Les recherches récentes menées sur le cancer s’accordent sur le fait que l’âge serait un des principaux facteurs de risque (Tubiana, 2002). C’est notamment le cas du cancer de la prostate, la plupart des cas étant constatés entre 60 et 90 ans (âge moyen de détection : 73 ans). Les personnes âgées se trouvent alors confrontées à différentes problématiques afférentes à la vieillesse, dont le cancer fait partie. Faire face à cette maladie n’est pas le seul défi du patient âgé, le cancer perturbant sa vie au niveau de tout son environnement affectif et social. Nous nous intéressons dans cette thèse à connaître l’impact psychologique du cancer de la prostate sur la vie quotidienne des patients âgés et de leurs épouses. Nous présentons les résultats menés auprès de 96 patients atteints du cancer de la prostate et de leur conjointe recrutés sur deux centres régionaux de lutte contre le cancer. Nous mettrons en place une nouvelle méthodologie : la méthode écologique d’échantillonnage des expériences qui se déroule sur 3 cycles d’évaluations durant 4 jours (en début de traitement, en milieu de traitement et en fin de traitement). Cette méthode nous permet d’établir les liens entre variables (/heure, /jour, /sujet, entre sujets et au sein du couple), et d’observer et de comparer l’ajustement des patients et de leur conjointe suivant différents âges (Swendsen, 1997 ; Czikszentmihalyi, 1984). Nos résultats mettent en évidence trois points essentiels : Tout d’abord il s’agit de distinguer les différences de ressentis et de stratégies de coping selon l’âge des couples pris en charge. Ensuite, le second point important de cette recherche est la notion d’inter individualité. Cette étude discrimine tout à fait les attitudes et les émotions que peuvent vivre au quotidien les patients des épouses. Enfin, le troisième point concerne le temps de la prise en charge. Il existe une réelle progression des ressentis et de l’ajustement psychologique des couples tout au long du traitement. Cette étude permet d’affiner nos connaissances sur le couple âgé confronté à la maladie et, plus spécifiquement, sur son ajustement émotionnel et sa qualité de vie lorsqu’il lui faut faire face au cancer de la prostate. Cette recherche est financée par la Ligue Nationale de Lutte Contre le Cancer, France. / Recent research consistently indicates that age is a major risk factor for cancer (Tubiana, 2002). Such is the case of prostate cancer, which is typically detected between the ages of 60 and 90 (average age of detection: 73 years). Coping with the physical effects of cancer is not the only challenge for elderly patients; cancer may also affect patient’s emotional and social lives as well. The current study presents results of an experience sampling study on the psychological impact of prostate cancer on the daily lives of elderly patients and their wives. We present data on 96 patients with prostate cancer and their spouse who were recruited from two Regional Center for the Fight Against Cancer in Bordeaux, France. Participants completed 3 daily assessments for 4 days (at the beginning of treatment, in the middle of treatment and at the end of treatment). The methodology has a number of advantages, including that it allows us to establish the relationship between variables (coping, quality of life, anxiety and depression), between subjects, and within the couple. The methodology also allows us to observe and compare the adjustment of patients and their partner following different ages (Swendsen, 1997, Czikszentmihalyi, 1984). Our results schowing three key points: First, we distinguiging the differences of feeling and coping strategies by spouses’age. The second point concern the concept of interindividual. This study discriminate behavior and emotions in everyday life of couples. The third important point concerns time management. There is an increased in feeling and psychosocial adjustement on the treatment. This study will help us to refine our knowledge and understanding of emotional adjustment and quality of life of patients with prostate cancer and their spouses. We will thus be able to realize the importance of taking into account the couple and not just patients in psychological interventions. This research is being funded by the National League for the Fight against Cancer, France.

Major depressive disorder (MDD) is a debilitating disorder characterized by significant mood disturbance. In laboratory studies, MDD has been characterized by both blunted positive (PER) and negative emotional reactivity (NER). However, mood disordered persons' emotional reactivity has rarely been studied in naturalistic settings, and it is unknown how less severe forms of depression relate to emotional reactivity. To address these issues, the current study utilized two naturalistic sampling methods (the Day Reconstruction Method and the Experience Sampling Method) to examine PER and NER to daily life events in 35 individuals currently experiencing a major depressive episode (MDD), 26 individuals currently experiencing a minor depressive episode (mD), and 38 healthy controls. Both methods demonstrated that individuals with major and minor depression exhibited blunted PER relative to controls. In surprising contrast to previous laboratory findings, both individuals with MDD and mD showed increased NER relative to controls. Correlational analyses with severity measures indicated that depression and anxiety severity were positively related to NER and negatively related to PER. Findings suggest that NER in mood disorders may diverge as a function of assessment context and may be heightened in naturalistic environments. Despite the fact that mD is a milder mood disorder, findings suggest that mD results in similar emotional impairments as found in MDD.

Les objectifs de cette thèse sont multiples: 1. concevoir un nouvel outil d'échantillonnage des expériences utilisant les technologies mobiles, qui soit durable et évolutif, et qui permette d'implémenter des tests cognitifs mobiles; 2. utiliser cet outil pour obtenir des informations écologiques sur les comportements et les performances cognitives; 3. valider la méthode; 4. analyser les interactions entre comportement et performance afin d'identifier les comportements sains ou à risque. / This thesis has several objectives: 1. design a new experience sampling tool that is durable and evolutive, and allows to implement mobile cognitive tests; 2. use this tool to obtain ecological information on behaviors and cognitive performance; 3. validate the method; 4. analyze the relationships between behavior and performance to identify which behaviors are healthy or risky.

<div>To capture the dynamic nature of frontline employees’ subjective well-being (SWB) and turnover intention in the hotel industry, this study used Affective Events Theory (Weiss & Cropanzano, 1996) and the unfolding model of employee voluntary turnover (Lee & Mitchell, 1994) to argue the short-term variability in SWB and turnover intention. Using the job demandsresources model (JD-R model) as the framework, this study examined the role of daily job</div><div>demands (challenge stressors, hindrance stressors, and emotional dissonance) and the role of daily job resources (supervisor support, coworker support, and job autonomy). Given that hotel employees work with different supervisors and co-workers and face various guest situations during each shift, these employees may face high work stress and workload. Furthermore, employees in this industry are often requested to perform non-routine tasks. Therefore, their work is highly associated with high job demands and resource variability. Moreover, the study results stress the importance of the moderating role of day-level job resources and the multilevel moderating effects of employees’ individual levels of resilience and self-efficacy. </div><div>The design of the study employed an experience sampling method. Participants were employees who are in guest-facing positions from food & beverage and front office departments in full-service or luxury hotels in the United States. Sixty-five participants completed a one-time baseline survey and a daily diary study twice per day for at least five working days, resulting in a total of 416 day-level observations. The data structure is day nested within each person. The multi-level data was analyzed by using multilevel linear modeling. </div><div>In summary, this study shows that SWB and turnover intention may not always be stable phenomena among hotel employees due to the daily influences of job demands and job resources. In addition, both personal resources and daily job resources were found to mitigate the negative daily influences of job demands. This study helps managers to better understand employees’ feelings on a daily basis and apply strategies for daily management of employee SWB and turnover intention.</div>

<p>  </p> <p>Social withdrawal is a disabling feature of schizophrenia. To understand its development, researchers have focused on social anhedonia— diminished pleasure from social interactions. Discrepancies in anticipated versus consummatory pleasure for non-social stimuli are well-documented in schizophrenia. Thus, a similar emotional paradox may underlie social anhedonia. If so, our understanding of social anhedonia—including how to treat it in schizophrenia—could be enhanced. This project used a 5-day experience sampling method (ESM) to measure discrepancies between anticipated and consummatory pleasure for real-world social activities in people with schizophrenia and healthy controls (<em>n=</em>30/group). Results suggest people with schizophrenia exhibited similar levels of anticipated and consummatory social pleasure as controls, and both groups were accurate in their short-term predictions of pleasure. Yet, healthy control participants were somewhat more precise in their short-term pleasure predictions, and clinical interviews revealed those with schizophrenia showed moderate deficits in long-term social pleasure prediction. Negative symptoms and cognitive impairment in schizophrenia were related to anticipated, but not consummatory, social pleasure, suggesting anhedonia is driven by deficits in thinking about pleasure, rather than inability to experience pleasure. Clinical implications include focusing on building upon short-term ability to predict pleasure in therapy in order to increase social motivation in schizophrenia. Moreover, exploratory analyses revealed differences in qualitative aspects of social activities such as level of engagement may lead to social anhedonia in schizophrenia and are a promising treatment target for addressing social dysfunction.</p>

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Près de 30% des patients ayant survécus à un AVC, développent une dépression (DPAVC) dont le retentissement sur la qualité de vie peut être majeur. Sa physiopathologie est encore méconnue et les critères diagnostiques ne sont pas clairement définis. Notre objectif est d'identifier des facteurs précoces neuropsychologiques et de neuroimagerie prédictifs d'une dépression 3 mois après l’AVC.Cinquante-cinq patients présentant un premier AVC, sans antécédent neurologique ou psychiatrique ont été inclus. Dix jours après l’AVC, la sévérité des symptômes dépressifs et anxieux a été évaluée d’une part, par les échelles standard d’Hamilton et d’autre part, en vie quotidienne durant 7 jours, par la méthode d’échantillonnage des expériences (ESM). Au même temps, un examen d’IRM multimodale a été réalisé (IRM fonctionnelle de repos, DTI et 3D T1) afin d'évaluer les modifications anatomo-fonctionnelles de l’organisation cérébrale. Trois mois après l’AVC, une mesure standard de la sévérité des symptômes dépressifs et anxieux est à nouveau effectuée. A partir de ces données nous avons exploré la relation existant entre 1/ la sévérité des symptômes dépressifs et les données IRM 2/ la sévérité des symptômes dépressifs et les données ESM 3/ la sévérité des symptômes dépressifs mesurée par ESM et les modifications anatomo-fonctionnelles cérébrales. Nous avons mis en évidence une modification de la connectivité fonctionnelle entre les régions postérieures du réseau en "default mode", de la même façon que dans les dépressions majeure et vasculaire ; et entre le cortex temporal moyen et ce réseau. A la phase aigue de l’AVC, 2 profils symptomatologiques se distinguent : le premier est caractérisé par une grande fatigue et une forte anhédonie, le deuxième est définit par de la tristesse, une forte anxiété, des pensées négatives et une forte réactivité émotionnelle. Ce dernier est associé au risque de DPAVC à 3 mois. Enfin, nous avons montré que les modifications fonctionnelles du DMN prédictives de l’AVC étaient associées à la réactivité émotionnelle, alors que le volume de substance grise du cervelet était corrélé à la fréquence des pensées positives et négatives.En conclusion, la physiopathologie de la DPAVC présenterait des similitudes avec celle de la dépression majeure et de la dépression vasculaire, mais aussi des différences comme l’engagement du cortex temporal moyen au sein du réseau en « default mode ». De plus, cette étude suggère qu'à côté de l'implication de la lésion cérébro-vasculaire, des critères de vulnérabilité psychobiologiques antérieurs à l’AVC influenceraient la survenue d’une dépression. / 30% of stroke survivors will experience Post-Stroke Depression (PSD) that is associated to a poor quality of life. PSD is still under-diagnosed due to the absence of clear diagnostic criteria and its pathophysiology remains unknown. The aim of this study was to identify early imaging and psychiatric risk factors of depression 3 months after stroke. Patients with a first ischemic stroke, without any neurologic and psychiatric history were included. Daily-life symptoms were evaluated using ESM 10 days after stroke. Brain MRI acquisition was performed at 10 days after stroke including DWI, FLAIR/T2, resting state fMRI and anatomical sequences. We explored the association between 1/ the severity of depressive symptoms and MRI data 2/ the severity of depressive symptoms and ESM data 3/ the severity of depressive symptoms measured by ESM and MRI data.Results revealed a modification of the functional connectivity between posterior structures of the DMN (Default Mode Network) and between the middle temporal cortex and the DMN. In the acute phase, depressed patients presented either high fatigue and anhedonia or another profile including high anxiety, negative thoughts and emotional reactivity which is associated to the risk of depression 3 months after stroke. Moreover, we demonstrated that functional connectivity modifications within the DMN and the cerebellum grey matter were respectively associated to emotional reactivity and the frequency of positive and negative thoughts.In conclusion, modifications of the DMN were implicated in the physiopathology of PSD in the same way that major or vascular depression, with a specificity represented by the new contribution of the middle temporal cortex within the DMN. Furthermore, this study suggests that more than a stroke lesion, anterior psychobiological vulnerabilities of an individual patient could mediate PSD occurrence.

Nonostante il maltrattamento all’infanzia costituisca un’esperienza relazionale patogena, alcuni bambini maltrattati mostrano un itinerario di sviluppo resiliente. La tesi si focalizza sul possibile ruolo giocato da meaning-making e mindfulness skills nel funzionamento resiliente. Il primo obiettivo è stato esplorare la relazione tra meaning-making, mindfulness skills e benessere in bambini non maltrattati. Il secondo obiettivo è stato valutare meaning-making e mindfulness skills in minori maltrattati, per determinare se il funzionamento resiliente fosse in relazione con questi costrutti. Il terzo obiettivo è stato creare un intervento per minori maltrattati ospitati in comunità (MBYR), testandone la fattibilità. Lo studio 1 ha esplorato il meaning-making in bambini non maltrattati, non evidenziando alcuna relazione con le loro competenze e difficoltà. Lo studio 2 ha mostrato che le mindfulness skills correlavano negativamente con outcome avversi, ma positivamente con le competenze dei bambini. Lo studio 3 ha esplorato la relazione tra funzionamento resiliente, meaning-making e mindfulness skills in minori maltratti, evidenziando che il meaning-making era legato a livelli più bassi di qualità della vita, mentre le mindfulness skills erano in relazione con il funzionamento resiliente. Questi risultati hanno informato il razionale dell’MBYR, che ha significativamente ridotto i sintomi traumatici, aumentando mindfulness skills e competenze generali (studio 4). / Child maltreatment is a pathogenic relational experience representing one of the most difficult challenges to children’s healthy adaptation; nonetheless, some maltreated children develop resiliently. The thesis focuses on the possible role played by meaning-making and mindfulness skills in resilient functioning. The first aim was to investigate the relation between meaning-making, mindfulness skills, and wellbeing in nonmaltreated children. The second aim was to explore meaning-making and mindfulness skills in maltreated children and adolescents, to determine whether resilient functioning was related to these constructs. Finally, the third aim was to design an intervention for maltreated youths in residential care (MBYR) and to test its feasibility. Study 1 explored meaning-making in nonmaltreated children, showing that it was not related to their competencies and difficulties. Study 2 highlighted that mindfulness skills were negatively related to adverse outcomes and positively related to children’s competencies. Study 3 explored the relation between different domains of resilient functioning, meaning-making, and mindfulness skills in maltreated youths, showing that meaning-making was related to lower levels of quality of life, whereas mindfulness skills were related to resilient functioning. These results informed the rationale for the MBYR, which significantly reduced traumatic symptoms while enhancing mindfulness skills and general competencies (study 4).

Deficient self-control leads to shortsighted decisions and incurs severe personal and societal costs. Although neuroimaging has advanced our understanding of neural mechanisms underlying self-control, the ecological validity of laboratory tasks used to assess self-control remains largely unknown. To increase ecological validity and to test a specific hypothesis about the mechanisms underlying real-life self-control, we combined functional MRI during valuebased decision-making with smartphone-based assessment of real-life self-control in a large community sample (N = 194). Results showed that an increased propensity to make shortsighted decisions and commit self-control failures, both in the laboratory task as well as during real-life conflicts, was associated with a reduced modulation of neural value signals in the ventromedial prefrontal cortex in response to anticipated long-term consequences. These results constitute the first evidence that neural mechanisms mediating anticipations of future consequences not only account for self-control in laboratory tasks but also predict real-life self-control, thereby bridging the gap between laboratory research and real-life behavior.

Family conversation between homes is difficult to initiate at mutually agreeable times as neither participant has exact knowledge of the other's activities or intentions. Whether calling to plan an important family gathering or simply to connect with family members, the question is: Is now a good time to call? People expect friends and family to learn their activity patterns and to minimize interruptions when calling. Can technology provide awareness cues to the caller, even prior to the initiation of the call? This research focuses on sampling the everyday activities of home life to determine environmental factors, which may serve as an indicator for availability. These external factors may be effective for identifying household routines of availability and useful in determining when to initiate conversation across homes. Several workplace studies have shown a person's interruptibility can be reliably assessed and modeled from specific environmental cues; this work looks for similar predictive power in the home. Copresence, location, and activity in the home were investigated as correlates to availability and for their effectiveness within the social protocol of family conversation. These studies indicate there are activities that can be sensed, either in real-time or over some time span, that correlate to self-reported availability. However, the type and amount of information shared is dependent upon individual preferences, social accessibility, and patterns of activities. This research shows friends and family can improve their predictions of when to call if provided additional context, and suggests that abstract representations of either routines or explicit availability status is sufficient and may be preferred by providers. Availability prediction is feasible in the home and useful to those outside the home, but the level of detail to provide in particular situations needs further study. This work has implications for the development of groupware systems, the automatic sensing of activity to deal with interruption, and activity recognition in the home.