Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

H παρούσα διατριβή ανήκει στο πεδίο της συγκριτικής μορφολογίας. Μελετάται η μορφολογική διαδικασία της σύνθεσης στη Νέα Ελληνική και τη Γερμανική, σε δύο γλώσσες που μοιράζονται πολλά κοινά μορφολογικά χαρακτηριστικά και στις οποίες το συγκεκριμένο φαινόμενο είναι ιδιαίτερα παραγωγικό. Συγκεκριμένα, τα θέματα που εξετάζονται είναι τα ακόλουθα: α) τα δομικά χαρακτηριστικά των λεγόμενων «πρωτοτυπικών συνθέτων» σε σύγκριση με τις «οριακές περιπτώσεις», όπου και η διαδικασία της παραγωγής εμπλέκεται στο σχηματισμό τους, β) η εμφάνιση συνδετικού στοιχείου και γ) ο σχηματισμός διαφόρων τύπων συνθέτων, όπως για παράδειγμα των εξωκεντρικών και των παρατακτικών συνθέτων. To θεωρητικό πλαίσιο που υιοθετείται είναι αυτό της γενετικής μορφολογίας. Τα κυριότερα συμπεράσματα της διατριβής αφορούν τον καθορισμό των παραμέτρων, βάσει των οποίων μπορούν να ερμηνευθούν οι διαφορές στο σχηματισμό συνθέτων των δύο αυτών γλωσσών. Οι πιο σημαντικοί παράμετροι που εξηγούν τις διαφορές των νεοελληνικών και γερμανικών συνθέτων είναι α) το είδος της μορφολογίας που προτιμά η κάθε γλώσσα, αν δηλαδή βασίζεται στο θέμα ή στη λέξη και β) τα πλούσια ή περιορισμένα ονοματικά κλιτικά παραδείγματα. Μέσω της συγκριτικής ανάλυσης ήρθαν στο φως και νέα συμπεράσματα που αφορούν επιμέρους ζητήματα της διαδικασίας της σύνθεσης των δύο αυτών γλωσσών, όπως για παράδειγμα ο μορφολογικός χαρακτήρας του συνδετικού στοιχείου και το είδος της κεφαλής των εξωκεντρικών συνθέτων της Γερμανικής, καθώς επίσης και τα μορφολογικά χαρακτηριστικά των ονοματικών παρατακτικών συνθέτων της Νέας Ελληνικής. / This thesis belongs to the field of contrastive morphology: it examines the morphological process of compounding in Modern Greek and German, two languages which share many common morphological features and in which the specific phenomenon is especially productive. In more detail, the topics examined are the following: a) the structural features of the so called “prototypical compounds” in contrast to the “borderline cases”, where the process of derivation is also involved in their formation, b) the appearance of the linking element and c) the formation of different types of compounds as for example the exocentric and the copulative ones. The theoretical framework adopted is that of generative morphology. The main conclusions of the thesis concern the definition of parameters that can explain the differences in the formation of compounds in these two languages. The most important parameters that determine the basic differences in the formation of Modern Greek and German compounds are a) the stem vs. word-based morphology and b) the rich vs. limited nominal inflectional paradigms. Through this contrastive analysis various new outcomes came into light concerning special issues in the process of compounding of these two languages, as for instance the morphological status of the linking element in German, the type of head that the German exocentric compounds display and the morphological features of the nominal copulative compounds in Modern Greek.

The objective of this study was to evaluate and promote the Good Handling Practices and Good Nutritional Practices in school canteens in the municipality of Santa Maria/RS. The study was conducted in 18 school cafeterias, with 7 of the municipal, state, and 5 of 6 within the particular context of education, the study took place from December 2012 to December 2013. Elaborated three instruments for the realization of research, an instrument for determining the profile of the school canteens, another to assess school canteens as the regulations in force and the third to check the sanitary conditions of the canteens. Was elaborated still a Training Program Best Practices, divided into three modules: Good Nutritional Practices, Good Handling Practices and Good Sustainable Practices. With the instruments gave a survey of the current situation of school canteens evaluated as well as a considerable number of trained food handlers and managers canteens and schools. Through the survey school canteens have low fitness in relation to existing laws, both in nutritional aspects, as in health. It is believed that this study will serve to support future projects, provide the basis for an update of state law for school canteens in force and can support public policy development. / O objetivo deste trabalho foi avaliar e promover as Boas Práticas de Manipulação e Boas Práticas Nutricionais em cantinas escolares do município de Santa Maria/RS. A pesquisa foi desenvolvida em 18 cantinas escolares, sendo 7 do âmbito municipal, 5 do âmbito estadual e 6 do âmbito particular de ensino, o estudo ocorreu no período de dezembro de 2012 a dezembro de 2013. Elaborou-se três instrumentos para a realização da pesquisa, um instrumento para determinar o perfil das cantinas escolares, outro para avaliar as cantinas escolares quanto as regulamentações em vigor e o terceiro para verificar as condições higiênico-sanitárias das cantinas. Elaborou-se ainda um Programa de Capacitação em Boas Práticas, distribuídos em três módulos: Boas Práticas Nutricionais, Boas Práticas de Manipulação e Boas Práticas Sustentáveis. Com os instrumentos, obteve-se um levantamento da atual situação das cantinas escolares avaliadas, bem como se capacitou um número considerável de manipuladores de alimentos e gestores de cantinas e de escolas. Por meio do levantamento realizado as cantinas escolares apresentam baixa adequação em relação as legislações vigentes, tanto nos aspectos nutricionais, como nos sanitários. Acredita-se que o presente estudo poderá servir de apoio para futuros projetos, servir de base para uma atualização da legislação estadual para cantinas escolares em vigor, bem como pode subsidiar elaboração de políticas públicas.

This research investigates formulation, compounding and thin-wall injection moulding of Polypropylene/clay nanocomposites (PPCNs) prepared using conventional melt-state processes. An independent study on single screw extrusion dynamics using Design of Experiments (DoE) was performed first. Then the optimum formulation of PPCNs and compounding conditions were determined using this strategy. The outcomes from the DoE study were then applied to produce PPCN compounds for the subsequent study of thin-wall injection moulding, for which a novel four-cavity injection moulding system was designed using CAD software and a new moulding tool was constructed based upon this design. Subsequently, the effects of moulding conditions, nanoclay concentration and wall thickness on the injection moulded PPCN parts were investigated. Moreover, simulation of the injection moulding process was carried out to compare the predicted performance with that obtained in practice by measurement of real-time data using an in-cavity pressure sensor. For the selected materials, the optimum formulation is 4 wt% organoclay (DK4), 4 wt% compatibiliser (Polybond 3200, PPgMA) and 1.5 wt% co-intercalant (erucamide), as the maximum interlayer spacing of clay can be achieved in the selected experimental range. Furthermore, DoE investigations determined that a screw speed of 159 rpm and a feed rate of 5.4 kg/h are the optimum compounding conditions for the twin screw extruder used to obtain the highest tensile modulus and yield strength from the PPCN compounds. The optimised formulation of PPCNs and compounding conditions were adopted to manufacture PPCN materials for the study of thin-wall injection moulding. In the selected processing window, tensile modulus and yield strength increase significantly with decreasing injection speed, due to shear-induced orientation effects, exemplified by a significantly increased frozen layer thickness observed by optical microscopy (OM) and Moldflow® simulation. Furthermore, the TEM images indicate a strong orientation of clay particles in the flow direction, so the PPCN test pieces cut parallel to the flow direction have 36.4% higher tensile modulus and 13.6 % higher yield strength than those cut perpendicular to the flow direction, demonstrating the effects of shear induced orientation on the tensile properties of thin-wall injection moulded PPCN parts. In comparison to injection speed, mould temperature has very limited effects in the selected range investigated (25-55 °C), in this study. The changes in moulding conditions show no distinctive effects on PP crystallinity and intercalation behaviour of clay. Impact toughness of thin wall injection moulded PPCN parts is not significantly affected by either the changes in moulding conditions or clay concentration (1-5 %). The SEM images show no clear difference between the fracture surfaces of PPCN samples with different clay concentrations. TEM and XRD results suggest that higher intercalation but lower exfoliation is achieved in PPCN parts with higher clay content. The composites in the thin sections (at the end of flow) have 34 % higher tensile modulus and 11 % higher yield strength than in the thicker sections, although the thin sections show reduced d001 values. This is attributed to the significantly enhanced shear-induced particle/molecular orientation and more highly oriented frozen layer, according to TEM, OM and process simulation results. In terms of the reduced d001 values in the thin sections, it is proposed that the extreme shear conditions in the thin sections stretch the PP chains in the clay galleries to a much higher level, compaction of clay stacks occurs as less interspacing is needed to accommodate the stretched chains, but rapid cooling allows no time for the chains to relax and expand the galleries back. Overall, data obtained from both actual moulding and simulation indicate that injection speed is of utmost importance to the thin-wall injection moulding process, development of microstructure, and thus the resulting properties of the moulded PPCN parts, in the selected experimental ranges of this research.

Durch das Einbringen von Additiven, Füll- und Verstärkungsstoffen in eine polymere Matrix oder durch das Blenden unterschiedlicher Polymere ist es möglich, die Eigenschaften von Kunststoffen gezielt auf den Anwendungsfall hin zu optimieren. Gerade durch diese „Einstellbarkeit“ der Eigenschaften und infolge ihrer vergleichsweise geringen Dichte verdrängen Kunststoffe zunehmend klassische Werkstoffe und erobern so neue Anwendungsgebiete. Die Entwicklung solcher innovativer Kunststoffrezepturen (Compounds) ist jedoch zeitaufwendig und kostenintensiv. Um die gewünschten Gebrauchseigenschaften des Endproduktes zu erreichen, ist oft eine Vielzahl unterschiedlicher Zusatzstoffe erforderlich; somit werden entsprechende Rezepturen schnell sehr komplex. Bei der klassischen Materialentwicklung wird zumeist nicht erfasst/ermittelt, welche Synergien die einzelnen Bestandteile - positiver oder negativer Art - untereinander haben. Eine gezielte systematische Untersuchung dieser Synergien mit klassischen Methoden ist aus Kosten- und Zeitgründen kaum möglich. Für eine zeitgemäße Materialentwicklung sind daher neue Methoden gefragt, die eine schnelle Rezepturvariation, gepaart mit einem schnellen Eigenschaftsscreening, ermöglichen. Mit der Entwicklung des kombinatorischen Compoundier und High Throughput Screening Systems (CC/HTS-Systems) wurde im Rahmen dieser Arbeit eine, auch industriell einsetzbare, Basisanlage für die schnelle Entwicklung von neuen und innovativen Compoundrezepturen erstellt und hinsichtlich der Übertragbarkeit der Ergebnisse verifiziert. Das CC/HTS-System besteht aus: • einem Doppelschneckenextruder (ZSK 18 MegaLab) Eine entscheidende Besonderheit dieses System resultiert aus der Möglichkeit, die Materialzufuhr und damit die Zusammensetzung über rechnergesteuerte Dosierwaagen kontinuierlich zu verändern. Die im Vergleich zur klassischen Vorgehensweise somit vorhandene schnelle Rezepturänderung ermöglicht es in kürzester Zeit, eine große Rezepturvielfalt abzuarbeiten. • einer Flachfolienanlage Durch die direkte Kopplung der Flachfolienanlage mit der Folienextrusion wird der Rezepturgradient in einer Folie, im Sinne einer 1-dimensionalen Library „eingefroren“. • integrierten Prüfeinrichtungen Durch den Einsatz von in das System zu integrierenden unterschiedlichen HTS-Methoden ist eine schnelle und aussagefähige Charakterisierung der so hergestellten Rezepturen direkt online möglich. Erst diese im Rahmen dieser Arbeit entwickelten und validierten mechanischen Online-Prüfungen, als neue HTS-Methoden, ermöglichen durch deren Integration in das Gesamtsystem ein schnelles Materialscreening, indem die im Rahmen des CC hergestellten Folien (Library) online auf ihre mechanische Performance hin geprüft werden. Die mechanische Online-Prüfeinrichtung wurde so konzipiert, dass drei unterschiedliche Tests simultan in einer Vorrichtung durchgeführt werden. Hierbei handelt es sich um: • einen Durchstoßversuch, • einen Weiterreißversuch (wahlweise in oder travers zur Folienabzugsrichtung), • einen modifizierten Zugversuch (wahlweise in oder travers zur Folienabzugsrichtung). Anhand dieser drei zeitgleich online gemessenen Werkstoffkennwerte sind Aussagen über die wichtigsten mechanischen Eigenschaften - Steifigkeit, Zähigkeit und Festigkeit - abhängig von der Werkstoffzusammensetzung möglich. Die Prüfeinrichtungen für den Zug- und den Weiterreißversuch sind so konstruiert, dass sie sich je nach Entwicklungsaufgabe in der Prüfeinrichtung um 90° drehen lassen, um auch mechanische Eigenschaften in und/oder travers zur Folienabzugsrichtung zu ermitteln. Durch das Entfernen der Kerbmesser in der Prüfeinrichtung des Weiterreißversuchs lässt sich dieser zu einem zweiten Online-Zugversuch umrüsten, um z. B. gleichzeitig in und travers zur Folienabzugsrichtung die Zugfestigkeit zu erfassen. Hierdurch ist es möglich, in einem Prozessdurchlauf das anisotrope Werkstoffverhalten rezeptur- und prozessabhängig zu charakterisieren. Die Entwicklung der mechanischen Online-Prüfeinrichtung wurde durch stetige Validierung der Prüfergebnisse abgesichert. Als Ergebnis dieser Validierungsschritte ist festzuhalten, dass die online und offline ermittelten mechanischen Eigenschaften gut miteinander korrelieren. Eine entscheidende Frage beim CC war neben der Korrelierbarkeit der mechanischen Eigenschaften die Zuordnung der Rezepturzusammensetzung - welche sich kontinuierlich infolge der Gradientendosierung verändert - zu den online ermittelten Materialeigenschaften. Hierbei ist das Verweilzeitverhalten des Gesamtsystems, bestehend aus Extruder und Flachfolienanlage, zu berücksichtigen. Zur Beantwortung dieser Fragestellung wurden zunächst verschiedene theoretische Modelle auf ihre Anwendbarkeit hin untersucht. Es konnte gezeigt werden, dass das Double Backflow Cell Model die gewählte Versuchsanordnung am besten beschreibt. Als Ergebnis dieser theoretischen Überlegungen ist festzuhalten, dass für eine gute Korrelation von Rezepturzusammensetzung und online ermittelten Materialeigenschaften nur die System-Totzeit bei hinreichend langer Gradientenzeit zu berücksichtigen ist. Diese Arbeitshypothese konnte durch einen Versuch mittels Gradientenzugabe von Glasfasern von 0 w% auf 30 w% in Polypropylen und anschließender Glührückstandsbestimmung experimentell bestätigt werden. Im Anschluss an die Entwicklung und Validierung des Gesamtsystems (Gradientendosierung und mechanische Online-Prüfung) wurden die Möglichkeiten des CC/HTS-Systems anhand eines praxisrelevanten Zweistoffsystems, bestehend aus Polypropylen und verschiedenen POEs, welche sich im Viskositätsverhältnis zum Polypropylen und dem α-Olefin-Anteil unterscheiden, aufgezeigt. Durch das Blenden von Polypropylen mit einem Polyolefinelastomer (POE) lässt sich Polypropylen schlagzäh modifizieren. Bei einem solchen Blend aus zwei in der Regel nicht mischbaren Polymeren ist die sich einstellende Phasenmorphologie für das mechanische Werkstoffverhalten von entscheidender Bedeutung. Die Phasenmorphologie, also die Form und Größe der POE-Partikel, in der Polypropylenmatrix ist stark von der ausgewählten POE-Type abhängig. Um Aussagen zur Blendmorphologie zu erhalten, wurde im Rahmen dieser Untersuchungen die mechanische Online-Prüfung erstmals mit einer Online-Kleinwinkellichtstreuung als HTS-Methoden gekoppelt. Durch die Online-Kleinwinkellichtstreuung ist es möglich, simultan zu den mechanischen Eigenschaften auch online Rückschlüsse auf die Blendmorphologie zu erhalten. Diese Untersuchungen zeigten, wie die Morphologie und die mechanischen Eigenschaften korrelieren und welche Bedeutung der Auswahl der Blendpartner - des POEs – für das mechanische Werkstoffverhalten zukommt. Interessant war, dass die untersuchten Prozessparameter von untergeordneter Bedeutung für die Performance eines solchen Blends sind. Abschließend wurde die CC/HTS Methode auf eine industrielle Fragestellung - Dreistoffsystem bestehend aus Polypropylen/Glasfasern/Koppler – angewandt. Die Anwendbarkeit des Systems auch auf komplexere Werkstoffzusammensetzungen wurde dabei bestätigt. Es konnte gezeigt werden, dass mit Hilfe dieser Methode / Versuchseinrichtung die Compoundentwicklung deutlich beschleunigt und ressourcenschonender durchgeführt werden kann und die Ergebnisse mit den klassisch erarbeiteten Werten korrelieren.

No description available.

No / OBJECTIVES: To compare the properties of solid dispersions of felodipine for oral bioavailability enhancement using two different polymers, polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), by hot-melt extrusion (HME) and spray drying. METHODS: Felodipine solid dispersions were prepared by HME and spray drying techniques. PVP and HPMCAS were used as polymer matrices at different drug : polymer ratios (1 : 1, 1 : 2 and 1 : 3). Detailed characterization was performed using differential scanning calorimetry, powder X-ray diffractometry, scanning electron microscopy and in-vitro dissolution testing. Dissolution profiles were evaluated in the presence of sodium dodecyl sulphate. Stability of different solid dispersions was studied under accelerated conditions (40 degrees C/75% RH) over 8 weeks. KEY FINDINGS: Spray-dried formulations were found to release felodipine faster than melt extruded formulations for both polymer matrices. Solid dispersions containing HMPCAS exhibited higher drug release rates and better wettability than those produced with a PVP matrix. No significant differences in stability were observed except with HPMCAS at a 1 : 1 ratio, where crystallization was detected in spray-dried formulations. CONCLUSIONS: Solid dispersions of felodipine produced by spray drying exhibited more rapid drug release than corresponding melt extruded formulations, although in some cases improved stability was observed for melt extruded formulations.

No / A systematic identification of the degradation products of hydroxypropyl methylcellulose phthalate (HPMCP) during hot melt extrusion (HME) has been performed. A reverse phase HPLC method was developed for the extrudates of both hydroxypropyl methylcellulose acetate succinate (HPMCAS) and HPMCP polymers to quantify their thermal hydrolytic products: acetic acid (AA), succinic acid (SA) for HPMCAS and phthalic acid (PA) for HPMCP, without hydrolysing the polymers in strong alkaline solutions. The polymers were extruded in the temperature range of 160-190 degrees C at different screw rotation speeds and hydrolytic impurities were analysed. Investigation of extruded HPMCP showed an additional thermal degradation product, who is structural elucidation revealed to be phthalic anhydride (PAH). Moreover, two environmental analytical impurities, dimethyl phthalate and methyl benzoate formed in situ were recorded on GC-MS and their origin was found to be associated with PAH derivatization. Using the experimental data gathered during this study, a degradation mechanism for HPMCP is proposed.

This thesis addresses the problem of the lack of a systematic approach to the modernisation of the indigenous languages of South Africa, with particular reference to Venda. Thus, a systematic approach is proposed in this study for the development of modem terminology in Venda. This approach is based on the canonical model for language planning. In this model, terminology development should follow the following four steps: (1) analysis of the terminological needs of the situation, (2) preparation of a plan and strategies for research, (3) implementation of terminology in practice by means of suitable policies, and lastly, (4) evaluation and constant updating of terminology. Within the canonical model for language planning, different models or frameworks are proposed. First is the theoretical model, which follows the pragmatic approach rather than a purist approach and takes into consideration other extralinguistic factors such as the nature of the special subject field, the needs of the target users and the socio-cultural context. The pragmatic approach is divided into two phases, namely the borrowing phase and the indigenisation phase. In the borrowing phase the borrowed terms are incorporated into the language with immediate effect and these terms may be replaced by indigenous terms in the indigenisation phase where less specialised communication is used. In the indigenisation phase, different language internal term formation strategies were identified, namely semantic shift, derivation, compounding, paraphrasing, initialisms, acronyms, clipping and new word manufacture. It was established that the use of these term formation strategies in Venda requires linguistic expertise, technical expertise and cultural expertise. Accordingly, a sociolinguistic approach is recommended rather than a purely linguistic approach. Lastly, a model of practical terminology work and a model for cooperation and coordination are proposed for terminology work in this language. With regard to the former, various steps that should be followed in terminology work are outlined. In the latter model various language agencies, such as government departments, parastatals and non-governmental organisations that may be involved in the modernisation of this language are identified. A framework in which these agencies could cooperate and coordinate their terminology work is proposed. / Linguistics / D.Litt. et Phil. (Linguistics)

"Endymion" è il traît d'union tra i juvenilia di Keats ("Poems", 1817) e i suoi lavori più conosciuti ("Lamia, Isabella ... and other Poems"). Per sua natura, è un'opera di transizione e quindi concede allo studioso un punto di vista privilegiato sullo sviluppo della poetica e della lingua di Keats. Inoltre, l'"Endymion" è l'opera keatsiana più aspramente contestata dalla critica romantica. Gli studiosi moderni hanno analizzato il problema alla luce di considerazioni socio-politiche, il mio lavoro mira invece ad un'analisi più strettamente linguistica. Ricostruisco il contesto linguistico del diciottesimo e diciannovesimo secolo al fine di spiegare il disagio dei recensori nei confronti di "Endymion". Sostengo che il prescrittivismo del Settecento nasce da una profonda ansia relativa alla lingua, causata dalle teorie di Locke. L'atteggiamento prescrittivista influenza la critica romantica e i critici di Keats in particolare, più di quanto potessero fare considerazioni di natura politica. Analizzo le peculiarità linguistiche e strutturali di "Endymion" al fine di provare che Keats elabora una 'poetica dell'incontrollabilità', una serie di strategie stilistiche e testuali, che violano le convenzioni linguistiche e narrative e che vengono quindi percepite come destabilizzanti e stranianti. / "Endymion" is the traît d’union between Keats’s juvenilia ("Poems", 1817)and his better known, and, conventionally, ’mature’ works ("Lamia, Is- abella ... and other Poems", 1820). By its nature, it is a transitional work, and thus gives the scholar special insight into the development of Keats’s poetics and idiom. Moreover, "Endymion" is the Keatsian work which most irritated and provoked contemporary critics; the two pieces of venomous invective it received in the periodical press of the time have become the stuff of scholarly legend. Recent scholarly work has analysed the language of "Endymion" in socio-political terms; my work focuses on more strictly linguistic concerns. I reconstruct the linguistic context of the eighteenth and early nineteenth centuries in order to explain the reviewers’ unease with regard to "Endymion". I maintain that eighteenth-century prescriptivism arose from a deep-seated anxiety regarding language, Lockian in origin, and that the ensuing desire to stabilize and therefore control language informed Romantic criticism in general, and the criticism of Keats’s work in particular, more fundamentally than politics could or did. I analyse the imaginative and linguistic markers of "Endymion" in order to prove that Keats had elaborated a “poetics of uncontrollability”, a series of textual and stylistic strategies, which violated linguistic and narrative standards and were therefore perceived as unsettling.