This thesis focuses on the propagation of charged particle beams in plasmas, and is divided into two main parts. In the second chapter, a novel theoretical model for underdense electron beam propagation during the nonlinear stage of the resistive Weibel instability (WI) is presented and is used to calculate the stopping time of the beam. The model and supporting simulation results lead to the conclusion that the WI initially enhances beam deceleration but then reduces it when compared to a filamentation-suppressed beam (without WI), so that the overall stopping time of the beam is essentially unaffected by the instability. Using the theoretical model, a criterion is derived that determines when deceleration is no longer enhanced by the instability. We also demonstrate that exotic plasma return current distributions can be obtained within and outside of beam filaments that sharply contrast those observed in collisionless systems. For example, the plasma return current is reversed in selected areas. In the next chapter, a new method for initiating the modulation instability (MI) of a proton beam in a proton driver plasma wakefield accelerator using a short laser pulse preceding the beam is presented. A diffracting laser pulse is used to produce a plasma wave that provides a seeding modulation of the proton bunch with the period equal to that of the plasma wave. Using the envelope description of the proton beam, this method of seeding the MI is analytically compared with the earlier suggested seeding technique that involves an abrupt truncation of the proton bunch. The full kinetic simulation of a realistic proton bunch is used to validate the analytic results. It is further used to demonstrate that a plasma density ramp placed in the early stages of the laser-seeded MI leads to its stabilization, resulting in sustained accelerating electric fields (of order several hundred MV/m) over long propagation distances (100-1000 m). The final chapter describes a harmonic expansion formalism that attempts to explain the post-linear stage of the MI. The formalism is developed first, and then several crippling problems with it are identified. / text

Structure and dynamics of nanoconfined glass-forming oligomers and diblock coplymers (BPCs) are investigated by a combination of infrared transition moment orientational analysis (IR-TMOA), positron annihilation lifetime spectroscopy (PALS), grazing incidence small angle X-ray scattering (GISAXS), atomic force microscopy (AFM), scanning electron microscopy (SEM) and broadband dielectric spectroscopy (BDS). The oligomers probed are the van der Waals type, tris(2-ethyhexyl)phosphate (TEHP) and the self-associating molecules of 2-ethyl-1-hexanol (2E1H). Symmetric and asymmetric poly(styrene-b-1,4-isoprene) P(S-b-I) are studied for the case of BCPs. The samples are confined either in one-dimensional (1D) in form of thin films or in 2D (nanopores) geometrical constraints. The molecular order of TEHP in nanopores as studied by IR-TMOA shows that about 7% of the molecules are preferentially oriented perpendicular to the long axis of the pores due to their interaction with the pore walls. PALS results reveal that 2E1H confined in nanopores exhibit larger free volume with respect to the bulk. In thin films (1D), P(S-b-I) having volume fraction of isoprene blocks f(PI)= 0.55 exhibits randomly oriented lamellae and their thicknesses are directly proportional to the film thickness d(film). For f(PI) = 0.73, perpendicular cylinders with respect to the substrate are observed for d(film)>50 nm but they lie along the substrate plane when d(film) < 50 nm. In AAO pores (2D) with average pore diameter d(pore) of 150 nm, straight nanorods are formed which change to helical structures in 18 nm pores. Molecular dynamics of 2E1H and TEHP constrained in nanopores (2D), is influenced by the interplay between confinement and surface effects. Confinement effects show up as an increase in the structural relaxation rate with decreasing pore sizes at the vicinity of the glass transition temperature. This is attributed to the reduced packing density of the molecules in pores as quantified by PALS results for 2E1H. Whereas the orientation and morphologies of the domains in P(S-b-I) and the chain dynamics of isoprene chains are influenced by the finite--size and dimensionality of confinement, the segmental motion, related to the dynamic glass transition (DGT) of both styrene and isoprene blocks remains unaffected-in its relaxation time-within experimental accuracy. Effects of nanoscale confinement on the molecular dynamics therefore depend on a number of factors: the type of molecules (polymers, low molecular liquids), interfacial interactions and the dimensionality of the constraining geometries.

Poor aqueous solubility is one of the greatest barriers for new drug candidates to enter toxicology studies, let alone clinical trials. This thesis focuses on contributing to solving this problem, evaluating the oral toxicity of mesoporous silica particles, and enhancing the apparent solubility and bioavailability of active pharmaceutical ingredients in vitro and in vivo using mesoporous silica particles. Toxicological studies in rats showed that two types of mesoporous silica particles given by oral administration were well tolerated without showing clinical signs of toxicity. Solubility enhancement, including in vivo bioavailability and in vitro intracellular activity, has been evaluated for selected drug compounds. Mesoporous silica was shown to effectively increase drug solubility by stabilizing the amorphous state of APIs, such as itraconazole (anti-fungal), dasatinib (anti-cancer), atazanavir (anti-HIV) and PA-824 (anti-tuberculosis). Itraconazole was successfully loaded into a variety of porous silica materials showing a distinct improvement in the dissolution properties in comparison to non-porous silica materials (and the free drug). Microporosity in SBA-15 particles has advantages in stabilizing the supersaturation state of dasatinib. Small pore sizes show better confinement of atazanavir, contributing to a higher dissolution of the drug compound. In the in vivo animal studies, NFM-1 loaded with atazanavir shows a four-fold increase in bioavailability compared to free crystalline atazanavir. PA-824 has a higher dissolution rate and solubility after loading into AMS-6 mesoporous particles. The loaded particles show similar antibacterial activity as the free PA-824. This thesis aims at highlighting some of the important factors enabling the selection of adequate mesoporous structures to enhance the pharmacokinetic profile of poorly water-soluble compounds, and preparing the scientific framework for uncovering the effects of drug confinement within mesopores of varying structural properties. / <p>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Submitted. Paper 3: Submitted. Paper 5: Submitted.</p>

Darbo tikslas: Išsiaiškinti pirmą kartą ir pakartotinai atliekančių bausmę nuteistųjų adaptacijos ypatumų ir asmenybės bruožų sąsajas. Tiriamieji: tyrimas buvo atliekamas nuo šių metų sausio mėnesio 8 dienos iki rugsėjo mėnesio 1 dienos ir vyko dviem etapais. Tyrime dalyvavo 316 bausmę atliekančių nuteistųjų (vyrų). Pirmajame etape tyrimo anketos buvo išdalintos pakartotinai bausmę atliekantiems nuteistiesiems, kuriems buvo pasibaigęs 3 mėnesių adaptacijos laikotarpis. Šią grupę sudarė 134 asmenys. Antrame etape tiriamųjų grupę sudarė 182 pirmą kartą atliekantys bausmę nuteistieji, kuriems buvo pasibaigęs adaptacijos programos taikymas. Tiriami asmenys buvo atrinkti pagal tai, ar jų adaptacijos laikotarpis jau buvo pasibaigęs. Tyrimui buvo naudotos Adaptacijos klausimynas, Eyesenck H. Ir S. klausimynas (asmenybės bruožų klausimynas), BDI (Beck Depression Inventary) metodikos. Išvados: tyrimo metu įvertinta, kokios įtakos nuteistųjų adaptacijai pataisos namuose gali turėti tokie veiksniai kaip išsilavinimas, darbas/ mokymasis, priklausomybės, nuteistųjų subkultūros tradicijų laikymasis, fizinė bei psichologinė sveikata, žalojimasis, santykiai su kitais nuteistaisiais, laisvalaikio prasmingumas, drausminės nuobaudos, bei kaip nuteistųjų adaptacija pataisos namuose susijusi su asmenybės bruožais. Nustatyta, jog pirmą kartą atliekantys bausmės nuteistieji adaptuojasi geriau nei pakartotinai atliekantys bausmę nuteistieji. Gauti rezultatai rodo, kad nuteistųjų amžius neturėjo... [toliau žr. visą tekstą] / The aim of the research: To investigate first time and repeatedly serving time convicts adaptation peculiarities and personal traits connection. The object of the research: research was performed from 8th of January till 1st of October of this year and took place in two stages. In this research participated 316 (three hundred and sixteen) convicts, who serve the punishment (males). In first stage of research forms were given out to convicts, who served punishment repeatedly, and whose three month adaptation period was expired. This group was formed out of 134 (one hundred and thirty- four) individuals. In second stage of research group was formed out of 182 (one hundred and eighty-two) convicts who serve punishment for the first time, and whose adaptation program application were expired. Individuals were selected based on their expired adaptation period. In this research was used Adaptation questioner, Eyesenck H. ir S. questioner (personal traits questioner), BDI (Beck Depression Inventory) methodic. Conclusions: at the time of research was evaluated, which influence to convicts adaptation in penitentiary can effect factors like education, job/ study, dependency, convicts subculture tradition observance, physical and mental health, relations with other convicts, free time meaning, discipline penalty, and how convicts adaptation in penitentiary were connected with personal traits. Established, that convicts serving time for the first time adapting better than convicts... [to full text]

Ce mémoire en recherche-création explore l’enfermement volontaire et les différents types de tensions qu’il provoque. Court roman prenant la forme du journal intime, La Parenthèse met en scène un jeune homme qui décide de s’enfermer chez lui une semaine durant et s’interdit tout contact avec l’extérieur – autant pour prendre un congé temporaire de la vie qu’il mène que pour examiner les raisons de sa détresse quotidienne. Le monologue intérieur se transforme rapidement en dialogue, dès lors qu’un double vindicatif, interrompant la voix principale par des « répliques » entre parenthèses, fait son apparition. Une relation houleuse – sous tension – se tisse entre ces deux facettes du personnage tout au long des sept jours de la réclusion, les passages de dispute alternant avec des récits de souvenirs. En somme, le roman tente de dramatiser la question de l’emprisonnement de soi-même et de la limitation de l’écriture, cette limitation pouvant être à la fois malsaine et libératrice. Quant à l’essai, Tensions et enfermement dans les Cent Vingt Journées de Sodome du marquis de Sade, il part du thème de l’enfermement (en l’occurrence, celui des quatre amis qui exécutent le projet de passer quatre mois dans un château isolé) pour postuler une « architecture du désir » dans Les Cent Vingt Journées de Sodome. L’essai mobilise les ressources de la narratologie en prenant en compte les effets du texte sur le lecteur ; sont ainsi mises en évidence les tensions – sexuelle pour les protagonistes, narrative pour le lecteur – élaborées par cette écriture de l’enfermement et de la contrainte, dans laquelle le désir est toujours maintenu mais rarement satisfait. / This M.A. thesis combining research and creative writing globally focuses on self-confinement and the various tensions that it creates. La Parenthèse, a novel in the form of a diary, depicts a young man who decides to confine himself in his apartment for a week without any contact with the outside world, taking a break of his life in order to question himself about his daily angst. The inner monologue changes quickly into a dialogue, as soon as a vindictive alter ego begins to interrupt the main voice with “repartees” in parenthesis. A stormy – tense – relationship builds itself between these two sides of the character throughout the seven days he stays locked indoors, passages of arguments alternating with recollections of memories. In short, the novel proposes a reflection about self-confinement and constrained writing, which is both unwholesome and liberatory. As for the essay, Tensions et enfermement dans Les Cent Vingt Journées de Sodome du marquis de Sade, it takes us from self-confinement (namely, the four friends deciding to confine themselves for four months in a distant castle) to an “architecture of desire” in Les Cent Vingt Journées de Sodome. The essay is based on narratology without neglecting the effects the text has on its reader to bring out the tensions – sexual ones regarding the protagonists, narrative ones regarding the reader – elaborated by Sade’s confinement writing, which unfolds a desire much celebrated but seldom fulfilled.

The backdrop for this research paper is the tunnelling that is currently nearing completion in the Epirus region of Northern Greece, as part of the Egnatia Odos Highway construction. Highly deformed and altered sediments and low grade rock masses dominate the near surface environment creating a variety of technical challenges for tunnelling. Accurate equivalent rock mass performance reductions for tunnels in these materials is complicated by geomorphologic peculiarities such as those found in Flysch materials. The mechanisms of rock-support interaction related to face or near-face reinforcement systems are poorly understood at this time. As well, the mechanics of weak rock materials in the complex deformation regime in advance of a tunnel face are not robustly integrated into current 2D design models. Design decisions are currently possible using empirical techniques and simplified models, but a true optimized and mechanicsbased design process for the various support technologies are not fully developed. This research addresses elements of such issues, such as: use of the Longitudinal Displacement Profile (LDP) of the Convergence-Confinement method of tunnel design, relating 2D numerical models to their distance from the face using the size of the plastic zone as an indicator, near face tunnel support analysis in weak rock masses, boundary condition assessment for numerical modelling of such weak rock masses, the influence of plasticity zones surrounding tunnel excavations, and modelling optimization techniques for weak rock tunnelling in order to optimize the design of such underground structures and better predict near-face deformation and yield development. This work involved the use of 2D and 3D numerical models of tunnel sequencing for numerical simulation of composite material behaviour and sequential tunnel deformation response. / Thesis (Ph.D, Geological Sciences & Geological Engineering) -- Queen's University, 2009-09-01 08:46:30.537

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In this thesis a model for saturated tearing mode islands is developed. The equations for the mode amplitudes are essentially those of R B White et al,after a pertubation expansion has been made. It is well known that these equations are not then analytic at the mode rational surface. In our model this problem is overcome when a suitable choice of the axisymmetric current density perturbation is added to the unperturbed equilibrium current density profile. The modelled axisymmetric current density perturbation flattens the unperturbed profile locally at the rational surface and is sufficient to induce an island. No modelling in the interior of the island is necessary. The axisymmetric perturbation has a free variable which adjusts the amount of local flattening. However, when the boundary conditions are taken into account, this free parameter is determined, and the problem becomes an eigenvalue problem. The boundary condition thus determines the amount of local flattening at the rational surface. The saturated island widths are determined using D.' (W) criterion. The model allows for non axsymmetric plasma surface in a simple way, requiring careful choice of D (W). The different criteria are compared to establish the validity of the use of such criteria for perturbed boundaries. In the cylindrical approximation, one or two modes may be included in the model. In the case of two modes, non-linear coupling via the current density profile is introduced. Toroidal coupling between modes can also be simply introduced. Two modes that are toroidally coupled are considered, but mode-mode coupling is ignored. The emphasis falls in large part on the boundary conditions. Various boundary conditions can be considered because distortion of the plasma surface can be fixed by wall effects, plasma rotation, external DC coil currents, plasma rotation with external coil currents, etc. Of particular interest is the case of toroidally coupled modes, coupled in turn to these external conditions as this is the first study of such a nature. Results flowing from the study include among others that: for the special case of circular boundaries the model agrees reasonably with the results of R B White et al. No significant difference was found between the D. I (W) criterion of P H Rutherford, which is valid for circular boundaries, and that of A H Reiman, which is also valid for perturbed boundaries, when the boundary is perturbed significantly. Toroidally coupled islands do not increase in size if the boundary condition of that particular mode is not changed. If a coil current of particular helicity is switched on, it will only affect the mode of that particular helicity. Toroidally induced sideband islands have approximately the same width as natural tearing islands when the size of the natural island is large. / Thesis (Ph.D.)-University of Natal, Durban, 1992.

The reversed-field pinch (RFP) is a device for magnetic confinement of fusion plasmas. The main objective of fusion plasma research is to realise cost-effective thermonuclear fusion power plants. The RFP is highly unstable as can be explained by the theory of magnetohydrodynamics (MHD). Feed-back control technology appears to enable a robustly stable RFP operation.  Experimental control and identification of nonaxisymmetric multimode MHD is pursued in this thesis. It is shown that nonparametric multivariate identification methods can be utilised to estimate MHD spectral characteristics from plant-friendly closed-loop operational input-output data. It is also shown that accurate tracking of the radial magnetic field boundary condition is experimentally possible in the RFP. These results appear generically useful as tools in both control and physics research in magnetic confinement fusion. / <p>QC 20120508</p>

La réaction sulfatique interne (RSI) dans les ouvrages en béton est une pathologie susceptible de se développer lorsque des conditions particulières portant sur la composition du béton, les conditions thermiques au jeune âge et l'environnement sont réunies. Ce phénomène est attribué à la formation d'ettringite différée qui provoque un gonflement du matériau et une fissuration dans la structure. Deux types de béton sont concernés par cette pathologie : les bétons préfabriqués traités thermiquement et les bétons coulés en place dans les pièces massives. Bien que largement étudiée depuis une dizaine d'années, la RSI n'est pas à ce jour parfaitement connue du fait de la complexité du phénomène au niveau des mécanismes mis en jeu, des paramètres influents et de ses conséquences tant à l'échelle microscopique qu'à l'échelle de l'ouvrage. Ce travail vise donc à apporter des éléments de réponse à plusieurs interrogations concernant cette pathologie, en se focalisant sur l'étude de l'impact de certains facteurs intervenant lors de la réaction et sur l'application nucléaire. De nombreuses études expérimentales ont été ainsi mises en œuvre. Une large étude est consacrée à évaluer le risque de développement de la RSI dans une enceinte de confinement d'une centrale nucléaire, du fait de la présence de structures massives dans ce type d'ouvrages. Ces travaux ont permis de mettre en évidence dans quelle mesure la pathologie influe sur les caractéristiques mécaniques et sur les propriétés de transfert du béton, et ainsi de vérifier si les exigences de sûreté attendues par ces structures sont mises en cause. Ensuite, nous nous sommes intéressés à étudier l'impact de l'hygrométrie du béton sur le développement de la RSI. Nous avons pu identifier le couplage qui existe entre l'humidité environnante et le gonflement. Le rôle joué par la lixiviation des alcalins a été également mis en évidence. Des suivis des propriétés de transfert ont été menés et confrontés aux gonflements observés. Enfin, nous nous sommes intéressés à caractériser le rôle joué par le squelette granulaire sur la cinétique et l'amplitude du gonflement par RSI. Les paramètres étudiés concernent la taille et la fraction volumique des inclusions granulaires. De plus, un exemple d'application d'une modélisation numérique mésoscopique du gonflement est proposé