Submitted by admin tede (tede@pucgoias.edu.br) on 2017-02-23T17:20:50Z No. of bitstreams: 1 KEILA CRISTINA FÉLIS.pdf: 1247728 bytes, checksum: 3c72be3ba99b9407d1bcf97679adc6b4 (MD5) / Made available in DSpace on 2017-02-23T17:20:50Z (GMT). No. of bitstreams: 1 KEILA CRISTINA FÉLIS.pdf: 1247728 bytes, checksum: 3c72be3ba99b9407d1bcf97679adc6b4 (MD5) Previous issue date: 2016-12-16 / This study aimed to understand the psychosocial effects of temporary infertility by stress in women. This is a descriptive cross-sectional study with qualitative and exploratory approach. The approach used in this study included conducting interviews with ten women who had proven diagnosis of temporary infertility by stress, the analysis of the interviews was based on the perspective of Grounded Theory. After transcription and subsequent analysis of the interviews, explanatory categories that emerged from the speeches of the interviewees were: No biological problems, undiagnosed; Impacts on social relationships; Impacts on the marital relationship; and the dream realized and future action. The results showed that the numbers of years of infertility treatment more positively also negatively influenced the lives of these women generating psychosocial stress. This study allowed the understanding of the psychosocial effects of temporary infertility by stress in women, which may contribute to work teams in developing strategies to support these, however there is the consistent data literature related to the subject, even in modern times whose infertility problem already set as a public health problem with increasing incidence in the world population. / O presente estudo objetivou compreender as repercussões psicossociais da infertilidade temporária por estresse em mulheres. Trata-se de um estudo transversal descritivo com abordagem qualitativa e exploratória. O procedimento metodológico utilizado nesse estudo compreendeu a realização de entrevistas com dez mulheres, que não apresentavam problema que impedisse a gestação mais tinham infertilidade temporária, a análise das entrevistas se baseou na perspectiva da Teoria Fundamentada nos Dados. Após a transcrição e posterior análise das entrevistas, as categorias explicativas que surgiram dos discursos das entrevistadas foram: sem problemas biológicos, sem diagnóstico; repercussões nas relações sociais; repercussões na relação conjugal; e o sonho realizado e providências futuras. Os resultados obtidos permitem concluir que os anos de tratamento de infertilidade influenciaram positivamente, mas também negativamente na vida dessas mulheres, gerando estresse psicossocial. Esse estudo permitiu a compreensão acerca das repercussões psicossociais da infertilidade temporária por estresse em mulheres, que pode contribuir para equipes de trabalho na elaboração de estratégias para o apoio a essas, entretanto não há na literatura dados consistentes relacionados ao tema, mesmo em tempos atuais cujo problema da infertilidade já se configura como um problema de saúde pública com crescente incidência na população mundial.

Ofrivillig barnlöshet är ett stort problem i Sverige idag och av kvinnor i barnafödande ålder är ca 1 av 10 drabbade. De flesta som lider av infertilitet använder sig av medicinsk hjälp som förstahandsmetod. Misslyckas man med den medicinska hjälpen går vissa par vidare med adoption direkt medan andra ser detta som en sista utväg. Adoptionsprocessen, som den oftast beskrivs i media, är en arbetsam process och upplevelsen av väntan är central. Tidigare forskning kring adoption fokuserar mest på adoptivbarns upplevelse. Tidsramen för att få adoptera ett barn innebär ofta en väntan på flera år. I studien belyses tankar och känslor som uppkommer under adoptionsprocessen hos par som önskar adoptera barn. Syftet med studien är att beskriva dessa pars upplevelse av infertilitet och adoptionsprocessen. Studien är en kvalitativ empirisk studie där datainsamlingsmetod är intervjuer och insamlat material analyserats med hjälp av kvalitativ innehållsanalys.I resultatet finner vi fyra huvudkategorier som lättnad, hoppfullhet, frustration och maktlöshet. Dessa huvudkategorier har svarat väl till vårt syfte. Abstract: Involuntary infertility is today a major problem in Sweden and 1 out of 10 women in childbearing age are affected. Most of them who suffer from infertility use medical help as their first choice. If the medical help fails, some couples directly move on to adoption while some see this as a last resort. The adoption progress, as it is commonly referred to in media, is a laborious procedure and the experience from the wait is central.Previous research on adoption focuses mainly at the experience of the adopted child. The timeframe to be granted an adoption often implies a wait of many years. Through our study we wish to highlight the thoughts and emotions that arise among the couples that wish to adopt a child during the adoption process. The purpose of our study is to describe the couples experience of infertility and adoption process. The study is a qualitative empirical study where data is collected using interviews and the collected material has been analyzed using a qualitative content analysis.We found four main categories as a result: relief, hopefulness, frustration and powerlessness. These main themes have matched our purpose well. / Program: Barnmorskeutbildning

Further studies were conducted to define an indispensable role of uterine bicarbonate secretion at pre-implantation for the success of blastocyst implantation. The in vitro implantation experiments showed that only when cultured in bicarbonate-containing medium, the blastocysts exhibited normal rate of attachment and outgrowth level. The forskolin-induced endometrial bicarbonate secretion measured by the Isc on pregnant day 4 was almost abolished by CA inhibitor acetazolamide. The efflux of intracellular bicarbonate, measured by intracellular pH-sensitive dye, was blocked by CFTR inhibitor, NPPB, and SLC26a6 inhibitor, DIDS, indicating their involvement in mediating uterine bicarbonate secretion. / In conclusion, the present findings have demonstrated an important role of CFTR in formation of optimal uterine fluid, in terms of both volume and composition, which is crucial for various reproductive events occurring in the uterus. Deviation from the normal uterine fluid composition and volume due to defects in CFTR function or abnormal regulation under pathological conditions, such as CF and genital bacteria infection, probably leads to infertility. The information obtained may provide insight into regulatory mechanism underlying fertility and infertility, as well as the rationale for development of treatment methods for female infertility and new strategies for female contraception. (Abstract shortened by UMI.) / The last part of the study was to demonstrate possible cause of infertility by disturbance of uterine fluid dynamic due to abnormal expression of CFTR using a model of uterine Chlamydia (C.) trachomatis infection, the most common infection-related sterility with the underlying cause unexplained. Uterine C. trachomatis infection induced up-regulated expression of CFTR with enhanced electrolyte and fluid transport as demonstrated by the increase in the cAMP-dependent Isc and uterine wet weight with obvious fluid accumulation in the lumen at diestrus stage, during which the endometrium normally undergoes a series of changes preparing for blastocyst implantation with minimum CFTR expression and uterine fluid volume. The abnormal uterine fluid accumulation upon uterine C. trachomatis infection significantly reduced implantation rate in uterine C. trachomatis infection mouse model. / The present study was aimed to elucidate the cellular and molecular mechanisms underlying the CFTR-related reproductive events in physiological and pathological conditions by using a variety of techniques, including RT-PCR, Western blot, intracellular and extracellular pH measurements, and the short-circuit current (Isc) measurement, in conjunction with mouse primary culture of endometrial cells and blastocyst, as well as several animal models including CF mouse, mouse uterine infectious model and overyectomized (OVX) mouse, etc. / We first examined dynamic changes in uterine bicarbonate secretion, as indicated by bicarbonate-dependent forskolin-induced Isc and epithelial surface pH measurement, and the expression profile of candidate genes and proteins known to be involved in bicarbonate secretion throughout the estrous cycle in mouse uterus. The results showed that the maximum mRNA and protein levels of CFTR, SLC26a6, carbonic anhydrase (CA)2 and CA12 were observed at proestrus stage and/or estrus stages. Luminal surface pH measured by 5-N-hexadecanoyl-aminofluorescein (HAF) showed that the basal endometrial epithelial surface pH at estrus stage was significantly higher than that in diestrus, which could be reduced significantly by CFTR inhibitor DPC, SLC26a6 inhibitor 4',4'-Diisothiocyanostilbene-2',2' Disulfonic Acid (DIDS) and CA suppressor acetazolamide. In the ovariectimized (OVX) mice and primary culture of endometrial cells, estrogen could induce up-regulation of CFTR, SLC26a6, CA2 and CA12 expression with corresponding increase in the bicarbonate-dependent Isc, suggesting a novel role of estrogen in regulating uterine bicarbonate secretion. / He, Qiong. / Source: Dissertation Abstracts International, Volume: 70-06, Section: B, page: 3247. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2008. / Includes bibliographical references (leaves 163-176). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese. / School code: 1307.

published_or_final_version / Nursing Studies / Master / Master of Nursing in Advanced Practice

Thesis (M.Sc. (Medical Sciences)) -- University of Limpopo, 2020 / Infertility affects nearly 186 million couples globally, with male factors contributing to half of the cases. Oxidative stress is an established cause of declining semen quality. Moringa oleifera has proven antioxidants. This study aimed to investigate in vitro effects of aqueous leaf extract of M. oleifera on human sperm functions. Semen samples from donors (n = 40) and patients (n = 30) were washed with HTF-bovine serum albumin (BSA), and then incubated with various concentrations of M. oleifera (0, 0.625, 6.25, 62.5, and 625 μg/ml) at 37°C for 1 hour. Sperm motility, vitality, mitochondrial membrane potential (MMP), reactive oxygen species (ROS), DNA fragmentation, capacitation, and acrosome reaction were assessed. Sperm motility, vitality, MMP, and capacitation were enhanced, while ROS production, and DNA fragmentation decreased after M. oleifera treatment. Uncapacitated spermatozoa increased significantly with a reduction in acrosome reaction in donors. M. oleifera antioxidant compounds suppressed excessive ROS, preserved mitochondrial membrane, DNA and acrosome integrity, while enhancing sperm motility and viability. / National Research Foundation (NRF)

<p>As a consequence of positioning women within the dominant gender role of motherhood, the inability to have a child has exposed women, and more notably women in Africa, to extreme social consequences that often violate their human rights and lead to socio-economic disempowerment. The aim of this study was to consider prevailing discursive construction that position women within dominant ideologies that engender motherhood for women, and to explore how women make sense of and construct meaning regarding their experience when they desire but are not able to have a child.</p>

Este trabalhou avaliou o stress e a ansiedade em 30 casais, que se submeteram à reprodução assistida no momento anterior à coleta dos óvulos e/ou espermatozóides, tendo um tempo de infertilidade que variou de 1 a 17 anos. Para avaliação da ansiedade foi aplicado o STAI-STATE TRAIT ANXIETY INVENTORY (STAI) e o Stress foi avaliado através do SCOPE-STRESS. No STAI foi acrescentada uma escala visual analógica para medir também a intensidade da ansiedade. A Ficha de Identificação avaliou questões como: idade, sexo, nacionalidade, profissão, ocupação, religião, grau de instrução, renda mensal, estado civil, tempo de casado e questões como: tempo de infertilidade, filhos naturais ou adotivos, profissionais implicados no tratamento, a existência de tentativas anteriores e os momentos de maior tensão emocional nas tentativas anteriores e a atual. Dentre os 36 sujeitos que já haviam feito tentativas anteriores de Reprodução Assistida, um dos três momentos de maior tensão emocional foi o de aguardar a gravidez. Dentre os 60 sujeitos, ou seja, todos os que estão na tentativa atual, aguardar a gravidez foi também um dos três momentos que geraram maior tensão. O diagnóstico de infertilidade foi misto em 33,3% dos casais, apenas feminino em 20% e apenas masculino em 46,7% dos casais. As mulheres apresentaram grau de ansiedade significantemente maior que os homens quanto às escalas Stai-Trait freqüência e intensidade e semelhantes quanto às escalas Stai-State freqüência e intensidade. Não houve diferença significante entre os escores médios dos homens e mulheres quanto às medidas descritivas do Scope-Stress. / This work evaluated stress and anxiety in 30 couples submitted to assisted reproduction, with an infertility period that ranged from 1 to 17 years, the moment just before the oocyte retrieval and/or semen sample. For anxiety evaluation the Stai-State Trait Anxiety Inventory (STAI) was applied, and stress was evaluated using the Scope-Stress. While applying STAI, a visual analogic scale was added to measure the intensity of anxiety. The identification form included information such as: age, gender, nationality, profession, occupation, religion, school level, monthly income, marital status, married time and issues such as: infertility period, existence of natural or adoptive children, professionals involved in infertility treatment, existence of previous attempts and the moments of major emotional stress during the previous attempts and during the present one. Among the 36 subjects submitted to previous attempts of Assisted Reproduction, one of the three moments of major emotional stress was the attendance of pregnancy confirmation. Among the all 60 subjects submitted to the present attempt, attendance of pregnancy confirmation also was one of the three moments of major emotional stress. Infertility diagnosis was mixed in 33,3% of the couples, exclusively feminine in 20% and exclusively masculine in 46,7% of the couples. Women presented a significantly higher anxiety degree than men, regarding the STAI-TRAIT scales of frequency and intensity and similar regarding the STAI-STATE scales of frequency and intensity. There was no significant difference between the mean scores of men and women regarding descriptive measures of the SCOPE-STRESS.

Ajonuma Louis Chukwuemeka. / "March 2004." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (p. 215-238). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

<p>As a consequence of positioning women within the dominant gender role of motherhood, the inability to have a child has exposed women, and more notably women in Africa, to extreme social consequences that often violate their human rights and lead to socio-economic disempowerment. The aim of this study was to consider prevailing discursive construction that position women within dominant ideologies that engender motherhood for women, and to explore how women make sense of and construct meaning regarding their experience when they desire but are not able to have a child.</p>

Submitted by Noeme Timbo (noeme.timbo@metodista.br) on 2018-01-04T18:48:22Z No. of bitstreams: 1 VictorZaia.pdf: 2047527 bytes, checksum: 7858d54d0ef6a892713e11b89f935efc (MD5) / Made available in DSpace on 2018-01-04T18:48:23Z (GMT). No. of bitstreams: 1 VictorZaia.pdf: 2047527 bytes, checksum: 7858d54d0ef6a892713e11b89f935efc (MD5) Previous issue date: 2017-11-07 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES / This study investigated whether and how Infertility Stress, Importance of Parenthood and resilience impacted on assisted reproductive treatment (ART) in infertile couples. 423 people participated in the research: 189 women, 183 men, mean age of 37 years, 72.1% first treatment of ART, 69.3% primary infertility, 64% sedentary life, 21.9% had aborted anteriorly, 71% had to make use of the in vitro fertilization technique. 49.3% of the participants believed they had over 60% chance of success in their treatment. To measure the variables, the instruments chosen were: Infertility Related-Stress Scale (IRSS); Importance of Parenthood in the Infertility Scale (IPIS) and Connor-Davidson Resilience Scale (CD-RISC 10) and treatment outcome measures in ART were verified. The main statistical analyzes indicated that the participants with the increased stress levels were: women, had more time of treatment in ART, lower monthly income, believed excessively in the success of the treatment; higher levels of importance of parenting were found in people who followed a religion and with a female’s infertility. Resilience has been positively associated with older people. Infertility Stress and Importance of Parenthood are positively correlated, and both are reverse with resilience. Furthermore, the importance of parenthood has been correlated to higher levels of displayed oocytes. The infertility stress, in intrapersonal domain, explains 6.5% of the variance of pregnancy, classifying 65% of cases correctly. The results indicate that women suffer more with infertility than men. When the cause of infertility is in both partners, adequate levels of importance of parenthood and scholastic level are protective factors for infertility stress. To believe excessively in the success of ART treatment and to follow a religion is not in itself negative. The ART outcome measures are altered by stress levels, which in turn is influenced by the resilience, which should be developed in individuals undergoing treatment for infertility. It is therefore necessary, a continuous focus on the emotional aspects of infertile patients, thus promoting the resilience, the reduction of stress levels, and the autonomy in the path chosen to have their children. Establishing protocols that measure levels of infertility stress, the importance of parenthood and resilience in patients receiving ART, would allow specific interventions that would lead to better adaptation to infertility and better outcomes measures in ART. / Este estudo investigou como e se o estresse, a importância da parentalidade e a resiliência impactaram no tratamento de infertilidade de casais. Participaram do estudo 423 pessoas, 189 mulheres e 183 homens, de média de idade de 37 anos, no primeiro tratamento em reprodução humana (72,1%), com infertilidade primária (69,3%), vida sedentária (64%) e histórico de aborto (21,9%) que iriam fazer fertilização in vitro (71%). Quase a metade deles (49,3%) acreditava possuir mais de 60% de chance de sucesso no tratamento que se iniciaria. Para avaliação das variáveis fez-se uso dos seguintes instrumentos: Infertility Related-Stress Scale (IRSS); Importance of Parenthood in Infertility Scale (IPIS) e Connor-Davidson Resilience Scale (CD-RISC 10), além de repostas ao tratamento de Reprodução Humana Assistida. Os principais resultados de análises estatísticas descritivas, correlacionais e de regressões logísticas indicaram que os participantes com maior estresse eram mulheres, tinham mais tempo de tratamento, menor renda e crença no sucesso do tratamento; maior importância da parentalidade em pessoas com alguma religião, causa feminina de infertilidade. A resiliência foi encontrada em maiores níveis em pessoas mais velhas. Estresse da infertilidade e importância da parentalidade se correlacionaram e ambas são inversas à resiliência. A importância da parentalidade também foi correlacionada a maiores níveis de oócitos visualizados. O estresse relatado da infertilidade, no domínio intrapessoal explica 6,5% da variância da gravidez, classificando 65% dos casos corretamente. Os resultados permitiram identificar que a mulher sofre maior impacto pela situação de infertilidade do que o homem. A causa de infertilidade em ambos os parceiros indica que melhor nível da importância da parentalidade e a escolaridade são fatores protetivos ao estresse. A crença no tratamento, apesar de supervalorizada, não é por si negativa, bem como o possuir alguma religião. Os resultados do tratamento podem ser modificados pelos níveis de estresse, que por sua vez são influenciados pela resiliência, a qual deveria ser trabalhada e ampliada nas pessoas em tratamento de infertilidade. É necessário, portanto, um olhar contínuo sobre os aspectos emocionais dos pacientes inférteis, de modo a favorecer a resiliência e a redução de estresse, de modo a possibilitar uma vivência de autonomia dessas pessoas na busca de terem o próprio filho. Para tanto, estabelecer protocolos de averiguação dos níveis de estresse, importância da parentalidade e resiliência, nos pacientes que iniciam o trajeto de reprodução humana, auxiliaria em intervenções mais específicas que favoreceriam melhor adaptação e melhores resultados no tratamento.