The purpose of this study was to investigate the effects of dialogic reading as an intervention on participant ability to answer “wh” comprehension questions correctly and independently. Previous research conducted on dialogic reading was primarily conducted with young individuals with autism spectrum disorder, leaving a gap in the research with older age participants. Participants of this study included four students in upper elementary grades 4-6, ages 8-12 who have been identified to have a known deficit in reading comprehension, a cognitive disability, or autism spectrum disorder (ASD) in an attempt to further extend the research on dialogic reading as an intervention strategy. A multiple probe across participants design was used to determine efficacy of the intervention. Data collection probes were conducted during baseline, intervention, generalization, and maintenance phases to determine efficacy of the intervention on participant ability to answer “wh” comprehension questions. Results indicate an increase in participant ability to answer comprehension questions while engaging in dialogic reading lessons for two participants. Limitations and implications for future research and practice will be discussed.

Learning to drive represents a rite of passage for many adolescents and young adults, which increases their access to vocational, education, and social opportunities (Almberg et al., 2015; Cox et al., 2012; Lindsay, 2016). When examining licensure rates for individuals with developmental disabilities and/or Autism Spectrum Disorder, research demonstrates lower licensure rates and more difficulties obtaining licensure (Almberg et al., 2015; Cox et al., 2012). Most research focusses on teaching on the road or simulation based driving skills to increase licensure rates, however little research addresses the barriers these individuals face obtaining their drivers permit (Huang et al., 2012; Pandolfe, 2015; Smigiel, 2020; Vindin et al., 2021); . The current research study sought to fill in gaps in the literature by investigating the effects of a traditional academic intervention, Incremental Rehearsal’s, effects on increasing participants knowledge of the drivers manual used for the driver’s permit exam. Results demonstrated positive increases in correct responding for one participant, however inconsistent results for the other two participants. Varying results may be partially due to differing participant characteristics, which could be important for future research considerations.

Facial expressions convey non-verbal cues. Humans use facial expressions to show emotions, which play an important role in interpersonal relations and can be of use in many applications involving psychology, human-computer interaction, health care, e-commerce, and many others. Although humans recognize facial expressions in a scene with little or no effort, reliable expression recognition by machine is still a challenging problem. Automatic facial expression recognition (FER) has several related problems: face detection, face representation, extraction of the facial expression information, and classification of expressions, particularly under conditions of input data variability such as illumination and pose variation. A system that performs these operations accurately and in realtime would be a major step forward in achieving a human-like interaction between the man and machine. This document introduces novel approaches for the automatic recognition of the basic facial expressions, namely, happiness, surprise, sadness, fear, disgust, anger, and neutral using relatively low-resolution noisy sensor such as the Microsoft Kinect. Such sensors are capable of fast data collection, but the low-resolution noisy data present unique challenges when identifying subtle changes in appearance. This dissertation will present the work that has been done to address these challenges and the corresponding results. The lack of Kinect-based FER datasets motivated this work to build two Kinect-based RGBD+time FER datasets that include facial expressions of adults and children. To the best of our knowledge, they are the first FER-oriented datasets that include children. Availability of children data is important for research focused on children (e.g., psychology studies on facial expressions of children with autism), and also allows researchers to do deeper studies on automatic FER by analyzing possible differences between data coming from adults and children. The key contributions of this dissertation are both empirical and theoretical. The empirical contributions include the design and successful test of three FER systems that outperform existing FER systems either when tested on public datasets or in realtime. One proposed approach automatically tunes itself to the given 3D data by identifying the best distance metric that maximizes the system accuracy. Compared to traditional approaches where a fixed distance metric is employed for all classes, the presented adaptive approach had better recognition accuracy especially in non-frontal poses. Another proposed system combines high dimensional feature vectors extracted from 2D and 3D modalities via a novel fusion technique. This system achieved 80% accuracy which outperforms the state of the art on the public VT-KFER dataset by more than 13%. The third proposed system has been designed and successfully tested to recognize the six basic expressions plus neutral in realtime using only 3D data captured by the Kinect. When tested on a public FER dataset, it achieved 67% (7% higher than other 3D-based FER systems) in multi-class mode and 89% (i.e., 9% higher than the state of the art) in binary mode. When the system was tested in realtime on 20 children, it achieved over 73% on a reduced set of expressions. To the best of our knowledge, this is the first known system that has been tested on relatively large dataset of children in realtime. The theoretical contributions include 1) the development of a novel feature selection approach that ranks the features based on their class separability, and 2) the development of the Dual Kernel Discriminant Analysis (DKDA) feature fusion algorithm. This later approach addresses the problem of fusing high dimensional noisy data that are highly nonlinear distributed. / PHD / One of the most expressive way humans display emotions is through facial expressions. The recognition of facial expressions is considered one of the primary tools used to understand the feelings and intentions of others. Humans detect and interpret faces and facial expressions in a scene with little or no effort, in a way that it has been argued that it may be universal. However, developing an automated system that accurately accomplishes facial expression recognition is more challenging and is still an open problem. It is not difficult to understand why facial expression recognition is a challenging problem. Human faces are capable of expressing a wide array of emotions. Recognition of even a small set of expressions, say happiness, surprise, anger, disgust, fear, and sadness, is a difficult problem due to the wide variations of the same expression among different people. In working toward automatic Facial Expression Recognition (FER), psychologists and engineers alike have tried to analyze and characterize facial expressions in an attempt to understand and categorize these expressions. Several researchers have considered the development of systems that can perform FER automatically whether using 2D images or videos. However, these systems inherently impose constraints on illumination, image resolution, and head orientation. Some of these constraints can be relaxed through the use of three-dimensional (3D) sensing systems. Among existing 3D sensing systems, the Microsoft Kinect system is notable because it is low in cost. It is also a relatively fast sensor, and it has been proven to be effective in real-time applications. However, Kinect imposes significant limitations to build effective FER systems. This is mainly because of its relatively low resolution, compared to other 3D sensing techniques and the noisy data it produces. Therefore, very few researchers have considered the Kinect for the purpose of FER. This dissertation considers new, comprehensive systems for automatic facial expression recognition that can accommodate the low-resolution data from the Kinect sensor. Moreover, through collaboration with some Psychology researchers, we built the first facial expression recognition dataset that include spontaneous and acted facial expressions recorded for 32 subjects including children. With the availability of children data, deeper studies focused focused on children can be conducted (e.g., psychology studies on facial expressions of children with autism).

O transtorno do espectro autista (ASD) é uma doença clinica e geneticamente heterogênea, com mecanismo etiológico ainda pouco conhecido. Assim, os principais objetivos deste trabalho foram descrever as características clínicas e genéticas de pacientes brasileiros com ASD, bem como determinar o risco de recorrência e a herdabilidade. Verificamos que a maioria das comorbidades avaliadas tem prevalência similar àquelas anteriormente descritas. A hipotonia exibiu maior prevalência no sexo feminino. A ausência de fala apresentou prevalência significativamente maior no grupo de pacientes com comorbidades, sendo que a gravidade da fala foi positivamente correlacionada com a presença das crises convulsivas. A herdabilidade estimada foi de 76% e o risco de recorrência ~5%. As alterações citogenéticas e os casos positivos para a Síndrome do X-Frágil explicaram cerca de 8% dos casos de ASD da nossa amostra. As CNVs nas regiões estudadas foram detectadas em 2,7% da amostra. Nós verificamos que há penetrância incompleta do ASD para as regiões. O estudo mais detalhado dos dois casos de duplicação da região 15q13.3, envolvendo somente o gene CHRNA7, mostrou que um dos pacientes (F5240) exibiu uma segunda CNV, possivelmente patogênica. A análise in silico sugeriu que genes que interagem diretamente com o CHRNA7 podem conter mutações patogênicas e, juntamente com a duplicação do 15q13.3, possivelmente estão envolvidos na etiologia do ASD. Este estudo mostrou que é necessário fazer uma ampla caracterização genética dos pacientes, para possibilitar o estudo dos possíveis mecanismos moleculares envolvidos na causa do ASD / Autism Spectrum Disorder (ASD) is a clinically and genetically heterogeneous disease and its etiological mechanisms are still poorly understood. The main objectives of this study were to describe the clinical and genetic features of Brazilian patients with ASD, and to determine the recurrence risk and heritability. Great part of the comorbidities assessed here had comparable prevalence to those of previous works. The hypotonia was significantly prevalent in the female sex. Absent speech was significantly more frequent in patients with comorbidities, and severity of speech problems was positively correlated with presence of seizures. Heritability was estimated as 76% and the recurrence risk as approximately 5%. Cytogenetic alterations and positive results for Fragile X Syndrome explain about 8% of the ASD etiology of our sample. The CNVs at the chromosomal regions 15q11-q13, 16p11.2 and 22q13 were present in 2.7% of the sample. Incomplete penetrance of ASD was observed for the 16p and 15q regions. Further investigation of the two cases with duplication of the region 15q13.3, involving only the CHRNA7 gene, revealed that one of them (F5240) exhibited a second possible pathogenic CNV. In silico analysis suggested that genes interacting directly with the CHRNA7 could harbor pathogenic mutations and, together with the duplication at 15q13.3, could be involved in the ASD etiology. This study showed the necessity of a broad genetic characterization of patients with ASD, to enable the elucidation of possible molecular mechanisms related to ASD etiology

As time keeps on passing, diagnosing a child with Autism keeps on expanding. The research study focuses on gathering data on the impact of mothers that have a child diagnosed on the Autism Spectrum Disorder (ASD). The members chose were from an online all mothers support group. The study was gathered utilizing the post positive approach. After fulfillment of the research the members will be able to view the results of this study by going to the California State University San Bernardino scholar works website. This research was conducted to share information to clinicians and any reader on the day by day battles and difficulties mothers face by caring for a child diagnosed with Autism.

Trots att studier visar att personer med autismspektrumdiagnos (ASD) ofta behöver hjälp med att sköta sin personliga hygien, samt att mödrar till barn med ASD ofta behöver assistera dem i deras aktiviteter i dagliga livet (ADL) saknas det forskning om vad detta stöd faktiskt består av. Syftet med den aktuella studien är att öka kunskapen om mödrars erfarenheter av att hjälpa ungdomar med ASD med deras personliga hygien samt med påklädning. 3 flickmödrar och 3 pojkmödrar intervjuades om hur de hjälpte sina barn med Dusch/Tvätt, Hårvård, Naglar, Påklädning, Tandborstning, Toalettbesök, Torka sig efter toalettbesök samt Torka sig med handduk. Flickmödrar fick också frågor om Menstruation. Analysen baserades på Anthony Giddens' teorier om Modernitet och Självidentitet. Intervjuerna skrevs om till 6 narrativ, vilka analyserades tillsammans med relevanta delar från intervjuerna. Resultatet presenteras som 3 huvudteman. Resultatet visar bland annat att ungdomarna hade ett omfattande hjälpbehov och att mödrarna hjälpte sina barn både fysiskt och verbalt. Mödrarnas förståelse för och lojalitet gentemot barnen och deras svårigheter var förhållandevis hög medan deras tillit till sakkunniga var relativt låg. / Although studies indicate that people with Autism Spectrum Disorder (ASD) often need help with their personal hygiene, in addition to the fact that mothers of children with ASD often need to assist them in their activities of daily living (ADL), little research has been made as to what this support actually consists of. The purpose of the present study is to investigate how mothers of children aged 10-15 with ASD help their children to manage their personal hygiene, and what effect this has on their mothers. 3 mothers of girls and 3 mothers of boys were interviewed about how they supported their children in the following activities: Dressing, Hair care, Nail cutting, Toilet use, Tooth brushing, Toweling, Washing and Wiping. Mothers of girls were also asked about Menstruation. The analyses were based on Anthony Giddens' theories on Modernity and Self Identity. Afterwards, the interviews were converted into six narratives. These narratives along with pertinent elements from the interviews were analyzed and the result presented as 3 main themes. Results show among other things that the mothers supported their children both physically and verbally. The mothers' appreciation and loyality with their children were proportionately high, whereas their confidence in experts was rather low.

O transtorno do espectro autista (ASD) é uma doença clinica e geneticamente heterogênea, com mecanismo etiológico ainda pouco conhecido. Assim, os principais objetivos deste trabalho foram descrever as características clínicas e genéticas de pacientes brasileiros com ASD, bem como determinar o risco de recorrência e a herdabilidade. Verificamos que a maioria das comorbidades avaliadas tem prevalência similar àquelas anteriormente descritas. A hipotonia exibiu maior prevalência no sexo feminino. A ausência de fala apresentou prevalência significativamente maior no grupo de pacientes com comorbidades, sendo que a gravidade da fala foi positivamente correlacionada com a presença das crises convulsivas. A herdabilidade estimada foi de 76% e o risco de recorrência ~5%. As alterações citogenéticas e os casos positivos para a Síndrome do X-Frágil explicaram cerca de 8% dos casos de ASD da nossa amostra. As CNVs nas regiões estudadas foram detectadas em 2,7% da amostra. Nós verificamos que há penetrância incompleta do ASD para as regiões. O estudo mais detalhado dos dois casos de duplicação da região 15q13.3, envolvendo somente o gene CHRNA7, mostrou que um dos pacientes (F5240) exibiu uma segunda CNV, possivelmente patogênica. A análise in silico sugeriu que genes que interagem diretamente com o CHRNA7 podem conter mutações patogênicas e, juntamente com a duplicação do 15q13.3, possivelmente estão envolvidos na etiologia do ASD. Este estudo mostrou que é necessário fazer uma ampla caracterização genética dos pacientes, para possibilitar o estudo dos possíveis mecanismos moleculares envolvidos na causa do ASD / Autism Spectrum Disorder (ASD) is a clinically and genetically heterogeneous disease and its etiological mechanisms are still poorly understood. The main objectives of this study were to describe the clinical and genetic features of Brazilian patients with ASD, and to determine the recurrence risk and heritability. Great part of the comorbidities assessed here had comparable prevalence to those of previous works. The hypotonia was significantly prevalent in the female sex. Absent speech was significantly more frequent in patients with comorbidities, and severity of speech problems was positively correlated with presence of seizures. Heritability was estimated as 76% and the recurrence risk as approximately 5%. Cytogenetic alterations and positive results for Fragile X Syndrome explain about 8% of the ASD etiology of our sample. The CNVs at the chromosomal regions 15q11-q13, 16p11.2 and 22q13 were present in 2.7% of the sample. Incomplete penetrance of ASD was observed for the 16p and 15q regions. Further investigation of the two cases with duplication of the region 15q13.3, involving only the CHRNA7 gene, revealed that one of them (F5240) exhibited a second possible pathogenic CNV. In silico analysis suggested that genes interacting directly with the CHRNA7 could harbor pathogenic mutations and, together with the duplication at 15q13.3, could be involved in the ASD etiology. This study showed the necessity of a broad genetic characterization of patients with ASD, to enable the elucidation of possible molecular mechanisms related to ASD etiology

Standard clinical and psychiatric thinking follows a unipolar logic that is centered at “normal” conditions characterized by optimal performance in everyday life, with more atypical conditions being defined by the (degree of) absence of “normality.” A similar logic has been used to describe cognitive control, assuming that optimal control abilities are characterized by a strong focus on the current goal and ignorance of goal-irrelevant information (the concept of willpower), while difficulties in focusing and ignoring are considered indications of the absence of control abilities. However, there is increasing evidence that willpower represents only one side of the control coin. While a strong focus on the current goal can be beneficial under some conditions, other conditions would benefit from a more open mind, from flexibility to consider alternative goals and information related to them. According to the metacontrol model, people can vary in their cognitive processing style, on a dimension with the extreme poles of “persistence” on the one hand and “flexibility” on the other. Whereas a high degree of persistence corresponds to the original idea of cognitive control as willpower, with a strong focus on one goal and the information related to it, a high degree of flexibility is characterized by a more integrative, less selective and exclusive processing style, which facilitates switching between tasks, ideas, and actions, and taking into consideration a broader range of possibilities. We argue that this approach calls for a more bipolar account in the clinical sciences as well. Rather than considering individuals as typical or atypical, it would theoretically and practically make more sense to characterize their cognitive abilities in terms of underlying dimensions, such as the persistence/flexibility dimension. This would reveal that possible weaknesses with respect to one pole, such as persistence, and tasks relying thereupon, may come with corresponding strengths with respect to the other pole, such as flexibility, and respective tasks. We bolster our claim by discussing available evidence suggesting that neurodevelopmental atypicality often comes with weaknesses in tasks related to one pole but strengths in tasks related to the other.

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