinct contribution of this study reflects on transformation of Hausa culture due to globalization, thus elaborating the existing works on Kanywood. Through a performance framework and a thorough analysis of selected corpus, the study shows how video film is seen as a provider of major social and cultural changes. It is not only a means through which an exploration of the concept of the transcending globalization is possible, but it is also a way of comprehending how the society transforms under some changing circumstances. While the general underlying question is whether or not culture is static, the study thereby negotiates specific questions such as how are performances re-enacted and re-framed during filmmaking process, and how far are traditionally encoded performance events altered, changed, subverted or enriched in video film? The study recommends the aesthetics of language as an area of further research, foregrounds that imitation, adaptation and appropriation of circulating artistic forms is a global phenomenon grounded in intertextuality, expounds that culture is not fixed but dynamic, and concludes that it is more appropriate to look at the video films and the filmmakers through the paradigm of cultural hybridity and modernization which enhance cultural shift, transformation and change in this era of globalization. Keywords: Kanywood, performance, oral heritage, transformation The study identifies and critically analyses Kanywood video films with particular emphasis on sources in oral literature and performance practices. By way of definition, Kanywood stands for both the film industry and video films produced in northern Nigeria. The study sticks to “Kanywood” as the label coined for the industry. However, “Kannywood” with the consonant cluster, as in Hollywood, Bollywood and Nollywood is a variant label, which some scholars have adopted. The study forgrounds that Kanywood filmmakers' appropriation of Bollywood have been excessively explored. But investigations in the area of re-enactment of performance in Kanywood video films are conceivably insufficiently undertaken. Therefore, the distinct contribution of this study reflects on transformation of Hausa culture due to globalization, thus elaborating the existing works on Kanywood. Through a performance framework and a thorough analysis of selected corpus, the study shows how video film is seen as a provider of major social and cultural changes. It is not only a means through which an exploration of the concept of the transcending globalization is possible, but it is also a way of comprehending how the society transforms under some changing circumstances. While the general underlying question is whether or not culture is static, the study thereby negotiates specific questions such as how are performances re-enacted and re-framed during filmmaking process, and how far are traditionally encoded performance events altered, changed, subverted or enriched in video film? The study recommends the aesthetics of language as an area of further research, foregrounds that imitation, adaptation and appropriation of circulating artistic forms is a global phenomenon grounded in intertextuality, expounds that culture is not fixed but dynamic, and concludes that it is more appropriate to look at the video films and the filmmakers through the paradigm of cultural hybridity and modernization which enhance cultural shift, transformation and change in this era of globalization. Keywords: Kanywood, performance, oral heritage, transformation The study identifies and critically analyses Kanywood Video films with particular emphasis on sources in oral literature and performance practices. By way of definition, Kanywood stands for both the film industry and video films produced in northern Nigeria. The study sticks to "Kanywood" as the label coined for the industry. However, "Kannywood" with the consonant cluster, as in Hollywood, Bollywood and Nollywood is a variant label, which some scholars have adopted. The study foregrounds that Kanywood filmmakers' appropriation of Bollywood have been excessively explored. But investigations in the area of re-enactment of performance in Kanywood video films are conceivably insufficiently undertaken. Therefore, the distinct contribution of this reflects on transformation of Hausa culture due to globalization, thus elaborating the existing works on Kanywood. Through a performance framework and a thorough analysis of selected corpus, the study shows how video film is seen as a provider of major social and cultural changes. It is not only a means through which an exploration of the concept of the transcending globalization is possible, but it is also a way of comprehending how the society transforms under some changing circumstances. While the general underlying question is whether or not culture is static, the study thereby negotiates specific questions such as how are performances re-enacted and re-framed during filmmaking process, and how far are traditionally encoded performance events altered, changed, subverted or enriched in video film? The study recommends the aesthetics of language as an area of further research, foregrounds that imitation, adaptation and appropriation of circulating artistic forms is a global phenomenon grounded in intertextuality, expounds that culture is not fixed but dynamic, and concludes that it is more appropriate to look at the video films and the filmmakers through the paradigm of cultural hybridity and modernization which enhance cultural shift, transformation and change in this era of globalization.