Os casos de reimplante tardio são considerados de prognóstico duvidoso pois a ocorrência de anquilose e reabsorções são fatos comuns para esta condição. Neste sentido, é proposta a utilização de drogas para imersão do dente antes do reimplante visando um favorecimento no prognóstico. Recentemente, o alendronato de sódio tem sido experimentalmente indicado com esta finalidade; porém, a capacidade de adsorção deste medicamento pelo dente é desconhecida. Neste estudo foi avaliada a adsorção de alendronato de sódio pelo dente utilizando-se a Cromatografia Líquida de Alta Eficiência. Para isto, realizou-se a imersão do dente em frascos contendo soluções deste medicamento nas concentrações de 3,2 Zg/ml (10-5M) e 32,0 Zg/ml (10-4M). Após períodos experimentais de 10, 15 e 30 minutos foram retiradas amostras das soluções para análise da concentração que foi comparada com a do controle que continha apenas a solução, sem presença do dente. Os resultados obtidos mostram que o dente adsorve alendronato de sódio quando imerso em solução e que para a concentração de 3,2 Zg/ml são necessários 15 minutos para que a saturação ocorra, já para a concentração de 32,0 Zg/ml uma elevada média de adsorção foi observada após 10 minutos de imersão. / Delayed tooth replantation is considered a poor prognosis because of ankylosis and root resorption occurrence. The use of drugs for topical treatment before replantation is recommended expecting better prognosis. Recently, the sodium alendronate has been experimentally indicated for this purpose; but tooth adsorption capability of this drug is unknown. The aim of this study was to evaluate the tooth adsorption of sodium alendronate utilizing the High Performance Liquid Chromatography. Six maxillary central incisors were immersed in solutions of alendronate in concentrations of 10-5 and 10-4M; after experimental times of 10, 15 e 30 minutes samples of solutions were obtained for concentration analysis. The concentrations obtained were compared with control concentrations (solutions without tooth immersion). The results showed the occurrence of adsorption when teeth were immersed in sodium alendronate solutions. At the concentration of 10-5M it is necessary to keep the tooth immersed for at least 15 minutes, while at the concentration of 10-4M after 10 minutes a high adsorption value is observed.

Os efeitos das cirurgias primárias sobre os arcos dentários vêm sendo objeto de estudo ao longo do tempo. O presente estudo se propõe a avaliar a relação oclusal dos arcos dentários de pacientes com fissura transforame incisivo unilateral submetidos à cirurgia de lábio e palato mole no primeiro tempo e palato duro no segundo tempo por meio de modelos de estudo documentados em pacientes portadores de fissura transforame incisivo unilateral em uma fase mais tardia. Para a avaliação das arcadas utilizou-se o índice oclusal de Goslon (Mars et al 1987) em uma amostra de 42 modelos de gesso de pacientes com idade entre 15 e 19 anos que reparam o palato mole aos 6 meses e o palato duro aos 40 meses. O objetivo dos índices consiste em facilitar o prognóstico e a aplicação de protocolos terapêuticos no tratamento dos pacientes com fissuras de lábio e palato. Em relação aos resultados, a distribuição do Índice oclusal de Goslon foi 42,86% dos pacientes no grupo 1 (G1), 19,05% no grupo 2 (G2), 16,67% no grupo 3 (G3), 7,14% no grupo 4 (G4) e 14,29% no grupo (G5). Para os escores agrupados do índice de Goslon, 61,90 % dos pacientes foram classificados nos grupos 1 e 2 (G1+G2) demonstrando uma relação interarcos satisfatória e 21,43% foram categorizados nos grupos 4 e 5 (G4+G5), considerando uma pobre relação interarcos. / The purpose of this work was to evaluate the outcomes of the application of delayed hard palate closure treatment protocol on the dental arch on a sample of Brazilian patients aging 15 to 19 years old. The sample comprised 42 patients with UCLP, on the permanent dentition, aging 15 to 19 years old, treated with the referred protocol. The mean age of closure was 6 (±3.15) and 40 (±36.07) months for soft and hard palate respectively. Dental casts were obtained and analyzed by a single calibrated (kappa > .71) examiner. Dental arch relationships were accessed on the by applying the Goslon Yardstick, which has been proved to be a useful method for longitudinal assessment of dental arch relationship. The frequencies of each Goslon Yardstick score were described in order to evaluate long-term treatment results on these patients. The distribution of the cases into their assigned Goslon Yardstick scores showed 18 (42.86%) cases on group 1, 8 (19.05%) cases on group 2, 7 (16.67%) cases on group 3, 3 (7.14%) cases on group 4 and 6 (14.29%) cases on group 5. In evaluating the results described, it was possible to conclude that long-term results of delayed hard palate closure treatment protocol for UCLP regarding dental arch relationships were satisfactory on the studied sample: 61.9% of the patients showed excellent or good arch relationship (G1+G2) while 21.43% were classified as having poor or very poor arch relationship (G4+G5).

A Doença de Chagas é uma infecção parasitária causada pelo Trypanosoma cruzi1, transmitida aos humanos principalmente pelas fezes contaminadas de insetos triatomídio. Esta patologia permanece endêmica na América Latina com grande impacto socioeconômico. O envolvimento cardíaco é a principal causa de morte, sendo que a fisiopatologia e a evolução clínica da doença não são completamente compreendidas e a estratificação de risco permanece desafiadora. A presença de disfunção miocárdica associada ou não à doença arterial aterosclerótica vem acompanhada de áreas de fibrose miocárdica e tem se mostrado como importante fator de pior prognóstico. Ressonância Magnética (RM) é um método já consagrado na detecção de fibrose miocárdica pela técnica de realce tardio (RT). Os objetivos deste trabalho foram: identificar e quantificar a área de realce tardio em pacientes com Cardiopatia Chagásica e disfunção contrátil do ventrículo esquerdo por meio da Tomografia Coronária; associar a extensão do RT pela tomografia com a FE do ventrículo esquerdo, medida pela ecocardiografia; determinar se há ou não associação da presença e extensão do realce tardio com a presença de coronariopatia significativa; determinar a presença de aterosclerose coronária neste subgrupo de pacientes chagásicos por meio do escore de cálcio; e identificar a presença de coronariopatia obstrutiva nesta população. Foram selecionados 36 pacientes com o diagnóstico confirmado de Doença de Chagas e disfunção ventricular (FE< 50%) confirmada pela ecocardiografia que respeitaram os critérios de inclusão e exclusão, e que assinaram o termo de consentimento livre e esclarecido. Todos os pacientes foram submetidos a angiotomografia coronária com a técnica de realce tardio e escore de cálcio. Todos os pacientes completaram o protocolo sem efeitos adversos com dose de radiação média de 11,17 +- 1,26 mSv e com exames interpretáveis. Observadores cegos e independentes, sem conhecimento prévio dos dados clínicos ou dos exames, realizaram análise visual e quantitativa do grau de estenose coronária, do escore de cálcio e do realce tardio. A média da idade foi de 57,5+- 8, dos quais 61,1% eram mulheres. A média da FE foi de 38,19 +- 6,91. Foram encontradas 2 lesões significativas (>50%) em 2 pacientes. A média do escore de cálcio foi de 19,06 +- 40,72. A fibrose miocárdica foi observada em 86,1% dos 36 pacientes e sua quantificação foi realizada de acordo com o esquema de segmentação miocárdica segundo a orientação da American Hear Association. A partir dos nossos achados, concluímos que, por meio da Tomografia coronária, é possível identificar áreas de fibrose miocárdica em pacientes chagásicos, que a quantidade de fibrose é inversamente proporcional à fração de ejeção ventricular esquerda (r= 0,52 p = 0,0011) e que a fibrose segue um padrão de localização específico da doença. Nossos achados permitem também inferir que a fibrose miocárdica nesse grupo de pacientes não se correlaciona à presença de obstruções coronárias, sendo o padrão de realce tardio diferente daquele observado em portadores de doença arterial coronária. Não houve correlação entre o escore de cálcio e áreas de fibrose vistas pela técnica de realce tardio (r= 0,04 p= 0,80). Desta forma, a tomografia pode ser uma alternativa à RM para a pesquisa de fibrose em pacientes chagásicos, aspecto que pode ser particularmente relevante naqueles que apresentam contraindicação formal à realização deste exame. / Chagas disease is a parasitic infection caused by Trypanosoma cruzi1. It is transmitted to humans mainly by the infected feces of triatomine insects. This pathological condition remains endemic in Latin America, posing a major socioeconomic impact on the region. Cardiac involvement is the principal cause of death of patients, given that the physiopathological mechanism and clinical evolution of the disease are not fully understood and risk stratification remains a challenge. Whether associated with arteriosclerotic vascular disease or not, the presence of myocardial dysfunction is accompanied by areas of myocardial fibrosis and has emerged as an important factor associated with poor prognosis. Magnetic resonance (MR) imaging is a well-established method of detecting myocardial fibrosis by the delayed enhancement (DE) technique. Objectives: The objectives of this thesis are to identify and quantify DE areas on left ventricular contractile dysfunction patients with chagasic cardiopathy using coronary tomography, to associate tomography DE extension with left ventricular ejection fraction (EF) measured by echocardiography, to determine whether the presence and extension of DE are associated with the presence of significant coronaropathy, and to identify the presence of obstructive coronaropathy in chagasic patients. Background: Methods: Thirty six patients with confirmed Chagas disease and ventricular dysfunction diagnosis (EF < 50%), as verified by echocardiography. All the patients underwent coronary computed tomographic (CT) angiography using DE technic. All the patients successfully completed the protocol with a mean radiation dose of 11.17 1.26 mSv, without adverse effects and undergoing measurable tests. Independent observers blinded to the clinical data or examinations of the patients performed visual and quantitative analyses of the degree of coronary stenosis, and DE. Results: The mean age was 57.5 8 years, and 61.1% of them were female. The mean EF was 38.19 6.91%. Two significant lesions (>50%) were identified in two patients. Myocardial fibrosis was observed in 86.1% of the 36 patients, and its quantification was assessed in accordance with the myocardial segmentation scheme and the American Heart Association guidelines The amount of fibrosis is inversely proportional to left ventricular EF (r = 0.52, p = 0.0011), and that the myocardial fibrosis in these patients follows the specific localization pattern of Chagas disease. Our findings reveal that myocardial fibrosis in this patient sub group was not related to coronary obstruction and that the DE pattern is different from the one found in patients who presented ischemic events. Computed tomography DE is also inversely related to left ventricle ejection fraction, another important prognosis marker. Therefore, computed tomography can provide an adequate alternative to MR in the assessment of myocardial fibrosis particularly in patients presenting formal contraindications to MR.

As características biológicas e comportamentais relacionadas aos doentes de tuberculose (TB) são importantes aspectos a serem considerados quando se almeja a precocidade da detecção dos casos, uma vez que determinam a procura e utilização dos serviços de saúde. Este estudo teve como objetivo descrever os aspectos relacionados aos doentes de TB que interferem no tempo de procura por um serviço de saúde após a percepção do início dos sintomas da doença na cidade de São José do Rio Preto - SP. Trata-se de um estudo epidemiológico descritivo e exploratório, do tipo inquérito. Participaram do estudo 100 doentes de TB entrevistados por meio de um instrumento que contemplou questões sócio-demográficas, clínicas, econômicas e comportamentais dos doentes. A partir da questão relacionada ao tempo para proceder a procura por um serviço de saúde realizou-se o cálculo da mediana e, por meio do valor obtido, definiu-se o ponto de corte a partir do qual se considerou atraso na procura por atendimento. O tempo mediano decorrido entre a percepção do início dos sintomas da TB e a primeira procura por um serviço de saúde foi de 15 dias, sendo a Unidade de Pronto Atendimento (UPA) o principal serviço de saúde procurado. Houve predominância de doentes do sexo masculino. Encontrou-se atraso (>15 dias) entre homens e indivíduos com idade entre 50 a 59 anos que procuraram pelas UPA e entre mulheres e indivíduos cuja faixa etária estava entre 18 a 29 e maiores de 60 anos que optaram pelas Unidades de Atenção Básica (UAB). No que se refere ao estado civil, somente tiveram atraso doentes que se declararam divorciados/separados. Doentes sem escolaridade ou com EF incompleto, sem remuneração e que possuíam a forma pulmonar da TB atrasaram ao buscar UPA. Doentes com forma extrapulmonar da TB e em recidiva/retratamento atrasaram quando a busca por atendimento ocorreu nas UAB. Co-infectados foram mais rápidos ao buscar por atendimento nos serviços especializados. Demoraram para buscar pelo primeiro atendimento aqueles que relataram os sintomas ao início da doença como sendo de fracos a moderados. Houve atraso entre doentes que não fumavam e procuraram por UAB e UPA. Houve demora superior a 15 dias somente quando a procura por assistência entre os doentes consumidores de bebidas alcoólicas ocorreu nas UAB. Tiveram retardo doentes com conhecimento precário que procuraram as UAB e aqueles com conhecimento satisfatório que optaram pelas UPA. A maioria dos doentes deste estudo tinham o hábito de procurar pelos serviços mais próximos do domicílio antes do diagnóstico da TB e não atrasaram ao buscar por atendimento em UAB e serviços especializados. Levanta-se a necessidade de maior atenção por parte da equipe dos serviços de saúde quanto às caracteristicas do perfil dos usuários que tiveram atraso na busca por atendimento. O reconhecimento dessas características e do padrão de utilização dos serviços de saúde é primordial para o planejamento em saúde e definição de estratégias que favoreçam a busca por atendimento entre os usuários em menor tempo, de modo a possibilitar o diagnóstico precoce da TB pelos serviços de saúde. / The biological and behavioral characteristics related to patients with tuberculosis (TB) are important aspects to be considered when the early detection of cases of the disease is aimed, since they seem to play an important role in demand and utilization of health services patterns. This study aimed to describe the aspects related to TB patients that affect time to search for a health facility after the perception of the onset of disease symptoms in Sao Jose do Rio Preto - SP. An epidemiological study, descriptive and exploratory type of investigation were conducted including 100 TB patients, who were interviewed by an instrument that included socio-demographic, clinical, economic and behavioral characteristics. From the issue related to time to search for a health service the median was calculated, and half the value obtained, we defined the cutoff point from which delay in seeking treatment was considered. The median time between the perception of TB symptoms\' onset and the first demand for a health service was 15 days, being the Emergency Unit (EU) the main health service sought. There was a predominance of male patients. A delay was found (> 15 days) among men and those with age from 50 to 59 years who sought first a EU and among women and those with age between 18 to 29, as well as seniors over 60, who opted for searching first a Primary Care Unit (PHU). Regarding to marital status, in general, only patients who declared themselves as divorced/separated had shown delay. Patients without education or with incomplete level of formation, without remuneration and who presented the TB pulmonary form seek the EU with delay. Patients with extrapulmonary TB and relapse/retreatment delayed when searching for treatment occurred in the PHU. Co-infection patients seek faster care at specialized services. Those who reported the symptoms of the disease as being low to moderate showed longer time to search. Patients who didn´t smoke and looked for PHU and EU also present delayed. Among patients who consumed alcohol, delay was greater than 15 days when demand for care occurred at UAB. Those who present poor knowledge and sought PHU and those with satisfactory knowledge that opted for the EU also showed longer delays. Most patients in this study were used to seek services closer to their homes before the diagnosis of TB and did not delay in seeking care at PHU and specialized services. Need for greater focus by the team of health services regarding the characteristics of the profile of users who have had to seek delays for care is raised. Recognition of patient\'s characteristics and health services\' utilization patterns, in their different ways of organizing and delivering assistance is central to health planning and developing strategies to promote the search for treatment among users in less time, in order to enable early diagnosis of TB at health services.

Hjärtinfarkt är en av de vanligaste dödsorsakerna i Sverige idag och kvinnor har en högre mortalitet vid hjärtinfarkt. Kvinnor dröjer med att söka vård vid symtom på hjärtinfarkt, det finns ett flertal orsaker som fördröjer tiden från första symtom till kontakt med sjukvården. Orsakerna till den ökade fördröjningstiden för kvinnor kommer att belysas i denna litteraturbaserade studie.  Resultatet redovisas i två teman på orsaker om varför kvinnor dröjer med att söka vård vid symtom på hjärtinfarkt. Kvinnor ville inte vara till besvär för sina anhöriga eller arbetsgivare. De ville heller inte vara till besvär för hälso- och sjukvårdpersonal då de inte ville belasta sjukvården i onödan och de upplevde även en rädsla att inte bli tagna på allvar utav hälso- och sjukvårdpersonal. Kvinnorna hade också vilseledande föreställningar om hjärtinfarkt. Föreställningarna kommer från massmedia samt erfarenheter från män i sin omgivning som drabbats av hjärtinfarkt. Kvinnorna hade även svårigheter att härleda symtomen till hjärtinfarkt och de försökte hitta andra förklaringar till sina symtom eller förminskade dessa. På grund av dessa svårigheter försökte kvinnorna hantera symtomen själv genom självmedicinering.   Sjuksköterskan behöver en ökad kompetens om kvinnor och hjärtinfarkt, då hon har en viktig funktion att utbilda kvinnor om hjärtinfarkt och symtombild. Detta är för att kvinnan ska kunna ta ett snabbt beslut att söka vård för att därmed förbättra prognosen vid hjärtinfarkt. / Background: Time is crucial for the forecast of myocardial infarction. It’s crucial for the prognosis and can decrease complications. Complications can include both physical and psychological ailments and can affect women’s daily life. Aim: The aim of this study was to illustrate why women delay seeking care for symptoms of myocardial infarction.  Method: A literature-based study. Results: The reasons that women delayed seeking care of their symptoms were fear of being an inconvenience for either their relatives and/or health care professionals. They had also a misleading conception about myocardial infarction and had difficulties to connect their symptoms to myocardial infarction. Therefore the women try to attempt to perform self-care rather than consult medical professionals. They also prioritized obligations against employer and related.  Conclusion: Women want to be self-sufficient enough to take care of themselves and not be a burden to their family or medical professionals. They had difficulties prioritizing themselves and the women has to start put herself first. Through increased knowledge about symptoms for myocardial infarction the result may be that women can take better and more informed decisions on when it is imperative to seek immediate medical care. This may in turn result in better prognosis for the affected women.

Kyoto University (京都大学) / 0048 / 新制・課程博士 / 博士(工学) / 甲第17234号 / 工博第3661号 / 新制||工||1556(附属図書館) / 29980 / 京都大学大学院工学研究科原子核工学専攻 / (主査)教授 中島 健, 教授 福山 淳, 准教授 山本 俊弘 / 学位規則第4条第1項該当

Responses of six severely language delayed (SLD) children were obtained on three measures of central auditory processing and one measure of language proficiency. The results of these measures were compared to the results obtained from six normal-hearing children, matched in age and Performance IQ on the WISC-R. The 12 children were tested with the Pitch Pattern Sequence Test (PPST), the Dichotic Digit Tests (DDT), and the Pediatric Speech Intelligibility Test (PSI). Differences in the central auditory abilities as well as the history of each child were presented in .a case study format. The results of the history information demonstrated no unusual problems among these 12 subjects. Ten out of 12 subjects demonstrated abnormal results on at least one measure of the central auditory battery.

Les cellules NK sont classiquement décrites comme des lymphocytes effecteurs du système immunitaire inné, dotées d’un jeu limité de récepteurs permettant la reconnaissance de cellules tumorales ou infectées par des pathogènes, et dépourvues de capacités de mémoire immunitaire. Des travaux récents montrent cependant que les cellules NK semblent douées de diverses propriétés « adaptatives » proches de celles des lymphocytes T (LT). L’étude princeps de ce nouvel aspect de la biologie des cellules NK a été réalisée dans un modèle murin d’hypersensibilité retardée (HSR) aux haptènes, et démontre qu’en l’absence des effecteurs classiques de ces réactions (LT), les cellules NK sont capablesd’induire des réactions d’HSR. La première partie de ce travail de thèse a consisté à étudier la contribution des cellules NK dans l’initiation et le développement des réactions d’HSR en présence des effecteurs classiques (LT). Nous montrons ainsi que bien que des cellules NK « mémoires » spécifiques de l’haptène soient retrouvées dans le foie des souris de type sauvage sensibilisées, leur contribution à la réaction d’HSR est mineure. Par contre, si ces cellules NK mémoires sont transférées à une souris receveuse dépourvues de LT nonsensibilisée, elles sont capables d’induire des réactions d’HSR lors d’un nouveau contact avec l’haptène. Dans la deuxième partie, nous avons comparé les réactions d’HSR induites par les cellules NK et les lymphocytes T mémoires dans ce système de transfert. Nous mettons en évidence que les réactions développées par les cellules NK sont d’une durée limitée et qu’elles impliquent un oedème avec peud’infiltration par les cellules immunitaires, au contraire des réactions induites par les cellules T mémoires. Enfin, dans la troisième partie de ce travail, nous avons analysé le compartiment cellulaire NK circulant chez des patients souffrant de pathologies inflammatoires cutanées dans lesquelles les LT ont un rôle clairement identifié à ce jour. Nous rapportons des modifications qualitatives et quantitatives de ces cellules, suggérant leur implication potentielle dans la physiopathologie de ces maladies. L’ensemble de ces données confirme donc l’existence de cellules NK « mémoires », dont le rôle physiologique en présence des effecteurs adaptatifs classiques reste encore aujourd’hui à démontrer. / NK cells are classically defined as lymphocytes of the innate immune system, equipped with a limited set of receptors involved in the recognition of tumoral or infected cells, and devoid of immune memory. However, recent studies showed that NK cells seem endowed with various "adaptive" properties similar to those of T lymphocytes (TL). The original description of this new aspect of NK cell biology was made in a murine model of delayed-type hypersensitivity (DTH) to haptens. In this model, NK cells were found to be able to induce DTH reactions in the absence of classical DTH effectors (TL). The aim of the first part of this PhD thesis was to study the contribution of NK cells in the initiation and development of HSR reactions in the presence of classical effectors (TL). We show that although hapten-specific "memory" NK cells are generated in the liver of hapten-sensitized wild type mice, their contribution to HSR reactions is minor. By contrast, if "memory" NK cells are transferred to unsensitized recipient mice lacking T cells, they can induce DTH reactions upon a new contact with the hapten. In the second part, we compared the DTH reactions induced by NK cells and memory T lymphocytes in thistransfer system. We showed that hapten-induced skin reactions mediated by NK cells are of limited duration and associated with a weak cellular infiltrate, in contrast to memory T cell-mediated reactions. Finally, in the third part of this work, we analyzed the circulating NK cell compartment in patients suffering from inflammatory skin diseases thought to be induced by T cells. We report qualitative and quantitative changes of NK cells in patients in comparison with healthy controls, suggesting the potential involvement of NK cells in the pathophysiology of these diseases. Altogether, our data confirm the existence of "memory" NK cells, whose physiological role in the presence of conventional adaptive effectors still remains to be assessed.

This study aimed to test the effectiveness of classroom translations of some laboratory procedures for teaching simple auditory discriminations to learners with developmental disabilities. Three participants with autism and mental retardation were trained to make topographically distinct responses in the presence of two different stimuli, either a pure tone and silence, or two tones. A portable electronic piano keyboard was used to produce tones. Delayed prompt and differential reinforcement procedures were used to teach the responses. None of the participants performed the discriminations accurately without prompting despite numerous revisions to the procedures.

Submitted by Haroudo Xavier Filho (haroudo.xavierfo@ufpe.br) on 2016-04-14T18:22:12Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação -Marciana S_ F_ Cordeiro _1_.certa.pdf: 3647564 bytes, checksum: f459470e06543d55f9f637a82005d075 (MD5) / Made available in DSpace on 2016-04-14T18:22:12Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação -Marciana S_ F_ Cordeiro _1_.certa.pdf: 3647564 bytes, checksum: f459470e06543d55f9f637a82005d075 (MD5) Previous issue date: 2015-02-25 / CNPq / O cloridrato de pilocarpina vem sendo utilizado no tratamento da xerostomia, entretanto sua atuação sistêmica promove reações adversas indesejáveis. Contudo, os atuais sistemas de liberação prolongada de fármacos, podem controlar variações de concentração plasmática e reduzir estes efeitos colaterais. Adicionalmente, a obtenção de comprimidos mucoadesivos associado a este sistema de liberação favorece a ação prolongada do fármaco na cavidade oral, trazendo benefícios importantes para o tratamento. Assim, este trabalho tem como objetivo o desenvolvimento de comprimidos mucoadesivos a base de cloridrato de pilocarpina para o tratamento da xerostomia, utilizando para este propósito a mistura física da goma do cajueiro/pilocarpina, quitosana/pilocarpina, mistura física de ambos os polímeros com pilocarpina e desenvolvimento de uma blenda polimérica por liofilização contendo goma de cajueiro e quitosana. Inicialmente a compatibilidade fármaco-polímero foi avaliada através da Calorimetria Exploratória Diferencial (DSC), Termogravimetria (TG), Espectroscopia de Infravermelho (IV) e Difração de Raios-X (DRX). Em seguida, foram obtidos comprimidos por compressão direta. Os comprimidos obtidos foram submetidos ao controle de qualidade, avaliação mucoadesiva e perfil de liberação. Na avaliação da mistura física (MF) dos polímeros/pilocarpina e da blenda/pilocarpina não foram encontrados sinais de incompatibilidades diante da avaliação pelas técnicas de DSC e TG. Dentre as formulações desenvolvidas, a blenda/pilocarpina demonstrou agregar propriedades mucoadesivas e retardo na liberação do fármaco, propriedades estas não encontradas nos polímeros individualmente e na mistura física/pilocarpina. A blenda/pilocarpina apresentou liberação de 53% do fármaco no tempo 180 min., tempo de mucoadesão de 510 min e incremento da força de mucoadesão. Esses resultados mostram o potencial do sistema polimérico para futuros desenvolvimentos na área farmacêutica. / The pilocarpine hydrochloride has been used in the treatment of xerostomia, however its systemic activity promotes undesirable side effects. However, the current prolonged release of drugs can control variations in plasma concentration and reduce these side effects. Additionally, to obtain tablets mucoadhesive associated with this delivery system favors prolonged drug action in oral cavity, which has important benefits for treatment. This work aims to develop mucoadhesive tablets pilocarpine hydrochloride base for the treatment of xerostomia, using for this purpose the physical mixture of cashew gum/pilocarpine, chitosan/pilocarpine, physical mixture of both polymers with pilocarpine and development of a polymer blend by lyophilization containing cashew gum and chitosan. Initially the drug-polymer compatibility was evaluated by Differential Scanning Calorimetry (DSC), thermogravimetry (TGA), Infrared Spectroscopy (IR) and X-ray Diffraction (XRD). Then, tablets were obtained by direct compression. The tablets were subjected to quality control, mucoadhesive evaluation and release profile. In assessing the physical mixture (MF) of the polymers / pilocarpine and blend / pilocarpine were not incompatible signals found on the evaluation by DSC and TG techniques. Among the developed formulations, the blend / pilocarpine shown add mucoadhesive properties and delayed drug release, these properties not found in polymers individually and physical / pilocarpine mixture. The blend / pilocarpine showed 53% release of the drug in time 180 min. Mucoadhesion time of 510 min, and increased strength mucoadhesion. These results show the potential of the polymer system for future developments in the pharmaceutical field.