O presente trabalho trata do tema da representação pictórica no contexto da representação artística e se concentra sobre as teses desenvolvidas sobre o tema nas teorias de Ernst Gombrich, Nelson Goodman, e Richard Wollheim. Procura evidenciar que, no panorama conceitual desses autores, é possível encontrar subsídios para o desenvolvimento de uma teoria da representação pictórica que suponha a dualidade entre a consciência da forma material e a consciência do conteúdo da representação de modo compatível com o tratamento do conceito em termos estruturais. O desenvolvimento do tema em Gombrich explica porque Wollheim desenvolve uma teoria da dualidade, e a hipótese interpretativa exposta no capítulo sobre o tema em Goodman visa a mostrar que uma abordagem estrutural da representação como sistema simbólico não implica em um convencionalismo estrito, na medida em que a percepção de semelhanças em um quadro relativo a aspectos estabelecidos comparativamente entre os objetos da representação e a própria representação é importante para o entendimento das imagens, de sua interpretação em um quadro aberto a convencionalizações que não sejam estabelecidas arbitrariamente, mas que atendam a uma linha de desenvolvimento compatível com o princípio de definição estabelecido pela prática artística. / This study deals with the issue of depiction in the context of artistic representation and focuses in the basic concepts developed on the subject by Ernst Gombrich, Nelson Goodman e Richard Wollheim. It focuses on the search for evidence in the conceptual framework of these authors for the support for the development of a theory of depiction that assumes twofoldness in a way that is compatible with the treatment of the concept in structural terms. Some specific drawbacks in relation to aspects of Gombrich's theory sets the ground for the explanation why Wollheim develops a twofoldness theory of depiction, and the interpretative hypothesis offered on this topic in relation to Goodman's theory aims to show that a structural approach of depiction as a symbolic system does not entail a strict or full blown conventionalism, insofar as the perception of similarities in relation to aspects in the comparison between the objects of representation and representations themselves are important for establishing the understanding of images, in an open framework of conventionalization that are no to be set arbitrarily, but that are compatible with the development with a principle of definition established by the artistic practice.

SCH-64874 (5) is a fungal metabolite that inhibits the epidermal growth factor receptor (EGFR), a high-profile oncology target, with an IC50 of 1.0µg/mL. It is of particular interest because it is unlikely to inhibit the protein’s intramolecular kinase domain (as typical chemical EGFR inhibitors do), and may act instead by obstructing the receptor’s ligand binding and/or dimerisation processes. / In this work, the epipolythiodiketopiperazine family of natural products is reviewed, leading to a discussion of the probable biosynthetic pathways by which these complex molecules are produced in nature. A laboratory synthesis based on this proposed biosynthesis was subsequently proposed and undertaken. / The oxidation of aromatic systems was investigated, which led to the synthesis, for the first time, of complex functionalised arene oxides such as 178. The regioselective epoxidation of 178 was accessed by derivatisation as the Diels-Alder adduct 180. Subsequent epoxidation and manipulation led to the amino alcohol 195b, possessing the exo-epoxide endo-alcohol stereochemistry shown. / This stereochemical assignment was based on detailed NMR analysis of the product, and also on AM1 semi-empirical molecular modelling and Ab initio molecular orbital calculations, which were used to evaluate the relative stabilities of the cyclisation products.

This dissertation is a study of a remarkable change that came about in the kind of drawings that architects used to present their work between the decades of 1960 and 1990. Drawings in this period, visually rich and compositionally complex, seemed to mark an entirely new sensibility towards their function; their goal seemed to be not so much to clearly depict the forms of a proposed building, but to instead focus on its conceptual aspects. In fact, in several cases, drawings seemed to be treated as graphic projects in their own right, over and above the work they presented. This trend was accompanied by two other developments. Around the same time, there was a sudden increase in theoretical interest in drawings within the architectural community leading to a flurry of published articles, essays and books on the topic. And all this happened to coincide with the time that the Postmodern movement came to dominate architecture. The study aims to understand the relationship between these trends, and to develop a better understanding of the reasons for these changes to have occurred. It does so by, first, developing a theoretical framework to help understand the nature and impact of the changes in drawings. Next, it presents a detailed historical account of these changes. This is followed by an in-depth study of a single architect, James Stirling, to show how the new types of drawings were not simply a means to present ideas, but played a formative role in design as well. Apart from developing a contextualized historical account of an important development in contemporary architectural history, the study also finds that the change in the drawing practice and the theoretical interests were not simply an outcome of Postmodern cultural theory of the period, but were instigated by concerns that arose from within architecture itself. It thus offers a useful case-study on how changes in disciplinary practice are brought about.

The thesis focuses on problem of authorship of the Internet content. It considers the question whether we can analyze the artwork purely as a closed structure of the symbols or whether it is necessary to take work as a broader structure. The first part of the thesis shows the Internet in general and its specifics it as a medium. The second part is devoted to the problem of authorship. It explains traditional view of Nelson Goodman, who examined the authenticity of artwork with regard to the internal arrangement of the elements structure of the object. The third part shows the later theories inconsistent with the views of Nelson Goodman, views of different contemporary authors who present the changes of authorship aspects in the environment which is under constant development, quickly sharing ideas and resources. New theories suggest to look beyond the authorship of the artwork domain, apply broader focous. The conclusion provides a synthesis of these views.

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The main goal of this PhD dissertation is to explore the relation between postmodern poetics and some features of other theories developed at the same time in various areas of knowledge – mainly metaphysics, physics and sociology. If we can say that the modern paradigm was born with the question of how a multiplicity of different points of view could coexist, the postmodern paradigm seems to arise with the awareness that a systematic legitimation of differences cannot be based on a sole foundation that leads to a complete inclusion. For this reason, we argue that the concept of possible world is not only a useful heuristic metaphor adopted in different areas of the artistic and scientific postmodern culture, but it can put in constructive conversation different areas of knowledge which are usually thought to be more isolated and refractory to mutual influence than they actually are. Precisely because of the diverse usages and meanings that the term ‘world’ acquires in different contexts, the ontological commitment toward possible worlds varies significantly. They can be godly concepts, fictional scenarios, real sums of individuals that are isolated from each other, or ideal set of objects that are associated with different and mutually exclusive frames of reference and cultural coordinates. To shed a light on these matters is the main goal of the first book, entitled "What is a possible world?". The second book, entitled "Entangled worlds: the postmodernist literature", is committed to explore the topology of the possible worlds projected by postmodernist texts; in fact, the paradoxical topology that emerges from these texts appears to be inherently connected with a vast range of issues concerning our world.

Dans ce mémoire, je présente le réseautage de trois ouvrages textuels : Manières de faire des mondes du philosophe Nelson Goodman, A Brave New World du romancier et essayiste Aldous Huxley, et Envisioning Information du théoricien en design d'information Edward Tufte. Ce travail me sert de base théorique à la réalisation de mon projet de maîtrise qui consiste à réorganiser la structure d'une oeuvre de création littéraire de façon visuelle et spatiale. Pour ce faire, je recours à certains principes de visualisation de l'information relevant du design d'information. Le passage du roman en sa structure réorganisée se décline en quatre versions qui correspondent à l'exploration de formes artistiques distinctes : la base de données et le livre d'artiste, l'affiche et l'installation. Il en résulte la transformation du roman en une traduction expérimentale schématisée, dans une pratique se situant entre le design d'édition et le design d'information de recherche.

The thesis is interested in the problem of musical sign. In which ways can we speak about musical sign and which elements of musical material can become signs? These are the basic questions which we are interested in. This thesis is divided into three parts. The first part attends to the common theory of sign. The historical survey with the main ideas of philosophers and thinkers will be helpful to find out basic terms and problems of semiotics. In the second part of thesis we look at the historical reflection of musical sign in order to find out in which way it was treated with music and musical sign in each historical period of European music. In the third part we focus on musical semiotics, but we will consider some problems of musical aesthetics and musical psychology, too. In the end we make recapitulation of answers to the aforesaid questions.

Le réalisme pictural peut être conçu, par-delà la pensée ontologique dualiste, comme expérience perceptive cognitive du spectateur d’avoir l’impression de voir le « réel » dans une configuration imagée picturale. Cette impression de réel n’est pas illusoire, mais subjectivement factuelle, sans être nécessairement consciente. Elle pourrait résulter de la facilité perceptive ou de la fluidité opérationnelle du processus perceptif cognitif. Lorsque l’activité perceptive cognitive opérante dans l’expérience du réalisme pictural est régulée par la valence hédonique immanente à cette fluidité opérationnelle sous-jacente à l’impression de réel, cette expérience « subjective » peut être également « esthétique » pour cette autosuffisance fonctionnelle de la « conduite cognitive » du spectateur. Cependant, l’expérience du réalisme pictural comporte une dimension anthropo-transculutrelle, comme on peut le constater notamment dans les récits littéraires des spectateurs coréens du 18e siècle qui illustrent leurs expériences visuelles des peintures occidentales « illusionnistes » réalisées par des missionnaires jésuites à Pékin. La culture est néanmoins opérante dans l’expérience « esthétique » du réalisme pictural. Son effet est double. D’une part, la culture fonctionne comme une des variables de la fonction complexe de l’apprentissage perceptif qui pourrait modifier la dynamique du processus perceptif cognitif ainsi que l’attention perceptive visuelle. D’autre part, elle pourrait opérer un effet dans la valence hédonique globale en participant à la modélisation de l’« affect idéal » distingué de l’« affect effectif ». / The pictorial realism can be conceived, beyond ontological dualistic thought, as beholder’s perceptual cognitive experience to have the impression of seeing the “real” in a picture. This impression or feeling of real is not illusory, but subjectively factual, without being necessarily conscious. It may result from perceptual easiness or from perceptual cognitive processing fluency. When the perceptual cognitive activity working in the pictorial realism experience is regulated by hedonic valence immanent in this processing fluency that underlies the impression of real, this subjective experience can also be “aesthetic” by functional self-sufficiency of beholder’s “cognitive conduct”. However, the experience of pictorial realism contains an anthropo-transcultural dimension, as we can observe especially in the stories written by 18th century Korean beholders, which illustrate their visual experiences of the western “illusionist” paintings produced by jesuit missionary painters in Beijing. Nevertheless, the culture comes into play in the “esthetic experience” of pictorial realism. Its effect is double. On the one hand, the culture acts as one of the variables of the complexe function of perceptual learning which could make difference in the perceptual cognitive processing dynamics and in the visual or perceptual attention. On the other hand, the culture might influence the global state of hedonic valence by participating in the modeling of “ideal affect” distinguished from “actual affect”.