No description available.

Orientador: Jorge Tulio Mujica Ascui / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matemática Estatística e Computação Científica / Made available in DSpace on 2018-08-27T12:08:37Z (GMT). No. of bitstreams: 1 MelendezCaraballo_Blas_M.pdf: 1140173 bytes, checksum: 61bc3f801fdfc8946dd6852692a39bfd (MD5) Previous issue date: 2015 / Resumo: Em 1960, Pelczynski [1] provou que, se X é um dos espaços c0 ou lp, com p número real maior ou igual do que um. Então todo subespaço complementado de dimensão infinita de X é isomorfo a X. Outro resultado clássico de Pelczynski [1] afirma que se p é um número real maior do que um, então o espaço Lp[0,1] contém um subespaço complementado isomorfo a l2. Nosso objetivo é estudar os resultados deste tipo, e introduzir alguns problemas abertos. BIBLIOGRAFIA [1] A. Pelczynski, Projections in certain Banach spaces, Studia Methematica, 19 (1960), pág. 209-228 / Abstract: In 1960, Pelczynski [1] showed that if X is one of the spaces c0 or lp, p real number greater than or equal to one. Then each infinite dimensional subspace complemented in X is isomorphic to X. Another classical result of Pelczynski [1] states that if p is a real number greater that one, then the space Lp[0,1] contains a complemented subspace isomorphic to l2. Our aim is to study results of this kind, and to introduce some open problems. BIBLIOGRAFIA [1] A. Pelczynski, Projections in certain Banach spaces, Studia Methematica, 19 (1960), pág. 209-228 / Mestrado / Matematica / Mestre em Matemática

Leishmania é um gênero de protozoários tripanossomatídeos, dimórficos, causadores das leishmanioses. As espécies do subgênero Viannia, como Leishmania (Viannia) braziliensis, são causadoras da leishmaniose cutânea e cutâneo-mucosa nas Américas Central e do Sul. A regulação da expressão gênica em Leishmania ocorre preferencialmente no nível póstranscricional com a participação de elementos regulatórios de ação cis e trans e proteínas ligantes de RNA. Neste contexto, RNAs não codificadores (ncRNAs) conhecidos por seus papéis regulatórios em diversos organismos, ainda são pouco explorados em Leishmania. Sendo assim, o presente estudo analisou o transcriptoma de L. braziliensis explorando o conteúdo codificador e não codificador do parasita. A investigação de expressão diferencial (DE), incluindo análises de enriquecimento de ontologias gênicas, confirmou padrões de expressão, por categoria funcional, como os já reportados para outras espécies de Leishmania durante o desenvolvimento. No entanto, a avaliação do conjunto desses genes DE, empregando a ortologia como parâmetro, sugeriu uma possível contribuição de genes parálogos para a diversidade entre espécies de Leishmania. Para a análise de ncRNAs, um pipeline desenvolvido por Patrícia C. Ruy possibilitou a identificação e caracterização de 11372 ncRNAs putativos em L. braziliensis. Análises acerca dos padrões de expressão diferencial foi conduzido e trinta e cinco ncRNAs putativos foram categorizados, selecionados e submetidos a Northern blotting para avaliação do tamanho e confirmação do padrão de expressão; seis genes foram selecionados para análises funcionais subsequentes. Para avaliação de uma possível função para os ncRNAs a serem investigados, foram gerados parasitos nocaute de cinco desses ncRNAs. O crescimento dos parasitos nocaute em cultura axênica não foi afetado pela ausência dos genes mas o perfil de infecção de macrófagos in vitro foi afetado em 4 dos 6 transfectantes; sugerindo que os ncRNAs sejam funcionais. Cinco ncRNAs foram submetidos a ensaios de pull-down e o conjunto de proteínas ligantes desses transcritos foi identificada. Esse estudo do transcriptoma de L. braziliensis contribui para o entendimento da modulação da expressão dos genes codificadores de proteínas, revela o conteúdo de ncRNA putativos, sua expressão diferencial durante o seu desenvolvimento e ensaia os primeiros estudos funcionais sobre os últimos / Leishmania is a genus of trypanosomatid protozoan parasites, causative agents of leishmaniases. Viannia sub-genera species as Leishmania (Viannia) braziliensis are the causative agents of cutaneous and muco-cutaneous leishmaniasis in Central and South America. The gene expression in this parasites is regulated via post-transcriptional mecanisms comprising the action of cis and trans regulatory elements and RNA binding proteins. In this context, non coding RNAs poorly explored as putative factors involved in regulation of gene expression in Leishmania must be investigated. In this study the transcriptome of coding and ncRNAs of L. braziliensis were analysed. Differential expression analysis, including gene ontology enrichment analysis, during the parasite development revealed the expected paterns for gene expression in Leishamnia spp. A comparative analysis, considering up-regulated genes suggested a contribution of paralogues genes to diversity between Leishmania. spp. To uncover putative ncRNAs, a computational pipeline was previous designed identifying and characterizing 11,372 putative ncRNAs in L. braziliensis, allowing a classification into different ncRNAs classes. The differential expression analysis revealed similar patterns to those observed for protein coding genes. Thirty-five putative ncRNAs were categorized, selected and subjected to Northern blotting being 6 of them selected to functional analysis. These selected group was investigated conducting and stablishing knockout lines, that revealed phenotypic differences concerning diminishing in promastigote growth and in vitro macrophage infection, suggesting possible functional roles of ncRNAs in L. braziliensis. Finnaly, the protein interactions of these ncRNAs were revealed and must be explored in the future to uncover possible regulatory roles of this ncRNAs until now, putative in L. braziliensis. This work represents an outline of L. braziliensis transcriptome contributing to improve the understanding of coding and noncoding RNA content in the parasite

Le macro-outillage est un outillage en pierre dont les supports sont bruts ou peu façonnés. Il est traditionnellement exclu des études de l’industrie lithique taillée et il en résulte une certaine méconnaissance de ce mobilier. Cette thèse tente de combler cette lacune dans l’Ouest de la France, du Néolithique ancien à l’âge du Bronze ancien. Sur la base d’une vingtaine d’assemblages fournissant un corpus de près de 3000 pièces, la typologie de cet outillage est d’abord établie. Une quarantaine de types d’outils sont ainsi décrits et interprétés, avec plus ou moins de précision selon la quantité et la qualité des données disponibles. La démarche est ensuite constamment transversale, pour interroger cet outillage sur un maximum d’aspects des premières sociétés agropastorales. Suivant le déroulement de la chaîne opératoire, une approche technofonctionnelle documente la conception et la gestion de cet outillage. Le macro-outillage se révèle être un sous-système technique cohérent, avec des stratégies adaptées aux ressources et aux besoins, de bonnes connaissances techniques et une grande importance économique. Une première approche chronoculturelle aboutit à des résultats mitigés, d’abord en raison d’une documentation relativement insuffisante comparée à l’étendue de l’espace-temps considéré dans ce travail, mais aussi parce qu’il s’agit d’un mobilier très faiblement empreint de caractères culturels. La géographie apparaît comme un facteur de variation plus important, le macro-outillage étant adapté tant aux ressources qu’aux besoins locaux. Les déterminismes environnementaux sont cependant peu marqués, les hommes ayant toujours pu effectuer des choix en fonction de critères techniques et fonctionnels, plus déterminants. Le macro-outillage se place ainsi à l’interface entre l’homme et son environnement et constitue un excellent marqueur économique. / Ground stone tools are stone tools whose blanks are raw or poorly shaped. They are usually excluded of the knapped stone studies, and consequently are rather unrecognized. This thesis tries to fill this gap in Western France, from the early Neolithic to the early Bronze Age. First, the ground stone tools typology is established by the study of twenty collections, supplying a corpus of about 3000 artefacts. About forty tool types are described and interpreted, with more or less precision depending on the quantity and the quality of the data available. The thesis then follows a diachronic approach, to question these tools on most aspects of the earliest farmers’ societies. Following the chaîne opératoire process, a techno-functional analysis documents the ground stone tools’ conception and management. These tools turn out to compose a coherent technical sub-system, with strategies suited to the people’s resources and to the needs; demonstrating good technical knowledge and a high economic importance. The chronological and cultural analysis leads to mixed results, firstly because data is relatively insufficient compared to the large area and the long period studied, but also because ground stone tools wear very few cultural marks. Geography appears to be a more significant variation factor, as ground stone tools are adapted to both local resources and needs. There is however little environmental determinism, as humans have always been able to make choices according to technical and functional criteria, which are more determining. Ground stone tools therefore link humans and their environment and make an excellent economic marker.

We administered the Motivation Assessment Scale (MAS) and the Questions About Behavioral Function (QABF) to five raters and compared the results with functional analysis outcomes for 12 cases in which agreement was obtained for at least four out of five raters on either anecdotal assessment. The scores for functional categories on the MAS and QABF were ranked by averaging the scores for the raters who agreed on the primary maintaining variable. Functional analysis results were ranked by examining average responding across all conditions. A comparison showed correspondence between the highest category and the highest functional analysis condition for 10 out of 11 cases for the MAS and all 10 cases for the QABF. Correspondence for the category and condition ranked second was found for 2 out of 11 cases for the MAS and 2 out of 10 cases for the QABF. The magnitude of difference between categories on the MAS/QABF did not appear to predict the amount of difference in responding in the corresponding functional analyses.

In this paper we derive the eigenfunctions to the Hamiltonian operator associated with the Harmonic Oscillator, and show that they are given by the Hermite functions. Then we prove that the Hermite functions form an orthonormal basis in the underlying Hilbert space. We also classify the inverse to the Hamiltonian operator as a Schatten-von Neumann operator. Finally, we derive the fundamental solution to the Schrödinger Equation corresponding to the Harmonic Oscillator using Mehler’s formula.

In my graduation thesis I analyse the present state of information system at a company. I focus on the general administration of an order and a choice of innovative system that will lead to automation of the entire process. As one of the possible solutions I recommend a new information system that uses Yourdon’s modern structured analysis. Another possibility is one of the commercial solutions already available in the market. The part of the new solution is functional analysis and economic evaluation of the investment.

The diploma thesis is focused on the use of technical innovation as a tool for increasing competitiveness of the wire saw for cutting silicon. In the paper are described theoretical bases for solving of product innovation. Based on market analysis, customer feedback and the results of functional analysis, in the diploma thesis are proposed innovations, which should contribute to increase competitiveness of the product on the global market.

Cette thèse est consacrée à l’étude de phénomènes de propagation et de concentration dans des modèles d’équations intégro-différentielles venant de la écologie. On étudie certaines équations de réaction-diffusion non locales apparaissant en dynamique de populations, ainsi que des modèles représentant l’évolution Darwinienne avec un mode de reproduction sexué.Dans une première partie, nous étudions la propagation spatiale pour une équation de réaction-diffusion ou la dispersion opère via un noyau de convolution à queue lourde. Nous mesurons de manière précise l’accélération du front de propagation de la solution. Nous proposons également une échelle adaptée pour mesurer les «petites» mutations. Dans les deux cas nous utilisons le formalisme des équations de Hamilton-Jacobi.Dans un second temps nous étudions un modèle de génétique quantitative, avec un mode de reproduction sexuée. Un petit paramètre mesure la déviation entre le trait des descendants est la moyenne des traits des parents. Dans le régime où ce paramètre est petit nous étudions l’existence de solutions stationnaires, puis le problème de Cauchy lié à ce modèle. Les solutions se concentrent autour des optima de sélection, sous la forme de perturbations de distributions Gaussiennes avec petite variance fixée par le paramètre. Notre analyse généralise le cas linéaire de la reproduction asexuée en utilisant des outils d’analyse perturbative. Enfin dans une dernière partie nous fournissons des simulations numériques et des méthodes mathématiques pour étudier la dynamique interne des équilibres dans le régime de petite variance, pour les deux modes de reproduction : asexué et sexué. / This manuscript tackles propagation and concentration phenomena in different integro-differential equations with a background in ecology. We study non local reaction-diffusion equations from population dynamics, and models for Darwinian evolution with a sexual or asexual mode of reproduction, with a preference for the former.In a first part, we study spatial propagation for a reaction diffusion equation where dispersion acts through a fat tailed kernel. We measure accurately the acceleration of the propagation front of the population. We propose as well a scaling well adapted to “small mutations” when we consider the model in the context of adaptative dynamics. This scaling is very natural following the previous spatial investigation. In both cases we look at the long time behavior and we use the Hamilton-Jacobi framework. Then we turn our attention towards a quantitative genetics model, with a sexual mode of reproduction, imposed by the “infinitesimal operator”. In this non-linear setting, a small parameter tunes the deviation between the phenotypic trait of the offspring and the mean of the traits of the parents. In the regime where this parameter is small, we prove existence of stationary solutions, and their local uniqueness. We also provide an example of non-uniqueness in the case where the selection function admits several extrema. We prove that the solution concentrates around the points of minimum of the selection function. The analysis is carried by the small perturbations of special profiles : Gaussian distributions with small variance fixed by the parameter.We then study the stability of the Cauchy problem associated to the previous model. This time we prove that at all times, for a well prepared initial data, the solutions is arbitrary close to a Gaussian distribution with small variance. The proof follows the framework of the previous : we use perturbative analysis tools, but this time an even more precise description of the correctors is needed and we linearize the equation to obtain it. In a final part we show numerical simulations and different mathematical approaches to study inside dynamics of phenotypic lineages in the regime of small variance, with a moving environement.

This thesis report aims to help the client developing their new product. The new product to be developed is a safety bracket for a safety system. The safety bracket connects different parts which create the safety system and it should be able to withstand impacts from moving objects. The client has a set of requirements that needs to be addressed during the product development process. One of the most important requirements that must be fulfilled is the given impact energy that the safety bracket must withstand. The methodology used during this thesis work is the product development processes (PDP). The product development process is used to find concepts that have the potential to answer the research questions and to fulfil the requirements. Some methods used in the product development process are brainstorming, brainwriting and combining working principles. The concepts were evaluated with a combination of Pugh´s matrix and weighting matrix. The three best concepts were selected for further development and tested with FEA simulation with Abaqus CAE. The impact simulation gave indications if the concepts could handle the impact energy and if they could fulfil the requirements. All three concepts could withstand the impact energy based on the simulations and most of the requirements could be fulfilled. The concepts with thinner profile walls had a reduction in stress and an increase in impact duration, where the kinetic energy is distributed throughout the impact. A protective shell helps with the reduction of stress and the energy absorption during the impact simulation.