This study seeks to develop a method that generalises the use of Adams-Bashforth to solve or treat partial differential equations with local and non-local differentiation by deriving a two-step Adams-Bashforth numerical scheme in Laplace space. The resulting solution is then transformed back into the real space by using the inverse Laplace transform. This is a powerful numerical algorithm for fractional order derivative. The error analysis for the method is studied and presented. The numerical simulations of the method as applied to the four-dimensional model, Caputo-Lu-Chen model and the wave equation are presented. In the analysis, the bifurcation dynamics are discussed and the periodic doubling processes that eventually caused chaotic behaviour (butterfly attractor) are shown. The related graphical simulations that show the existence of fractal structure that is characterised by chaos and usually called strange attractors are provided. For the Caputo-Lu-Chen model, graphical simulations have been realised in both integer and fractional derivative orders. / Mathematical Sciences / M. Sc. (Applied Mathematics)

Fractional calculus has been used as a research tool in the fields of pharmacology, biology, chemistry, and other areas [3]. The main purpose of this thesis is to calculate Green's functions of fractional difference equations, and to model problems in pharmacokinetics. We claim that the discrete fractional calculus yields the best prediction performance compared to the continuous fractional calculus in the application of a one-compartmental model of drug concentration. In Chapter 1, the Gamma function and its properties are discussed to establish a theoretical basis. Additionally, the basics of discrete fractional calculus are discussed using particular examples for further calculations. In Chapter 2, we use these basic results in the analysis of a linear fractional difference equation. Existence of solutions to this difference equation is then established for both initial conditions (IVP) and two-point boundary conditions (BVP). In Chapter 3, Green's functions are introduced and discussed, along with examples. Instead of using Cauchy functions, the technique of finding Green's functions by a traditional method is demonstrated and used throughout this chapter. The solutions of the BVP play an important role in analysis and construction of the Green's functions. Then, Green's functions for the discrete calculus case are calculated using particular problems, such as boundary value problems, discrete boundary value problems (DBVP) and fractional boundary value problems (FBVP). Finally, we demonstrate how the Green's functions of the FBVP generalize the existence results of the Green's functions of DVBP. In Chapter 4, different compartmental pharmacokinetic models are discussed. This thesis limits discussion to the one-compartmental model. The Mathematica FindFit command and the statistical computational techniques of mean square error (MSE) and cross-validation are discussed. Each of the four models (continuous, continuous fractional, discrete and discrete fractional) is used to compute the MSE numerically with the given data of drug concentration. Then, the best fit and the best model are obtained by inspection of the resulting MSE. In the last Chapter, the results are summarized, conclusions are drawn, and directions for future work are stated.

This work revolves around the use of fractional order calculus in control science. Techniques such as fractional order universal adaptive stabilization (FO-UAS), and the fascinating results of their application to real-world systems, are presented initially. A major portion of this work deals with fractional order modeling and control of real-life systems like heat flow, fan and plate, and coupled tank systems. The fractional order models and controllers are not only simulated, they are also emulated using analog hardware. The main aim of all the above experimentation is to develop a fractional order controller for plasma position control of the Saskatchewan torus-1, modified (STOR-1M) tokamak at the Utah State University (USU) campus. A new method for plasma position estimation has been formulated. The results of hardware emulation of plasma position and its control are also presented. This work performs a small scale test measuring controller performance, so that it serves as a platform for future research efforts leading to real-life implementation of a plasma position controller for the tokamak.

No description available.

Fractional calculus has been used as a research tool in the fields of pharmacology, biology, chemistry, and other areas [3]. The main purpose of this thesis is to calculate Green's functions of fractional difference equations, and to model problems in pharmacokinetics. We claim that the discrete fractional calculus yields the best prediction performance compared to the continuous fractional calculus in the application of a one-compartmental model of drug concentration. In Chapter 1, the Gamma function and its properties are discussed to establish a theoretical basis. Additionally, the basics of discrete fractional calculus are discussed using particular examples for further calculations. In Chapter 2, we use these basic results in the analysis of a linear fractional difference equation. Existence of solutions to this difference equation is then established for both initial conditions (IVP) and two-point boundary conditions (BVP). In Chapter 3, Green's functions are introduced and discussed, along with examples. Instead of using Cauchy functions, the technique of finding Green's functions by a traditional method is demonstrated and used throughout this chapter. The solutions of the BVP play an important role in analysis and construction of the Green's functions. Then, Green's functions for the discrete calculus case are calculated using particular problems, such as boundary value problems, discrete boundary value problems (DBVP) and fractional boundary value problems (FBVP). Finally, we demonstrate how the Green's functions of the FBVP generalize the existence results of the Green's functions of DVBP. In Chapter 4, different compartmental pharmacokinetic models are discussed. This thesis limits discussion to the one-compartmental model. The Mathematica FindFit command and the statistical computational techniques of mean square error (MSE) and cross-validation are discussed. Each of the four models (continuous, continuous fractional, discrete and discrete fractional) is used to compute the MSE numerically with the given data of drug concentration. Then, the best fit and the best model are obtained by inspection of the resulting MSE. In the last Chapter, the results are summarized, conclusions are drawn, and directions for future work are stated.

Orientadores: Edmundo Capelas de Oliveira, Ary Orozimbo Chiacchio / Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação Cientifica / Made available in DSpace on 2018-08-12T21:42:46Z (GMT). No. of bitstreams: 1 Camargo_RubensdeFigueiredo_D.pdf: 9956358 bytes, checksum: 45d7b7d76ae44d9b713d341ffc7a1ad5 (MD5) Previous issue date: 2009 / Resumo: Apresentamos neste trabalho um estudo sistemático e detalhado sobre integrais e derivadas de ordens arbitrárias, o assim chamado cálculo de ordem não-inteira, popularizado com o nome de Cálculo Fracionário. Em particular, discutimos e resolvemos equações diferenciais e integrodiferenciais de ordem não-inteira e suas aplicações em diversas áreas do conhecimento, bem como apresentamos resultados inéditos, isto é, teoremas de adição, envolvendo as funções de Mittag-Leffler. Após abordar as diferentes definições para a derivada de ordem não-inteira, justificamos o fato de utilizarmos, em nossas aplicações, a definição de derivada conforme proposta por Caputo, mais restritiva, e não a definição segundo Riemann-Liouville, embora seja esta a mais difundida. Nas aplicações apresentamos uma generalização para a equação diferencial associada ao problema do telégrafo na versão fracionária, cuja solução, obtida de duas maneiras distintas, deu origem a dois novos teoremas de adição envolvendo as funções de Mittag-Leffler. Numa segunda aplicação, discutimos o conhecido sistema de Lotka-Volterra na versão fracionária; por fim, introduzimos e resolvemos uma equação integrodiferencial fracionária, a assim chamada, equação de Langevin generalizada fracionária. / Abstract: At this work we present a systematic and detailed study about integrals and derivatives of arbitrary order, the so-called non-integer order calculus, popularized with the name Fractional Calculus. Particularly, we discuss and solve non-integer order differential and integrodifferential equations and its applications into several areas of the knowledge, as well as introduce some new results, i.e., addition theorems, involving the Mittag-Leffler functions. After approaching the different definitions to the non-integer order derivative, we justify the fact that we use, in our applications, the definition proposed by Caputo to the fractional derivative, which is more restrictive, instead of the Riemann-Liouville ones, although this one is best known. Into the applications we presented a fractional generalization to the equation associated with the telegraph's problem, whose solution, obtained by two different ways, was the origin of two new addition theorems to the Mittag-Leffler functions. As a second application, we present the fractional version of the Lotka-Volterra system; finally, we introduce and solve the fractional generalized Langevin equation. / Doutorado / Doutor em Matemática

Orientador: Edmundo Capelas de Oliveira / Dissertação (mestrado profissional) - Universidade Estadual de Campinas, Instituto de Matematica, Estatistica e Computação Cientifica / Made available in DSpace on 2018-08-11T17:01:55Z (GMT). No. of bitstreams: 1 Rosendo_DaniloCastro_M.pdf: 1231397 bytes, checksum: 33e1a80ea06fa615b7b7aec7917bbbe2 (MD5) Previous issue date: 2008 / Resumo: Neste trabalho abordamos um estudo da equação diferencial ordinária, linear, homogênea de segunda ordem com três singularidades regulares, incluindo uma no infinito de onde obtivemos a equação hipergeométrica e, através do método de Frobenius, introduzimos a função hipergeométrica com singularidade na origem. Por um conveniente processo de limite na equação hipergeométrica obtivemos a equação hipergeométrica confluente, bem como a função hipergeométrica confluente. Apresentamos a função de Mittag-Le²er como uma generalização da função exponencial e suas relações com outras funções, em especial com a função hipergeométrica confluente. Abordamos o conceito de integral e derivada de ordens fracionárias de algumas funções conhecidas. Através da metodologia da transformada de Laplace discutimos uma equação diferencial fracionária com coeficientes constantes de onde emergem as funções de Mittag-Leffler. Por fim, definimos as equações diferenciais fracionárias e, como aplicação, efetuamos um estudo sistemático do oscilador harmônico fracionário. / Abstract: This work presents an introductory study of a second order, linear and homogeneous, ordinary differential equation with three singular regular points, including a singularity at the infinity. We obtain the hypergeometric equation and, by means of the Frobenius method, we introduce the hypergeometric function which is regular at the origin. By a convenient limit process we obtain the confluent hypergeometric equation which has the confluent hypergeometric function as a regular solution at the origin. We introduce the Mittag-Leffler function as a generalization of the exponential function and present a relation with the confluent hypergeometric function. Finally, we present the so-called fractional ordinary differential equation and as an application we discuss the fractional harmonic oscillator / Mestrado / Mestre em Matemática

No description available.

Orientador: Rubens de Figueiredo Camargo / Resumo: O presente trabalho apresenta a nova modelagem fracionária, que considera propriedades hereditárias e efeitos de memória, no modelo de Gompertz, para descrever a evolução do câncer causado pela infecção do HPV 16. Devido a variabilidade do desenvolvimento do câncer em humanos, utiliza-se o crescimento in vivo do tumor em camundongo transgênico que expressam os oncogenes E6 e E7 tratados com DMBA / TPA (inicializador e promotor do HPV 16) para capturar as características gerais dessa variabilidade. Resultados mostram que a inserção de um novo parâmetro na correção dimensional da modelagem fracionária, descreve, em comparação ao modelo clássico, o progresso do volume tumoral em maior conformidade com os conjuntos de dados reais. / Abstract: The present work presents the fractional modeling, which considers hereditary properties and memory effects, to describe through the Gompertz model, the evolution of cancer caused by HPV 16 infection. Due to the variability of the development of cancer in humans, we used the in vivo growth of the transgenic mouse tumor expressing DMBA / TPA-treated E6 and E7 oncogenes (HPV 16 initiator and promoter) to capture the general characteristics of this variability. Results show that the insertion of a new parameter in the dimensional correction of fractional modeling describes, compared to the classical model, the progress of tumor volume in greater concorda with the actual data sets. / Doutor

<p dir="ltr">The continuous advancements in material science and manufacturing engineering have revolutionized the material design and fabrication techniques therefore drastically accelerating the development of complex structured materials. These novel materials, such as micro/nano-structures, composites, porous media, and metamaterials, have found important applications in the most diverse fields including, but not limited to, micro/nano-electromechanical devices, aerospace structures, and even biological implants. Experimental and theoretical investigations have uncovered that as a result of structural and architectural complexity, many of the above-mentioned material classes exhibit non-negligible nonlocal effects (where the response of a point within the solid is affected by a collection of other distant points), that are distributed across dissimilar material scales.</p><p dir="ltr">The recognition that nonlocality can arise within various physical systems leads to a challenging scenario in solid mechanics, where the occurrence and interaction of nonlocal elastic effects need to be taken into account. Despite the rapidly growing popularity of nonlocal elasticity, existing modeling approaches primarily been concerned with the most simplified form of nonlocality (such as low-dimensional, isotropic, and homogeneous nonlocal problems), which are often inadequate to identify the nonlocal phenomena characterizing real-world problems. Further limitations of existing approaches also include the inability to achieve a mathematically well-posed theoretical and physically consistent framework for nonlocal elasticity, as well as the absence of numerical approaches to achieving efficient and accurate nonlocal simulations. </p><p dir="ltr">The above discussion identifies the significance of developing theoretical and numerical methodologies capable of capturing the effect of nonlocal elastic behavior. In order to address these technical limitations, this dissertation develops an advanced continuum mechanics-based approach to nonlocal elasticity by using fractional calculus - the calculus of integrals and derivatives of arbitrary real or even complex order. Owing to the differ-integral definition, fractional operators automatically possess unusual characteristics such as memory effects, nonlocality, and multiscale capabilities, that make fractional operators mathematically advantageous and also physically interpretable to develop advanced nonlocal elasticity theories. In an effort to leverage the unique nonlocal features and the mathematical properties of fractional operators, this dissertation develops a generalized theoretical framework for fractional-order nonlocal elasticity by implementing force-flux-based fractional-order nonlocal constitutive relations. In contrast to the class of existing nonlocal approaches, the proposed fractional-order approach exhibits significant modeling advantages in both mathematical and physical perspectives: on the one hand, the mathematical framework only involves nonlocal formulations in stress-strain constitutive relationships, hence allowing extensions (by incorporating advanced fractional operator definitions) to model more complex physical processes, such as, for example, anisotropic and heterogeneous nonlocal effects. On the other hand, the nonlocal effects characterized by force-flux fractional-order formulations can be physically interpreted as long-range elastic spring forces. These advantages grant the fractional-order nonlocal elasticity theory the ability not only to capture complex nonlocal effects, but more remarkably, to bridge gaps between mathematical formulations and nonlocal physics in real-world problems.</p><p>An efficient nonlocal multimesh finite element method is then developed to solve partial integro-differential governing equations in the fractional-order nonlocal elasticity to further enable nonlocal simulations as well as practical applications. The most remarkable consequence of this numerical method is the mesh-decoupling technique. By separating the numerical discretization and approximation between the weak-form integral and nonlocal integral, this approach surpasses the limitations of existing nonlocal algorithms and achieves both accurate and efficient finite element solutions. Several applications are conducted to verify the effectiveness of the proposed fractional-order nonlocal theory and the associated multimesh finite element method in simulating nonlocal problems. By considering problems with increasing complexity ranging from one-dimensional to three-dimensional problems, from isotropic to anisotropic problems, and from homogeneous to heterogeneous nonlocality, these applications have demonstrated the effectiveness and robustness of the theory and numerical approach, and further highlighted their potential to effectively model a wider range of nonlocal problems encountered in real-world applications.</p>