Introduktion: Plyometrisk träning är en högintensiv träningsform för att förbättra atletisk prestation som exempelvis explosiv styrka och effektutveckling. Plyometrisk träning i vatten är däremot mindre undersökt men tidigare forskning tyder på att det verkar ha liknande effekter som landbaserad plyometrisk träning. Syfte: Litteraturundersökningens syfte är att undersöka om det finns en effekt av plyometrisk träning i vatten på hopphöjd, muskelstyrka och muskelömhet. Ytterligare ett syfte är att jämföra effekterna mellan plyometrisk träning i vatten med landbaserad plyometrisk träning på hopphöjd, muskelstyrka och muskelömhet. Metod: En systematisk sökning genomfördes i de vetenskapliga databaserna Pubmed och Web of Science. Utöver detta genomsöktes samtliga referenser på de artiklar som uppfyllde inklusionskriterierna. Resultat: Litteraturundersökningen visade att plyometrisk träning i vatten verkar ha en effekt på hopphöjd. Muskelstyrka och muskelömhet visade inget tydligt utfall. Plyometrisk träning i vatten verkar ha samma effekt på hopphöjd och muskelstyrka som landbaserad plyometrisk träning. Vattenbaserad plyometrisk träning verkar ge mindre muskelömhet jämfört med landbaserad plyometrisk träning. Konklusion: Det behövs mer forskning i området för att fastställa vilka faktorer som gör att vattenbaserad plyometrisk träning är lika effektiv som landbaserad träning för att förbättra hopphöjd. Det behövs mer forskning på plyometrisk träning i vatten associerad till muskelstyrka och muskelömhet för att få en tydligare bild av effekterna / Introduction: Effects of plyometric training to improve athletic performance such as explosive strength and power development are well-documented. However, less is known about the effects of aquatic plyometric training. Previous research suggests that it appears to have similar effects as land-based plyometric training. Purpose: The purpose of the literature review was to investigate if there is an effect of aquatic plyometric training on jump height, muscle strength and muscle soreness. Another aim was to compare the effects of plyometric training in water with land-based plyometric training on jump height, muscle strength and muscle soreness. Method: A systematic literature search was conducted in the scientific databases Pubmed and Web of Science. In addition, all references were manually searched on the articles that met the inclusion criteria. Results: The literature review shows that aquatic plyometric training seems to have an effect on jump height. Muscle strength and muscle soreness showed no clear outcome. Aquatic plyometric training seems to have the same effect on jump height and muscle strength as land-based plyometric training. Aquatic plyometric training seems to give less muscle soreness compared to land-based plyometric training. Conclusion: More research is necessary to determine which factors make aquatic plyometric training as effective as land-based plyometric training to improve jump height. More research is needed on aquatic plyometric training associated with muscle strength and muscle soreness to get a better understanding of the effects.

Le travail décrit dans ce manuscrit s’inscrit dans le cadre de la gestion de déchets nucléaires, de faible activité à vie longue (FA-VL), composés d’alliage de magnésium et de graphite, produits pendant l’exploitation de la première génération de réacteurs nucléaires en France. Il s’agit d’étudier la possibilité de leur immobilisation par cimentation et de comprendre le comportement des colis ainsi fabriqués tout au long de leur vie. Plusieurs mécanismes couplés sont à considérer : l’alliage de magnésium peut se corroder au sein de la matrice d’enrobage, en particulier lors du couplage galvanique avec le graphite. La croissance de produits de corrosion autour du métal et la restriction des déformations propres de la matrice cimentaire engendrent des contraintes à l’intérieur du matériau. La vérification de certaines exigences de sureté (stabilité dimensionnelle du colis et faible production d’hydrogène) nécessite donc le développement d’un outil numérique pouvant prédire le comportement mécanique des colis. En particulier, un mortier de laitier activé à la soude, qui présente un intérêt particulier, est examiné. Ce liant appartient à la famille des matériaux alcali-activés dont la modélisation numérique du comportement est peu abordée dans la littérature. La construction du modèle numérique passe ainsi par une large campagne expérimentale (caractérisation du comportement thermo-chemo-mécanique du mortier de laitier alcali-activé et de la corrosion du magnésium dans les matrices cimentaires) puis par un travail d’homogénéisation par éléments finis pour pouvoir déterminer les propriétés de l’ensemble (mortier + déchets) et mener des simulations à l’échelle du colis. Concernant le premier axe d’étude expérimentale, un faible échauffement accompagne l’avancement des réactions d’hydratation, ce qui est bénéfique vis-à-vis des contraintes internes résultantes de l’auto-restriction des déformations thermiques au sein des structures massives. Néanmoins, les déformations de retrait endogène montrent un développement important à long terme. Ceci peut générer des contraintes internes dans le colis (en présence de restrictions), mais la grande capacité de fluage du matériau empêche la fissuration. Concernant le deuxième axe d’étude expérimentale, le mortier de laitier activé est comparé avec deux autres mortiers à base de CEM I, pour évaluer le comportement à la corrosion de l’alliage de magnésium. Les observations microscopiques montrent que la corrosion galvanique de l’alliage est particulièrement agressive dans les mortiers à base de CEM I (corrosion localisée se manifestant par des creusements et des microstructures en feuillets) contre une corrosion uniforme, mais faible dans le mortier de laitier alcali-activé. La cinétique de corrosion est déterminée en utilisant des techniques gravimétriques et électrochimiques. Les résultats de ces deux types de mesure sont complémentaires et témoignent également d’une faible corrosion dans le mortier de laitier activé. De plus, ils montrent une certaine passivation du métal au-delà de 6 mois d’enrobage. Cette propriété spécifique du mortier de laitier activé peut être expliquée par une grande résistivité électrique par rapport aux mortiers de CEM I déterminée en analysant les données de spectroscopie d’impédence électrochimiques. Ensuite, des premières simulations simplifiées par éléments finis à l’échelle mésoscopique sont effectuées sur Cast3m, pour modéliser l’effet mécanique du développement de la corrosion sur le mortier d’enrobage. Plusieurs paramètres sont intégrés comme la cinétique de corrosion de l’alliage ainsi que la nature des produits formés et leurs propriétés mécaniques, identifiées par des observations MEB/EDS et nano-indentation. Les résultats indiquent que les contraintes générées dans la matrice d’enrobage n’entrainent pas d’endommagement. / The operation phase of the first generation of nuclear reactors in France has generated magnesium and graphite long lived low-level wastes (LLW-LL). Their conditioning in a hydraulic binder matrix is being addressed. In order to study the behavior of these packages, several coupled mechanisms have to be considered: the magnesium alloy can corrode within the encapsulating matrix, especially when galvanic coupling with the graphite occurs. The corrosion of the metal results in the development of corrosion products. The growth of corrosion products around the metal and the restriction of the hydraulic binder’s delayed strains may lead to the generation of internal stresses. The verification of certain safety requirements (dimensional stability of the package and low hydrogen production) is therefore essential. It requires the development of a numerical model able to predict the behavior of these packages.In particular, a sodium hydroxide activated blast furnace slag mortar is being addressed. It belongs to the family of alkali-activated materials for which the modelling of ageing behavior is rarely approached. Hence, the construction of the numerical model involves a large experimental campaign covering the thermo-chemo-mechanical behavior of the alkali-activated mortar and the corrosion of magnesium in hydraulic binders. Meso-scale homogenization calculations are undertaken in order to determine upscaled properties of the mix (matrix + wastes) and carry out simulations on the scale of the packages.Regarding the first experimental study axis, a relatively low hydration heat is measured. This is beneficial with respect to the internal stress generated from the self-restriction of the thermal strains within massive structures.Nevertheless, the materials undergoes a particular autogenous shrinkage strains showing an increase even at long term. However, its basic creep strains are shown to be important which could result in stress relaxation and avoids damage related to shrinkage restriction.Regarding the metal’s corrosion behavior in the alkali-activated mortar, it is compared to the one in two different ordinary Portland cement (OPC) based mortars. Microscopic observations are conducted on samples especially designed to monitor the galvanic corrosion of the alloy. They show the aggressiveness in OPC mortars (localized corrosion manifested by holes and layered microstructure) against limited homogeneous corrosion in alkali-activated mortar. Additionnaly, corrosion kinetics are determined using different experimental methods: mass loss and electrochemical measurements. The complementary results of these two types of measurements also show a low corrosion in the alkali-activated slag mortar with a passive state of the metal achived at 6 months of embedment. This advantage of slag mortar is explained by a high electrical resistivity with respect to OPC mortars, determined by electrochemical impedance spectroscopy.Finite element simulations are performed using Cast3m software on meso-scale in order to evaluate the mechanical effect of the corrosion layer development on the surrounding matrix. The corrosion kinetics of the alloy, the nature of corrosion products and their mechanical properties identified using SEM/EDS and nano-indentation techniques are implemented. The calculations indicate low stress generation in the alkali-activated mortar.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第20269号 / 医博第4228号 / 新制||医||1021(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 横出 正之, 教授 湊谷 謙司, 教授 瀬原 淳子 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

No description available.

Maternal obesity has significant consequences on the lifelong health of the developing child and rising global incidences make it one of the most common comorbidities during pregnancy. Offspring of obese mothers are at an increased risk of hospitalization for respiratory infections throughout childhood, which predispose these children to non-communicable respiratory diseases in later life. Animal models of maternal high fat diet (mHFD) feeding have observed common inflammatory outcomes with obesogenic models, but the effect on offspring varies with timing of the nutritional challenge and diet composition across studies. These studies demonstrate significant alterations to circulating and lung specific immune cells but the sequence of events that link maternal diet to these fetal outcomes are unclear, nor have they been tested in the context of a bacterial respiratory infection. Streptococcus pneumonaie is the most common causative pathogen of bacterial pneumonia and meningitis, making it of high clinical relevance. We aimed to investigate the effect of a mHFD (45% kcal from fat) during gestation and lactation, on offspring outcome and recovery from Streptococcus pneumoniae infection. Immunophenotyping, both before and after infection, revealed a hypo-inflammatory phenotype in circulating monocytes of the mHFD offspring with a decreased capacity to both initiate and terminate inflammatory responses. These offspring had significantly higher bacterial counts in lung tissues during infection and sustained cellular inflammation in survivors. In this thesis, we present foundational work on the detrimental influence of excess maternal nutrition on offspring immune function and infection outcomes, which may be involved in susceptibility to inflammatory and chronic disease in later life. A better understanding of this deep and lasting influence of the maternal environment will allow us to target preconception health as a form of harm reduction, informing stake holders and institutions to direct efforts towards DOHaD knowledge translation. / Thesis / Master of Science (MSc)

No description available.

Background: Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) has been extensively investigated, but the impact of collateralization remains unclear. We investigated the predictive value of collateral activation for delayed cerebral ischemia (DCI)-related infarctions and functional outcome. Methods: Data from 43 patients with CVS (January 2014 to August 2021) were evaluated for the angiographic presence of leptomeningeal and ophthalmic collaterals (anterior falcine artery (AFA), supratrochlear artery (STA), dorsal nasal artery (DNA)) on internal carotid artery angiograms. Vasospasm-related infarction and the modified Rankin Scale (mRS) score after six months were chosen as the endpoints. Results: 77% of the patients suffered from DCI-related infarctions. In 233 angiograms (at hospitalization, before spasmolysis, after six months), positive vessel signs were observed in 31 patients for STA, 35 for DNA, and 31 for AFA. The STA sign had the highest positive (84.6%) and negative (85.7%) predictive value for unfavorable outcome (mRS 4–6) in patients aged 50 years. DNA and AFA signs were not meaningful predictors for either endpoint. Leptomeningeal collaterals showed a positive Pearson’s correlation with the STA sign in 87.5% (p = 0.038) without providing any prediction for either endpoint. Conclusions: The STA sign is associated with clinical outcome in patients with CVS after SAH aged 50 years, and was correlated with the occurrence of leptomeningeal collaterals.

Background: Cerebral vasospasm (CVS) continues to account for high morbidity and mortality in patients surviving the initial aneurysmal subarachnoid hemorrhage (SAH). Nimodipine is the only drug known to reduce delayed cerebral ischemia (DCI), but it is believed not to affect large vessel CVS. Milrinone has emerged as a promising option. Our retrospective study focused on the effectiveness of the intra-arterial application of both drugs in monotherapy and combined therapy. Methods: We searched for patients with aneurysmal SAH, angiographically confirmed CVS, and at least one intra-arterial pharmacological angioplasty. Ten defined vessel sections on angiograms were assessed before and after vasodilator infusion. The improvement in vessel diameters was compared to the frequency of DCI-related cerebral infarction before hospital discharge and functional outcome reported as the modified Rankin Scale (mRS) score after 6 months. Results: Between 2014 and 2021, 132 intra-arterial interventions (144 vascular territories, 12 bilaterally) in 30 patients were analyzed for this study. The vasodilating effect of nimodipine was superior to milrinone in all intradural segments. There was no significant intergroup difference concerning outcome in mRS (p = 0.217). Only nimodipine or the combined approach could prevent DCI-related infarction (both 57.1%), not milrinone alone (87.5%). Both drugs induced a doubled vasopressor demand due to blood pressure decrease, but milrinone alone induced tachycardia. Conclusions: The monotherapy with intra-arterial nimodipine was superior to milrinone. Nimodipine and milrinone may be used complementary in an escalation scheme with the administration of nimodipine first, complemented by milrinone in cases of severe CVS. Milrinone monotherapy is not recommended.

Rocket Factory Augsburg (RFA) a German New Space Startup is developing a three-stage rocket launcher aiming at LEO/SSO orbits. A fundamental responsibility of the GNC team is the development of the rocket navigation algorithm to estimate the attitude, position, and velocity allowing the guidance and control loops to autonomously steer the rocket. This thesis focuses on the analysis and design of a Hybrid Navigation system able to satisfy the various necessities of a launch vehicle, such as delay compensation and GNSS outages. The navigation architecture was chosen to be a Closed Loop, Loosely Coupled, Delayed Error State Kalman Filter thanks to the proven capability of COTS receivers to autonomously provide a consistent PVT solution throughout the flight. A preliminary analysis used a reference trajectory to evaluate the effect of the sensor grade on inertial performances and choose an appropriate integration scheme. The filter’s system model was explored using approximate analytical results on observability. The developed navigation module was then tested within a Monte Carlo simulation environment by perturbating the sensor parameter in accordance with the sensor datasheet. As a further verification, the modeled IMU output was compared to the engineering model, to assure that the simulation result would yield conservative errors. Due to concern over the visibility of GNSS satellites during flight, a simplified Almanac-based GPS model has been developed, proving that enough satellite visibility is available along the trajectory. The estimation error was compared with the filter’s estimated covariance and found well within the bounds. Through the study of the covariance evolution, it was determined that given the reference dynamics, the sensor misalignments are the least observable states. Realistic signal outages were introduced in the most critical flight intervals. The filter was indeed found to be robust and the tuning proved to be adequate to capture the dead reckoning drift. Finally, the entire navigation module was deployed onto the avionics engineering model, including the flight computer, IMU, GNSS, and antennas, in a configuration equivalent to flight. The navigation module was then tested to ensure that the execution was in performance under severe multipath errors and prolonged GNSS outages with the covariance estimates correctly covering the uncertainty. / Rocket Factory Augsburg (RFA), ett tyskt nystartat rymdföretag, utvecklar en trestegsraket som siktar på LEO/SSO-banor. Ett grundläggande ansvar för GNC-teamet är utvecklingen av raketnavigationsalgoritmen för att uppskatta attityd, position och hastighet så att styr- och kontrollslingorna kan styra raketen autonomt. Avhandlingen fokuserar på analys och design av ett hybridnavigeringssystem som kan uppfylla de olika krav som ställs på en bärraket, såsom kompensation för fördröjningar och GNSS-avbrott. Navigationsarkitekturen valdes att vara ett Closed Loop, Loosely Coupled, Delayed Error State Kalman Filter tack vare den bevisade förmågan hos COTS-mottagare att autonomt tillhandahålla en konsekvent PVT-lösning under hela flygningen. En preliminär analys använde en referensbana för att utvärdera effekten av sensorkvaliteten på tröghetsprestanda och välja ett lämpligt integrationsschema. Filtrets systemmodell undersöktes med hjälp av approximativa analytiska resultat om observerbarhet. Den utvecklade navigeringsmodulen testades sedan i en Monte Carlo-simuleringsmiljö genom att störa sensorparametern i enlighet med sensorns datablad. Som en ytterligare verifiering jämfördes den modellerade IMU-utgången med den tekniska modellen, för att säkerställa att simuleringsresultatet skulle ge konservativa fel. På grund av oro över GNSS-satelliternas synlighet under flygning har en förenklad Almanac-baserad GPS-modell utvecklats, som bevisar att tillräcklig satellitsikt finns tillgänglig längs banan. Uppskattningsfelet jämfördes med filtrets uppskattade kovarians och låg väl inom gränserna. Genom att studera kovariansutvecklingen fastställdes det att givet referensdynamiken är sensorernas feljusteringar de minst observerbara tillstånden. Realistiska signalavbrott infördes i de mest kritiska flygintervallen. Filtret visade sig verkligen vara robust och inställningen visade sig vara tillräcklig för att fånga upp dödberäkningens drift. Slutligen installerades hela navigeringsmodulen på den flygtekniska modellen, inklusive flygdator, IMU, GNSS och antenner, i en konfiguration som motsvarar en flygning. Navigationsmodulen testades sedan för att säkerställa att utförandet var i prestanda under allvarliga multipath-fel och långvariga GNSS-avbrott med kovariansuppskattningarna som korrekt täcker osäkerheten.

Animals learn from past experience to guide future behavior and improve survival. This ability relies in part on specific episodic memories of past events encoded by neuronal activity and stored by updated connectivity between neurons. The unique architecture and activity of the hippocampus and related cortical regions are crucial for supporting these episodic memories. Hippocampal models propose the need for a pattern separation function to disambiguate similar memories and a pattern completion function to recall the full breadth of an experience from a partial cue. Past work suggests that neuronal activity in the dentate gyrus (DG) of hippocampus contributes to memory-guided navigation and plays a role in pattern separation. We tested the role of specific DG neuronal ensembles (i.e. engrams) in supporting the pattern separation function and altering downstream neural activity and, ultimately, behavior. To that end, we used an activity-dependent labeling paradigm to identify and manipulate engram ensembles during navigational and contextual fear conditioning (CFC) tasks. The results of our first experiment revealed that the DG partially disambiguates specific maze trajectories while still exhibiting greater overlap than chance levels. These findings suggest that the DG contributes to memory-guided navigation by both pattern separation and completion. Our second experiment manipulated nonspecific memory-related DG populations to assess the functional role of these cells in task generalization across contexts and ongoing spatial working memory. Optogenetic activation of these ensembles disrupted performance accuracy and exhibited a time-dependent impairment effect suggesting a role of the DG in task generalization between contexts. The final experiments investigated the physiological ramifications of artificial memory ensemble reactivation during ongoing navigation behavior. We recorded local field potential (LFP) and single unit responses in mouse DG and CA1 during artificial reactivation of a DG-mediated CFC memory engram. Stimulation of the DG entrained LFP and individual cell spiking in a subpopulation of CA1 pyramidal cells. Their spatial information was disrupted by stimulation despite stable navigational representation before and after the manipulation. Further, the presence of stimulation could be reliably decoded by the firing rate of the network, suggesting that engram reactivation forced the CA1 to adopt a repeatable state, perhaps to support behavioral expression of memories. In summary, my dissertation work presents empirical and theoretical evidence for the role of the dentate gyrus as a single node of an extended separation/completion circuit distributed anatomically and temporally as a neural mechanism supporting episodic memory.