No description available.

No description available.

Background: Bloodstream infection (BSI) caused by Klebsiella pneumoniae (KP), is a leading cause of hospitalassociated childhood mortality. There are limited data on how poor outcomes of KPBSI can be predicted in poorly resourced areas. This study aimed to assess if the profile of differential counts from full blood counts (FBC) taken at two time points in children <13 years with KPBSI could be used to predict the risk of death. Methods We conducted a retrospective study of a cohort of children admitted to hospital between 2006-2011 with KPBSI. FBC collected within 48 hours (T1) of blood culture and 5-14 days later (T2), were reviewed. Differential counts were classified as abnormal if they were higher or lower than laboratory ranges for normal results. The risk of death was assessed for each category of differential counts. Risk ratios adjusted (aRR) for potential confounders were used to estimate the effect of cell counts on risk of death using multivariable analysis. Data were stratified by HIV status. Results: Of 296 children included, median age 5 (IQR:2-13) months, 82 were HIV -infected. Ninety-five (32%) of the children with KPBSI died. Mortality in HIV-infected and uninfected children was 39/82 (48%) and 56/214 (26%), respectively (p <0.001). Independent associations with mortality were observed with leucopenia, neutropenia and thrombocytopenia. Risk of mortality in children with thrombocytopenia at T1 and T2 was aRR 2.5 (95% CI: 1.34-4.64) and 3.18 (95% CI: 1.31-7.73) respectively in the HIV-uninfected group, whereas the risk for mortality in the HIV-infected group with thrombocytopaenia at T1 and T2 was aRR 1.99 (95% CI: 0.94-4.19) and 2.01 (95% CI: 0.65-5.99) respectively. Neutropenia in the HIV-uninfected group at T1 and T2, showed aRR 2.17 (95% CI: 1.22- 3.88) and 3.70 (95% CI 1.30-10.51) respectively, while in the HIV-infected group, they were aRR 1.18 (95% CI 0.69-2.03) and 2.05 (0.87-4.85) at similar time points. Risk of mortality related to leucopenia at T2 was associated with mortality in HIV-uninfected and HIV-infected patients was aRR 3.22 (95%CI 1.22-8.51) and 2.34 (1.09-5.04) respectively. Persistently high band cell percentage at T2 in HIVinfected children indicated a risk of mortality of aRR 2.91 (95% CI 1.20-7.06). Conclusion Abnormal neutrophil counts and thrombocytopenia are independently associated with significant mortality in children with KPBSI. In resource-limited countries haematological markers have the potential to predict KPBSI mortality.

Accessibility in back-end development is often overlooked, with the majority of discussions and efforts centered on front-end design. To make applications usable for a wider audience, developers must also prioritize incorporating accessibility from the back-end. Back-end web accessibility encompasses the design and development of web-based systems and applications that are accessible to all users, including those with disabilities. This involves optimizing the underlying code and infrastructure for accessibility and implementing features that enable users with disabilities to navigate and interact with the site or application. Ensuring back-end web accessibility is crucial for creating an inclusive online environment accessible to everyone, regardless of their abilities. Presently, there is a significant gap in research regarding back-end accessibility specifics. This study investigates the challenges in implementing back-end accessibility, explores best practices, and aims to facilitate future research on its impact on user experience and system performance.

Within the professional field of TESOL (Teaching English to Speakers of Other Languages), it is not unusual for highly qualified instructors to teach several part-time jobs in order to support themselves. Despite advocacy efforts carried out by the international TESOL organization, finding rewarding full-time employment in the United States can be very challenging. In addition, with the current state of the economy and high unemployment, TESOL professionals like others in various fields are seeking stable employment. Although this research will not solve the lack of full-time jobs, the intention is to help job seekers better prepare themselves for today's job market by knowing the skills, knowledge, and personal characteristics that employers are looking for in potential hires. To identify this information, a 12-month review was conducted of three well-established employment websites in an effort to capture advertisements seeking to hire TESOL professionals full-time for ESL related positions in the U.S. A total of 169 job advertisements were collected and reviewed to identify the skills, knowledge, and personal characteristics employers were seeking in qualified individuals. Data from the advertisements were organized into a 42-category coding scheme in an effort to delineate the skills, knowledge, and job characteristics mentioned previously. In addition, a second coding scheme containing 12 categories was created for analyzing the personal characteristics listed in the advertisements Results from this data revealed that employers seek applicants who have knowledge and experience in curriculum development, teacher education, and program administration. Top skills include written and oral communication and basic computer skills. With regards to personal characteristics, employers are most interested in individuals possessing strong interpersonal and teamwork skills. In addition to these skills and qualifications, the data provide important insights concerning the distribution of jobs by job type, degree, institution type, and salary across five regions of the United States.

Vi ville, med en fysisk struktur som slutmål, undersöka och reflektera kring vilka svårigheter och möjligheter som byggd arkitektur möter. I ett försök att inledningsvis frigöra oss från en alltför formalistisk arbetsprocess utgick vi från leken som en kreativ katalysator. Leken, och speciellt den lekande människan, kom att informera projektet på era sätt. Exempelvis har det hela tiden funnits en stark känsla av serendipitet under projektutvecklingen som vi bejakat och tagit på allvar. Vi har drivits av ett lätt situationistiskt tankesätt, där handling, speciellt under projektets tidiga faser, tilllåtits gå före rigid logik. Med visst instämmande i Debords resonemang i Skådespelarsamhället har vi velat bryta mot skolans och samhällets passiviserande inverkan. / We wanted to, with a physical structure, investigate and reflect on the difficulties and opportunities that built architecture meets. In an attempt to initially free ourselves from an overly formalistic work process, we saw the art of play as a catalyst for creativity. The play, and especially the playful human, influenced the project in several ways. For example, there has always been a strong sense of serendipity during the project development. We have been driven by a situationist mindset, in which action, especially during the early stages of the project, has prevailed over planning. In agreement with Debord’s reasoning in “The Society of the Spectacle” and Lefebvres “Right to the City”, we saw an opportunity to go against the passivizing influence induced by school and society.

Most art galleries around the world look the same; a large white room with a few artworks placed far apart. This standard way of designing art spaces together with locating them almost exclusively in the city centers makes them both physically and culturally distant for many people.  This project aims to explore other ways of displaying art to make it accessible to more people through small architectural interventions. It is an exploration about the relation between space the body and the object. A prototype for a mobile art gallery has been built as a testing device.

The aim of this study was to investigate whether there is a statistically significant difference in quality of instruction as delivered by full-time and part-time adjunct faculty in community colleges by utilizing data obtained from the Kentucky Community and Technical College (KCTCS) student evaluation of instruction instrument at Southeast Kentucky and Hazard community and technical colleges. The evaluation instrument is used to rate the instructor in the following areas: (a) clarity of course goals; (b) clarity of attendance policy; (c) examinations being a fair measure of progress; (d) clear standards of grading; (e) presentation of course material; (f) clear and to the point explanations of concepts; (g) instructor?s enthusiasm towards subject material; (h) instructor?s concern for student progress in the course; (i) instructor availability before and after class; (j) the instructor?s teaching methods promote interest in the subject area; (k) how much the course has taught the student about the subject; (l) syllabus detailing course requirements and policies was provided and explained; (m) class starts on time and as scheduled; (n) instructor meets the class for the full-time scheduled. SPSS version 14.0 was used in this project. Cross tabulations were performed for each question in the evaluation. Group statistics were computed for the data providing the means, standard deviation, and standard error of the mean for each question. Independent sample tests were also performed, including Levene?s test for equality of variances and T tests for equality of means. The findings of the study indicate that there was no statistically significant difference in student satisfaction in classes taught by adjunct (part-time) instructors and full-time instructors. Discussion of the findings and theoretical and policy implications were offered.

A simulation-based reliability analysis method is presented and evaluated. This method is intended for problems for which most probable point of failure (MPP) search-based methods fail or provide inaccurate results, and for which Monte Carlo simulation and its variants are too costly to apply. This may occur in the evaluation of complex engineering problems of low failure probability. The method used to address this problem is a variant of conditional expectation and works by sampling on the failure boundary without relying on the MPP. The effectiveness of the method is compared to a selection of other commonly available reliability methods considering a variety of analytical as well as more complex engineering problems. The results indicate that the method has the potential to deliver solutions of high efficiency and accuracy for a wide range of difficult reliability problems.

No description available.