Перинатальный артериальный ишемический инсульт - это цереброваскулярное заболевание, возникающее между 20-й неделей беременности и 28-м послеродовым днем, вызывающее двигательный и немоторный дефицит, причем церебральный паралич является частым исходом. Молодой мозг реагирует, реорганизуя свои поврежденные сети в ипсилезионное и/или контральезионное полушария, причем последнее больше связано с двигательными нарушениями. Префронтальная кора считается одной из наиболее уязвимых областей с когнитивным дефицитом, возникающим с задержкой, из-за ее длительного развития, достигающего своего пика синаптогенеза после первого послеродового года, в то время как другие области, такие как первичная кора, обычно проходят свою основную фазу синаптогенеза в течение первого послеродового семестра. Таким образом, раннее обнаружение низкого синаптогенеза может быть ранним признаком настоящего или предстоящего дефицита и привести к раннему вмешательству. Бета-диапазон недавно был предложен в качестве возможного биомаркера синаптогенеза, причем активность ГАМК связана с нейропластичностью и синаптогенезом. Основной целью настоящего исследования является установление роли абсолютной бета-1 мощности в синаптогенезе и исследование уязвимости префронтальной коры головного мозга. Были набраны сорок типичных детей и 10 детей с перинатальным артериальным ишемическим инсультом в их подкорковой средней мозговой артерии и были созданы 3 возрастные подгруппы: 5-месячная, 10-месячная и 24-месячная подгруппы. Запись ЭЭГ и тест Бейли-III использовались для измерения их фоновой активности и уровня развития. Хотя статистический анализ с помощью непараметрических инструментов (U-тест Манна-Уитни, тест Крускалла Уоллиса) не показал решающих результатов, потенциальная связь бета-диапазона с синаптогенезом может быть обнаружена при наблюдении низкой мощности бета-1 в моторных и когнитивных областях мозга и низкой моторной и когнитивной производительности, а также при обнаружении заднего или переднего созревания. Кроме того, ранняя уязвимость префронтальной коры может быть обнаружена в снижении двусторонней бета-1 мощности у 24-месячных детей с перинатальным инсультом, по сравнению с типичными детьми и более ранними односторонними различиями, наряду с некоторыми когнитивными дефицитами, которые начинают проявляться в той же группе. / Perinatal Arterial Ischemic Stroke is a cerebrovascular disease occurring between the 20th gestational week and the 28th postnatal day, causing motor and non-motor deficits with cerebral palsy being a frequent outcome. The young brain reacts by reorganizing its injured networks to ipsilesional and/or contralesional hemisphere with the latter relating more to motor impairment. The Prefrontal Cortex is considered one of the most vulnerable areas with cognitive deficits emerging with a delay, due to its lengthy development reaching its synaptogenesis peak after the first postnatal year, while other areas, such as the Primary Cortices undergo generally their major synaptogenesis phase during the first postnatal semester. So early detection of low synaptogenesis could be an early mark of present or upcoming deficits and lead to an early intervention. Beta band has been recently suggested as a possible biomarker of synaptogenesis with GABA’s activity being connected with neuroplasticity and synaptogenesis. The main goal of the current study is to establish the role of of the absolute beta-1 power to synaptogenesis and the investigate the vulnerability of the Prefrontal Cortex. Fourty typical children and 10 children with Perinatal Arterial Ischemic Stroke in their subcortical Middle Cerebral Artery were recruited and were created 3 age subgroups; 5month, 10month and 24month subgroup. EEG recording and Bayley-III test were used to measure their background activity and developmental level. Although the statistical analysis via non-parametric tools (Mann-Whitney U-test, Kruskall Wallis test) didn’t show decisive results, a potential connection of beta-band with synaptogenesis could be detected when observing low beta-1 power in motor and cognitive brain areas and low motor and cognitive performance and also by detecting a posterior to anterior maturation. Moreover the early vulnerability of Prefrontal Cortex may be found in the decreased bilateral beta-1 power in the 24month children with perinatal stroke, when compared with the typical children and the earlier unilateral differences, along with some cognitive deficits which begin to emerge in the same group.

Evaluer, maintenir et restaurer les conditions écologiques des rivières nécessitent des mesures du fonctionnement de leurs écosystèmes. De par leur complexité, notre compréhension de ces systèmes est imparfaite. La prise en compte des incertitudes et variabilités liées à leur évaluation est donc indispensable à la prise de décision des gestionnaires. En analysant des données nationales (~ 1654 sites), les objectifs principaux de cette thèse étaient de (1) tester certaines hypothèses intrinsèques aux bio-indicateurs et (2) d'étudier les incertitudes de l'évaluation écologique associées à la variabilité temporelle des bio-indicateurs et à la prédiction des conditions de référence. (1) Ce travail met en évidence (i) le rôle prépondérant des facteurs environnementaux naturels dans la structuration des communautés aquatiques en comparaison des facteurs anthropiques (définis à l'échelle du bassin versant, du corridor riparien et du tronçon), (ii) les réponses contrastées des communautés aquatiques aux pressions humaines (dégradations hydro-morphologiques et de la qualité de l'eau) et (iii) plus généralement, les forts impacts des barrages et de l'altération de la qualité de l'eau sur les communautés aquatiques. (2) Une méthode Bayésienne a été développée pour estimer les incertitudes liées à la prédiction des conditions de référence d'un indice piscicole (IPR+). Les incertitudes prédictives de l'IPR+ dépendent du site considéré mais aucune tendance claire n'a été observée. Par comparaison, la variabilité temporelle de l'IPR+ est plus faible et semble augmenter avec l'intensité des perturbations anthropiques. Les résultats de ce travail confirment l'avantage d'indices multi-métriques basés sur des traits fonctionnels par rapport à ceux relatifs à la composition taxonomique. Les sensibilités différentes des macrophytes, poissons, diatomées et macro-invertébrés aux pressions humaines soulignent leur complémentarité pour l'évaluation des écosystèmes fluviaux. Néanmoins, de futures recherches sont nécessaires à une meilleure compréhension des effets d'interactions entre types de pressions et entre pressions humaines et environnement. / Sensitive biological measures of ecosystem quality are needed to assess, maintain or restore the ecological conditions of rivers. Since our understanding of these complex systems is imperfect, river management requires recognizing variability and uncertainty of bio-assessment for decision-making. Based on the analysis of national data sets (~ 1654 sites), the main goals of this work were (1) to test some of the assumptions that shape bio-indicators and (2) address the temporal variability and the uncertainty associated to prediction of reference conditions.(1) This thesis highlights (i) the predominant role of physiographic factors in shaping biological communities in comparison to human pressures (defined at catchment, riparian corridor and reach scales), (ii) the differences in the responses of biological indicators to the different types of human pressures (water quality, hydrological, morphological degradations) and (iii) more generally, the greatest biological impacts of water quality alterations and impoundments. (2) A Bayesian method was developed to estimate the uncertainty associated with reference condition predictions of a fish-based bio-indicator (IPR+). IPR+ predictive uncertainty was site-dependent but showed no clear trend related to the environmental gradient. By comparison, IPR+ temporal variability was lower and sensitive to an increase of human pressure intensity. This work confirmed the advantages of multi-metric indexes based on functional metrics in comparison to compositional metrics. The different sensitivities of macrophytes, fish, diatoms and macroinvertebrates to human pressures emphasize their complementarity in assessing river ecosystems. Nevertheless, future research is needed to better understand the effects of interactions between pressures and between pressures and the environment.

Geographical indications (GIs) are one form of protective labelling used to indicate the origin of food and alcohol products. The role of protected geographical indicators as a promising sustainable rural development tool is the basis for this research. The protection of geographical indications is a rather controversial subject and much research is still required for both sides of the debate. The research method employed for this study is qualitative critical social science. Two Case studies are used to investigate the benefits brought to rural areas through the protection of GIs. The case studies include the GIs Jersey Royal and Welsh Lamb both from the United Kingdom a member of the European Union (the EU is in favour of extended protection of GIs for all agro-food products under the 1994 WTO/TRIPS agreement on geographical indications). Twenty-five indepth interviews were conducted for this study the duration of the interviews was approximately one hour. The study identifies predominantly indirect links between GIs and sustainable rural development, through economic and social benefits bought to rural areas by the GIs investigated - less of a connection was found to ecological elements. No considerable cost for GI protection was discovered. This finding suggests that GIs are worthwhile for implementation in New Zealand as a rural development tool.

How might ‘the digital’ be conceived of in an ‘expanded field’ of art practice, where ontology is flattened such that it is not defined by a particular media? This text, together with an installation of art work at the Exhibition Research Lab, Liverpool John Moores University (13-24 March), constitutes the thesis submission as a whole, such that in the practice of ‘reading’ the thesis, each element remains differentiated from the other and makes no attempt to ‘represent’ the other. In negating representation, such practices present a ‘radical’ rethinking of the digital as a differentiated in-itself, one that is not defined solely by entrenched computational narratives derived from set theory. Rather, following Nelson Goodman’s nominalistic rejection of class constructs, ‘the digital’ is thus understood in onto-epistemic terms as being syntactically and semantically differentiated (Languages of Art 161). In the context of New Zealand Post-object Art practices of the late 1960s, as read through Jack Burnham’s systems thinking, such a digitally differentiated ontology is conceived of in terms of the how of practice, rather than what of objects (“Systems Aesthetics”). After Heidegger, such a practice is seen as an event of becoming realised by the method of formal indication, such that what is concealed is brought forth as a thing-in-itself (The Event; Phenomenological Interpretations 26). As articulated through the researcher’s own sculptural practice – itself indebted to Post-object Art – indication is developed as an intersubjective method applicable to both artists and audience. However, the constraints imposed on the thing-in-itself by the Husserlian phenomenological tradition are also taken as imposing correlational limitations on the ‘digital’, such that it is inherently an in-itself for-us and thus not differentiated in-itself. To resolve such Kantian dialectics, the thesis draws on metaphysical arguments put forward by contemporary speculative ontologies – in particular the work of Quentin Meillassoux and Tristan Garcia (After Finitude; Form and Object). Where these contemporary continental philosophies provide a means of releasing events from the contingency of human ‘reason’, the thesis argues for a practice of ‘un-reason’ in which indication is recognized as being contingent on speculation. Practice, it is argued, was never reason’s alone to determine. Instead, through the ‘radical’ method of speculative indication, practice is asserted as the event through which the differentiated digital is revealed as a thing-in-itself of itself and not for us.

Introduction : Le cancer de l’ovaire est le cancer gynécologique le plus fatal dans le monde et est associé à un fardeau économique considérable pour les systèmes de santé publique, les patients et leurs familles. Actuellement, la prévention de ce cancer passe par l’identification des facteurs de risque, dont l’inflammation. Le double rôle de l’inflammation dans la carcinogenèse (transformation néoplasique et stimulation de la croissance pour l’inflammation chronique, mais également l’inhibition de la croissance pour inflammation aiguë) a déjà été observé au 19ième siècle, par Rudolf Virchow et par l’allemand Bruns, respectivement. Plusieurs preuves suggèrent aussi que le cancer de l’ovaire pourrait être lié à l’inflammation chronique de l’épithélium ovarien d’où l’hypothèse selon laquelle les analgésiques ayant une action anti-inflammatoire comme les anti-inflammatoires non stéroïdiens (AINS) et l’acétaminophène pourraient prévenir le cancer de l’ovaire. Contrairement à l’inflammation chronique, un autre facteur intéressant qui pourrait jouer un rôle sur le cancer de l’ovaire par le biais d’une inflammation aiguë est la mastite puerpérale qui est la forme la plus courante de mastite. Cependant, la littérature existante, examinant l’usage des analgésiques (aspirine, AINS non aspirine et acétaminophène) et le risque de cancer ovarien, est incohérente avec des différences populationnelles (cohortes de naissance différentes) et méthodologiques : variations des définitions de l’utilisation régulière, des variables d’ajustement, mais aussi dans la prise en compte d’une possible causalité inverse. De plus, aucune étude n’a tenté d’évaluer l’association dépendante du temps entre l’utilisation régulière de ces médicaments et le risque de cancer ovarien. Pour la mastite puerpérale pendant l’allaitement, deux articles avaient évalué son association avec le risque de cancer épithélial de l’ovaire (CEO), mais avec des limites méthodologiques : violation de la positivité avec l’inclusion des femmes qui n’ont jamais eu de grossesse et sur-ajustement avec la durée d’allaitement qui est dans le chemin causal. Objectif : Cette thèse visait à atteindre deux objectifs généraux qui sont de fournir de nouvelles preuves concernant les associations entre : 1) l’utilisation régulière d’analgésiques et le risque de CEO ; 2) la mastite puerpérale et le risque de CEO. Méthode : Nous avons utilisé les données d’une étude cas-témoin populationnelle visant à documenter les facteurs pour la prévention du cancer de l’ovaire au Québec (Étude PROVAQ). Cette étude a été menée dans la grande région de Montréal, Canada, de mars 2011 à septembre 2016 avec 498 cas et 908 témoins. Notre approche méthodologique a été effectuée en trois étapes. Premièrement, nous avons utilisé l’ensemble des données de PROVAQ pour l’évaluation des associations entre l’utilisation régulière de types de médicaments analgésiques, et aussi selon l’indication et le risque de CEO. Deuxièmement, à partir des données de PROVAQ, nous avons évalué l’association dépendante du temps entre l’utilisation régulière d’un type de médicaments et le risque de CEO à l'aide d'un indice cumulatif pondéré flexible d'exposition dans des modèles de régression logistique conditionnelle. Enfin, nous avons évalué l’association entre la mastite puerpérale et le risque de CEO chez les femmes allaitantes (174 cas et 431 témoins). La régression logistique a été utilisée pour estimer ces associations. Résultats : Nos résultats suggèrent que l'utilisation régulière d’aspirine et d'AINS non aspirine était inversement associée au CEO avec des rapports de cotes (RC) ajustés de 0,81 (IC à 95 % : 0,57–1,12) et 0,74 (IC à 95 % : 0,54–1,00), respectivement. Pour l'utilisation régulière d'AINS non aspirine, les RCs ajustés des COX-2 non sélective et sélective étaient de 0,73 (IC à 95 % : 0,50–1,00) et de 0,83 (IC à 95 % : 0,48–1,40), respectivement. Des associations similaires ont été observées selon le niveau de durée cumulative à vie ou de quantité cumulative à vie de prises d’aspirine et d’AINS non aspirine. Cependant, les associations entre les types de médicaments analgésiques et le CEO peuvent différer selon leurs indications. Aucune association n’a été trouvée entre le moment de l'utilisation régulière d’un type de médicaments analgésiques au cours des 40 années précédant la date index et le CEO. Aucune association significative n’a été aussi trouvée entre la mastite puerpérale pendant l'allaitement et le CEO (RC = 1,15 ; IC à 95 % : 0,71–1,84). Conclusions : Cette thèse fournit des preuves qui appuient l'hypothèse selon laquelle l'utilisation régulière d'aspirine et d'AINS non aspirine sont inversement associées au CEO. Nos résultats suggèrent également l'importance de considérer les indications d'utilisation lors de l'examen des relations entre les types de médicaments analgésiques et le CEO. Elle n’a pas trouvé d'association entre le moment de l'utilisation régulière d’analgésiques et le CEO mais aussi entre la mastite puerpérale pendant l’allaitement et le CEO. Cependant, notre étude a manqué de puissance. / Introduction: Ovarian cancer is the most fatal gynecological cancer in the world and is associated with a considerable economic burden for public health systems, patients and their families. Currently, the prevention of this cancer requires the identification of risk factors including inflammation. The dual role of inflammation in carcinogenesis (neoplastic transformation and stimulation of cancer growth for chronic inflammation, but also inhibition of cancer growth for acute inflammation) has already been observed in the 19th century, by Rudolf Virchow and by the German Bruns, respectively. Several pieces of evidence also suggest that ovarian cancer could be linked to chronic inflammation of the ovarian epithelium, hence the hypothesis that analgesics with an anti-inflammatory action such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen could prevent ovarian cancer. Unlike chronic inflammation, another interesting factor that could play a role in ovarian cancer through acute inflammation is puerperal mastitis which is the most common form of mastitis. However, the existing literature examining the use of analgesics (aspirin, non-aspirin NSAIDs and acetaminophen) and the risk of ovarian cancer is inconsistent with population (different birth cohorts) and methodological differences: variations in definitions of regular use, adjustment variables but also in taking into account a possible reverse causality. In addition, no studies have attempted to assess the time-dependent association between regular use of these drugs and the risk of ovarian cancer. For puerperal mastitis during breastfeeding, two articles had assessed its association with the risk of epithelial ovarian cancer (EOC) but with methodological limitations: violation of positivity with the inclusion of women who never had of pregnancy and over-adjustment with the duration of breastfeeding which is in the causal path. Objective: This thesis aimed to achieve two general objectives which are to provide new evidence regarding the associations between: 1) the regular use of analgesics and the risk of EOC; 2) puerperal mastitis and the risk of EOC. Method: We used data from a population-based case-control study aimed at documenting factors for the prevention of ovarian cancer in Quebec (PROVAQ study). This study was conducted in the greater Montreal area, Canada, from March 2011 to September 2016 with 498 cases and 908 controls. Our methodological approach was carried out in three stages. First, we used the PROVAQ dataset to assess associations between regular use of analgesic drugs types, and also by indication and EOC risk. Second, from PROVAQ data, we evaluated the time-dependent association between regular use of a type of medication and the risk of EOC using a flexible weighted cumulative index of exposure in conditional logistic regression models. Finally, we evaluated the association between puerperal mastitis and the risk of EOC in lactating women (174 cases and 431 controls). Unconditional logistic regression was used to estimate associations between regular use of analgesic drugs types, puerperal mastitis during breastfeeding and EOC risk. Results: Our results suggest that regular use of aspirin and non-aspirin NSAIDs were inversely associated with EOC with adjusted ORs of 0.81 (95% CI: 0.57–1.12) and 0.74 (95% CI: 0.54–1.00), respectively. For regular non-aspirin NSAID use, the adjusted ORs for non-selective and selective COX-2 were 0.73 (95% CI: 0.50–1.00) and 0.83 (95% CI: 0.48–1.40), respectively. Similar associations were observed according to the level of lifetime cumulative duration or lifetime cumulative quantity of aspirin and non-aspirin NSAID. However, the associations between analgesic drug types and EOC may differ according to their indications. No association was found between the time of regular use of any type of analgesic medication in the 40 years prior to the index date and EOC. No significant association was also found between puerperal mastitis during breastfeeding and EOC (OR = 1.15; 95% CI: 0.71–1.84). Conclusions: This thesis provides evidence that supports the hypothesis that regular use of aspirin and non-aspirin NSAIDs are inversely associated with EOC. Our results also suggest the importance of considering indications for use when examining relationships between analgesic drug types and EOC. We found no association between the timing of regular analgesic use and EOC but also between puerperal mastitis during breastfeeding and EOC. However, our study was underpowered.

The therapeutic privilege is a defence in terms of which a doctor may withhold information from a patient if disclosure of such information could harm the patient. This study explores the defence of therapeutic privilege and provides a critical evaluation. A comparative investigation is undertaken, while arguments springing from a variety of disciplines are also incorporated. A number of submissions are made for limiting the ambit of the defence. The main submission is that the therapeutic privilege should comply with all the requirements of the defence of necessity. In addition, it should contain some of the safeguards afforded to the patient by the requirements of the defence of negotiorum gestio so that therapeutic privilege is out of the question if medical treatment is administered against the patient's will, or the doctor has reason to believe (or knows) that the patient will refuse to undergo an intended intervention once properly informed. / Jurisprudence / L.L.M. (Jurisprudence)

The topic of this work is the administration of medicine following a face-to-face and telephone madication-related orders at hospitals. The methods used in the theoretic part of this work included both discussions with representatives of health care providers and the analysis of documents. Based on the description and analysis of the set-up of verbal madication-related orders as featured in the accreditation standards of four healthcare accreditation organisations and internal rules of five hospitals, the author of this work seeks to identify any possible risk elements of verbal orders, and to propose ways how to modify such parts of standards and rules so as to make the verbal ordination less risky. Whether or not the verbal medication-related orders at hospitals is a lege artis procedur depends first of all on the situation in which the verbal order is issued, on the authorization or qualifications of health employees who are involved in the implementation of such verbal order, and on the strict observance of procedures concerning the communication (including its recording into the medical documentation). Although verbal madication-related order represents risk arising from the ordinance's communication, forensic, or specialist consequence, no greater attention has been paid to them so far. There...

Made available in DSpace on 2016-04-26T20:29:19Z (GMT). No. of bitstreams: 1 Sylvio do Amaral Rocha Filho.pdf: 1233618 bytes, checksum: 9fa8d06c34df8f3b347019f0be4931fb (MD5) Previous issue date: 2009-05-29 / Geographic Indications (GI s) do not have uniform treatment in the world-wide doctrine what is reflected in the diverse manifestations about it as demonstration of itself, therefore in each place the institute is treated as peculiar and unique. Even in only one country GI s have, many times, different treatments. We understand Law ex facto oritur jus (from the fact law is born) and from that, we create our agreement of what it is happening in the domain of the Geographical Indications. Geographical indication is a set of words that aims to transmit only one concept, but in fact, it apparently transmits two disconnected concepts that are not: 1 - Geographical indication is the official nomination of one certain place where a Good of the same name occurs and is typical, regional and peculiar with guarantee of origin and with traditional and recognized quality for the loyal, responsible and constant repetition. 2 - Geographic indication is the typical, regional and peculiar Good, with a certain name officially recognized as originating of a place, region or country, named differently but granting quality, reputation and characteristic recognized for the loyal, responsible and constant repetition. Geographic indication is for the target of this work the sort from which flows out the two types: Indication of Source (IS) and Appellation of Origin (AO). It must be noticed that in the same region or place the two types can coexist, that is, a same place can present Indication of Source and Appellation of Origin, depending. An Indication of Source is a local manifestation of more generic character; an Appellation of Origin is a local manifestation of very typical character and, consequently, more generous. Beyond these trouble makers factors there are others: the doctrine does not deal with and does not even mention the several internal classifications of quality that permeate a Geographical Indication and tint it; it insists only on the mention to Geographical Indication, Indication of Source and Appellation of Origin as if it was enough, without informing that almost always there is a proper qualitative internal system of each Geographical Indication, system that enlarges, accentuates or diminishes the classic divisions into Geographical Indication and its species Indication of Source and Appellation of Origin with which it always coexists, case by case / Indicações Geográficas (IG s) não têm tratamento uniforme na doutrina mundial o que se reflete nas diversas manifestações a respeito fazendo do tema uma demonstração de si mesmo, pois em cada lugar o instituto é tratado como peculiar e único. Mesmo dentro de um país as IG s têm, muitas vezes, tratamentos diferentes. Entendemos que em Direito ex facto oritur jus (do fato nasce o direito) e daí criamos nosso entendimento do que se passa no domínio das Indicações Geográficas. Indicação Geográfica é um conjunto de palavras que visa transmitir um só conceito, mas, na realidade, transmite dois conceitos aparentemente desconexos entre si, mas que não são: 1 - Indicação Geográfica é a nomeação oficial de um local certo em que se dá Bem do mesmo nome e que seja típico, regional e peculiar com garantia de procedência e com qualidade tradicional e reconhecida pela repetição leal, responsável e constante. 2 - Indicação Geográfica é o Bem típico, regional e peculiar, com nome certo e reconhecido oficialmente como originário de local, região ou país nomeado diferentemente, mas que lhe confere qualidade, reputação e característica reconhecida pela repetição leal, responsável e constante. Indicação Geográfica é para o escopo deste trabalho o gênero de que defluem as espécies Indicação de Procedência (IP) e Denominação de Origem (DO). Remarque-se que na mesma região ou local podem conviver os dois tipos, ou seja, um mesmo local pode apresentar IP s e DO s, dependendo. A IP é manifestação local de caráter mais genérico; a DO é manifestação local de caráter muito típico e, assim, mais generoso. Além destes fatores motivadores de confusão há mais outros: a doutrina não aborda sob nenhum prisma e nem sequer menciona as diversas classificações internas de qualidade que permeiam uma IG e dão-lhe matiz; insiste apenas na menção à IG, IP e DO, como se isto bastasse, sem avisar que quase sempre há sistema classificatório qualitativo interno e próprio de cada IG, sistema esse que expande ou acentua ou diminui as clássicas divisões em IG e suas espécies IP e DO com as quais sempre convive, caso a caso

Géant lusophone d’Amérique Latine et deuxième puissance agro-exportatrice mondiale, le Brésil est un pays émergent. Depuis les années 1990, de nouveaux outils de promotion de l’origine des produits agroalimentaires se développent à l’initiative du gouvernement et de la société civile. Leur foisonnement interroge les modes d’interprétation et d’appropriation de référentiels de normes internationaux et nationaux. En Europe, le lien à l’origine et l’ancrage territorial des produits locaux se sont forgés sur un temps assez long et confirment l’hypothèse de la construction sociale de la qualité. Pays du nouveau monde, la première image associée au Brésil est celle d’un pays dont la frontière agricole ne cesse d’avancer et donc a priori sans ancrage fort des populations à un territoire. Or la structure et les modes d’occupation de l’espace sont plus complexes. Ils résultent des traditions des différentes vagues d’immigration, de leur mode d’appropriation locale et de la construction d’identités spécifiques. La construction du lien à l’origine reflète l’insertion au marché international d’un pays qui, à l’heure actuelle, participe pleinement à une économie mondialisée. Aussi, la promotion de l’origine au Brésil réactualise-t-elle le regard porté sur l’agriculture brésilienne, dépassant le champ d’une agriculture d’exportation et interrogeant celui de l’économie locale et régionale. Au-delà des intérêts économiques liés à l’ouverture à l’export de marchés de niche, la revendication du local apparaît comme un indice de l’émergence d’un marché national enclin à protéger et promouvoir son patrimoine culturel et naturel ; un marché où le local fait sens pour des acteurs qui mobilisent l’origine. / Lusophone giant of Latin America and second world’s largest agricultural exporter, Brazil is an emerging country. Since the 1990s, new tools for promoting the origin of food products have been developed at the initiative of the government and civil society. Their profusion questions the interpretation and appropriation modes of international and national standards. In Europe, the origin-link and the territorial roots of local products were forged on long term and confirm the hypothesis of the social construction of quality. New World country, the first image associated to Brazil is a country where the agricultural frontier continues to move forward and therefore, a population without strong anchoring to a territory. However, the structure and modes of occupation of space are more complex. They result from the tradition of different waves of immigration, their mode of local appropriation and construction of specific identities. The construction of the origin-link also reflects the inclusion in the international market of a country that, at present, participates fully in the global economy. Thus, the promotion of origin in Brazil refreshes the perspective on Brazilian agriculture, beyond the scope of export agriculture and questioning the local and regional economy. Beyond economic interests related to the opening in the export of niche markets, the local claiming appears to be an indication of the emergence of a national market inclined to protect and promote its cultural and natural heritage; a market which makes sense for the local actors who promotes the concept of origin. / Gigante lusófono da América Latina e segunda potência agroexportadora mundial, o Brasil é um país emergente. Desde os anos 1990, novas ferramentas de promoção da origem dos produtos agroalimentares se desenvolvem por iniciativa do governo e da sociedade civil. A profusão de estratégias questiona os modos de interpretação e apropriação de modelos de normas internacionais e nacionais. Na Europa, a ligação com a origem e a inscrição territorial dos produtos locais construíram-se em um tempo bastante longo e confirmam a hipótese da construção social da qualidade. País do novo mundo, a primeira imagem associada ao Brasil é aquela de um país cuja fronteira agrícola continua avançando, condicionando a inexistência de uma ligação forte das populações a um território. No entanto, a estrutura e os modos de ocupação do espaço são muito mais complexos. Resultam das tradições formadas em diferentes ondas de imigração, dos modos de apropriação local do espaço e da construção de identidades específicas. A construção da ligação à origem reflete também a inserção no mercado internacional de um país que, atualmente, participa plenamente de uma economia mundial. Assim, a promoção da origem no Brasil reatualiza o olhar sobre a agricultura brasileira, indo além do âmbito de uma agricultura de exportação e questionando aquele da economia local e regional. Além dos interesses econômicos relacionados à abertura para exportação em mercados de nicho, a reinvindicação do local aparece como um indício da emergência de um mercado nacional propenso a proteger e promover seu patrimônio cultural e natural; um mercado onde o “local” faz sentido para os atores que mobilizam a noção de origem.

台灣早期係以農業為主的社會，加上位處亞熱帶，植物品種豐富，生長期長，稻作可一年三穫。又二十世紀初，台灣處於日治時期，製糖、樟腦、茶葉、稻米進入工業化生產時代，技術持續進步，產量也逐漸上升，奠定生產優良農產品的實力。另外一方面，台灣的花卉業也不容忽視，蝴蝶蘭的育種具有世界水準，而台灣與外界隔絕之海島地形，加上地處亞熱帶，具有豐富且特殊的生物基因資源，以上因素皆奠定台灣發展農業科技之基礎。 1980年代起，生物技術日益發達，基因轉殖或是基因改造的方法逐漸與傳統嫁接、配種等植物育種方法並行，隨著國際化的腳步、經濟的發展，農業技術的進步，植物新品種的培育愈來愈容易進行，且新品種樣態也愈來愈繁多。但另一方面，植物的流通日益複雜，熟悉育種技術者可由新品種植物種子、枝條、葉片等便於攜帶部位輕易繁殖，導致辛苦育成新品種的育種者心血結晶易被他人盜用，使育種人逐漸失去創造新品種之動力。為解決此問題，國際間有以植物新品種保護國際聯盟(UPOV)及與貿易相關之智慧財產權協定(TRIPS)規範之植物品種權及專利權制度保護育種者之智慧財產權，我國目前亦有植物品種及種苗法保護植物品種權，專利法則正在修法開放植物為專利標的。 然而，除了法律制度健全外，還需要有效的執行政策確保能實際達到立法目的，以植物相關智慧財產權法為例，需讓育種者了解自己有哪些權利、申請方式及行使方式，再遇到侵權事件時，能第一時間防止侵害、順利主張權利、請求賠償及去除侵害。再者，確保權利得以主張後，如何將此權利產業化、商品化以換取利益亦為重要課題。完成上述一連串政策後，才能順利達到提升產業、讓社會大眾享受到科技成果之目的。 由於農產品不同於電子或醫藥產業之產品可全球通行，依據不同地區有不同的主食及盛行作物，美國、中國、日本及歐洲等農村結構、農業技術、氣候及產品等亦大不相同，故國際間對於農業或植物相關智慧財產權之保護及商品化政策都因地制宜，不盡相同。 台灣的近鄰 --- 日本，有著與台灣類似的農村結構、飲食習慣及盛行作物，同時植物智財保護政策也對其高產值的精緻農業有所貢獻，例如日本特有的獨立行政法人植物種苗管理中心以及品種保護對策官(G-Men)制度，在行政上發揮有效的智慧財產管理作用。同時日本善用其地方文化結合農產品發展出地方特產、一村一特產等，提升國內外觀光潛力，使遊客聽到北海道即聯想到「夕張哈密瓜」、聽到京都即聯想到「宇治抹茶」，松坂市有「松阪牛」、青森有「青森蘋果」等等，以地名行銷農畜產品之方式相當成功。 綜上所述，本研究認為台灣在發展農業技術上之潛力不亞於日本，並期待「台灣」一詞有朝一日能在國際上代表「品質優良的農產品、水果、花卉及先進的農業技術」，使台灣之農產業能成為繼電子產業後另一項能在國際間發光之產業，故本研究以日本為研究對象，以植物相關智慧財產權政策之角度分析其精緻農業成功因素，並針對台灣之特色，提出因地制宜之政策變革方向。