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The Global ETD Search service is a free service for researchers
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Showing 1 to 10 of 13 (0.128 seconds)Spelling suggestions: "subject:"diastolic dysfunktion"" "subject:"diastolic analysfunktion""
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Stellenwert von GDF-15 bei Patienten mit einer diastolischen Dysfunktion und Herzinsuffizienz mit erhaltener linksventrikulärer Ejektionsfraktion / The significance of GDF-15 for patients with diastolic dysfunction and heart failure with preserved ejection fractionGabriel, Fabian 03 June 2014 (has links)
No description available.
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Effekte eines körperlichen Trainingsprogrammes auf die diastolische Funktion und die Leistungsfähigkeit bei Patienten mit diastolischer Herzinsuffizienz / Effects of exercise training on diastolic function and exercise capacity in patients with heart failure with preserves ejection fractionFröhling, Stefan 04 December 2012 (has links)
No description available.
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Die Herzfunktion während milder Hypothermie bei anästhesierten Schweinen: gesteigerte Inotropie auf Kosten einer diastolischen Dysfunktion / Cardiac function during mild hypothermia in pigs: increased inotropy at the expense of diastolic dysfunction.Christoph, Johannes 23 April 2012 (has links)
No description available.
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Einfluss einer leitliniengerechten Behandlung des arteriellen Hypertonus auf echokardiographische Parameter der diastolischen Funktion / Impact of arterial hypertension and guideline adherence on left ventricular diastolic functionBremecker, Kerstin 27 October 2010 (has links)
No description available.
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Einfluss einer diabetischen Stoffwechsellage auf die diastolische Funktion des linken Ventrikels / Influence of diabetes mellitus on left ventricular diastolic functionSchönbrunn, Lisa Christiane 10 August 2011 (has links)
No description available.
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Die Bedeutung der natriuretischen Peptide für die Diagnose einer diastolischen oder systolischen Funktionsstörung / Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunctionUhlir, Marc 27 September 2011 (has links)
No description available.
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Mechanismen der Belasstungseinschränkung von Patienten mit diastolischer Herzinsuffizienz im vergleich zu Patienten mit diastolischer Dysfunktion unter besonderer Berücksichtigung der neurohumoralen Aktivierung / Mechanism of reduced exercise capacity in patients with diastolic heart failure compaired to patients witch diastolic dysfunction and the role of neurohumoral activationDuvinage, André 28 September 2011 (has links)
No description available.
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Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractilityAdams, Volker, Schauer, Antje, Augstein, Antje, Kirchhoff, Virginia, Draskowski, Runa, Jannasch, Anett, Goto, Keita, Lyall, Gemma, Männel, Anita, Barthel, Peggy, Mangner, Norman, Winzer, Ephraim B., Linke, Axel, Labeit, Siegfried 22 January 2024 (has links)
Background About half of heart failure (HF) patients, while having preserved left ventricular function, suffer from diastolic dysfunction (so-called HFpEF). No specific therapeutics are available for HFpEF in contrast to HF where reduced ejection fractions (HFrEF) can be treated pharmacologically. Myocardial titin filament stiffening, endothelial dysfunction, and skeletal muscle (SKM) myopathy are suspected to contribute to HFpEF genesis. We previously described small molecules interfering with MuRF1 target recognition thereby attenuating SKM myopathy and dysfunction in HFrEF animal models. The aim of the present study was to test the efficacy of one small molecule (MyoMed-205) in HFpEF and to describe molecular changes elicited by MyoMed-205. - Methods Twenty-week-old female obese ZSF1 rats received the MuRF1 inhibitor MyoMed-205 for 12 weeks; a comparison was made to age-matched untreated ZSF1-lean (healthy) and obese rats as controls. LV (left ventricle) unction was assessed by echocardiography and by invasive haemodynamic measurements until week 32. At week 32, SKM and endothelial functions were measured and tissues collected for molecular analyses. Proteome-wide analysis followed by WBs and RT-PCR was applied to identify specific genes and affected molecular pathways. MuRF1 knockout mice (MuRF1-KO) SKM tissues were included to validate MuRF1-specificity. - Results By week 32, untreated obese rats had normal LV ejection fraction but augmented E/e′ ratios and increased end diastolic pressure and myocardial fibrosis, all typical features of HFpEF. Furthermore, SKM myopathy (both atrophy and force loss) and endothelial dysfunction were detected. In contrast, MyoMed-205 treated rats had markedly improved diastolic function, less myocardial fibrosis, reduced SKM myopathy, and increased SKM function. SKM extracts from MyoMed-205 treated rats had reduced MuRF1 content and lowered total muscle protein ubiquitination. In addition, proteomic profiling identified eight proteins to respond specifically to MyoMed-205 treatment. Five out of these eight proteins are involved in mitochondrial metabolism, dynamics, or autophagy. Consistent with the mitochondria being a MyoMed-205 target, the synthesis of mitochondrial respiratory chain complexes I + II was increased in treated rats. MuRF1-KO SKM controls also had elevated mitochondrial complex I and II activities, also suggesting mitochondrial activity regulation by MuRF1. - Conclusions MyoMed-205 improved myocardial diastolic function and prevented SKM atrophy/function in the ZSF1 animal model of HFpEF. Mechanistically, SKM benefited from an attenuated ubiquitin proteasome system and augmented synthesis/activity of proteins of the mitochondrial respiratory chain while the myocardium seemed to benefit from reduced titin modifications and fibrosis.
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Neurohumorale Aktivierung in einem kardiovaskulären Risikokollektiv - Einfluss von diastolischer oder systolischer Dysfunktion / Neurohumoral activation in a cardiovascular risk population - influence of diastolic or systolic dysfunctionRahn, Ingmar 17 January 2011 (has links)
No description available.
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Prävalenz, Risikofaktoren und klinische Ausprägung der systolischen und diastolischen Herzinsuffizienz in einem hausärztlichen Risikokollektiv sowie Wertigkeit echokardiographischer Parameter und natriuretischer Peptide zur Diagnosestellung der diastolischen Herzinsuffizienz / Prevalence, risk factors and clinical characteristics of systolic and diastolic heart failure in patients with risk factors for heart failure from general practitioner`s practice and diagnostic relevance of echocardiography and natriuretic peptides for diastolic heart failure.Scheele, Frauke 10 August 2011 (has links)
No description available.
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