The overall aim of the study was to gain some understanding of the lived experience of the care-giving spouses regarding their experiences of the manifestations of the disease, perception of their own health, the possibility of influencing the interpretation of the past, the present and future, outlook on life, surrounding contacts and intimate relationships with their sick partners. The spouses (n=13) of Alzheimer victims were followed with the help of personal interviews, diaries and telephone interviews during a two-years period. The texts was analysed according to a phenomenological-hermeneutic method. The main findings in the study showed that the spouses own health remained quite stable over time. Their perception of the development of their own health seemed to be influenced by how they saw their power to influence their situation, which seemed to be determined by how they interpreted the cause of their health problems.The social network was another important factor for understanding the spouses' experiences. The findings imply that spouses' images of themselves in relation to others were important for their perception of the overall social network. The spouses mostly regarded their relationships positively and their social networks were described as quite stable over time. The spouse's marital relationships, in most cases, seemed to undergo changes with the progress of the disease. Some spouses could maintain feelings of love but mostly the relationships were transformed into ones of tenderness, pity and estrangement. The spouses' valuation of their demented partner was mostly in the form of one of two divergent perspectives. On the one hand, spouses who seemed to perceive their partner as a person separate from the disease, could function as complementary ego aids. On the other hand some spouses were unable to make a distinction between the spouse as a person and the disease.The spouses' experiences regarding their previous relationship with parents, value system, philosophy of life, competence and autonomy seemed to be critical in their experiences of their caring situation. It appears that there is a sub-group of vulnerable carers, as suggested by the concurrence of psychological, physical, and social morbidity, along with deterioration in their marital relationship.The findings are discussed in relation to searching for meaning, the importance of significant others, perceiving and valuing the other, and caring relationships within a life-span perspective. / digitalisering@umu

Women who have transitioned to a lesbian identity from a previously heterosexual one lack a voice in the academic literature. Identity formation in this subset of women, those who chose a heterosexual marriage, had children, and later in life self identify as lesbian, has not been fully investigated. For this project, eight women were asked to answer this question: How have you negotiated the path from heterosexuality to lesbianism? Four main themes were found dealing with heteronormativity and accountability, relationship with children, transition, and acceptance by the lesbian community. Additionally, I introduce a new term---gender-normativity---to describe these women who only after marrying, having children and raising those children, and going through a process of self-reflection, realized they wanted to make a transition and spend the rest of their lives in an intimate relationship with a woman.

Demographic researchers have identified a crossover pattern between the mortality rates of the Caucasian-American and African-American oldest-old (80+) populations for over a century. Debate has centered on whether the crossover effect is due to age misreporting or the heterogeneity hypothesis or if it continues beyond age 99. This thesis addresses these issues by using new data from the SSA’s study of supercentenarians. The study identified 355 persons aged 110 or older whose ages could be verified, creating the first reliable American dataset for this population group. Analysis of the data has indicated that mortality rates at ages 110-115 were significantly lower for African-American supercentenarians than for their Caucasian-American counterparts, and that the African-American proportion of the population increased steadily with age. The results of this analysis show that the crossover phenomenon is multicausal and cannot be fully accounted for by age misreporting, suggesting a need to consider genetic and environmental impacts on racial variations in maximum human longevity.

Syftet med denna studie är att undersöka skillnader mellan vad som motiverar olika åldersgrupper i arbetslivet. Studiens hypoteser bygger på tidigare forskning som visade att betydelsen av interna motivationsfaktorer ökar med ålder, samt att betydelsen av externa faktorer minskar. Studien genomfördes på en multinationell logistikorganisation i mars 2015 genom en kvantitativ enkätundersökning på 119 deltagare. Reliabilitetstest för studien visade på god reliabilitet för både externa faktorer (α=0,85) och interna faktorer (α=0,79). Korrelations- och variansanalyser genomfördes för att analysera data. En signifikansnivå på p=0,05 användes och resultatet visade att betydelsen av de externa faktorerna lön, karriärmöjligheter, status, beröm och auktoritet minskade med ökad ålder, samt att betydelsen av de interna faktorerna tillhörighet, egen prestation, flexibilitet, självständighet, intresse och utmaningar ökade med ålder. Samtliga nämnda motivationsfaktorer var signifikanta och hade en signifikansnivå mellan p=0,000 och p=0,019. Denna studie kastar därmed ljus på hur individers åldrande leder till att betydelsen av externa motivationsfaktorer förskjuts till en ökad betydelse av interna motivationsfaktorer.

The Canadian sport system is challenged by the lack of representation of female leaders and coaches. This is, in spite of statistics showing that female athletes account for almost half of all participants in sport, a number that is still growing (Sport Canada, 1999). Women have acquired equity in many areas of life and are accepted in leadership roles, however in the area of sport, women have yet to gain the full credibility and professional respect equal to their male counterparts. Previous research indicates that women who pursue a career in coaching face many adversities and struggle to attain a level of leadership where they can achieve their highest potential (Acosta & Carpenter, 2002). The purpose of this research is to gain an understanding of the lived experiences of elite female coaches, using Erikson’s (1950) theory of psychosocial development. In this study, the qualitative method of life history was used to learn about the experiences of female coaches, specifically the process of becoming and being elite coaches. Five elite Canadian coaches were interviewed. The major themes that developed through the analysis of the interviews were: (a) Support, (b) Overcoming Obstacles, (c) Personal Qualities and (d) The Bigger Picture. The study noted the importance of various support systems through one’s lifespan and some of the challenges a female athlete and coach must overcome to become a successful athlete, coach and mother. The study shares insight into the five women’s personal qualities that helped them grow into elite coaches. Finally, the participants described the process by which they came to find a leadership style with which they were comfortable, as coaches and as women.

Thesis (M. Soc. Sc.)--University of Hong Kong, 1997. / Includes bibliographical references (leaf 81-84).

Thesis (M. Soc. Sc.)--University of Hong Kong, 1997. / Includes bibliographical references (leaf 81-84). Also available in print.

Thesis (M.Soc.Sc. Psychology)--University of Waikato, 2006. / Includes bibliographical references (leaves 101-115) Also available via the World Wide Web.

O proteassomo é um complexo proteico responsável pela degradação de proteínas poli-ubiquitinadas. É constituído por uma unidade catalítica denominada de proteassomo 20S (20SPT) e por unidades regulatórias (19S) acopladas em uma ou ambas as extremidades para formar o proteassomo 26S. O 20SPT é capaz de degradar proteínas por um processo independente de ATP e ubiquitina. Este mecanismo é considerado preventivo de agregação proteica, uma vez que o acúmulo de proteínas oxidadas está diretamente associado ao envelhecimento e doenças neurodegenerativas. Foi observado pelo grupo que o 20SPT da levedura S.cerevisiae sofre S-glutatiolação nos resíduos de Cys 76 e Cys 221 da subunidade 5. Dados obtidos por microscopia eletrônica de transmissão mostraram que a S-glutatiolação promove a abertura da câmara catalítica e consequentemente o aumento da degradação de proteínas. Recentemente, foram obtidas linhagens com mutações sítio-específicas pela substituição dos dois resíduos de Cys glutatioláveis pela Ser. Ensaios realizados com a linhagem C221 mostraram um aumento da longevidade e resistência ao estresse oxidativo quando comparada com a linhagem selvagem, enquanto que a linhagem C76 mostrou uma dificuldade no crescimento. Foi verificado também que a população de proteassomo isolada da linhagem C221 apresenta maior proporção da forma aberta da câmara catalítica. Resultados opostos foram observados na linhagem C76S. No entanto, constatamos um aumento de proteínas oxidadas e de agregados proteicos na linhagem C221 em comparação a selvagem. Esses dados não condizem com o aumento do tempo de vida cronológico desta linhagem, porém acreditamos que esses agregados estejam relacionados a um tipo de sequestro de proteínas potencialmente prejudiciais, como será discutido neste trabalho. / The proteasome is a protein complex responsible for the degradation of poly-ubiquitinated proteins. It comprises a catalytic unit called 20S proteasome (20SPT) and regulatory units (19S) coupled at one or both ends to form the 26S proteasome. The 20SPT is able to degrade proteins by an ATP and ubiquitin independent process. This mechanism is considered preventive of protein aggregation, since the accumulation of oxidized proteins is directly related to aging and neurodegenerative diseases. It was observed by our group that the yeast 20SPT (S. cerevisiae) is modified by S-glutathiolation in the residues Cys 76 and Cys 221 of the 5 subunit. Data obtained by transmission electron microscopy showed that the S-glutathiolation promotes the opening of the catalytic chamber and consequently increased degradation of oxidized proteins. Recently, strains were obtained by site-specific mutations by replacing the two glutathiolable Cys residues by Ser. Tests performed with the C221 strain showed an increased longevity and resistance to oxidative stress when compared to the wild type strain, whereas the C76 strain showed a slower growth. It was also found that the isolated population of the 5-C221S proteasome presents the highest frequency of open catalytic chamber conformation. Opposite results were observed in the C76S lineage. However, we noted an increased pool of oxidized proteins and protein aggregates in the C221 strain compared to the wild type. These data do not match with the increase of chronological life span observed in this lineage, but we believe that these aggregates are related to a kind of \"sequestration\" of potentially damaging proteins, as will be discussed in this work.

This thesis has been an attempt to observe the role antibodies play in extending the life span of tumor infected Akr mice.