La décompensation cardiaque se manifeste par une symptomatologie de dyspnée et de fatigue, et par une diminution de l’aptitude aérobie. La décompensation cardiaque peut être globale ou gauche (DCG), ou droite comme dans le cas de l’hypertension artérielle pulmonaire (HTAP). Les mesures fonctionnelles de repos (fonction ventriculaire gauche ou pression artérielle pulmonaire moyenne) sont peu corrélées à l’aptitude aérobie, qui est cependant un élément important de la mise au point et du suivi clinique des patients atteints de DCG ou d’HTAP. <p>\ / Doctorat en Sciences de la motricité / info:eu-repo/semantics/nonPublished

Diplomová práce se zabývá problematikou zvyšování produktivity pomocí metody štíhlé výroby zvané Lean. V dnešní době je potřeba udržet si přízeň zákazníka a finanční prosperitu firmy. Právě štíhlá výroba se zaměřuje na spokojenost zákazníka a na zvýšení finančního přínosu firmě, tím, že se snaží odstranit plýtvání, která se vyskytují v procesu. Lean Six Sigma je metoda, která se zaměřuje na spokojenost zákazníka (Lean) a na zdokonalování procesů (Six Sigma). Jejím cílem je zvýšit kvalitu a zároveň snížit náklady a dobu dodání. První část diplomové práce se zabývá nástroji štíhlé výroby a detailně popisuje metody, které budou použity v praxi. V praktické části diplomové práce byly využity nástroje Lean Six Sigma především metoda DMAIC, která je označována za systematický přístup k řešení problémů. Skládá se z pěti částí: definování, měření, analýza, zlepšení a kontrola.

Submitted by Nadir Basilio (nadirsb@uninove.br) on 2018-06-19T16:11:19Z No. of bitstreams: 1 Natalia Pereira da Silva.pdf: 971997 bytes, checksum: 4c5816fd5b9a093d74b751b628111118 (MD5) / Made available in DSpace on 2018-06-19T16:11:19Z (GMT). No. of bitstreams: 1 Natalia Pereira da Silva.pdf: 971997 bytes, checksum: 4c5816fd5b9a093d74b751b628111118 (MD5) Previous issue date: 2016-02-03 / Background: Little is known about the functional cardiorespiratory capacity of children with Cerebral Palsy (CP). Many questions also arise regarding the modulation of the autonomic nervous system for different motor severity of them. Consolidating evaluative forms of functional capacity easily accessible and simple understanding for these children that are reliable and reproducible. Objective: Study 1: To investigate whether the six-minute walk test (6MWT) and walk test 10 meter (TC10m) are performed to assess functional capacity in children and adolescents with CP. Study 2: To investigate whether there are differences in autonomic modulation in different levels of motor severity in children with CP. Study 3: To investigate the reproducibility of the 6MWT and Shuttle Walk Test Incremental (SWTI) in children with CP in different levels System Functional Classification Engine Gross (GMFCS) I to III. Material and Methods: Study 1: This is a systematic review with meta-analysis. The survey was conducted until November 2015 in 5 databases: Pubmed, Pedro, Medline, Cochrane, CINAHL under results criteria in 6MWD and TC10m. Study 2: This is a cross-sectional study. Attended by 30 children with levels of GMFCS I to III. The Heart Rate (HR) and RR interval data were collected through a HR monitor (Polar RS800CX Polar, Finland). Children were instructed to remain lying in the supine position for 10 minutes then remained standing for 10 minutes. Study 3: This is a cross-sectional study. Each child held 2 times the same test (6MWT and SWTI) with an interval of 30 minutes between them. The reproducibility of both tests was tested for children with CP, GMFCS I to III. Results: Study 1: 39 studies met the criteria consistent with the objective of the systematic review. We conducted a meta-analysis of 5 studies, including three studies reported the 6MWT, only one is in favor of the experimental group (EG); and 2 to TC10m, both close in favor of GE. Study 2: There were no statistically significant differences (p> 0.05) on the parameters LF, HF and LF / HF ratio between different classifications of GMFCS. Study 3: The distance covered on the 1st and 2nd test, for both tests was not statistically significant (p = 0.63 for 6MWT and p = 0.39 for SWTI). Conclusion: Simple and valid tools are likely to become practice of professional conduct on behalf of individuals with CP. The autonomic modulation is not correlated with the severity of motor children with CP. Field tests: 6MWT and SWT are reproducible and reliable for this population. / Introdução: Pouco se conhece da capacidade funcional cardiorrespiratória de crianças com Paralisia Cerebral (PC). Muitas dúvidas também surgem a respeito da modulação do sistema nervoso autônomo para diferentes gravidades motoras das mesmas. Consolidar formas avaliativas da capacidade funcional de fácil acesso e simples entendimento para essas crianças, que sejam confiáveis e reprodutíveis. Objetivo: Estudo 1: Investigar se os testes de caminhada de seis minutos (TC6) e teste de caminhada de 10 metros (TC10m) são realizados para avaliação da capacidade funcional em crianças e adolescentes com PC. Estudo 2: Investigar se existem diferenças na modulação autonômica em diferentes níveis de gravidade motora em crianças com PC. Estudo 3: Investigar a reprodutibilidade do TC6 e Shuttle Walk Test Incremental (SWTI) em crianças com PC em diferentes níveis do System Classification Functional Motor Gross (GMFCS) I a III. Material e Métodos: Estudo 1: Trata-se de uma Revisão Sistemática com Metanálise. A pesquisa foi realizada até novembro de 2015 em 5 bases de dados: Pubmed, Pedro, Medline, Cochrane, CINAHL sob critérios de resultados em distância percorrida no TC6 e TC10m. Estudo 2: Trata-se de um estudo transversal. Participaram 30 crianças com níveis do GMFCS I a III. A Frequência Cardíaca (FC) e os dados de intervalos RR foram coletados por meio de um monitor de FC (Polar RS800CX Polar, Finlândia). As crianças foram instruídas a permanecerem deitadas em posição supina durante 10 minutos, em seguida, permanecerem em pé durante 10 minutos. Estudo 3: Trata-se de um estudo transversal. Cada criança realizou 2 vezes o mesmo teste (TC6 e SWTI) com intervalo de 30 minutos entre eles. A reprodutibilidade de ambos os testes foi testada para crianças com PC, GMFCS I a III. Resultados: Estudo 1: 39 estudos apresentaram critérios compatíveis com o objetivo da revisão sistemática. Realizou-se a metanálise de 5 estudos, dentre eles 3 estudos se reportaram ao TC6, apenas 1 sendo favorável ao grupo experimental (GE); e 2 ao TC10m, ambos próximos a favor do GE. Estudo 2: Não houve diferenças estatísticas significativas (p>0,05) nos parâmetros LF, HF e de relação LF/HF entre classificações diferentes do GMFCS. Estudo 3: A distância percorrida no 1º e 2º teste, para ambos os testes, não foi estatisticamente significativa (p=0,63 para TC6 e p=0,39 para SWTI). Conclusão: Ferramentas simples e válidas podem vir a tornar-se prática da conduta profissional em prol dos indivíduos com PC. A modulação autonômica não está correlacionada com a gravidade motora das crianças com PC. Os testes de campo: TC6 e SWT são reprodutíveis e confiáveis para esta população.

The focus of this study is on South Africa's transition to democracy. It is argued in this thesis, that an analysis of the transition to democracy in South Africa and the transformation of the con ict that prevailed in this divided society could generate new avenues for theorising about transitions to democracy in divided societies amidst con ict. The aim with this thesis is to contribute towards a more comprehensive understanding of the complex nature of the process of transition to democracy, and the relevant theory involved, particularly with regard to transitions in divided societies. One consequence of the deep divisions within South African society has been the increase in violence, which followed liberalisation. The transition to democracy in South Africa, as a result, was characterised by continuing and escalating violence. In South Africa, the authoritarian regime deteriorated mainly because of internal factors, but external factors also played an important role. The analysis of the transition has been guided by the hypothesis that the democratisation of South Africa was accomplished through a compromise that was negotiated between the major political actors and which re ected the intra-, as well as the inter-dynamics in the domains of, state - political society - civil society. Thus, the main theme of this thesis is, that in the analysis of the dynamics of the tran- sition to democracy in South Africa, a basic framework in which the domains of, state - political society - civil society, are the domains where structural variables (such as culture, economic development, class structures, increased education and the international environ- ment) and behavioural variables (such as major political actors, elite factions, organisations from civil society) interact. Thus, in the diachronic analysis of South Africa's transition, an interactive approach, that seeks to relate structural constraints to the shaping of contingent choice, is followed. At the same time, the institutional substitution of a new democratic political dispensation is examined. In conclusion, democracies are complex phenomena, and they are caused by many di er- ent forces and synthesizing the relevant theoretical approaches to political change provides a more cogent and comprehensive explanation of democratic transition in South Africa. / (D. Litt. et Phil. (International Politics))

Title: Neuro Biomechanical principles in robot-assisted gait training for pediatric patients Background: There is a lack of data on how robot-assisted gait training (RAGT) contributes to gait changes in children with cerebral palsy (CP). Methods: This research study investigated efficacy of a 4-week RAGT intervention in twelve ambulatory spastic diparesis children with CP (10.8±2.6 years old; 2 girls and 10 boys; Gross Motor Function Classification System I-III) by using computerized gait analysis (CGA); passive joint range of motion (PROM); selective control assessment of lower limbs evaluation (SCALE), and the six-minute walk test (6MWT). Pre-post RAGT intervention data of children with CP was compared with the normative data curves of typically developing children by cross-correlation, and further statistically evaluated by a Wilcoxon test. Results: Significant pre-post RAGT intervention differences (p<0.05) that indicate more physiological gait comparing to the normative data curves were found. Biceps femoris, rectus femoris, and tibialis anterior decreased activity almost across all gait cycle phases. Medial gastrocnemius decreased activity mainly in terminal stance, mid-swing, and terminal swing phases. Internal hip rotations and foot progress angles decreased almost across all gait cycle...

The aim of master´s thesis is analysis of utilization of large-capacity battery energy storage systems, used in cooperation with facility Červený mlýn to supply ancillary services to ČEPS, a.s.. In the first part, categorisation of ancillary services is presented. Within the categorisation technical and legislative requirements on subjects providing individual services are defined, the overview of ancillary services providers is listed and the mechanisms of ancillary services procurement are elucidated. The thesis continues with an overview of accumulation technologies used in high-capacity application around the world and in Czech republic. Subsequently three technologies are presented – Li-Ion, NaS and VRB, which are considered as suitable technological solutions for given application. The last part of thesis deals with specification of parameters of the accumulation system, with selection of installation site within the facility and with description of operating modes while providing ancillary services. In order to evaluate the investment from an economic point of view, a model of sensitivity analysis is created and described and its outputs are presented and discussed at the end of the thesis.

The theoretical part of this master’s thesis introduces to the reader problems of production management tools, and optimization of the manufacturing process. It explains basic concepts, principles and methods that has aim to clarify systems and methods used in the practical part to the reader. The practical part describes the implementation of these methods and optimization of specific part of the manufacturing process. The result of optimization is evaluated from the perspective of time and finance.

This dissertation deals with analysis and follow-up suggestion of efficiency improvement on the production line in DAIKIN DEVICE CZECH REPUBLIC Ltd. Mentioned steps are performed with the help of production philosophy called Lean production or TPS (Toyota Production System) and production procedures like Just in Time, Jidoka and Kaizen. The target of this work is to find out and eliminate inefficiencies of manufacturing process, design an improvement project (saving cost, safeness, reduction of working positions etc.). Perform evaluation of this project and suggest testing procedure for follow-up improvement in the future.

Introduction : Le Test de Marche de 6 Minutes (6MWT) est le test le plus utilisé chez les patients atteints de cancer, évaluant la capacité fonctionnelle, tout en demeurant simple, sécuritaire et standardisé. Toutefois, aucune équation actuelle ne peut prédire la consommation maximale d’oxygène ("V" ̇O2 max) chez les survivants de cancer. Ainsi, l’objectif principal est de valider une équation spécifique pour prédire le "V" ̇O2 max à partir du 6MWT, alors que le second est de valider une équation spécifique pour prédire la distance de marche (6MWD) à partir du 6MWT. Méthodes : Au total, 250 survivants d’au moins cinq ans de la leucémie lymphoblastique aigüe (LLA) (n=80 femmes (48%); n=88 hommes (52%)) avec un âge moyen de 22 ans (22.2 ± 6.3) ont été recrutés. Parmi ceux-ci, 168 survivants ont réalisé un 6MWT ainsi qu’un test d’effort maximal sur ergocycle pour évaluer respectivement leur capacité fonctionnelle et leur fonction cardiorespiratoire. Une évaluation de leur pratique d’activités physiques a été réalisée par questionnaire. Les survivants ont ensuite été randomisés en deux groupes : le premier (n=118 (70%)) pour créer les équations et le deuxième groupe (n=50 (30%)) pour valider les équations créées. Des régressions linéaires multiples ont été réalisées pour prédire chacune des équations ("V" ̇O2 max et 6MWD) à partir du 6MWT. Les variables incluses dans les équations comprenaient l’âge, le poids, la taille, la fréquence cardiaque à la fin du test (FCfin), la distance de marche effectuée (6MWD), le niveau de la pratique d’activités physiques (MVLPA), la perception d’effort (EPE) ainsi que la durée des traitements (DT). La méthode de Bland et Altman a été utilisée pour valider chacune des équations en déterminant les différences moyennes et en comparant nos équations avec des équations de références. Résultats : Équation spécifique "V" ̇O2 max (différence moyenne = 2.51mL.kg-1.min-1) = (-0,236 * âge(années)) - (0,094 * poids(kg)) - (0,120 * FCfin(bpm)) + (0,067 * 6MWD(mètres)) + (0,065 * MVLPA(min/jour)) - (0,204 * DT(années)) + 25,145 ; R2=0.61. Équation spécifique 6MWD (différence moyenne = 10.86 mètres) = (3,948 * taille(cm)) - (1,223 * poids(kg)) + (1,913 * FCfin(bpm)) - (6,863 * EPE(/10)) + (0,556 * MVLPA(min/jour)) - 242,241 ; R2=0.36. Conclusion : Il s’agit de la première étude qui prédit le "V" ̇O2 max et la 6MWD en utilisant des variables cliniques et spécifiques des survivants de LLA. Nos résultats permettent d’évaluer la capacité cardiorespiratoire des survivants de LLA et facilitera leur suivi. / Introduction: In cancer patients, the 6-Minute Walking Test (6MWT) is the most widely used test because it can assess the functional capacity in patients, while remaining simple, safe and standardized. However, it is reported that the actual equations cannot accurately predict a valid "V" ̇O2 peak value or a 6-minute walk distance (6MWD) in cancer survivors. Thus, the first aim is to validate a specific equation using the 6MWT to predict "V" ̇O2peak, while the second is to validate a specific equation to predict walk distance during 6MWT. Methods: A total of 250 childhood acute lymphoblastic leukemia (ALL) survivors were enrolled in this study, among which 168 participants aged 22 years on average (22.2 ± 6.3) (n=80 females (48%); n=88 males (52%)) underwent a cardiopulmonary exercise test (CPET) and a 6MWT to assess their functional capacity and their cardiorespiratory fitness. Additionally, participants completed a physical activity questionnaire. Participants were randomly divided in two groups to create (n=118 (70%)) and to validate (n=50 (30%)) the equations. Multiple linear regression analyses were used to determine a new prediction equation for "V" ̇O2 peak and 6MWD from 6MWT. The validity in between the measured and predicted "V" ̇O2 peak and between the measured and predicted 6MWD was assessed using the Bland and Altman method. Results: Specific "V" ̇O2 peak equation (mean of bias=2.51mL.kg-1.min-1) = (-0.236*age(years)) - (0.094*weight(kg)) - (0.120*HR end(bpm)) + (0.067*6MWD(meters)) + (0.065*MVLPA(min/day)) - (0.204*DT(years)) + 25.145. Specific 6MWD equation (mean of bias=10.86meters) = (3.948*height(cm)) - (1.223*weight(kg)) + (1.913*HR end(bpm)) - (6.863*RPE) + (0.556*MVLPA(min/day)) - 242.241 Conclusion: This is the first study that predicted "V" ̇O2 peak and 6MWD using clinical and specific variables related to the disease from a 6MWT in childhood ALL survivors. It refines an already available tool that will strengthen an objective evaluation of the patient.

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