China’s rural-urban migration has resulted in 61 million children living apart from their parent(s) in rural communities. Previous studies have failed to examine the long-term effects of parental migration on left-behind children’s nutritional health, and have not examined the gender differences (of parents and children) in those associations. This research uses a mixed-methods design that incorporates quantitative and qualitative techniques to explore links between parental migration, care-giving arrangements and left-behind children’s nutritional health in rural China. The quantitative analyses draw on a longitudinal dataset – the China Health and Nutrition Survey (CHNS) (1997, 2000, 2004, 2006, and 2009) to examine the relationships between children’s nutritional outcomes and different patterns of parental migration including being left behind in different stages of childhood, and being left behind by the father or the mother. The qualitative component consists of analyses of interviews with 32 caregivers (21 grandparents, 9 mothers, and 2 uncles/aunts), and children’s diaries (26 children aged 6-12, 21 left-behind children and 5 non-left-behind children) to explore the care-giving practices for left-behind children from the perspectives of a group of children and their caregivers in rural northern central China. Results of the quantitative analyses show negative associations between parental migration, especially maternal migration, and left-behind children’s nutritional outcomes indicated by anthropometric measures and macronutrient intakes, and this is particularly true for boys left behind during early life in rural China. The qualitative findings highlight the importance of socio-cultural factors, since there seems to be a paradox of intergenerational obligations for boys in a culture where sons are more valued than daughters. This is because parents migrate to save for their sons’ adult lives, reducing the remittances sent to support their sons who stay behind. There is less pressure to save for daughters’ adult lives and so more potential for remittances to support their nutrition. The research also recognizes the importance of grandparents as carers, and their experiences and beliefs about healthy eating for children. Grandparents, particularly on the paternal side, are expected to fulfil social obligations to care for left-behind grandchildren even without immediate financial returns. Inadequate financial support from the migrant parents of left-behind boys in rural China, in particular boys cared for by paternal grandparents, may result in greater risk of poor nutrition during the early childhood. This potentially renders such left-behind boys vulnerable to developmental delays. These findings are important for policy-makers to develop effective interventions to improve left-behind children’s nutritional well-being in rural China.

The Czech Republic has subscribed to fulfil the conclusions of the Fourth World Conference about Women held in Beijing in 1995. The state therefore took upon itself the obligations to address and resolve issues of equality between men and women. During the period of the 21st century gender equality has became one of the major issues being in the centre of attention of the Government, ministries and other state organs. The data and information divided by gender are collected, analyzed and presented by the Czech Statistical Office in gender statistics. The main objective of this thesis is, by using the available data statistics, to compare the status of men and women in selected areas, and with help of the concerned economic and social indicators, to map the situation and developments in the Czech society in the 21st century. In other word to find out where and to what extent the gender differences mainly occur. The analytical part of the thesis then investigates whether there have been any more significant after-shift, change, or development of selected indicators of gender statistics during the 21 century and, if so, in which analyzed area, what gender and to what extent.

abstract: It has been repeatedly shown that females have lower stability and increased risk of ankle injury when compared to males participating in similar sports activities (e.g., basketball and soccer), yet sex differences in neuromuscular control of the ankle, including the modulation of ankle stiffness, and their contribution to stability remain unknown. To identify sex differences in human ankle stiffness, this study quantified 2- dimensional (2D) ankle stiffness in 20 young, healthy men and 20 young, healthy women during upright standing over a range of tasks, specifically, ankle muscle co-contraction tasks (4 levels up to 20% maximum voluntary co-contraction of ankle muscles), weight-bearing tasks (4 levels up to 90% of body weight), and ankle torque generation tasks accomplished by maintaining offset center-of-pressure (5 levels up to +6 cm to the center-of-pressure during quiet standing). A dual-axial robotic platform, capable of perturbing the ankle in both the sagittal and frontal planes and measuring the corresponding ankle torques, was used to reliably quantify the 2D ankle stiffness during upright standing. In all task conditions and in both planes of ankle motion, ankle stiffness in males was consistently greater than that in females. Among all 26 experimental conditions, all but 2 conditions in the frontal plane showed statistically significant sex differences. Further analysis on the normalized ankle stiffness scaled by weight times height suggests that while sex differences in ankle stiffness in the sagittal plane could be explained by sex differences in anthropometric factors as well as neuromuscular factors, the differences in the frontal plane could be mostly explained by anthropometric factors. This study also demonstrates that the sex differences in the sagittal plane were significantly higher as compared to those in the frontal plane. The results indicate that females have lower ankle stiffness during upright standing thereby providing the neuromuscular basis for further investigations on the correlation of ankle stiffness and the higher risk of ankle injury in females. / Dissertation/Thesis / Masters Thesis Biomedical Engineering 2020

Background: Major depressive disorder (MDD) is a universally prevalent, genetic, and environment dependent mental condition that disables people of every culture, race, gender, and age. While the gender differences for MDD have been widely reported in literature, few genome-wide analyses of gender differences have been reported to date. Methods: We conducted a genome-wide association analysis of gender differences for MDD using the Netherlands NESDA and NTR population-based samples (1726 cases and 1630 controls). PLINK software was used to analyze the genome-wide association data of Perlegen 600 K SNP Chips. Results: We identified 40 male-specific and 56 female-specific MDD associated SNPs with P-values less than 10- 4. The best male-specific SNP was rs9352774 (P = 2.26 × 10- 6) within LGSN gene while the best female-specific SNP was rs2715148 (P = 5.64 × 10- 7) within PCLO gene. We also found 38 SNPs showing gene × gender interactions in influencing MDD (P < 10- 4). The best SNP was rs12692709 (P = 5.75 × 10- 6) near FIGN gene at 2q24.3 while the next best SNP was rs11039588 (P = 1.16 × 10- 5) within OR4B1 gene. Limitations: The findings from this study need be replicated in other populations. Conclusions: These results provide genetic basis for gender differences in MDD and will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in MDD.

No study has focussed on the longitudinal effect of APOE-ε4 genotype on the logical memory delayed recall total (LDELTOTAL) score in late-onset Alzheimer’s disease (AD). The LDELTOTAL scores were collected at baseline, 12, 24, 36 and 48 months from 382 participants with AD, 503 with cognitive normal (CN), 1293 with mild cognitive impairment (MCI) in the Alzheimer's Disease Neuroimaging Initiative (ADNI). A linear mixed model (LMM) was used to investigate the effect of APOE-ε4 on the longitudinal changes in the LDELTOTAL scores adjusted for age, gender, education and baseline Mini Mental State Examination score. There were significant differences in LDELTOTAL scores among AD, CN, and MCI (P < 0.0001) and among APOE-ε4 alleles at baseline (P < 0.0001). In the multivariable LMM, elders with 75+ years (P = 0.0051), females (P < 0.0001), lower education (P < 0.0001), AD and MCI (both P values < 0.0001) were associated with decreased LDELTOTAL values, while the individuals with 1 or 2 APOE-ε4 allele revealed significantly lower LDELTOTAL scores (both P values <0.0001) compared with individuals without APOE-ε4 allele. Further, APOE-ε4 alleles had significant interactions with four follow-up visits, where all follow-up visits showed significantly higher LDELTOTAL score. In addition, gender showed interaction with age, education and APOE-ε4 with follow-up visits. Our findings provide the first evidence of the effect of APOE-ε4 genotype on the logical memory declines related to AD. Further, APOE-ε4 alleles showed interactions with gender and follow-up visits.

Purpose: We investigated the associations of early onset polysubstance use prior to age 18 with the prevalence of bronchitis among U.S. adults and tested whether the associations differ by gender. Methods: A total of 77,950 adults, of them 2,653 with bronchitis in the past year, were from the combined 2013 and 2014 National Survey on Drug Use and Health data. The variable cluster analysis was used to classify nine variables about substance use prior to age 18 (cigarettes, cigars, smokeless tobacco, marijuana, cocaine, heroin, methamphetamines, ecstasy, and phencyclidine). Weighted multivariate logistic regression analysis (MLR) was used to examine the associations with bronchitis. Results: Nine variables were divided into two clusters: early onset poly tobacco use (three tobacco use variables) and early onset poly drug use (six drug use variables). The overall prevalence of bronchitis was 3.8% (5.1% for females and 2.3% for males). MLR analysis showed that being female, elderly (ages 65 and above), obese, and early onset poly tobacco use were associated with increased odds of bronchitis (p < 0.05). Gender-stratified analyses showed that early-onset poly tobacco use was significantly associated with bronchitis only in males, whereas early onset poly drug use was associated with bronchitis only in females. Moreover, obesity and tobacco use in the past year revealed associations with bronchitis regardless of gender. Conclusions: Obesity, early onset poly tobacco use prior to age 18, and tobacco use in the past year were positively associated with bronchitis; furthermore, the associations of early onset polysubstance use with bronchitis differed by gender, which indicated that gender differences should be considered in developing effective prevention strategies.

The words exchanged between teachers and students don't just stay in the classroom, they weave the invisible threads that shape learners' educational climate and self-confidence, paving the way for a future of success and fulfilment. The aim of this thesis is to understand how verbal interactions between students and PE teachers impact on students' gendered self-esteem, and what the consequences are for their investment in practice. Recent studies have revealed that specific feedback and encouragement from teachers can positively boost students' self-esteem, thereby promoting their engagement in the learning process. However, gender disparities in verbal interactions have also been observed, with different consequences for boys and girls. An in-depth analysis of these dynamics will provide a better understanding of how verbal interactions in the classroom can be optimized to create an inclusive and stimulating learning environment, fostering the personal and academic development of all students. Through a systemic review of qualitative and quantitative studies conducted over the last 20 years, I will identify gender differences in students' perceived verbal interactions and their positive or negative consequences on students' psychological well-being and investment in sport. The study helps to understand the role of the teacher as a facilitator of students' self- esteem and engagement, as well as providing a framework for effective and caring verbal interactions.

Terrorist organizations have always been predominantly dominated by male members in numbers of participants, supporters, and leaders. Despite men having the majority of the roles, oftentimes the world witnesses attack executed by female terrorists which deal a substantial amount of damage to the infrastructure and the peaceful civilians surrounding them. Furthermore, the sense of unpredictability and unpreparedness from the counterterrorist forces and the general public adds up to the overall advantage women possess in the field of terrorism over men. Considering these observations, one can argue that women have grown to be far more dangerous and successful in the field of terrorism than men, who still hold the absolute majority in terrorist organizations. This thesis will investigate the phenomenon of women as nontraditional terrorists through answering the question of who deals more damage per terrorist attacks between males and females by looking at four major distinct terrorist organizations and their individual cases of attacks reported in the Global Terrorism Database. The unit of measurement for this study will be the average of death and wounded tolls, while the variables investigated will be individual male/female attacks and mixed-group/male group/female group attack to evaluate the impact of female member’s presence in group-attack settings. The goal of this thesis is to raise awareness on female lethality in terrorist organizations to the counterterrorist forces and the general public which is extremely important for domestic and foreign policy/security measures.

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