The ignition of a solid is an inherently complex phenomenon influenced by heat and mass transport mechanisms that are, even to this day, not understood in entirety. In order to use ignition data in meaningful engineering application, significant simplifications have been made to the theory of ignition. The most common way to classify ignition is the use of material specific parameters such as such as ignition temperature (Tig) and the critical heat flux for ignition (CHF). These parameters are determined through standardized testing of solid materials – however, the results of these tests are generally used in applications different from the environments in which these parameters were actually determined. Generally, ignition temperature and critical heat flux are used as material properties and are presented readily in sources such as the SFPE Handbook. However, these parameters are not truly material properties; each are inherently affected by the environment in which they are tested. Ignition parameters are therefore system dependent, tied to the conditions in which the parameters are determined. Previous work has demonstrated that ignition parameters (such as Tig or CHF) for the same material can vary depending on whether the sample is tested in a vertical or horizontal orientation. While the results are clear, the implications this may have on the use of ignition data remains uncertain. This work outlines the fundamental theory of ignition as well as a review of studies related to orientation. The aim of this study it to analyze the influence of sample orientation on ignition parameters. All experimental work in this study was conducted using cast black polymethyl methacrylate (PMMA or commonly referred to as acrylic). This study explores ignition parameters for PMMA in various orientations and develops a methodology through which orientation can be incorporated into existing ignition theory. An additional study was also conducted to explore the statistical significance of current flammability test methodologies. Ultimately, this study outlines the problem of the system dependency of ignition and provides commentary on the use of ignition data in engineering applications.

With advances in high-throughput techniques, the availability of large-scale omics data has revolutionized the fields of medicine and biology, and has offered a better understanding of the underlying biological mechanisms. However, the high-dimensionality and the unknown association structure between different data types make statistical integration analyses challenging. In this dissertation, we develop three dimensionality reduction methods to detect nonlinear association structure using omics data. First, we propose a method for variable selection in a nonparametric additive quantile regression framework. We enforce a network regularization to incorporate information encoded by known networks. To account for nonlinear associations, we approximate the additive functional effect of each predictor with the expansion of a B-spline basis. We implement the group Lasso penalty to achieve sparsity. We define the network-constrained penalty by regulating the difference between the effect functions of any two linked genes (predictors) in the network. Simulation studies show that our proposed method performs well in identifying truly associated genes with fewer falsely associated genes than alternative approaches. Second, we develop a canonical correlation analysis (CCA)-based method, canonical distance correlation analysis (CDCA), and leverage the distance correlation to capture the overall association between two sets of variables. The CDCA allows untangling linear and nonlinear dependence structures. Third, we develop the sparse CDCA (sCDCA) method to achieve sparsity and improve result interpretability by adding penalties on the loadings from the CDCA. The sCDCA method can be applied to data with large dimensionality and small sample size. We develop iterative majorization-minimization-based coordinate descent algorithms to compute the loadings in the CDCA and sCDCA methods. Simulation studies show that the proposed CDCA and sCDCA approaches have better performance than classical CCA and sparse CCA (sCCA) in nonlinear settings and have similar performance in linear association settings. We apply the proposed methods to the Framingham Heart Study (FHS) to identify body mass index associated genes, the association structure between metabolic disorders and metabolite profiles, and a subset of metabolites and their associated type 2 diabetes (T2D)-related genes. / 2023-11-05T00:00:00Z

Background & Purpose: The current standard dosimetry in brachytherapy treatment planning, the TG-43 formalism, ignore the presence of non-water media and finite patient dimensions. This can cause clinically relevant errors in dose estimates. To over- come the limitations of the TG-43 formalism, Model-Based Dose Calculation Algorithms (MBDCAs) have evolved. One of the commercial available MBDCAs is the Advanced Collapsed cone Engine (ACE) by Elekta. In ACE, the total dose is divided into three components, the primary, the first-scattered and the multiple-scattered dose, where the two last mentioned are calculated by the means of the Collapsed Cone Algorithm. In this study the performance of ACE has been investigated. The study has been di- vided into 2 parts, where the aim of part 1 was to analyze the relationship between the so called discretization artifacts, caused by the collapsed cone approximation, and the number of dwell positions. The severeness of the artifact is thought to decrease as the number of dwell positions are increased. The second part focus on ACE’s behavior in cortical bone, with the aim to form a hypothesis (explanation and solution) to the previously observed dose underestimation of the dose to bone made by ACE. Materials and Methods: The generic 192Ir source, the Oncentra Brachy (OcB) treatment planning system (TPS) and the Monte Carlo (MC) platform ALGEBRA have been utilized. In the first part of the study, six source configurations, all with a different number of dwell positions, were created and placed in the center of large water phantoms, i.e. under TG-43 conditions in which the TG-43 formalism can be assumed to yield a high accuracy of the estimated dose. The accuracy of ACE has been judged by its’ deviation from TG-43. In the second part of the study, a cubic source configuration, of 27 dwell positions, was positioned at the center of a cubic water phantom. Three cases where constructed, with a small cortical bone heterogeneity positioned at different distances from the source configu- ration. The ACE calculated dose distribution has been divided into its’ three constituents. The accuracy of ACE and TG-43 has been judged by its’ deviation from MC. Results: Part 1 showed that increasing the number of dwell positions does not guar- antee an improved accuracy of ACE. Local dose difference ratios of > 2%, caused by the artifacts, were mainly located outside the 5% isodose line. A general dose underestima- tion was observed in ACE, with an increased magnitude as the dose level decreased. The majority of local dose difference ratios below -4% were found where the multi-resolution voxelization grid of ACE has a voxel size of ≥23 mm3, that is at a distance of ≥8 cm from the closest dwell position when using the ACE standard accuracy level. In part 2, ACE underestimated the dose to cortical bone, with an increased magnitude as the bone was positioned farther away from the source configuration. The TG-43 formalism gave slightly better estimates of the mean dose to bone than ACE, especially at higher dose levels. For a mean dose to the cortical bone heterogeneity equal to 45% of the prescribed dose, TG-43 and ACE underestimated the mean dose with 1% and 4%, respectively. The estimated mean dose to a volume located directly behind the heterogeneity agreed within 1% between ACE and MC. However, an increased amount of positive local dose difference ratios were observed in this volume. Conclusions: Increasing the number of dwell positions cause a ”blurring” effect of the artifact, but may also increase the fluence gradient. In such situations the severeness of the artifact may not be improved. In patient cases the dwell positions are usually added in a more random manner which may favor the ”blurring effect”. The underestimations observed in ACE are thought to be caused by both the multiple- resolution voxelization grid of ACE and the relationship between the dimensions of the phantom in which the multiple-scattered kernel has been generated and the current calcu- lation volume. ACE was unsuccessful to predict the dose to cortical bone, and should hence be used with caution when cortical bone is an organ at risk, as long as the problem remains. The results indicates that the error in ACE is located in the scatter dose calculations and that the heterogeneity cause ACE to displace the dose. The error is thought to be located in the multiple-scattered dose component, which was also shown by Terribilni et al.. A hypothesis is that the problem is caused by the neglected effect of media dependent absorption coefficients in the multiple-scattered dose calculation. A suggested solution, left to be proven, is to use effective attenuation scaling factors.

<div>Experiments were performed on a sharp-nosed 7° half-angle cone at a 6° angle of attack in the Boeing/AFOSR Mach-6 Quiet Tunnel (BAM6QT) to study the stationary crossflow instability and its receptivity to small surface roughness. Heat transfer measurements were obtained using temperature sensitive paint (TSP) and Schmidt Boelter (SB) heat transfer gauges. Great care was taken to obtain repeatable, quantitative measurements from TSP.</div><div></div><div>Consecutive runs were performed at a 0° angle of attack, and the heat transfer measured by the SB was found to drop as the initial model temperature increased, while other initial conditions such as stagnation pressure were held constant. This agreed with calculations done using a similarity solution. It was found that repeatable measurements at a 6° angle of attack could be made if the initial model temperature was controlled and the patch location that was used to calibrate the TSP was picked in a reasonable and consistent manner.</div><div></div><div>The Rod Insertion Method (RIM) roughness, which was used to excite the stationary crossflow instability, was found to be responsible for the appearance of the streaks that were analyzed. The signal-to-noise ratio in the TSP was too low to properly measure the streaks directly downstream of the roughness insert. The heat transfer along the streak experienced linear growth, peaked, and then slightly decayed. It is possible this peak was saturation. The general trend was that the growth of the streaks moved farther upstream as the roughness element height increased, which agreed with past computations and low speed experiments. The growth of the streak also moved farther upstream as the freestream Reynolds number increased. The amplitude of the streaks was calculated by non-dimensionalizing the heat transfer using the laminar theoretical mean-flow solution for a 7° half-angle cone at a 6° angle of attack. The relationship between the amplitude and the non-dimensional roughness height was approximately linear in the growth region of the streaks.</div>

Thesis advisor: Andrew Prevot / Decisions: Political Theology and the Challenges of Postmodernity, argues that political theologies are both partially responsible for and responsive to the intrinsically related problems of racism, capitalism, and essentialist metaphysical thinking. Relying on dialectical materialist and post-structuralist theories, Decisions critically engages a wide range of classical and contemporary figures such as Karl Marx, Søren Kierkegaard, Carl Schmitt, Jacques Derrida, James Cone, Chantal Mouffe, Cornel West, Martin Hågglund, and Karl ove Knausgaard. These engagements are attentive to not only the particular theoretical and political decisions any one thinker makes, but also to the ways in which “decision” is itself understood as an important theoretical and political category. Although “decisionism” has become a popular motif in contemporary political theology, the concept remains under theorized. This is unfortunate, because contemporary ontological racisms and exploitative market structures aim to prevent political decisions: ontological racism decides in advance the essential “racial” characteristics of a person and market economies ensure that the distribution of goods is “decided” by the so- called invisible hand of the market. Moreover, both racisms and capitalism can imply an underlying modern metaphysics of substance and essence. While the postmodern critique of metaphysics is often read as a challenge to religion, this reading suggests that postmodernity presents an opportunity for the reemergence of an historical and politically engaged form of religion. Such an emancipatory and non-metaphysical approach can be found throughout various religious traditions, but is especially prominent amongst black political theologians working out of the Christian tradition. / Thesis (PhD) — Boston College, 2020. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Theology.

Climate change during the Quaternary played an important role in the distribution of extant plants. Herein, cone scales of Cedrus (Pinaceae) were uncovered from the Upper Pliocene Sanying Formation, Longmen Village, Yongping County of Yunnan Province in southwestern China. Detailed comparisons show that these fossils all belong to the genus Cedrus (Pinaceae), and a new species is proposed, Cedrus angusta sp. nov. This find expands the known distribution of Cedrus during the Late Pliocene to Yunnan, where the genus no longer exists in natural forests. Based on the analysis of reconstructed Neogene climate data, we suggest that the intensification of the East Asian winter monsoon during the Quaternary may have dramatically increased seasonality and given rise to a much drier winter in Yunnan. Combined with information on Cedrus fossil records and its seed physiology, we conclude that the intensification of a drier climate after the Late Pliocene may have prevented the survival of Cedrus seedlings, leading to the eventual disappearance of Cedrus in western Yunnan. This study indicates that the topography in southwestern China acted as a vital refuge for many plants during the Quaternary, but that other species gradually disappeared due to the intensification of the monsoonal climate.

Climate change during the Quaternary played an important role in the distribution of extant plants. Herein, cone scales of Cedrus (Pinaceae) were uncovered from the Upper Pliocene Sanying Formation, Longmen Village, Yongping County of Yunnan Province in southwestern China. Detailed comparisons show that these fossils all belong to the genus Cedrus (Pinaceae), and a new species is proposed, Cedrus angusta sp. nov. This find expands the known distribution of Cedrus during the Late Pliocene to Yunnan, where the genus no longer exists in natural forests. Based on the analysis of reconstructed Neogene climate data, we suggest that the intensification of the East Asian winter monsoon during the Quaternary may have dramatically increased seasonality and given rise to a much drier winter in Yunnan. Combined with information on Cedrus fossil records and its seed physiology, we conclude that the intensification of a drier climate after the Late Pliocene may have prevented the survival of Cedrus seedlings, leading to the eventual disappearance of Cedrus in western Yunnan. This study indicates that the topography in southwestern China acted as a vital refuge for many plants during the Quaternary, but that other species gradually disappeared due to the intensification of the monsoonal climate.

Due to an increasing amount of aging tendencies in Swedish embankment dams, failures such as internal erosion has become a more common problem. Internal erosion is a phenomenon where certain soil material within the embankment dam is removed, often over a longer period of time. It is most common to occur at the inner core of the dam, and if it is allowed to continue for a longer time period the consequences can be disastrous. During the internal erosion, the inner material is washed out, creating larger voids and lowering the geotechnical stability of the dam. When larger voids start to appear, the seepage will increase allowing more material to be washed out and accelerating the process.  In order to repair an embankment dam, exposed to inner erosion, it requires both the location of the faults as well as a suitable method of repairing. A method to repair internal erosion is by using grout and injecting it into the location of the fault. The knowledge regarding what type of grout and how it should be treated is today lacking.  There are reasons to believe that a hardening mixture within an embankment dam using a till core will not cooperate well. For that reason, a grout with non-hardening properties is of interest. this thesis focuses on the Geomechanical strength parameters of two similar experimental non-hardening grouts. One with maximum grain size of 2 mm referred as grout 0/2, and one with maximum grain size of 4 mm, referred to as grout 0/4. The grouts consist of natural aggregates, calcium carbonate, water, bentonite, superplasticizer and defoamer.   The grouts are evaluated by its undrained shear strength, water content, bulk- and dry density using fall cone tests and uniaxial compressive strength tests. To evaluate the grouts angle of friction and angle of dilatancy together with young’s modulus, consolidated, drained triaxial tests were performed. Three tests with different consolidation pressures (50, 150 and 300 kPa) were performed for each grout. Since the grout will gain strength with time, the tests have been performed after certain number of days in order to see the development of the grouts. The laboratories stretch from 0 to 112 days since the time of mixing the grout, and was performed at Luleå University of technology.  Fall cone tests showed that the grout should most likely be mixed on site and left unstirred. Continuously stirring the grout quickly removed the grouts flowability which is why longer transportation should be avoided. At the same time, the accuracy of the grouts mixing is very demanding which needs to be taken into consideration.  Triaxial tests showed that the grout 0/2 had dilatant behavior for 50 and 150 kPa consolidation pressure while 300 kPa showed contractive behavior. The grout 0/4 had dilatant behavior for 50 kPa consolidation pressure while 150 and 300 kPa showed contractive behavior. A theory to explain this behavior was constructed where the bentonite is believed to be behind it. Bentonite slurries behave as a Bingham fluid, where it requires a certain amount of shear stress for the fluid to start to flow. With the same reasoning, the low consolidation pressures do not exceed that threshold, resulting in dilatant behavior. But once that threshold is surpassed the grout starts to contract. In addition, flow curve tests were performed for additives, superplasticizer and defoamer. Both these substances showed Newtonian behavior which leaves Bentonite to be the only additive with Binghamian behavior. / På grund av en ökad mängd med föråldrandetendenser hos svenska jordfyllningsdammar har brott så som inre erosion blivit ett alltmer vanligt problem. Inre erosion är ett fenomen där en viss jord inom jordfyllningsdammen är avlägsnad, generellt över en längre tidsperiod. Oftast inträffar detta vid den inre damkärnan och om erosionen är tillåten att fortskrida sig över en längre period kan konsekvenserna bli förödande. Inre erosion fungerar så att jordmaterial tvättas ut vilket skapar hålutrymmen och minskar den geotekniska hållfastheten för dammen. När större hålutrymmen bildats ökar läckaget som i sin tur tillåter mer material att bli urtvättat och processen blir accelererad. För att kunna reparera en jordfyllningsdam, utsatt för inre erosion, krävs både att platsen för brottet och metoden för att reparera är kända. En metod för att reparera inre erosion är genom att använda injektering och injektera hålutrymmet. Dock är kunskapen gällande vad för typ av injektering och hur den ska hanteras icke existerande i dagsläget. Det finns anledning att tro att ett härdande bruk inom en jordfyllningsdam, med en moränkärna, inte kommer samarbeta särskilt bra. På grund av det har ett bruk med icke-härdande egenskaper undersökt. Den här uppsatsen fokuserar på de geotekniska hållfasthetsegenskaperna för två liknande experimentella icke-härdande bruk. Ett med maximal kornstorlek på 2 mm benämnd som bruk 0/2 och ett med maximal kornstorlek på 4 mm, benämnd som bruk 0/4. Bruket består av natursand, kalciumkarbonat, vatten, bentonit, mjukgöringsmedel och skumdämpare. Bruken är utvärderade genom deras odränerade skjuvhållfasthet, vattenkvot, skrym- och torrdensiteten som har tagits fram från fallkorns-test och enaxiella trycktest (UCS).  För att utvärdera brukens friktionsvinkel och dilationsvinkel tillsammans med styvheten (initiella och 50 %) har konsoliderat, dränerat triaxiala tests utförts. Tre test med varierande konsolideringstryck (50, 150 och 300 kPa) har utförts för båda bruken. I och med att brukens hållfasthet kommer att öka med tiden, har testerna utförts efter ett visst antal dagar, för att se hur utvecklingen ser ut. Laborationerna har sträckt sig från 0 till 112 dagar sedan det att bruken har blandats, och utfördes vid Luleå Tekniska Universitet. Fallkornstesten visade att bruken bör med största sannolikhet blandas på arbetsplatsen och därefter förbli orörda. Kontinuerlig omrörning visade sig frånta brukens flytförmåga, vilket också är anledning till varför längre transporter bör undvikas. Samtidigt så är noggrannheten vid brukens blandning krävande vilket bör tas i beaktning. De triaxiala tester visade att bruk 0/2 visade ett dilatant beteende för både 50 och 150 kPa konsolideringstryck medan 300 kPa hade ett kontrakterande beteende. Bruket 0/4 hade dilatant beteende för 50 kPa konsolideringstryck medan 150 och 300 kPa visade kontrakterande beteende. En teori för att förklara detta beteende togs fram där bentoniten är den troliga orsaken. Bentonitblandningar (bentonite slurry) beter sig som en Bingham-vätska, där det krävs en viss mängd skjuvspänning för att få vätskan att börja flyta. Med samma resonemang applicerade på bruken innebar det att de låga konsolideringstrycken inte översteg tröskelvärdet, vilket resulterade i ett dilatant beteende. Däremot, när tröskelvärdet väl är överstiget börjar bruket att kontraktera istället. Det gjordes även flödestester på tillsatsmedlen, mjukgöringsmedel och skumdämpare. Testerna visade att båda medel betedde sig Newtoniskt, vilket lämnar bentoniten som det enda tillsatsmedlet med Bingham-beteende.

Indiana University-Purdue University Indianapolis (IUPUI) / Introduction: In order to successfully treat an infected root canal system (RCS), it is required to locate all root canals and have an access path to the apex of each canal. This can be challenging in teeth with pulp canal obliteration (PCO), often leading to increased chair time and increased risk of iatrogenic errors. Guided endodontic access (GEA) combines information from a cone-beam computed tomography (CBCT) scan with an intra-oral scan to create a stent. GEA stents with or without fixation pins have been shown to be successful in accurately negotiating a RCS with PCO. Objective: Compare the degree of deviation and difference in 3D offset at the base to apical tip of the drill from the designed access path when a GEA stent with and without pin fixation is used to access tooth #8 with PCO. Materials and Methods: A 3-D printed maxillary model of an anonymous patient had a GEA stent designed using coDiagnonstiX software. The stent extended from tooth #3 to tooth #14 with the guide sleeve over tooth #8. Tooth #8 with no calcification, calcification to the cervical third, and calcification to the middle third of the RCS were designed in the coDiagnostiX software. Tooth #8 will be accessed using a 1.3 mm drill that fits a 1.3 mm sleeve used for both access and pin fixation. 15 of the 30 GEA samples will utilized pin fixation, while the other 15 samples did not utilize pin fixation. Following GEA in all 30 samples a CBCT was taken of each sample. Each post-operative CBCT was aligned with the pre-operative CBCT in the coDiagnostiX software. The coDiagnostiX software was able to calculate the degree of deviation and difference in 3D offset between the base and apical tip of the drill during GEA. Paired t-tests were used to test each group for significant differences in 3D offset between base and tip. Two-way ANOVA was used to evaluate the effects of pin fixation and calcification on the degree of deviation and the deviation of 3D offset of the entry point and tip. Results: There was a significant interaction between use of pin fixation and calcification level on the degree of deviation of GEA. GEA with pin fixation had a significantly larger degree of deviation than GEA without pin fixation with calcification extending to the middle third of the RCS. GEA with and without pin fixation did not have a significant difference when calcification extended to the cervical third of the RCS or no calcification was present. There was a significant interaction between use of pin fixation and calcification level on 3D offset difference. GEA with pin fixation had a significantly larger 3D offset difference than GEA with no pin fixation for calcification in the middle third of the RCS. For GEA with and without pin fixation there was no significant difference when calcification extended to the cervical third of the RCS or no calcification was present. Conclusion: The use of pin fixation did not result in a decrease of degree of deviation or difference in 3D offset during GEA access. It can be concluded that the use of pin fixation is not necessary for GEA of teeth with PCO when a full dentition is present to provide stability and retention of the stent. / 2022-06-21

Magister Scientiae Dentium - MSc(Dent) / Previously, many studies have used cone beam computed tomography (CBCT) to detect and confirm the exact location of the MB2 canal in maxillary molars. It is now considered the gold standard, as it allows clinicians to visualize complex anatomical structures and to perform endodontic treatment safely. However, in the context of this study, the prevalence and location of the MB2 in maxillary first and second permanent molars among the Libyan population is limited. The aim of this in vivo study is to describe the prevalence and location of the MB2 in the mesiobuccal root of first and second maxillary molars and to describe a methodology to enable its geometric location in the Libyan population using CBCT imaging.