Thesis (M.S.)--Brigham Young University. Dept. of Geography, 2004. / Includes bibliographical references (p. 73-80).

Thesis--Wisconsin. / Vita. Includes bibliographical references (leaves 377-400).

No description available.

Chaga och Reishi svamparna har använts i ett flertal länder som t.ex. Kina och Ryssland som folkmedicin. I tidigare studier har Chaga och Reishi svamparna uppvisat ett flertal hälsoeffekter som antiinflammatoriska egenskaper, antivirala effekter, antitumorala effekter samt förhindrandet av mikrobiell tillväxt. Syftet med projektet var att studera Chaga och Reishi svampars antibakteriella effekt. Detta kan leda till nya alternativa bakteriehämmande medel för användning och bekämpning av den ökade spridningen av resistenta bakterier. För att utvinna de hälsobringande ämnena från Chaga och Reishi svamparna utfördes vatten- och etanolextraktioner. Tillväxtkurvor för grampositiva bakterien S. aureus och gramnegativa bakterien E. coli studerades för att se ifall Chaga och Reishi extrakten hämmade bakterietillväxten. Resultatet visade att tillväxtkurvorna med etanolextrakten visade en hämning på både den grampositiva bakterien och den gramnegativa bakterien medan tillväxtkurvorna med vattenextrakten visade svag hämning av bakterietillväxten förutom i tillväxtkurvan för S. aureus med Chaga vattenextrakt. MIC test utfördes för att se vid vilken koncentration som svampextrakten hämmade bakterietillväxten och endast vid koncentrationerna 125 mg/ml och 100 mg/ml hämmades bakterietillväxten med Chaga- och Reishi etanolextrakt. När det gällde Chaga- och Reishi vattenextrakt sågs ingen hämning av bakterietillväxten vid samtliga koncentrationer. / The fungi: Chaga and Reishi have been used in several countries for example China and Russia as folk medicine. In previous studies, Chaga and Reishi have shown numerous health effects such as anti-inflammatory, antiviral, anti tumoral as well as preventing microbial growth. The aim of the project was to study the antibacterial effect of Chaga and Reishi. It may result in knowledge about more alternative bacteriostatic agents produced to combat the expansion of resistant bacteria. The extraction of the medicinal ingredients from Chaga and Reishi was carried out with aqueous- and ethanol extraction. Growth curves for the gram-positive bacterium S. aureus and the gram-negative bacterium E. coli was studied to see if Chaga and Reishi extracts inhibited the growth of the bacteria. The growth curves of ethanol extracts showed inhibition of these gram-positive bacteria and gram-negative bacteria, while the growth curves of aqueous extracts showed no further inhibition of bacterial growth, except in the growth curve of S. aureus with Chaga aqueous extract. MIC test was set up to see at what concentration Chaga and Reishi extracts inhibited the growth of the bacteria and at the concentrations of 125 mg/ml and 100 mg/ml the bacterial growth with Chaga- and Reishi ethanol extract was inhibited. Whereas for Chaga- and Reishi aqueous extract there was no sign of bacterial growth inhibition.

This dissertation is an ethnographic description of how pastors (and other ministers) in the Northern Diocese of the Evangelical Lutheran Church of Tanzania understand and carry out their ministry: How they reflect, mediate, and influence local Christian practice and identities; how theology and theologizing forms an integral part of their social worlds; and how navigating and maintaining relationships with Christian mission partnerships (including “short-term mission”) becomes an important part of their ministry. Drawing from fieldwork conducted between June 2014 and September 2015, I present an account of Christianity that adds to anthropological scholarship by emphasizing the role of theology as a grounded social practice, and considers the increasingly divergent character of Christian mission and its role in modern Tanzanian Christianity. Additionally, I offer a contribution to existing scholarship on Christianity by focusing on pastors as a central mediating figure in Christianity, showing how, in their work, Christian practice, theology, and mission are experienced in social relationships. I demonstrate how theology and theologizing directly address local negotiations of Christian identity and practice, I examine the articulation between theological debates and Tanzanian experiences of mission, and I describe how mission in Tanzania has been and continues to be contextually understood with reference to the local practice of Christianity.

A doença de Chagas é endemia que afeta grande parte da América Latina. Estima-se que de 18 a 20 milhões de pessoas estejam infectadas pelo parasita causador da doença e que ocorram, aproximadamente, 50.000 mortes relacionadas à doença de Chagas por ano, nos 21 países da área endêmica. O arsenal terapêutico atualmente usado contra a parasitose, constituído por apenas dois fármacos, é insuficiente, considerando-se, também, que ambos não apresentam ação adequada na fase crônica da doença. Em razão de se tratar de parasitose que acomete apenas países em desenvolvimento, o interesse na pesquisa de novos antichagásicos é consideravelmente baixo por parte dos países que se destacam na introdução de novos fármacos na terapêutica. Resta aos países envolvidos a procura por novas alternativas quimioterápicas. Face ao exposto e ante à alta atividade, em testes in vitro contra o Trypanosoma cruzi, do derivado hidroximetilado do nitrofural, intermediário de síntese de bases de Mannich, obtido em trabalhos anteriores, o objetivo do presente projeto foi sintetizar bases de Mannich desse derivado com aminoácidos lisina e arginina e o dipeptídio lisina-arginina resultante. Os compostos foram sintetizados utilizando-se métodos clássicos e alternativos e grupos protetores, normalmente utilizados na síntese de peptídios e outros, tentativamente empregados, como os grupos metílico e etílico. Em adição, experimentos foram efetuados com o objetivo de otimizar a síntese do hidroximetilnitrofural. Os derivados sintetizados foram analisados por IV, RMN 1H e 13C, e alguns deles, também, por espectrometria de massas. Eles serão submetidos a testes in vitro em cultura de células infectadas com T. cruzi tão logo os grupos protetores sejam removidos. Além disso, serão efetuados testes de liberação para estudo da respectiva estabilidade. Dessa forma, esperam-se obter subsídios importantes para estudos mais aprofundados do seu mecanismo de ação e da possível mutagenicidade envolvida. / Chaga\'s disease is an endemic disease that aftects most part of Latin Arnerica. About 18 to 20 million people are infected by the parasite and around 50 thousand deaths are related to Chagas\' disease each year, in the 21 countries of endemic areas. The therapeutic armamentarium available against the disease is constituted by only two drugs and is insufficient, considering, also, that the drugs are not efficient in the chronic phase of the disease. As a parasitosis that only occurs in developing countries, the interest in the research for new antichagasic agents is considerably low in countries that are responsible for the introduction of new drugs in the therapeutics. So, the search for new chemotherapeutic alternatives is a task for the involved countries. In view of the situation and taking into account the high activity in in vitro tests against Trypanosoma cruzi showed by nitrofurazone hydroxymethyl derivative, an intermediary of Mannich bases reaction previously synthesized, the objective of this work was to synthesize its Mannich bases. The carriers used were aminoacids lysine and arginine and its dipeptide, lysinearginine. The compounds were synthesized using classic and alternative methods and protecting groups, currently used in peptide synthesis and others temptatively employed, as methyl and ethyl groups. Also, many experiments were performed in order to achieve the optimization of hydroxymethylnitrofurazone synthesis. The derivatives synthesized were analyzed by IR, 1H and 13C NMR, and some also by mass spectrometry. They will be submitted to in vitro tests with cell infected with T. cruzi as soon as the protecting groups are removed. Besides, tests of drug release will be performed to study their stability. We expect to obtain important information toward better comprehension of their mechanism of action and possible mutagenicity involved.

A doença de Chagas é endemia que afeta grande parte da América Latina. Estima-se que de 18 a 20 milhões de pessoas estejam infectadas pelo parasita causador da doença e que ocorram, aproximadamente, 50.000 mortes relacionadas à doença de Chagas por ano, nos 21 países da área endêmica. O arsenal terapêutico atualmente usado contra a parasitose, constituído por apenas dois fármacos, é insuficiente, considerando-se, também, que ambos não apresentam ação adequada na fase crônica da doença. Em razão de se tratar de parasitose que acomete apenas países em desenvolvimento, o interesse na pesquisa de novos antichagásicos é consideravelmente baixo por parte dos países que se destacam na introdução de novos fármacos na terapêutica. Resta aos países envolvidos a procura por novas alternativas quimioterápicas. Face ao exposto e ante à alta atividade, em testes in vitro contra o Trypanosoma cruzi, do derivado hidroximetilado do nitrofural, intermediário de síntese de bases de Mannich, obtido em trabalhos anteriores, o objetivo do presente projeto foi sintetizar bases de Mannich desse derivado com aminoácidos lisina e arginina e o dipeptídio lisina-arginina resultante. Os compostos foram sintetizados utilizando-se métodos clássicos e alternativos e grupos protetores, normalmente utilizados na síntese de peptídios e outros, tentativamente empregados, como os grupos metílico e etílico. Em adição, experimentos foram efetuados com o objetivo de otimizar a síntese do hidroximetilnitrofural. Os derivados sintetizados foram analisados por IV, RMN 1H e 13C, e alguns deles, também, por espectrometria de massas. Eles serão submetidos a testes in vitro em cultura de células infectadas com T. cruzi tão logo os grupos protetores sejam removidos. Além disso, serão efetuados testes de liberação para estudo da respectiva estabilidade. Dessa forma, esperam-se obter subsídios importantes para estudos mais aprofundados do seu mecanismo de ação e da possível mutagenicidade envolvida. / Chaga\'s disease is an endemic disease that aftects most part of Latin Arnerica. About 18 to 20 million people are infected by the parasite and around 50 thousand deaths are related to Chagas\' disease each year, in the 21 countries of endemic areas. The therapeutic armamentarium available against the disease is constituted by only two drugs and is insufficient, considering, also, that the drugs are not efficient in the chronic phase of the disease. As a parasitosis that only occurs in developing countries, the interest in the research for new antichagasic agents is considerably low in countries that are responsible for the introduction of new drugs in the therapeutics. So, the search for new chemotherapeutic alternatives is a task for the involved countries. In view of the situation and taking into account the high activity in in vitro tests against Trypanosoma cruzi showed by nitrofurazone hydroxymethyl derivative, an intermediary of Mannich bases reaction previously synthesized, the objective of this work was to synthesize its Mannich bases. The carriers used were aminoacids lysine and arginine and its dipeptide, lysinearginine. The compounds were synthesized using classic and alternative methods and protecting groups, currently used in peptide synthesis and others temptatively employed, as methyl and ethyl groups. Also, many experiments were performed in order to achieve the optimization of hydroxymethylnitrofurazone synthesis. The derivatives synthesized were analyzed by IR, 1H and 13C NMR, and some also by mass spectrometry. They will be submitted to in vitro tests with cell infected with T. cruzi as soon as the protecting groups are removed. Besides, tests of drug release will be performed to study their stability. We expect to obtain important information toward better comprehension of their mechanism of action and possible mutagenicity involved.

Orientador: Aparecido Antonio Camacho / Banca: Wagner Luís Ferreira / Banca: Ruthnéa Aparecida Lázaro Muzzi / Resumo: A cardiomiopatia chagásica está presente na história da humanidade, desde os primórdios da civilização. No continente americano, aproximadamente 200 milhões de pessoas estão afetadas por essa doença, principalmente em seu Hemisfério Sul, ocasionando importantes danos econômicos e sociais. A grande variedade de cepas e seu comportamento clínico obscuro na fase crônica indeterminada intensificam as falhas de diagnóstico e morte súbita. Sendo o cão um modelo experimental adequado para o estudo dessa doença em humanos, realizou-se este trabalho visando a caracterizar as alterações eletrocardiográficas, ecodopplercardiográficas e hematimétricas, de cães experimentalmente infectados com Trypanosoma cruzi, cepa Colombiana, em sua fase crônica indeterminada. Para tanto, 13 cães adultos, fêmeas foram infectados com o referido protozoário e submetidos a avaliações eletrocardiográfica, hematimétrica, bioquímico-sérica e ecocardiográfica durante sua fase crônica (1997 a 2004). A arritmia sinusal respiratória foi o ritmo predominante durante todo o período experimental, com baixa prevalência de bloqueio de ramo direito e crescente incidência de bloqueio atrioventricular de primeiro grau. A avaliação ecodopplercardiográfica revelou inversão das ondas E e A mitral, confirmando o distúrbio diastólico nesses animais. A avaliação bioquímica revelou atividade enzimática aumentada, confirmando a lesão cardíaca provocada pela infecção mesmo nesta fase. Desta forma, o presente ensaio contribui de forma singular para o conhecimento clínico desta afecção, trazendo mais informações acerca da tênue e obscura linha que separa a fase crônica indeterminada e a fase crônica cardíaca, na espécie canina experimentalmente infectada pela cepa Colombina do Trypanosoma cruzi. / Abstract: The Chagasic cardiomiopathy is present in the human history since the first civilization. In the American continent, 200 millions people have been affecting by this disease, mainly in south hemisphere, causing important economics and social damages. The great number of strains and obscure clinical behavior in the indeterminate phase, intensify diagnostic failure and increase sudden death. The dog is an excellent experimental model to study this disease in human, therefore this research was developed to characterize the electrocardiographic, echodopplercardiographic and haematological changes, in experimentally infected dogs with Trypanosoma cruzi, Colombian strain, in a chronic indeterminate phase. For that, thirteen infected adult dogs, female, were submitted to electrocardiographic, haematological, biochemical and echocardiographic evaluations during a chronic phase (1997 to 2004). The respiratory sinus arrhythmia was the most frequent rhythm during this research, with low prevalence of right bundle branch block and growing incidence of first degree atrioventricular block. The echocardiographic mitral waves E and A inversion, demonstrated the diastolic dysfunction on this animals. All tested serum enzymes had increased activity, confirming the cardiac lesion caused by the infection even in that phase. Therefore, this research contributed in a unique way for the clinic knowledge of this disease, bringing more information about this fine transition line between the indeterminate and cardiac phase, in experimentally Trypanosoma. cruzi, Colombian strain infection of canine species. / Mestre

FN:s globala mål nummer sex och femton fodrar skyddandet av vatten och landsburna ekosystem. För att nå målen krävs bland annat bevarandet och restaureringen av naturskogar och ett främjande av ett hållbart skogsbruk. Denna studie syftar till att undersöka huruvida sprängtickan kan inom småskalig skogsförvaltning kan ses som en resurs för konsumenter och för skogsägare ur ett konsumentperspektiv genom att besvara frågeställningen; Hur kan design ha betydelse för ett urvals konsumenters inställning till sprängtickan som livsmedel? Samt genom en kartläggning över den produktmarknad med sprängticka som existerar i Sverige idag. Studien besvaras genom att koppla till teorier inom FoodTech, Food design thinking samt nudging. Undersökningen har genomförts genom en visuell innehållsanalys samt en kvantitativa enkätundersökning. Resultatet av de båda metoderna visar att det finns stor potential för sprängtickan att utnyttjas som konsumentvara och på så sätt hjälpa privat skogsägare att bevara urskogarna. Studien visar dock en problematik i den nuvarande svenska marknaden med sprängticka och att det finns stora utvecklingsmöjligheter inom detta område.

Chagga women who control land on Mt. Kilimanjaro, Tanzania, have a deep and profound sense of attachment to their lands and homes. This thesis compares their reasons for attachment to the systemic model. The systemic model states that community attachment is dependent on social ties and interactions. The three factors that lead to these ties are length of residence, social status, and age. In-depth interviews with women in 2002 and 2003, a survey from 2002, and field notes from 2002 and 2003 are used to explain the main factors of attachment of women in three villages on the mountain: Mbahe, Marangu, and Chekereni. This research finds that social ties are not dependent on length of residence, but do have some connections with social status and age. Women have social ties regardless of their length of residence. They interact with each other no matter the social status of the other, but this occurs more frequently as the women are more involved in education and religion. Western influences, land shortages, and economic pressures are causing the interactions of the young and old to be more strained. Though social ties are partly related so social status and age, this thesis finds that the attachment of Chagga women does not completely follow the systemic model. Instead, the women's attachment is primarily associated with family ties. The land has provided food and income for their families for generations and it is the hope of each of the women that it will continue to care for their families in such a way.