The Evening Shadow, a six-minute work for symphony orchestra, is a short symphonic poem composed with the intent of evoking a sensation of lament and eventual deliverance. Drawing from the “Neapolitan Complex” found in Beethoven’s string quartet in C-sharp minor, op. 131 (exploitation of the semitone between C#-D), I attempted to create a dramatic “storyline” utilizing the semitone relation between E and F. From a programmatic standpoint, upward motion from E to F is meant to represent yearning (mm. 5-6, violins, mm. 14-15, violin/vibraphone, m. 18, cello, embedded in m. 20, flute 2) while downward motion from F to E (mm. 110-113, brass) symbolizes rescue and redemption. Motivic transformation was paramount to the construction of The Evening Shadow. Five primary motives are stated and developed. The first appears in the solo violin from mm. 3-4 and is transformed at m. 44 in the oboe and 2nd violins. The second motive is stated in mm. 9-12 in the 1st violins, and returns in canon from mm. 96-106. The third motive appears in the oboe in mm. 29-30 and is developed extensively (mm. 41-42, 47-48, 110-113). The fourth motive is stated in the 1st violins at m. 33 and returns in m. 52 in the 2nd violins. The final motive is first heard in the horns in mm. 39-40 and ends the piece from mm. 127-129. The motivic transformations make use of transposition, modal “adjustment,” and built in rubato effects, as well a large degree of fragmentation and recombination. Traditional contrapuntal technique was utilized throughout the work. Global harmonic motion of the piece, which makes use of skeletal tonic/dominant relations, can be heard as a progression through the following “tonicizations” and respective modalities: E/F (pitch-centric, no modality, mm. 1-33), D (Dorian, mm. 34-55), A (Dorian, mm. 52-54), E (pseudo-Phrygian, mm. 65-87), C (Mixolydian, mm. 108-121), G (Mixolydian, mm. 127-132), and E/F (pitch-centric, no modality, mm. 133-137). Atonal pitch-class set sonorities were used as structural rhetoric throughout. The aggregate collection, drawing from dodecaphonic theory, is used sparingly both melodically (mm. 16-17, violins and violas), and harmonically (mm. 2-3, 64, 66, 69, 137). Conceptual difficulties arise from orchestrational considerations in a contemporary work due to the broad array of possibilities demonstrated in the scores that span the history of orchestral music. I sought to create a hybrid of advanced traditional orchestration (Mahler, Strauss) and texturalist practices (Lutoslawski, Ligeti).

名古屋大学博士学位論文 学位の種類:博士(医療技術学) (課程) 学位授与年月日:平成20年3月25日

An engineering analysis of the fugitive particulate matter emissions from a feedyard is not simple. The presence of an evening dust peak in concentration measurements downwind of a feedyard complicates the calculation of an average 24-h emission flux for the feedyard. The evening dust peak is a recurring event that occurs during evening hours when particulate matter concentration measurements increase and decrease dramatically during a short period of time. The concentrations measured during the evening can be up to 8 times the concentrations measured throughout the rest of the day. There is a perception that these concentration increases are due to increases in cattle activity as the temperature decreases during the evening. The purpose of Objective 1 of this research was to quantify the changes in concentrations based on changes in meteorological conditions and/or cattle activity. Using ISCST3, a Gaussian-based EPAapproved dispersion model used to predict concentrations downwind of the feedyard , the results of this work indicate that up to 80% of the increase in concentrations can be attributed to changes in meteorological conditions (wind speed, stability class, and mixing height.)The total fugitive particulate matter emissions on a cattle feedyard are due to two sources: unpaved roads (vehicle traffic) and pen surfaces (cattle activity). Objective 2 of this research was to quantify the mass fraction of the concentration measurements that was due to unpaved road emissions (vehicle traffic). A recent finding by Wanjura et al. (2004) reported that as much as 80% of the concentrations measured after a rain event were due to unpaved road emissions. An engineering analysis of the potential of the unpaved road emissions versus the total feedyard emissions using ISCST3 suggests that it is possible for 70 to 80% of the concentration measurements to be attributed to unpaved road emissions. The purpose of Objective 3 was to demonstrate the science used by ISCST3 to predict concentrations downwind of an area source. Results from this study indicate that the ISCST3 model utilizes a form of the Gaussian line source algorithm to predict concentrations downwind of an area source.

Thesis (M. Div.)--St. Vladimir's Orthodox Theological Seminary, Crestwood, N.Y., 2002. / Abstract. Includes bibliographical references (leaves 110-112).

The aim of this study was to investigate the effect of different penetration enhancers containing essential fatty acids (EFAs) on the transdermal delivery of flurbiprofen. Flurbiprofen was used as a marker / model compound. Fatty acids were chosen as penetration enhancers for their ability to reversibly increase skin permeability through entering the lipid bilayers and disrupting their ordered domains. Fatty acids are natural, non-toxic compounds (Karande & Mitragotri, 2009:2364). Evening primrose oil, vitamin F and Pheroid™ technology all contain fatty acids and were compared using a cream based-formulation. This selection was to ascertain whether EFAs exclusively, or EFAs in a delivery system, would have a significant increase in the transdermal delivery of a compound. For an active pharmaceutical ingredient (API) to be effectively delivered transdermally, it has to be soluble in lipophilic, as well as hydrophilic mediums (Naik et al., 2000:319; Swart et al., 2005:72). This is due to the intricate structure of the skin, where the stratum corneum (outermost layer) is the primary barrier, which regulates skin transport (Barry, 2001:102; Moser et al., 2001:103; Venus et al., 2010:469). Flurbiprofen is highly lipophilic (log P = 4.24) with poor aqueous solubility. It has a molecular weight lower than 500 g/mol indicating that skin permeation may be possible, though the high log P indicates that some difficulty is to be expected (Dollery, 1999:F126; Hadgraft, 2004:292; Swart et al., 2005:72; Karande & Mitragotri, 2009:2363; Drugbank, 2012). In vitro transdermal diffusion studies (utilising vertical Franz diffusion cells) were conducted, using donated abdominal skin from Caucasian females. The studies were conducted over 12 h with extractions of the receptor phase every 2 h to ensure sink conditions. Prior to skin diffusion studies, membrane release studies were performed to determine whether the API was released from the formulation. Membrane release studies were conducted over 6 h and extractions done hourly. Tape stripping experiments were performed on the skin circles after 12 h diffusion studies to determine the concentration flurbiprofen present in the stratum corneum and dermisepidermis. The flurbiprofen concentrations present in the samples were determined using high performance chromatography and a validated method. Membrane release results indicated the following rank order for flurbiprofen from the different formulations: vitamin F > control > evening primrose oil (EPO) >> Pheroid™. The control formulation contained only flurbiprofen and no penetration enhancers. Skin diffusion results on the other hand, indicated that flurbiprofen was present in the stratum corneum and the dermisepidermis. The concentration flurbiprofen present in the receptor phase of the Franz cells (representing human blood) followed the subsequent rank order: EPO > control > vitamin F >> Pheroid™. All the formulations stipulated a lag time shorter than that of the control formulation (1.74 h), with the EPO formulation depicting the shortest (1.36 h). The control formulation presented the highest flux (8.41 μg/cm2.h), with the EPO formulation following the closest (8.12 μg/cm2.h). It could thus be concluded that fatty acids exclusively, rather than in a delivery system, had a significant increase in the transdermal delivery of flurbiprofen. / Thesis (MSc (Pharmaceutics))--North-West University, Potchefstroom Campus, 2013.

The aim of this study was to investigate the effect of different penetration enhancers containing essential fatty acids (EFAs) on the transdermal delivery of flurbiprofen. Flurbiprofen was used as a marker / model compound. Fatty acids were chosen as penetration enhancers for their ability to reversibly increase skin permeability through entering the lipid bilayers and disrupting their ordered domains. Fatty acids are natural, non-toxic compounds (Karande & Mitragotri, 2009:2364). Evening primrose oil, vitamin F and Pheroid™ technology all contain fatty acids and were compared using a cream based-formulation. This selection was to ascertain whether EFAs exclusively, or EFAs in a delivery system, would have a significant increase in the transdermal delivery of a compound. For an active pharmaceutical ingredient (API) to be effectively delivered transdermally, it has to be soluble in lipophilic, as well as hydrophilic mediums (Naik et al., 2000:319; Swart et al., 2005:72). This is due to the intricate structure of the skin, where the stratum corneum (outermost layer) is the primary barrier, which regulates skin transport (Barry, 2001:102; Moser et al., 2001:103; Venus et al., 2010:469). Flurbiprofen is highly lipophilic (log P = 4.24) with poor aqueous solubility. It has a molecular weight lower than 500 g/mol indicating that skin permeation may be possible, though the high log P indicates that some difficulty is to be expected (Dollery, 1999:F126; Hadgraft, 2004:292; Swart et al., 2005:72; Karande & Mitragotri, 2009:2363; Drugbank, 2012). In vitro transdermal diffusion studies (utilising vertical Franz diffusion cells) were conducted, using donated abdominal skin from Caucasian females. The studies were conducted over 12 h with extractions of the receptor phase every 2 h to ensure sink conditions. Prior to skin diffusion studies, membrane release studies were performed to determine whether the API was released from the formulation. Membrane release studies were conducted over 6 h and extractions done hourly. Tape stripping experiments were performed on the skin circles after 12 h diffusion studies to determine the concentration flurbiprofen present in the stratum corneum and dermisepidermis. The flurbiprofen concentrations present in the samples were determined using high performance chromatography and a validated method. Membrane release results indicated the following rank order for flurbiprofen from the different formulations: vitamin F > control > evening primrose oil (EPO) >> Pheroid™. The control formulation contained only flurbiprofen and no penetration enhancers. Skin diffusion results on the other hand, indicated that flurbiprofen was present in the stratum corneum and the dermisepidermis. The concentration flurbiprofen present in the receptor phase of the Franz cells (representing human blood) followed the subsequent rank order: EPO > control > vitamin F >> Pheroid™. All the formulations stipulated a lag time shorter than that of the control formulation (1.74 h), with the EPO formulation depicting the shortest (1.36 h). The control formulation presented the highest flux (8.41 μg/cm2.h), with the EPO formulation following the closest (8.12 μg/cm2.h). It could thus be concluded that fatty acids exclusively, rather than in a delivery system, had a significant increase in the transdermal delivery of flurbiprofen. / Thesis (MSc (Pharmaceutics))--North-West University, Potchefstroom Campus, 2013.

Tyrimų metu nustatyta, kad iš visų tešmens ketvirčių daugiau primelžta pieno rytinio nei vakarinio melžimo metu. Rytinio melžimo metu nustatytas 1,39 proc. didesnis tešmens indeksas palyginus su vakariniu melžimu. Palyginus primelžto pieno kiekį iš priekinių ir užpakalinių tešmens ketvirčių nustatyta, kad daugiau pieno primelžta iš užpakalinių tešmens tiek rytinio, tiek vakarinio melžimo metu. Rytinio melžimo metu iš užpakalinių tešmens ketvirčių primelžta vidutiniškai 3,05 kg daugiau, o vakarinio melžimo metu 2,76 kg daugiau negu iš priekinių ketvirčių (p<0,01). Išanalizavus priekinių ir užpakalinių tešmens ketvirčių melžimo trukmę rytinio ir vakarinio melžimo metu, nustatyta ilgesnė melžimo trukmė užpakaliniuose tešmens ketvirčiuose. Rytinio melžimo metu užpakalinių tešmens ketvirčių melžimo trukmė buvo 1,07 min. ilgesnė nei priekinių (p<0,01). Vakarinio melžimo metu šis skirtumas buvo 0,95 min. (p<0,01). Priekiniuose tešmens ketvirčiuose melžimo trukmė buvo 0,53 min. (p<0,01) ilgesnė, o užpakaliniuose 0,65 min.(p<0,01) rytinio melžimo metu palyginus su vakariniu. Tiek priekinių, tiek užpakalinių tešmens ketvirčių melžimo greitis didesnis nustatytas rytinio melžimo metu palyginus su vakariniu. Priekiniuose tešmens ketvirčiuose nustatyta 0,09 kg/min., o užpakaliniuose 0,07 kg/min. didesnis melžimo greitis rytinio melžimo metu palyginus su vakariniu. Suskirsčius karves į grupes pagal SLS klases palygintas atskirų tešmens ketvirčių primelžto pieno kiekis rytinio ir... [toliau žr. visą tekstą] / The analyses showed that all quarters of the udder produced more milk during the morning milking compared to the evening milking. During the morning milking the udder index was by 1.39 % higher than during the evening milking. The comparison of the quantity of milk produced by the front and rear quarters of the udder showed that the rear quarters of the udder produced more milk both during the morning and evening milking. During the morning milking the rear quarters of the udder produced 3.05 kg more milk on average compared to the front quarters, whereas during the evening milking they produced 2.76 kg more milk on average compared to the front ones (p<0.01). The analysis of the duration of milking the front and rear quarters of the udder during the morning and evening milking showed that the milking duration was longer in the case of the rear quarters of the udder. During the morning milking the duration of milking the rear quarters of the udder was by 1.07 min longer compared to the front quarters (p<0.01). During the evening milking the difference was 0.95 min (p<0.01). During the morning milking the milking duration was by 0.53 min (p<0.01) longer in the case of the front quarters and by 0.65 min (p<0.01) longer in the case of the rear quarters compared to the evening milking. After dividing the cows into groups according to the classes determined by the number of somatic cells, the quantities of milk produced by the separate quarters of the udder during the morning and... [to full text]

Thèse (M.Ed.) -- Université du Québec à Chicoutimi, en association avec Universidade do Estado da Bahia, 2005. / Bibliogr.: f. 168-171. Document électronique également accessible en format PDF. CaQCU

Thesis (M. Div.)--St. Vladimir's Orthodox Theological Seminary, Crestwood, N.Y., 2002. / Abstract. Includes bibliographical references (leaves 110-112).

Thesis (M. Div.)--St. Vladimir's Orthodox Theological Seminary, Crestwood, N.Y., 2002. / Abstract. Includes bibliographical references (leaves 110-112).